SCHEDULE 14A
                                 (Rule 14a-101)

                            SCHEDULE 14A INFORMATION
Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934
                                (Amendment No. )

Filed  by  the  Registrant                          [x]
Filed  by  a  Party  other  than  the  Registrant   [ ]

Check  the  appropriate  box:

[ ]  Preliminary  Proxy  Statement
[ ]  Confidential, for  Use  of  the Commission  Only  (as  permitted  by Rule
     14a-6(e)(2))
[ ]  Definitive  Proxy  Statement
[x]  Definitive  Additional  Materials
[ ]  Soliciting  Material  Pursuant  to  14a-12

                                 EXELIXIS, INC.
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               (Name  of  Registrant  as  Specified  in  Its  Charter)

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     (Name  of  Person(s)  Filing  Proxy Statement if other than the Registrant)

Payment  of  Filing  Fee  (Check  the  appropriate  box)

[x]  No  fee  required.
[ ]  Fee  computed  on  table below per Exchange Act Rules 14a-6(i)(4) and 0-11.

     (1)  Title  of  each  class  of  securities  to  which transaction applies:

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     (2)  Aggregate  number  of  securities  to  which  transaction  applies:

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     (3)  Per  unit  price  or  other  underlying  value of transaction computed
     pursuant  to  Exchange  Act  Rule  0-11  (Set forth the amount on which the
     filing  fee  is  calculated  and  state  how  it  was  determined):

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     (4)  Proposed  maximum  aggregate  value  of  transaction:

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     (5)  Total  fee  paid:

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[ ]  Fee  paid  previously  with  preliminary  materials:

[ ]  Check box if any part of the fee is offset as provided by Exchange Act Rule
     0-11(a)(2) and identify the filing for which the offsetting fee was paid
     previously. Identify the previous filing by registration statement number,
     or the Form or Schedule and the date of its filing.

     (1)  Amount  Previously Paid:

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     (2)  Form,  Schedule  or  Registration  Statement  No.:

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     (3)  Filing  Party:

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     (4)  Date  Filed:

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                                 EXELIXIS, INC.
                    PROXY SOLICITED BY THE BOARD OF DIRECTORS
                     FOR THE ANNUAL MEETING OF STOCKHOLDERS

                          TO BE HELD ON JUNE 16, 2003

     The  undersigned  hereby  appoints  George A. Scangos and Glen Y. Sato, and
each  of  them,  as attorneys and proxies of the undersigned, with full power of
substitution,  to  vote  all  of the shares of stock of Exelixis, Inc. which the
undersigned  may  be entitled to vote at the 2003 Annual Meeting of Stockholders
of Exelixis, Inc. to be held at the Company's offices located at 170 Harbor Way,
South  San  Francisco,  California  94080 on Monday, June 16, 2003 at 8:00 a.m.,
local  time,  and  at  any and all postponements, continuations and adjournments
thereof,  with  all  powers  that  the  undersigned  would possess if personally
present, upon and in respect of the following matters and in accordance with the
following  instructions,  with  discretionary  authority as to any and all other
matters  that  may  properly  come  before  the  meeting.

     UNLESS  A CONTRARY DIRECTION IS INDICATED, THIS PROXY WILL BE VOTED FOR ALL
NOMINEES  LISTED IN PROPOSAL 1 AND FOR PROPOSAL 2 AS MORE SPECIFICALLY DESCRIBED
IN  THE PROXY STATEMENT. IF SPECIFIC INSTRUCTIONS ARE INDICATED, THIS PROXY WILL
BE  VOTED  IN  ACCORDANCE  THEREWITH.

    DO NOT RETURN YOUR PROXY CARD IF YOU ARE VOTING BY TELEPHONE OR INTERNET.


                            (Continued on other side)



     MANAGEMENT RECOMMENDS A VOTE FOR ALL THE NOMINEES NAMED IN PROPOSAL 1.

PROPOSAL  1: To elect two Class I directors to hold office until the 2006 Annual
Meeting  of  Stockholders.

[ ] FOR all nominees listed below (except as marked to the contrary below)

[ ] WITHHOLD AUTHORITY to vote for all nominees listed below.

Nominees:   01  Charles  Cohen,  Ph.D.  and  02  Geoffrey  Duyk,  M.D.,  Ph.D.

To withhold authority to vote for any nominee(s) write such nominee(s) name(s)
below:

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                  MANAGEMENT RECOMMENDS A VOTE FOR PROPOSAL 2.

PROPOSAL 2: To ratify the selection of Ernst & Young LLP as independent auditors
            of Exelixis, Inc. for its fiscal year ended December 31, 2003.

         [ ]   For          [ ]   Against          [ ]   Abstain



Date
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                                             SIGNATURE(S)
                                   Please  sign  exactly  as  your  name appears
                                   hereon.  If  the  stock  is registered in the
                                   names  of  two  or  more persons, each should
                                   sign.  Executors,  administrators,  trustees,
                                   guardians  and  attorneys-in-fact  should add
                                   their  titles.  If a signer is a corporation,
                                   please  give  full  corporate name and have a
                                   duly  authorized  officer sign stating title.
                                   If  a partnership, please sign in partnership
                                   name  by  authorized  person.



Please vote, date and promptly return this proxy in the enclosed return envelope
which  is  postage  prepaid  if  mailed  in  the  United  States.