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     UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549

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                                    FORM 8-K
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                                 CURRENT REPORT
     PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934

       DATE OF REPORT (DATE OF EARLIEST EVENT REPORTED): October 28, 2002

      EXELIXIS, INC. (Exact name of registrant as specified in its charter)
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                DELAWARE                               0-30235                      04-3257395
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(State or other jurisdiction of incorporation)  (Commission File No.)  (I.R.S. Employer Identification No.)


                                 170 Harbor Way
                                  P.O. Box 511
                          South San Francisco, CA 94083
          (Address of principal executive offices, including zip code)
                                  (650) 837-7000
              (Registrant's telephone number, including area code)

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ITEM  5.  OTHER  EVENTS

On October 28, 2002, Exelixis, Inc. ("Exelixis") and GlaxoSmithKline plc ("GSK")
announced  the  formation  of  a  broad  alliance  to  discover,  develop  and
commercialize  novel therapeutics in the areas of vascular biology, inflammatory
disease  and  oncology.  The  alliance  combines Exelixis' powerful gene-to-drug
discovery  platform  and  GSK's strength in development and commercialization by
means  of  an  innovative  model  for  sharing  risks and potential rewards in a
research  and  development  collaboration.  GSK  will make an upfront payment of
$30.0  million  to  Exelixis.  GSK will also initially acquire two million newly
issued  shares  of  Exelixis  common  stock  at $7 per share, which represents a
premium  of  approximately  100%  to  the  current stock price. Exelixis has the
option to sell GSK additional shares at a specified time in the future. Over the
initial  six years of the agreement, GSK will provide Exelixis with a minimum of
$90.0 million in development funding. A copy of the press release announcing the
alliance  is  attached  hereto  as  Exhibit  99.1  and is incorporated herein by
reference.

ITEM  7.  FINANCIAL  STATEMENTS  AND  EXHIBITS

(c) Exhibits

EXHIBIT
NUMBER       DESCRIPTION
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99.1         EXELIXIS AND GLAXOSMITHKLINE FORM BROAD ALLIANCE TO DISCOVER AND
             DEVELOP NOVEL THERAPEUTICS

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                                    SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, as amended,
the registrant has duly caused this report to be signed on its behalf by the
undersigned, thereunto duly authorized.

Dated: October 28, 2002

                                 Exelixis,  Inc.

                                 /s/ Glen Y. Sato
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                                 Glen Y. Sato
                                 Chief Financial Officer, Vice President,
                                 Legal  Affairs  and Secretary
                                (Principal  Financial  and  Accounting  Officer)
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