Prepared by MERRILL CORPORATION
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As filed with the Securities and Exchange Commission on July 9, 2001.

Registration No. 333-    



SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549


FORM S-4

REGISTRATION STATEMENT

UNDER

THE SECURITIES ACT OF 1933


APPLERA CORPORATION

(Exact Name of Registrant as Specified in Its Charter)

Delaware   3826   06-1534213
(State or Other Jurisdiction of
Incorporation or Organization)
  (Primary Standard Industrial
Classification Code Number)
  (I.R.S. Employer
Identification Number)

301 Merritt 7
Norwalk, Connecticut 06851-1070
(203) 840-2000

(Address, Including Zip Code, and Telephone Number, Including
Area Code, of Registrant's Principal Executive Offices)

William B. Sawch, Esq.
Senior Vice President and General Counsel
Applera Corporation
301 Merritt 7
Norwalk, Connecticut 06851-1070
(203) 840-2000

(Name, Address, Including Zip Code, and Telephone Number, Including Area Code, of Agent For Service)


Copies to:

Richard Capelouto, Esq.   Ora T. Fisher, Esq.
Simpson Thacher & Bartlett   Latham & Watkins
3330 Hillview Avenue   135 Commonwealth Drive
Palo Alto, California 94304   Menlo Park, California 94025
(650) 251-5000   (650) 328-4600

   Approximate date of commencement of proposed sale to the public: As soon as practicable after the effective time of the merger of a wholly owned subsidiary of the registrant with Axys Pharmaceuticals, Inc., which shall occur as soon as practicable after the effective date of this registration statement and the satisfaction of all conditions to the closing of such merger.


   If the securities being registered on this form are to be offered in connection with the formation of a holding company and there is compliance with General Instruction G, check the following box. / /

   If this form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. / /

   If this form is a post-effective amendment filed pursuant to Rule 462(d) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. / /


CALCULATION OF REGISTRATION FEE


Title of each Class of
Securities to be Registered

  Amount to be
Registered(1)

  Proposed Maximum
Offering Price
Per Share

  Proposed Maximum
Aggregate
Offering Price

  Amount of
Registration Fee(2)


Applera Corporation—Celera Genomics Group Common Stock, par value $0.01 per share (including the rights associated with those shares pursuant to Applera Corporation's Stockholder Protection Rights Agreement)(3)   6,910,674 shares   Not applicable   $249,000,207   $62,250.05

(1)
Represents the maximum number of shares of Applera Corporation—Celera Genomics Group Common Stock, par value $0.01 per share ("Celera Genomics common stock"), including the rights associated with those shares pursuant to Applera Corporation's Stockholder Protection Rights Agreement, issuable upon consummation of the merger based upon a maximum exchange ratio of 0.1355 shares of Celera Genomics common stock to be exchanged for (a) each share of common stock, par value $.001 per share, of Axys Pharmaceuticals, Inc., that would be outstanding if all Axys Pharmaceuticals, Inc. stock options and warrants outstanding on June 12, 2001 were exercised, and all Axys Pharmaceuticals, Inc. 8% Senior Secured Convertible Notes due 2004 outstanding on June 12, 2001 were converted and (b) each share of Axys Pharmaceuticals, Inc. common stock that could be issued upon the exercise of stock options granted by Axys Pharmaceuticals, Inc. to employees hired after June 12, 2001, but before the effective time of the merger.

(2)
Pursuant to Rules 457(f) and 457(c) under the Securities Act, the fee was calculated on the basis of $36.0313 per share, the average of the high and low sales prices for shares of Celera Genomics common stock on the New York Stock Exchange (NYSE: CRA) on July 6, 2001.

(3)
Includes associated rights to purchase 1/1000th of a share of Applera Corporation's Series B participating junior preferred stock. Until the occurrence of certain prescribed events, the rights are not exercisable, are evidenced by the certificates representing Celera Genomics common stock and will be transferred only with such shares of Celera Genomics common stock.



   The Registrant hereby amends this Registration Statement on such date or dates as may be necessary to delay its effective date until the Registrant shall file a further amendment which specifically states that this Registration Statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933, as amended, or until this Registration Statement shall become effective on such date as the Securities and Exchange Commission, acting pursuant to said Section 8(a), may determine.




[Axys Pharmaceuticals, Inc. Letterhead]

Axys Pharmaceuticals, Inc.
180 Kimball Way
South San Francisco, California 94080

[           ], 2001

Dear Stockholder:

    You are cordially invited to attend our special meeting of stockholders on [            ], 2001, at 10:00 a.m., Pacific Time, at Axys' headquarters located at 180 Kimball Way, South San Francisco, California 94080.

    At the special meeting, we will ask you to vote on the merger of Axys and Applera Corporation. In the merger, you will receive shares of Applera Corporation—Celera Genomics Group Common Stock (NYSE: CRA). Applera conducts its business through two groups: the Celera Genomics group and the Applied Biosystems group. The Celera Genomics common stock that you will receive in the merger is a class of stock of Applera that is intended to reflect the relative performance of the Celera Genomics group. The exact number of shares of Celera Genomics common stock that you will receive will be determined by an exchange ratio that is described in more detail in the enclosed proxy statement/prospectus. The exchange ratio is calculated based on the average closing price of Celera Genomics common stock over the 10 trading days immediately preceding (but excluding) the second trading day prior to the closing of the merger. If the merger had closed at the time the merger agreement was signed, for each of your shares of Axys common stock you would have received a fractional share of Celera Genomics common stock having an average closing price during the calculation period equivalent to $4.65 per share of Axys common stock. We urge you to obtain current market quotations for Celera Genomics common stock and Axys common stock prior to making any decision with respect to the merger. We expect that the merger will be tax-free to you for United States federal income tax purposes, except for cash received in place of fractional shares.

    We cannot complete the merger unless holders of a majority of the outstanding shares of Axys common stock vote for the approval and adoption of the merger agreement. Only stockholders who hold shares of Axys common stock at the close of business on [            ], 2001 will be entitled to vote at the special meeting.

    The enclosed proxy statement/prospectus gives you detailed information about the proposed merger and includes the merger agreement as an annex. We encourage you to read carefully the proxy statement/prospectus, including its annexes. You should also consider the matters discussed under "Risk Factors" on page 22 of the accompanying proxy statement/prospectus before voting.

    After careful consideration, the Axys board of directors has unanimously approved the merger agreement, has unanimously determined that the merger is advisable and fair to you and in your best interests and unanimously recommends that you vote "FOR" the approval and adoption of the merger agreement and the approval of the merger.

    Your vote is very important. Whether or not you plan to attend the special meeting, please complete, sign and date the enclosed proxy card and return it in the enclosed prepaid envelope. If you attend the special meeting, you may revoke your proxy and vote in person if you wish, even if you have previously returned your proxy card. Your prompt cooperation will be greatly appreciated.



Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved the merger described in the accompanying proxy statement/prospectus or the Celera Genomics common stock to be issued in connection with the merger, or determined if the accompanying proxy statement/prospectus is accurate or adequate. Any representation to the contrary is a criminal offense.


    This proxy statement/prospectus is dated [            ], 2001, and is first being mailed to the stockholders of Axys Pharmaceuticals, Inc. on or about [            ], 2001.


AXYS PHARMACEUTICALS, INC.

NOTICE OF SPECIAL MEETING OF STOCKHOLDERS
TO BE HELD ON [            ], 2001

    A special meeting of stockholders of Axys Pharmaceuticals, Inc. will be held at Axys' headquarters located at 180 Kimball Way, South San Francisco, California 94080 on [            ], 2001 at 10:00 a.m. Pacific Time, to consider and vote on the following matters described in the accompanying proxy statement/prospectus:

    The board of directors of Axys has fixed the close of business on [            ], 2001 as the record date for the determination of stockholders entitled to receive notice of and to vote at the special meeting. A list of the stockholders entitled to vote will be open to the examination of stockholders at the offices of Axys at 180 Kimball Way, South San Francisco, California 94080, during ordinary business hours for 10 days prior to the date of the meeting.

    Axys cannot complete the merger unless the holders of a majority of the outstanding shares of Axys common stock vote to adopt the merger agreement. Holders of Axys common stock will not have appraisal rights under Delaware law in connection with the merger.

    The board of directors of Axys has unanimously approved the merger agreement and the merger and recommends that you vote FOR approval and adoption of the merger agreement and approval of the merger. The proposal is described in more detail in the accompanying proxy statement/prospectus, which you should read in its entirety before voting. A copy of the merger agreement is attached as Annex A to the accompanying proxy statement/prospectus.

South San Francisco, California
[            ], 2001

Your Vote Is Important!

    To be sure your shares are represented at the meeting, please complete, date, sign and return your proxy card in the enclosed postage-paid envelope as soon as possible. You may vote in person at the meeting even if you send in your proxy card.



REFERENCE TO ADDITIONAL INFORMATION

    This proxy statement/prospectus "incorporates by reference" important business and financial information about Applera that is not included or delivered with this proxy statement/prospectus. You may obtain documents incorporated by reference in this proxy statement/prospectus without charge by requesting them in writing or by telephone from Applera at the following address:

    If you would like to request any documents, please do so by [            ], 2001 in order to receive them before the special meeting.

    For a more detailed description of the information incorporated by reference by Applera into this proxy statement/prospectus and how you may obtain it, see "Where You Can Find More Information" on page 141.



TABLE OF CONTENTS

 
  Page
QUESTIONS AND ANSWERS ABOUT THE MERGER   1

SUMMARY OF THE PROXY STATEMENT/PROSPECTUS

 

6

SELECTED HISTORICAL CONSOLIDATED AND COMBINED FINANCIAL INFORMATION AND SELECTED UNAUDITED PRO FORMA CONSOLIDATED FINANCIAL INFORMATION

 

12
  Applera Selected Historical Consolidated Financial Information   12
  Celera Genomics Group Selected Historical Combined Financial Information   14
  Selected Unaudited Pro Forma Consolidated Financial Information of Applera and Axys   15
  Selected Unaudited Pro Forma Combined Financial Information of the Celera Genomics Group and Axys   16

SELECTED HISTORICAL CONSOLIDATED FINANCIAL INFORMATION OF AXYS

 

17

COMPARATIVE PER SHARE INFORMATION (UNAUDITED)

 

18

COMPARATIVE PER SHARE MARKET PRICE AND DIVIDEND INFORMATION

 

20

RISK FACTORS

 

22
  Risks Related to the Merger   22
  Risks Related to the Celera Genomics Group   23
  Risks Related to a Capital Structure with Two Separate Classes of Common Stock   31
  Risks Related to Axys   37

THE SPECIAL MEETING

 

46
  Date, Time and Place   46
  Purpose of the Special Meeting   46
  Record Date; Stock Entitled to Vote   46
  Quorum   46
  Vote Required   46
  Share Ownership of Management and Others   47
  Voting of Proxies   47
  Revoking Proxies   47
  Proxy Solicitation   47

THE MERGER

 

49
  Background of the Merger   49
  Reasons of Axys for the Merger   52
  Recommendation of the Axys Board of Directors   53
  Reasons of Applera for the Merger   54
  Opinion of the Financial Advisor to the Axys Board of Directors   54
  Structure of the Merger   60
  Closing Matters   60
  Consideration to Be Received in the Merger   60
  Treatment of Axys Stock Options   61
  Exchange of Certificates in the Merger   62
  Fractional Shares   62
  Effect on Axys Convertible Notes and Warrants   62
  Representations and Warranties   63
  Covenants   64

i


  Conditions to the Merger   68
  Stock Exchange Listings   69
  Regulatory Approvals Required   69
  Termination of the Merger Agreement   69
  Amendment and Waiver of the Merger Agreement   71
  Expenses   71
  Effect on Employee Benefits and Related Agreements   72
  Material United States Federal Income Tax Consequences   72
  Accounting Treatment   74
  Interests of Certain Persons in the Merger   74
  Resale of Celera Genomics Common Stock   78
  Dissenters' Rights   79

INFORMATION ABOUT AXYS

 

80

MANAGEMENT OF AXYS

 

103

INFORMATION ABOUT APPLERA AND ANGEL ACQUISITION

 

113
  Applera   113
  Management Following the Acquisition   113

UNAUDITED PRO FORMA CONDENSED CONSOLIDATED AND COMBINED FINANCIAL STATEMENTS

 

114

DESCRIPTION OF APPLERA CAPITAL STOCK

 

124
  General   124
  Celera Genomics Common Stock   124
  Celera Genomics Designated Shares   132
  Applied Biosystems Common Stock   132
  Rights Agreement   133

COMPARISON OF STOCKHOLDER RIGHTS

 

136

EXPERTS

 

140

LEGAL OPINIONS

 

140

SUBMISSION OF STOCKHOLDER PROPOSALS

 

140

SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS

 

140

WHERE YOU CAN FIND MORE INFORMATION

 

141

INDEX TO FINANCIAL STATEMENTS OF AXYS PHARMACEUTICALS, INC.

 

F-1

REPORT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS

 

F-2

ANNEXES

Annex A  Agreement and Plan of Merger

Annex B  Opinion of JPMorgan H&Q

ii




QUESTIONS AND ANSWERS ABOUT THE MERGER

Q:   What am I being asked to vote upon?

A:

 

You are being asked to vote to approve and adopt the merger agreement entered into between Axys and Applera and to approve the merger contemplated by the merger agreement. In the merger, a wholly owned subsidiary of Applera will be merged with and into Axys. After the merger is completed, Axys, which will be the company surviving the merger, will be a wholly owned subsidiary of Applera. After the merger, the operations of Axys will be integrated into the research and development and business operations of the Celera Genomics group of Applera, which is one of the two operating groups through which Applera conducts its business.

Q:

 

Why is Axys proposing to merge?

A:

 

Since its inception, Axys has been focused on developing a state-of-the-art drug discovery platform that integrates "best-of-breed" technologies in both high throughput screening as well as in structure-based drug design. Axys believes that the effectiveness of this platform in bringing optimized leads to clinical development has been demonstrated in its partnerships with Merck, Bayer and Aventis. To more fully take advantage of the potential of these technologies as well as the expertise of Axys' scientific teams, Axys has determined that it needs a source of new therapeutic targets. The delivery of potential targets for drug discovery has been at the core of the work of the Celera Genomics group in the human genome, and in its future plans for proteomics. Axys believes that the integrated genomic, proteomic, bioinformatic and computing platforms of the Celera Genomics group can be expected to yield targets that can be evaluated and selected in an effort to develop breakthrough drugs that work by interacting with the targets in novel ways. Hence, Axys believes that Axys and the Celera Genomics group have complementary strengths which are expected to enable the combined company to move forward more quickly and effectively in the research and development of innovative small molecule therapeutics. In addition, holders of Axys common stock will have the opportunity to participate in a larger and better capitalized organization and to benefit from potential appreciation in Celera Genomics common stock. For a more detailed discussion of why Axys is proposing to merge, see "The Merger—Background of the Merger" and "The Merger—Reasons of Axys for the Merger" in this proxy statement/prospectus.

Q:

 

Why is the Axys board of directors recommending that I vote for adoption of the merger agreement?

A:

 

In reaching its decision to approve the merger agreement and the merger and to recommend approval and adoption of the merger agreement and approval of the merger by the Axys stockholders, the Axys board of directors consulted with Axys management, as well as Axys' financial and legal advisors, and considered the terms of the merger agreement and the transactions contemplated by the merger agreement. In addition, the Axys board of directors unanimously approved the merger agreement and the merger, and believes that the terms of the merger agreement and the merger are fair to, and in the best interests of, Axys and its stockholders.

Q:

 

What will I receive in the merger for my shares of Axys common stock?

A:

 

If the merger is completed, you will receive shares of Applera Corporation—Celera Genomics Group Common Stock (NYSE: CRA) (which we refer to in this proxy statement/prospectus as Celera Genomics common stock) in exchange for your shares of Axys common stock. Celera Genomics common stock is a "tracking stock" issued by Applera that is designed to reflect the performance of the business conducted by the Celera Genomics group.

1



 

 

 

 

 

The exact number of shares of Celera Genomics common stock that you will receive will be determined by an exchange ratio that will fluctuate with the market price of Celera Genomics common stock and be subject to a version of a mechanism commonly referred to as a "collar" that reduces your exposure to losses and gains from market price fluctuation within certain market price ranges. The exchange ratio is calculated based on the average closing price of Celera Genomics common stock over the 10 trading days immediately preceding (but excluding) the second trading trading day prior to the closing of the merger. The actual number of shares of Celera Genomics common stock that you will receive in exchange for your shares of Axys common stock will be calculated at the time of the closing of the merger. If the closing had occurred at the time the merger agreement was signed, for each of your shares of Axys common stock you would have received a fractional share of Celera Genomics common stock having an average closing price during the calculation period equivalent to $4.65 per share of Axys common stock.

 

 

The exchange ratio will be determined at the time of the merger as follows:

 

 


 

if the 10-day average closing price of a share of Celera Genomics common stock immediately preceding (but excluding) the second trading day prior to the closing date of the merger is equal to or greater than $45.77 and less than or equal to $48.23, the fraction will be 0.1016 shares, or $4.65 divided by $45.77, the 10-day average closing price of a share of Celera Genomics common stock immediately preceding (but excluding) the second trading day prior to the signing of the merger agreement;

 

 


 

if the 10-day average closing price of a share of Celera Genomics common stock immediately preceding (but excluding) the second trading day prior to the closing date of the merger is greater than $48.23 and less than or equal to $60.29, the fraction will be $4.90 divided by this 10-day average closing price;

 

 


 

if the 10-day average closing price of a share of Celera Genomics common stock immediately preceding (but excluding) the second trading day prior to the closing date of the merger is greater than $60.29, the fraction will be fixed at 0.0813 shares;

 

 


 

if the 10-day average closing price of a share of Celera Genomics common stock immediately preceding (but excluding) the second trading day prior to the closing date of the merger is less than $45.77 and greater than or equal to $34.33, the fraction will be $4.65 divided by this 10-day average closing price; and

 

 


 

if the 10-day average closing price of a share of Celera Genomics common stock immediately preceding (but excluding) the second trading day prior to the closing date of the merger is less than $34.33, the fraction will be fixed at 0.1355 shares.

 

 

If the closing of the merger were to have occurred on [            ], 2001, each issued and outstanding share of Axys common stock would have been exchanged for [      ] shares of Celera Genomics common stock. Therefore, if the closing of the merger were to have occurred on [            ], 2001, for each of your shares of Axys common stock you would have received Celera Genomics common stock having an average closing price during the calculation period equivalent to $[      ] per share of Axys common stock, and the total consideration paid to all holders of Axys common stock would have been Celera Genomics common stock with a total price of $[      ] million, based on its average closing price during the calculation period.

2



Q:

 

What is a "tracking stock"?

A:

 

Celera Genomics common stock is a "tracking stock" which is issued by Applera and is intended to reflect the relative performance of the Celera Genomics group. It is listed on the New York Stock Exchange under the ticker symbol "CRA." If the merger is completed, the business of Axys will be conducted as part of the Celera Genomics group.

 

 

A "tracking stock" is a class of stock of a corporation designed to "track" the performance of a specific business within the larger corporation. Although holders of a "tracking stock" are equity holders of the larger corporation, "tracking stock" is intended to reflect or "track" the performance of a group of assets or division within the larger corporation. Investors commonly refer to this type of common stock as "tracking stock," "targeted stock" or "letter stock."

 

 

Applera conducts its business through two operating groups: the Celera Genomics group and the Applied Biosystems group. Applera Corporation—Applied Biosystems Group Common Stock (NYSE: ABI) (which we refer to in this proxy statement/prospectus as Applied Biosystems common stock) is a "tracking stock" intended to reflect the relative performance of the Applied Biosystems group of Applera. The Applied Biosystems group and the Celera Genomics group are not separate legal entities, and holders of these stocks are stockholders of a single company, Applera. This means that the assets Applera attributes to one group could be subject to the liabilities of the other group. Holders of Celera Genomics common stock will be subject to all of the risks relating to an investment in Applera, including the Applied Biosystems group. For more information about "tracking stock," see "Risk Factors—Risks Related to a Capital Structure with Two Separate Classes of Common Stock" in this proxy statement/prospectus.

Q:

 

Will I be able to sell the shares of Celera Genomics common stock I receive in the merger?

A:

 

Yes. All stockholders of Axys, other than those deemed to be affiliated or controlling stockholders, will generally be free to sell their shares of Celera Genomics common stock received in the merger. Affiliates of Axys will be able to sell their shares of Celera Genomics common stock within the limits permitted by Rule 145 under the Securities Act.

Q:

 

What will happen to options to purchase shares of Axys common stock?

A:

 

Each option to purchase Axys common stock outstanding at the time of the merger will be assumed by Applera and converted into an option to purchase shares of Celera Genomics common stock. The option will be exercisable for a number of shares of Celera Genomics common stock equal to the number of shares of Axys common stock subject to the option multiplied by the exchange ratio (rounded down to the nearest whole share) and the exercise price per share will equal the existing option exercise price divided by the exchange ratio (rounded up to the nearest whole cent). However, in no event will the option exercise price for stock options held by Axys employees and consultants be higher than the closing price of a share of Celera Genomics common stock on the date immediately prior to the closing of the merger.

Q:

 

What if the merger is not completed?

A:

 

If the merger is not completed, Axys will continue to operate as an independent company, and neither Applera nor Axys will be under any obligation to purchase your Axys common stock. Axys may be required to pay a termination fee if the merger is not completed for certain reasons described under "The Merger—Termination of the Merger Agreement—Termination Fee" in this proxy statement/prospectus.

3



Q:

 

What are the tax consequences of the merger to stockholders?

A:

 

Holders of Axys common stock who exchange their shares of Axys common stock solely for shares of Celera Genomics common stock pursuant to the merger will not recognize any gain or loss on the exchange for United States federal income tax purposes, except with respect to cash, if any, received instead of fractional share interests of Celera Genomics common stock. The merger will not have any tax consequences for Applera stockholders. To review the tax consequences to stockholders in greater detail, see "Material United States Federal Income Tax Consequences" in this proxy statement/prospectus.

Q:

 

What tax basis will holders of Axys common stock have in the Celera Genomics common stock they receive in the merger?

A:

 

Your tax basis in your shares of Celera Genomics common stock will equal your current tax basis in your Axys common stock reduced by the amount of basis allocable to fractional shares for which you receive a cash payment.

Q:

 

Will Applera stockholders receive any shares as a result of the merger?

A:

 

No. Applera stockholders will continue to hold the Applera shares they currently own.

Q:

 

Does Applera currently own any shares of Axys common stock?

A:

 

No. Applera is not an Axys stockholder.

Q:

 

Where can I get information regarding Applera, Axys and the merger?

A:

 

We urge you to read and consider the information contained in this proxy statement/prospectus, including its annexes. You should also review the additional documents related to Applera referenced under "Where You Can Find More Information" in this proxy statement/prospectus.

Q:

 

Who may vote at the special meeting?

A:

 

All Axys stockholders of record as of the close of business on [            ], 2001 may vote. You are entitled to one vote per share of Axys common stock that you own on the record date.

Q:

 

How do I vote?

A:

 

After carefully reading and considering the information contained in, or incorporated by reference in, this proxy statement/prospectus, please complete and sign your proxy and return it in the enclosed return envelope as soon as possible so that your shares may be represented at the special meeting. If you sign and send in your proxy and do not indicate how you want to vote, we will count your proxy as a vote in favor of approval and adoption of the merger agreement and approval of the merger. If you abstain from voting or do not vote your shares by proxy or in person, it will have the same effect as a vote against approval and adoption of the merger agreement and approval of the merger.

 

 

The special meeting will be held at Axys' headquarters located at 180 Kimball Way, South San Francisco, California 94080 on [            ], 2001 at 10:00 a.m. Pacific Time. You may attend the special meeting and vote your shares in person, rather than signing and mailing your proxy.

Q:

 

If my shares are held in a brokerage account or in "street name" by my broker, how do I vote?

A:

 

Your broker will vote your shares only if you provide instructions on how to vote. You should follow the directions provided by your broker on how to instruct your broker to vote your shares. If you do not instruct your broker, your shares will not be voted, which will have the same effect as a vote against adoption of the merger agreement.

4



Q:

 

Can I change my vote after I have mailed my proxy card?

A:

 

Yes. You can change your vote at any time before your proxy is voted at Axys' special meeting. You can do this in one of three ways. First, you can send a written notice to the Secretary of Axys, William J. Newell, stating that you would like to revoke your proxy. Second, you can complete and submit a new proxy card by following the instructions on the proxy card. Third, you can attend Axys' special meeting and vote in person.

Q:

 

Should I send in my stock certificates now?

A:

 

No. After the merger is completed, you will receive written instructions for exchanging your stock certificates. Please do not send in your stock certificates with your proxy.

Q:

 

When do you expect the merger to be completed?

A:

 

We are working to complete the merger as quickly as possible. We expect the merger to be completed in [      ] of 2001. The merger agreement requires that the merger be completed by December 31, 2001.

Q:

 

Who can help answer my questions?

A:

 

If you have more questions about the merger or need assistance in voting your shares, you should contact:

 

 

MacKenzie Partners, Inc.
156 Fifth Avenue
New York, New York 10010
212-929-5500 or 1-800-322-2885

5



SUMMARY OF THE PROXY STATEMENT/PROSPECTUS

    We are sending this proxy statement/prospectus to holders of Axys common stock. This summary highlights selected information from this proxy statement/prospectus and may not contain all the information that is important to you. To better understand the merger, you should read this entire document carefully, including the agreement and plan of merger attached as Annex A, the opinion of JPMorgan H&Q, a division of J.P. Morgan Securities, Inc., attached as Annex B, and the other documents to which we refer. In addition, we incorporate by reference in this proxy statement/prospectus important business and financial information about Applera. You may obtain the information incorporated by reference in this proxy statement/prospectus without charge by following the instructions in the section entitled "Where You Can Find More Information" on page 141. We have included page references parenthetically to direct you to a more complete description of the topics presented in this summary.

The Companies

APPLERA CORPORATION (see page 113)
301 Merritt 7
Norwalk, Connecticut 06851-1070
(203) 840-2000

    Applera Corporation was incorporated in Delaware in 1998 and succeeded by recapitalization to the business of PE Corporation (NY) (formerly The Perkin-Elmer Corporation) in May 1999. Applera conducts its business through two operating groups: the Celera Genomics group and the Applied Biosystems group. Applera has two classes of common stock, Celera Genomics common stock and Applied Biosystems common stock, that are intended to reflect the relative performance of these groups. For more information about Applera's two classes of common stock, see "Description of the Applera Capital Stock" and "Risk Factors—Risks Related to a Capital Structure with Two Separate Classes of Common Stock" in this proxy statement/prospectus.

    The Celera Genomics group is engaged principally in the generation, sale, and support of genomic information and enabling data management and analysis software. The Celera Genomics group's customers use this information for commercial applications in the pharmaceutical and life sciences industries in the specific areas of target identification, drug discovery, and drug development. The Celera Genomics group also provides gene discovery, genotyping, and related genomics services. The Celera Genomics group has recently expanded its business into the emerging fields of functional genomics, in particular, proteomics and personalized health/medicine. The Celera Genomics group intends to leverage its industrialized approach to biology to develop platforms for enabling diagnostic and therapeutic discoveries both for its own internal product development and for its customers, including its collaboration partners.

    The Applied Biosystems group is a world leader in the development, manufacture, sale and service of instrument systems and associated consumable products for life science research and related applications. Its products are used in various applications including the synthesis, amplification, purification, isolation, analysis and sequencing of nucleic acids, proteins and other biological molecules.

    The information contained on Applera's website is not incorporated by reference in this proxy statement/prospectus.

6


AXYS PHARMACEUTICALS, INC. (see page 80)
180 Kimball Way
South San Francisco, California 94080
(650) 829-1000

    Axys, a Delaware corporation, is an integrated small molecule drug discovery and development company that has a broad pipeline of product candidates for chronic therapeutic applications that are partnered with world-class pharmaceutical companies, or for which Axys is seeking partners, and a proprietary product portfolio in oncology. Axys also has investments in affiliated businesses that leverage the Axys technologies. Currently, these companies include Discovery Partners International, Inc. (Nasdaq:DPII), a chemistry services company, DNA Sciences, Inc., a genetics company and Akkadix Corporation, an agricultural biotechnology company.

    The information contained on Axys' website is not incorporated by reference in this proxy statement/prospectus.

ANGEL ACQUISITION SUB, INC. (see page 113)
c/o Applera Corporation
301 Merritt 7
Norwalk, Connecticut 06851-1070
(203) 840-2000

    Angel Acquisition, a Delaware corporation, is a wholly owned subsidiary of Applera that was organized solely for purposes of completing the merger.

The Special Meeting (see page 46)

    The special meeting of stockholders of Axys will be held at 10:00 a.m. Pacific Time, on [            ], 2001, at Axys' headquarters located at 180 Kimball Way, South San Francisco, California 94080.

    At the special meeting, we will ask the holders of shares of Axys common stock to:

Record Date; Stock Entitled to Vote (see page 46)

    You can vote, or submit a proxy to vote, at the special meeting if you were a record holder of Axys common stock at the close of business on [      ], 2001, the record date for determining which holders of Axys common stock are entitled to vote at the special meeting. At the record date, there were [            ] shares of Axys common stock entitled to vote at the special meeting.

    Holders of Axys common stock as of the record date are entitled to one vote per share on each matter to be voted on at the special meeting.

Quorum (see page 46)

    For a quorum to exist and for the special meeting to proceed, a majority of the shares issued and outstanding and entitled to vote must be present in person or represented by proxy.

7


Vote Required (see page 46)

    The merger will be approved only if the holders of a majority of the outstanding shares of Axys common stock entitled to vote at the special meeting vote for the proposal to approve and adopt the merger agreement and approve the merger.

The Merger (see page 49)

    The merger agreement contemplates that Angel Acquisition, a wholly owned subsidiary of Applera formed for the purpose of the merger, will merge with and into Axys. As a result, Axys will become a wholly owned subsidiary of Applera.

    We have attached the merger agreement, which is the legal document that governs the merger, as Annex A to this proxy statement/prospectus. We encourage you to read the merger agreement.

Reasons of Axys for the Merger (see page 52)

    Since its inception, Axys has been focused on developing a state-of-the-art drug discovery platform that integrates "best-of-breed" technologies in both high throughput screening as well as in structure-based drug design. Axys believes that the effectiveness of this platform in bringing optimized leads to clinical development has been demonstrated in its partnerships with Merck, Bayer and Aventis. To more fully take advantage of the potential of these technologies as well as the expertise of Axys' scientific teams, Axys has determined that it needs a source of new therapeutic targets. The delivery of potential targets for drug discovery has been at the core of the work of the Celera Genomics group in the human genome, and in its future plans for proteomics. Axys believes that the integrated genomic, proteomic, bioinformatic and computing platforms of the Celera Genomics group can be expected to yield targets that can be evaluated and selected in an effort to develop breakthrough drugs that work by interacting with the targets in novel ways. Hence, Axys believes that Axys and the Celera Genomics group have complementary strengths which are expected to enable the combined company to move forward more quickly and effectively in the research and development of innovative small molecule therapeutics. In addition, holders of Axys common stock will have the opportunity to participate in a larger and better capitalized organization and to benefit from potential appreciation in Celera Genomics common stock.

Recommendation of the Axys Board of Directors (see page 53)

    The Axys board of directors has unanimously approved the merger agreement and the merger and has determined that the merger is advisable and fair to, and in the best interests of, Axys and its stockholders. The board of directors of Axys unanimously recommends that holders of Axys common stock vote FOR the approval and adoption of the merger agreement and the approval of the merger.

Opinion of Financial Advisor to the Axys Board of Directors (see page 54)

    In deciding to approve the merger, the board of directors of Axys considered an opinion dated as of June 12, 2001 from its financial advisor, JPMorgan H&Q, a division of J.P. Morgan Securities Inc., that, as of the date of the opinion and subject to the assumptions and limitations in the opinion, the "exchange ratio" specified in the merger agreement was fair, from a financial point of view, to the holders of Axys common stock.

    This opinion is attached as Annex B to this proxy statement/prospectus. We encourage you to read this opinion in its entirety.

8


Terms of the Merger Agreement

Conversion of Shares and Options (see page 60)

    In the merger, each share of Axys common stock will be exchanged for a fraction of a share of Celera Genomics common stock as determined in accordance with the merger agreement and as described in this proxy statement/prospectus. Holders will receive only whole shares of Celera Genomics common stock, and will receive cash instead of fractional shares, as described in this proxy statement/prospectus under "The Merger—Fractional Shares."

Conditions to the Completion of the Merger (see page 68)

    Several conditions must be satisfied or waived before the merger will be completed. These include:

Non-Solicitation Covenant (see page 66)

    Axys has agreed, subject to limited exceptions, not to initiate or engage in discussions with another party about a business combination with the other party prior to the termination of the merger agreement.

Termination (see page 69)

    Applera and Axys may mutually agree to terminate the merger agreement at any time. In addition, either Applera or Axys may terminate the merger agreement if specified events do or do not occur. These include:

9


    Applera may also terminate the merger agreement if:

    The merger agreement may also be terminated by Axys if the Axys board of directors concludes in good faith after consultation with outside legal counsel that in order to avoid violating its fiduciary duties in connection with a proposal for an alternative transaction that meets certain standards, it must withdraw or modify its recommendation of the merger agreement and the merger and it withdraws or modifies its recommendation. For more information with respect to Axys' ability to terminate the merger agreement because of the fiduciary duties of its board of directors, see "The Merger—Termination of the Merger Agreement" in this proxy statement/prospectus.

    The merger agreement will become void and have no effect upon its termination without any liability or obligation on the part of Applera, Angel Acquisition or Axys, except for any termination fee that may become payable by Axys and provisions relating to matters such as confidentiality and non-solicitation of employees that will survive as expressly provided in the merger agreement. However, no party will be relieved from liability for any breach of the merger agreement prior to its termination.

Termination Fee (see page 70)

    Axys will pay Applera a fee of $5.6 million and up to $900,000 in out-of-pocket expenses if the merger agreement is terminated under circumstances including a withdrawal of or change in the recommendation of the Axys board of directors in a manner that is adverse to Applera or the completion of an alternative transaction that was publicly announced prior to the termination of the merger agreement. These circumstances are described in detail in "The Merger—Termination of the Merger Agreement—Termination Fee" in this proxy statement/prospectus.

Regulatory Matters (see page 69)

    Under the Hart-Scott-Rodino Act, Axys and Applera cannot complete the merger until they have provided certain information and materials to the United States Federal Trade Commission and the United States Department of Justice, and a required waiting period has expired or been terminated. On June 29, 2001, Applera and Axys filed the requisite Pre-Merger Notification and Report Forms with the United States Federal Trade Commission and the United States Department of Justice. The waiting period under the Hart-Scott-Rodino Act will terminate on July 30, 2001, unless prior to that time the United States Department of Justice or the United States Federal Trade Commission makes a request for additional information or the waiting period is otherwise extended.

Accounting Treatment (see page 74)

    For accounting and financial reporting purposes, the merger will be treated as a purchase by Applera under generally accepted accounting principles.

10


NYSE Listing (see page 69)

    Applera will list the Celera Genomics common stock to be issued in the merger on the New York Stock Exchange.

Material United States Federal Income Tax Consequences (see page 72)

    We intend that the merger will qualify as a reorganization within the meaning of Section 368(a) of the Internal Revenue Code of 1986, as amended, for United States federal income tax purposes and have conditioned the merger upon the receipt of legal opinions that the merger will so qualify. Assuming the merger qualifies as a reorganization, neither Applera nor Axys, nor their respective stockholders, will recognize any gain or loss for United States federal income tax purposes as a result of the merger, except for tax that may be payable by holders of Axys common stock because of cash received for fractional shares.

    Tax matters can be complicated, and the tax consequences of the merger to you will depend on your particular tax situation. You should consult your own tax advisor to fully understand the tax consequences of the merger to you.

Interests of Axys' Officers and Directors in the Merger (see page 74)

    When considering the recommendation of the Axys board of directors, you should be aware that certain Axys officers and directors have interests in the merger that may be different from, or in addition to, your interests as stockholders. These interests exist in part because of rights they may have under Axys employment agreements and benefits plans. In addition, the merger agreement requires that after completion of the merger Applera must cause Axys, as the company surviving the merger, to indemnify the directors and officers of Axys for events occurring before the merger, including events that are related to the merger.

Dissenters' Rights (See Page 79)

    Under Delaware law, stockholders of Axys will not be entitled to exercise dissenters' appraisal rights in connection with the merger.

Comparative Market Price and Dividend Information (See Page 20)

    Shares of Celera Genomics common stock are listed on the New York Stock Exchange under the symbol "CRA". On June 12, 2001, the last full trading day prior to the public announcement of the proposed merger, Celera Genomics common stock closed at $41.75 per share. On [      ], 2001, the last full trading day prior to the date of this proxy statement/prospectus, Celera Genomics common stock closed at $[      ] per share.

    Shares of Axys common stock are traded on the Nasdaq National Market under the symbol "AXPH". On June 12, 2001, the last full trading day prior to the public announcement of the proposed merger, Axys' common stock closed at $3.45 per share. On [      ], 2001, the last full trading day prior to the date of this proxy statement/prospectus, Axys' common stock closed at $[      ] per share.

Exchange of Stock Certificates (See Page 62)

    After the merger occurs, the exchange agent appointed by Applera in connection with the merger will send a letter of transmittal to Axys stockholders that will provide instructions on the procedure for exchanging Axys common stock certificates for Celera Genomics common stock certificates.

11



SELECTED HISTORICAL CONSOLIDATED AND COMBINED FINANCIAL INFORMATION
AND SELECTED UNAUDITED PRO FORMA CONSOLIDATED AND
COMBINED FINANCIAL INFORMATION

Applera Selected Historical Consolidated Financial Information

    The following selected consolidated financial information has been derived from the consolidated financial statements of Applera for each of the five fiscal years in the period ended June 30, 2000, and the nine month periods ended March 31, 2000 and 2001. The information set forth below should be read in conjunction with the Applera (formerly PE Corporation) consolidated financial statements and notes thereto contained in the Applera Annual Report to Stockholders for the year ended June 30, 2000, and in the Applera Quarterly Report on Form 10-Q for the quarterly period ended March 31, 2001, each incorporated herein by reference. The data for the nine month periods ended March 31, 2000 and 2001 has been derived from unaudited financial statements that, in the opinion of management, reflect all adjustments, consisting only of normal recurring adjustments, necessary for a fair presentation of results for the periods covered. The operating results for the nine months ended March 31, 2001 are not necessarily indicative of the results that may be expected for the entire fiscal year.

    On May 6, 1999, Applera recapitalized and issued two new classes of common stock, the Celera Genomics common stock and the Applied Biosystems common stock, to the stockholders of Applera's predecessor. Effective November 30, 2000, Applera, which was named "PE Corporation" at the time of the recapitalization, was renamed "Applera Corporation," and the Applied Biosystems group, which was named the "PE Biosystems" group at the time of the recapitalization, was renamed the "Applied Biosystems" group. Therefore, neither the Celera Genomics common stock nor the Applied Biosystems common stock was issued or outstanding at any time prior to May 6, 1999.

    All share and per share amounts have been restated to reflect all prior stock splits of Applied Biosystems common stock and Celera Genomics common stock.

    A number of items impact the comparability of this information. Before-tax amounts include:

12



 
  Fiscal Years Ended June 30,
  Nine Months Ended March 31,
 
 
  1996
  1997
  1998
  1999
  2000
  2000
  2001
 
 
  (Dollar amounts in thousands except per share amounts)

 
Financial Operations                                            
Net revenues   $ 642,218   $ 768,368   $ 944,306   $ 1,216,897   $ 1,371,035   $ 979,337   $ 1,227,765  
Income from continuing operations     1,310     102,492     15,694     96,797     95,496     62,105     80,256  
  Per share of common stock:                                            
    Basic     .03     2.16     .32                          
    Diluted     .03     2.07     .31                          
Income (loss) from discontinued operations (net of income taxes)     (37,833 )   27,906     40,694     79,058                    
Net income (loss)     (36,523 )   130,398     56,388     175,855     95,496     62,105     80,256  
  Per share of common stock:                                            
    Basic     (.80 )   2.74     1.16                          
    Diluted     (.77 )   2.63     1.12                          
Dividends per share     .68     .68     .68     .51                    

Applied Biosystems Group

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 
Income from continuing operations   $ 3,899   $ 132,739   $ 24,009   $ 148,365   $ 186,247   $ 129,608   $ 164,767  
  Per share of common stock:                                            
    Basic                       .74     .90     .63     .78  
    Diluted                       .72     .86     .60     .74  
Income (loss) from discontinued operations (net of income taxes)     (37,833 )   27,906     40,694     79,058                    
Net income (loss)     (33,934 )   160,645     64,703     227,423     186,247     129,608     164,767  
  Per share of common stock:                                            
    Basic                       1.13     .90     .63     .78  
    Diluted                       1.10     .86     .60     .74  
Dividends per share                       .0425     .17     .17     .17  

Celera Genomics Group

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 
Net loss   $ (2,589 ) $ (30,247 ) $ (8,315 ) $ (44,894 ) $ (92,737 ) $ (67,783 ) $ (84,480 )
  Per share of common stock:                                            
    Basic and diluted                       (.89 )   (1.73 )   (1.29 )   (1.40 )

Other Information

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 
Cash and cash equivalents and short-term investments   $ 121,145   $ 217,222   $ 84,091   $ 308,021   $ 1,505,642   $ 1,286,184   $ 1,374,851  
Working capital     229,639     354,742     287,991     471,350     1,479,027     1,445,501     1,457,818  
Capital expenditures     28,198     58,057     71,820     176,035     125,815     94,379     140,808  
Total assets     809,856     1,006,793     1,135,276     1,519,307     3,083,315     2,754,401     3,025,864  
Long-term debt     33,694     59,152     33,726     31,452     82,115     82,039     30,715  
Total debt     89,801     89,068     45,825     35,363     97,808     117,454     51,130  
Stockholders' equity     373,727     504,270     564,248     821,525     2,220,492     1,956,116     2,217,229  

13


Celera Genomics Group Selected Historical Combined Financial Information

    The following selected combined financial information has been derived from the combined financial statements of the Celera Genomics group for each of the five fiscal years in the period ended June 30, 2000, and the nine month periods ended March 31, 2000 and 2001. The information set forth below should be read in conjunction with the Celera Genomics group combined financial statements and notes thereto contained in the Applera (formerly PE Corporation) Annual Report to Stockholders for the year ended June 30, 2000, and in the Applera Quarterly Report on Form 10-Q for the quarterly period ended March 31, 2001, each incorporated herein by reference. The data for the nine month periods ended March 31, 2000 and 2001 has been derived from unaudited financial statements that, in the opinion of management, reflect all adjustments, consisting only of normal recurring adjustments, necessary for a fair presentation of results for the periods covered. The operating results for the nine months ended March 31, 2001 are not necessarily indicative of the results that may be expected for the entire fiscal year.

    On May 6, 1999, Applera recapitalized and issued two new classes of common stock, the Celera Genomics common stock and the Applied Biosystems common stock, to the stockholders of Applera's predecessor. Effective November 30, 2000, Applera, which was named "PE Corporation" at the time of the recapitalization, was renamed "Applera Corporation," and the Applied Biosystems group, which was named the "PE Biosystems" group at the time of the recapitalization, was renamed the "Applied Biosystems" group. Therefore, neither the Celera Genomics common stock nor the Applied Biosystems common stock was issued or outstanding at any time prior to May 6, 1999.

    All share and per share amounts have been restated to reflect the prior stock split of Celera Genomics common stock.

    Items impacting the comparability of information included acquired research and development charges of $2.1 million for fiscal 1996 and $26.8 million for fiscal 1997, and $5.6 million of charges for fiscal 1999 relating to the recapitalization and transformation of Applera.

 
  Fiscal Years Ended June 30,
  Nine Months Ended March 31,
 
 
  1996
  1997
  1998
  1999
  2000
  2000
  2001
 
 
  (Dollar amounts in thousands)

 
Financial Operations                                            
Net revenues   $ 159   $ 903   $ 4,211   $ 12,541   $ 42,747   $ 27,666   $ 61,947  
Net loss     (2,589 )   (30,247 )   (8,315 )   (44,894 )   (92,737 )   (67,783 )   (84,480 )

Other Information

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 
Cash and cash equivalents and short-term investments   $   $   $   $ 71,491   $ 1,111,034   $ 991,107   $ 1,035,056  
Note receivable from the Applied Biosystems Group                       150,000           150,000        
Working capital (deficit)     (340 )   (421 )   (1,160 )   192,803     1,081,039     1,118,023     985,433  
Capital expenditures     1,073     411     3,648     94,541     30,673     24,442     21,419  
Total assets     977     2,983     6,339     344,720     1,413,257     1,283,393     1,323,650  
Total allocated debt                             46,000     46,000        
Group equity (deficit)     611     (3,464 )   (1,259 )   293,867     1,290,816     1,186,389     1,214,829  

14


Selected Unaudited Pro Forma Consolidated Financial Information of Applera and Axys

    The following selected unaudited pro forma consolidated financial information is derived from unaudited pro forma consolidated financial statements and the notes thereto, which are included elsewhere in this proxy statement/prospectus and should be read in conjunction with those statements and related notes. See "Unaudited Pro Forma Condensed Consolidated and Combined Financial Statements" in this proxy statement/prospectus.

    The unaudited pro forma consolidated balance sheet assumes that the merger took place on March 31, 2001 and combines Applera's March 31, 2001 unaudited consolidated balance sheet with Axys' March 31, 2001 unaudited balance sheet. The unaudited pro forma consolidated statements of operations for the nine months ended March 31, 2001 and the year ended June 30, 2000 give effect to the merger as if it occurred on July 1, 1999. Because Applera and Axys have two different fiscal years, and the combined company will adopt the fiscal year of Applera, pro forma operating results are presented on a June 30 fiscal year basis.

    The unaudited pro forma consolidated financial information is presented for illustrative purposes only and is not necessarily indicative of the consolidated financial position or results of operations of future periods or the results that actually would have been realized had the entities been a single entity during these periods.


Applera Corporation
Selected Unaudited Pro Forma Consolidated Financial Information

 
  Year
Ended
June 30,
2000

  Nine Months
Ended
March 31,
2001

 
(Dollar amounts in thousands except per share amounts)              
Financial Operations              
Net revenues   $ 1,384,636   $ 1,234,903  
Income from continuing operations     49,474     36,124  

Applied Biosystems Group

 

 

 

 

 

 

 
Net income   $ 186,247   $ 164,767  
  Per share of common stock              
    Basic     0.90     0.78  
    Diluted     0.86     0.74  
Dividends per share     0.17     0.17  

Celera Genomics Group

 

 

 

 

 

 

 
Loss from continuing operations   $ (138,759 ) $ (128,612 )
  Per share of common stock              
    Basic and diluted     (2.37 )   (1.97 )

 


 

 


 

March 31, 2001

 

Other Information

 

 

 

 

 

 

 
Cash and cash equivalents and short-term investments         $ 1,404,281  
Working capital           1,471,624  
Total assets           3,284,905  
Long-term debt           56,715  
Total debt           77,130  
Stockholders' equity           2,426,517  

15


Selected Unaudited Pro Forma Combined Financial Information of the Celera Genomics Group and Axys

    The following selected unaudited pro forma combined financial information is derived from unaudited pro forma combined financial statements and the notes thereto, which are included elsewhere in this proxy statement/prospectus and should be read in conjunction with those statements and related notes. See "Unaudited Pro Forma Condensed Consolidated and Combined Financial Statements."

    The unaudited pro forma combined balance sheet assumes that the merger took place on March 31, 2001 and combines the Celera Genomics group's March 31, 2001 unaudited combined balance sheet with Axys' March 31, 2001 unaudited balance sheet. The unaudited pro forma combined statements of operations for the nine months ended March 31, 2001 and the year ended June 30, 2000 give effect to the merger as if it occurred on July 1, 1999. Because the Celera Genomics group and Axys have two different fiscal years, and the combined company will adopt the fiscal year end of the Celera Genomics group, pro forma operating results are presented on a June 30 fiscal year basis.

    The unaudited pro forma combined financial information is presented for illustrative purposes only and is not necessarily indicative of the combined financial position or results of operations of future periods or the results that actually would have been realized had the entities been a single entity during these periods.


Celera Genomics Group
Selected Unaudited Pro Forma Combined Financial Information

 
  Year
Ended
June 30,
2000

  Nine Months
Ended
March 31,
2001

 
 
  (Dollar amounts in thousands)

 
Financial Operations              
Net revenues   $ 56,348   $ 69,085  
Loss from continuing operations     (138,759 )   (128,612 )

 

 

 


 

March 31, 2001


 

Other Information

 

 

 

 

 

 

 
Cash and cash equivalents and short-term investments         $ 1,064,486  
Working capital           999,239  
Total assets           1,582,691  
Long-term debt           26,000  
Total debt           26,000  
Group equity           1,424,117  

16



SELECTED HISTORICAL CONSOLIDATED FINANCIAL INFORMATION OF AXYS

    The following selected consolidated financial information has been derived from the consolidated financial statements of Axys (and its predecessor company) for each of the five fiscal years in the period ended December 31, 2000, and the three month period ended March 31, 2001. The operating results for the three months ended March 31, 2001 are not necessarily indicative of the results that may be expected for the entire fiscal year. The information set forth below should be read in conjunction with the Axys audited financial statements and notes thereto which are included in this proxy statement/prospectus commencing on page F-1, and "Axys Management's Discussion and Analysis of Financial Condition and Result of Operations" commencing on page 94 of this proxy statement/prospectus.

 
  Year Ended December 31
  Quarter Ended March 31,
 
 
  1996
  1997(1)
  1998(1)(2)
  1999(1)
  2000
  2000
  2001
 
 
  (in thousands, except per share amounts)

 
 
   
   
   
   
   
  (unaudited)

 
Consolidated Statements of Operations:                                            
Revenues   $ 21,560   $ 20,499   $ 35,760   $ 24,084   $ 6,990   $ 1,414   $ 3,070  
Operating costs and expenses:                                            
  Research and development     24,319     27,062     57,502     55,174     36,575     7,858     8,929  
  General and administrative     5,409     7,153     13,411     10,872     9,999     2,814     3,242  
  Non-cash compensation expense                             (1,051 )
  Restructuring charge                 5,175     (592 )   (545 )    
  Acquired in-process research and development     230         124,888                  
   
 
 
 
 
 
 
 
Total operating costs and expenses     29,958     34,215     195,801     71,221     45,982     10,127     11,120  
   
 
 
 
 
 
 
 
Operating loss     (8,398 )   (13,716 )   (160,041 )   (47,137 )   (38,992 )   (8,713 )   (8,050 )
Interest income (expense), net     2,470     2,422     2,317     341     (4,105 )   (35 )   (943 )
Equity in losses of joint venture             (2,393 )   (836 )   (3,208 )       (9,059 )
Other income/expense, net                 (852 )   889         (978 )
   
 
 
 
 
 
 
 
Net loss from continuing operations     (5,928 )   (11,294 )   (160,117 )   (48,484 )   (45,416 )   (8,748 )   (19,030 )
Discontinued operations         327     3,993     (279 )   (5,941 )   256      
Cumulative effect of change in accounting principle                             972  
Gain on disposal of segments                     61,213          
   
 
 
 
 
 
 
 
Net income (loss)   $ (5,928 ) $ (10,967 ) $ (156,124 ) $ (48,763 ) $ 9,856   $ (8,492 ) $ (18,058 )
   
 
 
 
 
 
 
 
Net loss per share, basic and diluted from continuing operations   $ (0.45 ) $ (0.75 ) $ (5.38 ) $ (1.59 ) $ (1.29 ) $ (0.27 ) $ (0.51 )
Net income (loss) per share, basic and diluted   $ (0.45 ) $ (0.73 ) $ (5.25 ) $ (1.60 ) $ 0.28   $ (0.26 ) $ (0.48 )
Weighted average number of shares used in computing basic and diluted net loss per share     13,177     15,025     29,758     30,385     35,281     32,067     37,345  
 
  December 31
  March 31,
 
 
  1996
  1997
  1998
  1999
  2000
  2000
  2001
 
 
   
   
   
   
   
  (unaudited)

 
Consolidated Balance Sheet Data:                                            
Cash, cash equivalents and marketable investments   $ 66,720   $ 53,408   $ 72,717   $ 26,657   $ 41,776   $ 48,484   $ 29,430  
Total assets     80,832     73,584     107,262     55,734     118,696     78,839     110,710  
Long-term obligations     10,676     15,331     16,816     57     27,889     42     28,300  
Accumulated deficit     (62,804 )   (73,771 )   (229,895 )   (277,211 )   (267,355 )   (285,703 )   (285,413 )
Total stockholders' equity     52,900     43,890     60,512     14,047     79,565     39,827     71,657  

(1)
Reclassified results of operations in accordance with Accounting Principles Board Opinion No. 30, "Reporting the Results of Operations—Reporting the Effects of Disposal of a Segment of a Business, and Extraordinary, Unusual and Infrequently Occurring Events and Transactions" in connection with the sale of Axys Advanced Technologies and PPGx, Inc. during 2000.

(2)
Includes the results of operations of Sequana Therapeutics, Inc. from January 8, 1998 through December 31, 1998, including a one-time charge for acquired in-process research and development. Excluding this one-time charge, net loss and net loss per share would have been $31,236,000 and $1.05 per share, respectively.

17



COMPARATIVE PER SHARE INFORMATION (UNAUDITED)

    The following table summarizes per share information for Applera and Axys on a historical and unaudited pro forma consolidated basis for Applera and a historical and equivalent pro forma basis for Axys. The following information should be read in conjunction with the audited consolidated financial statements of Applera, which are incorporated herein by reference, the audited financial statements of Axys, the unaudited interim consolidated financial statements of Applera and Axys, the selected historical consolidated financial information of Applera and Axys, the selected unaudited pro forma consolidated and combined financial information and the unaudited pro forma condensed consolidated and combined financial statements included elsewhere in this proxy statement/prospectus. The pro forma information is presented for illustrative purposes only and is not necessarily indicative of the operating results or financial position that would have occurred if the merger had been consummated as of the beginning of the periods presented, nor is it necessarily indicative of the future operating results or financial position of the combined companies.

 
  Year
Ended
June 30,
2000

  Nine
Months Ended
March 31,
2001

 
Applera Corporation:              
Applied Biosystems Group              
  Net income:              
    Historical:              
      Basic   $ 0.90   $ 0.78  
      Diluted     0.86     0.74  
    Pro forma:              
      Basic   $ 0.90   $ 0.78  
      Diluted     0.86     0.74  
  Dividends:              
    Historical   $ 0.17   $ 0.17  
    Pro forma     0.17     0.17  
  Book Value:              
    Historical   $ 4.48   $ 4.78  
    Pro forma     4.48     4.78  
Celera Genomics Group              
  Loss from continuing operations:              
    Historical:              
      Basic and diluted   $ (1.73 ) $ (1.40 )
    Pro forma              
      Basic and diluted(1)   $ (2.37 ) $ (1.97 )
  Dividends:              
    Historical   $   $  
    Pro forma              
  Book Value:              
    Historical   $ 21.75   $ 19.83  
    Pro forma(1)     23.24     21.52  

18


Axys Pharmaceuticals, Inc.:              
  Loss from continuing operations:              
    Historical:              
      Basic and diluted   $ (1.33 ) $ (1.27 )
    Equivalent pro forma:              
      Basic and diluted(1)   $ (0.29 ) $ (0.24 )
  Dividends:              
    Historical   $   $  
    Equivalent pro forma              
  Book Value:              
    Historical   $ 1.74   $ 1.91  
    Equivalent pro forma(1)   $ 2.84   $ 2.63  

(1)
The Axys per share equivalent pro forma information is calculated by multiplying the per share amounts for the Celera Genomics group by 0.1220, which is the exchange ratio that would have been applied to the Axys common stock under the merger agreement had the merger occurred on July 9, 2001. If the merger had occurred on July 9, 2001, the average closing price of Celera Genomics common stock during the calculation period that would have been used in the determination of the exchange ratio was $38.108. Provided below is a sensitivity analysis of the pro forma per share information based on a 20% increase in the average closing price of Celera Genomics common stock during the calculation period, which would result in an exchange ratio of 0.1017, and a 20% decrease in the average closing price of Celera Genomics common stock during the calculation period, which would result in an exchange ratio of 0.1355.
 
  Year
Ended
June 30,
2000

  Nine
Months Ended
March 31,
2001

 
20% increase in price of Celera Genomics common stock              
Applera Corporation:              
Celera Genomics Group              
  Loss from continuing operations:              
    Pro forma basic and diluted   $ (2.40 ) $ (1.99 )
  Book Value:              
    Pro forma   $ 23.54   $ 21.79  
Axys Pharmaceuticals, Inc.              
  Loss from continuing operations:              
    Equivalent pro forma basic and diluted   $ (0.24 ) $ (0.20 )
  Book Value:              
    Equivalent pro forma   $ 2.39   $ 2.22  
20% decrease in price of Celera Genomics common stock              
Applera Corporation:              
Celera Genomics Group              
  Loss from continuing operations:              
    Pro forma basic and diluted   $ (2.26 ) $ (1.89 )
  Book Value:              
    Pro forma   $ 22.67   $ 20.98  
Axys Pharmaceuticals, Inc.              
  Loss from continuing operations:              
    Equivalent pro forma basic and diluted   $ (0.31 ) $ (0.26 )
  Book Value:              
    Equivalent pro forma   $ 3.07   $ 2.84  

19



COMPARATIVE PER SHARE MARKET PRICE AND DIVIDEND INFORMATION

    Celera Genomics common stock is listed on the New York Stock Exchange under the symbol: "CRA".

    The following table sets forth the range of high and low sale prices of Celera Genomics common stock as reported by the New York Stock Exchange Composite Tape since May 6, 1999. On May 6, 1999, Applera recapitalized and issued two new classes of stock, the Celera Genomics common stock and the Applied Biosystems common stock, to the stockholders of Applera's predecessor. Effective November 30, 2000, Applera, which was named "PE Corporation" at the time of the recapitalization, was renamed "Applera Corporation," and the Applied Biosystems group, which was named the "PE Biosystems" group at the time of the recapitalization, was renamed the "Applied Biosystems" group. Therefore, neither the Celera Genomics common stock nor the Applied Biosystems common stock was issued or outstanding at any time prior to May 6, 1999. The table gives effect to the two-for-one stock split of Celera Genomics common stock effected in the form of a 100% stock dividend distributed on February 18, 2000. Applera has not paid any cash dividends with respect to Celera Genomics common stock and does not anticipate paying any cash dividends on Celera Genomics common stock in the foreseeable future.

 
  High
  Low
FISCAL YEAR ENDED JUNE 30, 1999            
Fourth Quarter (from May 6, 1999)   $ 11.2500   $ 7.0938

FISCAL YEAR ENDED JUNE 30, 2000

 

 

 

 

 

 
First Quarter   $ 26.9063   $ 7.8750
Second Quarter   $ 96.4063   $ 15.1875
Third Quarter   $ 276.0000   $ 73.0000
Fourth Quarter   $ 151.0000   $ 50.1875

FISCAL YEAR ENDED JUNE 30, 2001

 

 

 

 

 

 
First Quarter   $ 118.5625   $ 80.1875
Second Quarter   $ 100.5000   $ 29.2500
Third Quarter   $ 54.9000   $ 24.0000
Fourth Quarter   $ 49.9000   $ 26.2000

FISCAL YEAR ENDING JUNE 30, 2002

 

 

 

 

 

 
First Quarter (through July 6, 2001)   $ 39.9500   $ 34.9400

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    Axys common stock is traded on the Nasdaq National Market under the symbol "AXPH".

    The following table sets forth the range of high and low sale prices of Axys common stock as reported on the Nasdaq National Market since January 7, 1998, the date when Arris Pharmaceuticals Corporation and Sequana Therapeutics merged to form Axys. Axys has not paid any cash dividends since its inception and does not anticipate paying any cash dividends in the foreseeable future.

 
  High
  Low
FISCAL YEAR ENDED DECEMBER 31, 1998            
First Quarter (from January 7, 1998)   $ 10.75   $ 7.66
Second Quarter   $ 8.75   $ 6.50
Third Quarter   $ 7.75   $ 3.38
Fourth Quarter   $ 7.06   $ 3.69

FISCAL YEAR ENDED DECEMBER 31, 1999

 

 

 

 

 

 
First Quarter   $ 8.13   $ 3.75
Second Quarter   $ 4.50   $ 3.00
Third Quarter   $ 5.97   $ 3.56
Fourth Quarter   $ 4.97   $ 2.69

FISCAL YEAR ENDED DECEMBER 31, 2000

 

 

 

 

 

 
First Quarter   $ 20.25   $ 3.88
Second Quarter   $ 9.00   $ 3.53
Third Quarter   $ 8.88   $ 5.00
Fourth Quarter   $ 7.13   $ 3.56

FISCAL YEAR ENDING DECEMBER 31, 2001

 

 

 

 

 

 
First Quarter   $ 6.75   $ 2.50
Second Quarter   $ 4.40   $ 2.19
Third Quarter (through July 3, 2001)   $ 4.25   $ 4.03

    The following table sets forth the closing price per share of Celera Genomics common stock on the New York Stock Exchange and of Axys common stock on the Nasdaq National Market on June 12, 2001, the last full trading day prior to the announcement of the merger agreement; on [            ], 2001, the last full trading day before the date of this proxy statement/prospectus; and the equivalent per share prices for Axys common stock based on Celera Genomics common stock prices using an exchange ratio calculated under the merger agreement as if the closing of the merger had occurred on those dates.

 
  Celera Genomics
Common Stock

  Axys
Common Stock

  Estimated Equivalent
Axys Per Share Price

June 12, 2001   $ 41.75   $ 3.45   $ 4.65
[      ] 2001   $ [  ]   $ [  ]   $ [  ]

    The actual equivalent per share price of a share of Axys common stock that holders of Axys common stock will receive if the merger is completed may increase or decrease from that noted in the table above due to continuous fluctuations in the per share price of Celera Genomics common stock on the New York Stock Exchange and application of the applicable exchange ratio as further discussed in this proxy statement/prospectus under "The Merger—Consideration to be Received in the Merger".

    We urge Axys stockholders to obtain current market quotations for Celera Genomics common stock and Axys common stock prior to making any decision with respect to the merger. We cannot give any assurance as to the future prices or markets for Celera Genomics common stock. Following the merger, Celera Genomics common stock will continue to be traded on the New York Stock Exchange, and there will be no further market for Axys common stock.

21



RISK FACTORS

    By voting in favor of approving and adopting the merger agreement and approving the merger, you will be choosing to invest in Celera Genomics common stock. You should carefully consider the following factors, in addition to those factors discussed in the documents that Applera has filed with the Securities and Exchange Commission that we have incorporated by reference into this document, and the other information included in this proxy statement/prospectus, before voting on the proposal to approve and adopt the merger agreement and the merger.

Risks Related to the Merger

The number of shares of Celera Genomics common stock to be received in the merger by holders of Axys common stock may vary due to the formula for calculating the exchange ratio.

    In the merger, each share of Axys common stock will be converted into the right to receive a number of shares of Celera Genomics common stock equal to the exchange ratio. The exchange ratio, or the number of shares of Celera Genomics common stock into which each share of Axys common stock will be converted, will fluctuate, within specified limits, depending upon the 10-day average closing price of a share of Celera Genomics common stock immediately preceding (but excluding) the second trading day prior to the closing date of the merger. See "The Merger—Consideration to be Received in the Merger" in this proxy statement/prospectus for a discussion of the determination of the exchange ratio. In addition, the volatility of the market price of Celera Genomics common stock directly affects the exchange ratio calculation, as described in this proxy statement/prospectus. See "Summary—Comparative Per Share Market Price and Dividend Information" in this proxy statement/prospectus for more detailed Celera Genomics common stock share price information. Variations in the Celera Genomics common stock share price may be the result of various factors including:

    At the time of the special meeting, holders of Axys common stock will not necessarily know the exact number or the exact market price of the Celera Genomics common stock that will be issued in connection with the merger. The number of shares that will be received for each share of Axys common stock will be calculated using the exchange ratio described in this proxy statement/prospectus, and will vary accordingly based on the trading price of Celera Genomics common stock after the special stockholders meeting. Stockholders of Axys are urged to obtain current market quotations for Celera Genomics common stock prior to the date of the special stockholders meeting.

The requirement for regulatory approvals may delay consummation of the merger.

    Consummation of the merger is conditioned upon the receipt of all material governmental authorizations, consents, orders and approvals, including the expiration or termination of the applicable waiting periods, and any extension of the waiting periods, under antitrust laws. Applera and Axys intend to vigorously pursue all required regulatory approvals. No assurance can be given, however, that these approvals will be obtained, or, if they are obtained, as to the terms, conditions and timing of these approvals. The requirement for these approvals could delay the consummation of the merger after holders of Axys common stock have approved the proposals relating to the merger at the special meeting. See "The Merger—Conditions to the Merger" in this proxy statement/prospectus for a

22


discussion of the conditions to the consummation of the merger and "The Merger—Regulatory Approvals Required" in this proxy statement/prospectus for a description of the regulatory approvals necessary in connection with the merger.

The interests of management may be different from those of Axys stockholders.

    Some members of Axys' management and board of directors have various interests in the merger that may be different from, or in addition to, the interests of holders of Axys common stock. These interests include agreements with Axys that may entitle members of Axys management and board of directors to receive severance or termination pay or to accelerated stock option vesting upon completion of the merger. See "The Merger—Interests of Certain Persons in the Merger" in this proxy statement/prospectus for more information concerning matters relating to the employment and compensation of the directors and executive officers of Axys.

The Celera Genomics group may encounter difficulties in the integration and development of the business of Axys and in attracting and retaining employees of Axys.

    The Celera Genomics group's strategy to integrate and develop the combined businesses of the Celera Genomics group and Axys following the merger involves a number of elements that management may not be able to implement as expected. For example, the Celera Genomics group may encounter operational difficulties in the integration of facilities and employees of the two companies. In addition, the Celera Genomics group's expansion into the drug discovery area as a result of the integration of the capabilities of the Celera Genomics group and Axys may not be achieved as successfully or as rapidly as currently anticipated, if at all, and may require the acquisition or development of additional technologies and capabilities. The consolidation of operations and scientific teams presents significant managerial challenges. There can be no assurance that these actions will be accomplished as successfully or as rapidly as currently anticipated, if at all. There can also be no assurance that the employees of Axys will be willing to continue their employment with Axys after the merger. In addition, some of Axys' collaboration and other agreements contain provisions that might permit the other party to the contract to terminate certain aspects of the contractual relationship relating to research and development if the merger takes place. There is no assurance that the parties to these contracts with Axys will not seek to exercise these termination rights, or that the Celera Genomics group will be able to maintain all of Axys' existing commercial relationships after the merger.

Risks Related to the Celera Genomics Group

The Celera Genomics group has incurred net losses to date and may not achieve profitability.

    The Celera Genomics group has accumulated net losses of $263.3 million as of March 31, 2001, and expects that it will continue to incur additional net losses for the foreseeable future. These losses may increase as the Celera Genomics group expands its investments in new technology and product development, including the development of its functional genomics and personalized health/medicine and drug discovery and development efforts. As an early stage business, the Celera Genomics group faces significant challenges in simultaneously expanding its operations, pursuing key scientific goals and attracting customers for its information products and services. As a result, there is a high degree of uncertainty that the Celera Genomics group will be able to achieve profitable operations.

The Celera Genomics group's business plan is unique and expanding.

    No organization has ever attempted to combine in one business organization all of the Celera Genomics group's businesses. In addition, as the Celera Genomics group moves beyond the genome database business, it is expanding its business plan to provide new scientific capabilities and services to

23


customers in areas such as functional genomics, personalized health/medicine, proteomics, and drug discovery and development. The offering of genomics databases, functional genomics, proteomics, personalized health/medicine capabilities and drug discovery and development targeted at a wide variety of customers, from pharmaceutical companies to university researchers, has a number of risks, including pricing and volume issues, technology and access concerns, computer security, pursuit of key scientific goals and protection of intellectual property. The addition of the functional genomics, personalized health/medicine, proteomics, and drug discovery and development efforts will add further complexity and require additional management attention and resources as these new markets are addressed.

The Celera Genomics group's business plan depends heavily on continued assembly and annotation of the human and mouse genomes.

    The Celera Genomics group will continue to update its assembly of the human and mouse genome as it continues to annotate these genomes. The Celera Genomics group's ability to retain its existing customers and attract new customers for its genome database business is heavily dependent upon the continued assembly and annotation of these genomes. Also, this information is essential to the functional genomics, personalized health/medicine and drug discovery and development components of the Celera Genomics group's business strategy in which the Celera Genomics group intends to make substantial investments in the near future. As a result, failure to update the assembly and annotation efforts in a timely manner may have a material adverse effect on the Celera Genomics group's business.

The Celera Genomics group's revenue growth depends on retaining existing customers and adding new customers.

    The Celera Genomics group reported approximately 40 customers at the close of the March 31, 2001 quarter, the revenues from which will offset only a small portion of its expenses. In order to generate significant additional revenues, the Celera Genomics group must obtain additional customers and retain its existing customers. The Celera Genomics group's ability to retain existing customers and add new customers depends upon customers' continued belief that the Celera Genomics group's products can help accelerate their drug discovery and development efforts and fundamental discoveries in biology. Although customer agreements typically have multiple year terms, there can be no assurance that any will be renewed upon expiration. The Celera Genomics group's future revenues are also affected by the extent to which existing customers expand their agreements to include new services and database products. In some cases, the Celera Genomics group may accept milestone payments or future royalties on products developed by its customers as consideration for access to the Celera Genomics group's databases and products in lieu of a portion of subscription fees. Such arrangements are unlikely to produce revenue for the Celera Genomics group for a number of years, if ever, and depend heavily on the research and product development, sales and marketing and intellectual property protection abilities of the customer.

Use of genomics information to develop or commercialize products is unproven.

    The development of new drugs and the diagnosis of disease based on genomic information is unproven. Few therapeutic or diagnostic products based on genomic discoveries have been developed and commercialized and to date no one has developed or commercialized any therapeutic, diagnostic or agricultural products based on the Celera Genomics group's technologies. If the Celera Genomics group or its customers are unsuccessful in developing and commercializing products based on the group's databases or other products or services, customers and the group may be unable to generate sufficient revenues and the Celera Genomics group's business may suffer as a result. Development of these products will be subject to risks of failure, including that these products will be found to be toxic,

24


be found to be ineffective, fail to receive regulatory approvals, fail to be developed prior to the successful marketing of similar products by competitors or infringe on proprietary rights of third parties.

The industry in which the Celera Genomics group operates is intensely competitive and evolving.

    There is intense competition among entities attempting to interpret segments of the human genome and identify genes associated with specific diseases and develop products, services and intellectual property based on these discoveries. The Celera Genomics group faces competition in these areas from genomic, pharmaceutical, biotechnology and diagnostic companies, academic and research institutions and government or other publicly-funded agencies, both in the United States and abroad. A number of companies, other institutions and government-financed entities are engaged in gene sequencing, gene discovery, gene expression analysis, positional cloning, the study of genetic variation, functional genomics and other genomic service businesses. Some of these competitors are developing databases containing gene sequence, gene-expression, genetic variation or other biological information and are marketing or plan to market their data to pharmaceutical and biotechnology companies and academic and research institutions. Additional competitors may attempt to establish databases containing this information in the future. The Celera Genomics group has licensed some of its key technology on a non-exclusive basis from third parties and therefore this technology may be available for license by competitors of the Celera Genomics group.

    Competitors may also discover, characterize or develop important genes, drug targets or leads, drug discovery technologies, or drugs in advance of the Celera Genomics group or its customers, or which are more effective than those developed by the Celera Genomics group or its customers, or may obtain regulatory approvals of their drugs more rapidly than the Celera Genomics group or its customers do, any of which could have a material adverse effect on any of the similar programs of the Celera Genomics group or its customers. Moreover, these competitors may obtain patent protection or other intellectual property rights that would limit the Celera Genomics group's rights or its customers' ability to use the Celera Genomics group's products to commercialize therapeutic, diagnostic or agricultural products. In addition, a customer may use the Celera Genomics group's services to develop products that compete with products separately developed by the group or its other customers.

    Future competition will come from existing competitors as well as other companies seeking to develop new technologies for drug discovery, drug development, and diagnostics based on gene sequencing, target gene identification, bioinformatics and related technologies. In addition, certain pharmaceutical and biotechnology companies have significant needs for genomic information and may choose to develop or acquire competing technologies to meet those needs. The Celera Genomics group also faces competition from providers of software. A number of companies have announced their intent to develop and market software to assist pharmaceutical and biotechnology companies and academic researchers in managing and analyzing their own genomic data and publicly available data.

The Celera Genomics group's current and potential customers are primarily from, and are subject to risks faced by, the pharmaceutical and biotechnology industries.

    The Celera Genomics group derives a substantial portion of its revenues from fees for its information products and services paid by pharmaceutical companies and larger biotechnology companies, including Amgen Inc., Novartis Pharma AG, Pharmacia & Upjohn, Pfizer Inc., Takeda Chemical Industries, Ltd., American Home Products Corporation, Immunex Corporation and Yamanouchi Pharmaceutical Co., Ltd.. The Celera Genomics group expects that pharmaceutical companies and larger biotechnology companies will continue to be the Celera Genomics group's primary source of revenues for the foreseeable future. As a result, the Celera Genomics group is subject to risks and uncertainties that affect the pharmaceutical and biotechnology industries and to reduction and delays in research and development expenditures by companies in these industries.

25


    In addition, the Celera Genomics group's future revenues may be adversely affected by mergers and consolidation in the pharmaceutical and biotechnology industries, which will reduce the number of the group's potential customers. Large pharmaceutical and biotechnology customers could also decide to conduct their own genomics programs or seek other providers instead of using the Celera Genomics group's products and services.

The Celera Genomics group relies on its strategic relationship with the Applied Biosystems group.

    The Celera Genomics group believes that its strategic relationship with the Applied Biosystems group has provided it with a significant competitive advantage in its efforts to date to sequence the human and other genomes. The Celera Genomics group's timely completion of that work and successful extension of its business into the functional genomics, personalized health/medicine and proteomics arenas will depend on the Applied Biosystems group's ability to continue to provide leading edge, proprietary technology and products, including technologies relating to genetic analysis, protein analysis and high throughput screening. If the Applied Biosystems group is unable to supply these technologies, the Celera Genomics group will need to obtain access to alternative technologies, which may not be available, or may only be available on unfavorable terms. Any change in the relationship with the Applied Biosystems group that adversely affects the Celera Genomics group's access to the Applied Biosystems group's technology or failure by the Applied Biosystems group to continue to develop new technologies or protect its proprietary technology could adversely affect the Celera Genomics group's business.

Introduction of new products may expose the Celera Genomics group to product liability claims.

    New products developed by the Celera Genomics group could expose the Celera Genomics group to potential product liability risks that are inherent in the testing, manufacturing and marketing of human therapeutic and diagnostic products. Product liability claims or product recalls, regardless of the ultimate outcome, could require the Celera Genomics group to spend significant time and money in litigation and to pay significant damages.

The Celera Genomics group could incur liabilities relating to hazardous materials that it uses in its research and development activities.

    The Celera Genomics group's research and development activities involve the controlled use of hazardous materials, chemicals and various radioactive materials. In the event of an accidental contamination or injury from these materials, the Celera Genomics group could be held liable for damages in excess of its resources.

The Celera Genomics group's sales cycle is lengthy and it may spend considerable resources on unsuccessful sales efforts or may not be able to complete deals on the schedule anticipated.

    The Celera Genomics group's sales cycle is typically lengthy because the group needs to educate potential customers and sell the benefits of its products and services to a variety of constituencies within those companies. In addition, each agreement involves the negotiation of unique terms. The Celera Genomics group's ability to obtain new customers for genomic information products, value-added services, and licenses to intellectual property depends on its customers' belief that the Celera Genomics group can help accelerate their drug discovery efforts. The Celera Genomics group may expend substantial funds and management effort with no assurance that an agreement will be reached with a potential customer. Actual and proposed consolidations of pharmaceutical and biotechnology companies have affected and may in the future affect the timing and progress of the Celera Genomics group's sales efforts.

26


Scientific and management staff have unique expertise which is key to the Celera Genomics group's commercial viability and which would be difficult to replace.

    The Celera Genomics group is highly dependent on the principal members of its scientific and management staff, particularly J. Craig Venter, its President and Chief Scientific Officer. Additional members of the Celera Genomics group's medical, scientific and bioinformatics staff are important to the development of information, tools and services required for implementation of its business plan. The loss of any of these persons' expertise would be difficult to replace and could have a material adverse effect on the Celera Genomics group's ability to achieve its goals.

The Celera Genomics group's competitive position may depend on patent and copyright protection, which may not be sufficiently available.

    The Celera Genomics group's ability to compete and to achieve profitability may be affected by its ability to protect its proprietary technology and other intellectual property. While the Celera Genomics group's business is currently primarily dependent on revenues from access fees to its discovery and information system, the Celera Genomics group expects that obtaining patent protection may become increasingly important to its business as it moves beyond the genome database business. The Celera Genomics group would be able to prevent competitors from making, using or selling any of its technology for which it obtains a patent. However, patent law affecting the Celera Genomics group's business, particularly gene sequences, gene function and polymorphisms, is uncertain, and as a result, the Celera Genomics group is uncertain as to its ability to obtain intellectual property protection covering its information discoveries sufficient to prevent competitors from developing similar subject matter. Patents may not issue from patent applications that the Celera Genomics group may own or license. In addition, because patent applications in the United States are maintained in secrecy until patents issue, third parties may have filed patent applications for technology used by the Celera Genomics group or covered by the Celera Genomics group's pending patent applications without the Celera Genomics group being aware of those applications.

    Moreover, the Celera Genomics group may be dependent on protecting, through copyright law or otherwise, its databases to prevent other organizations from taking information from those databases and copying and reselling it. Copyright law currently provides uncertain protection regarding the copying and resale of factual data. As such, the Celera Genomics group is uncertain whether it could prevent that copying or resale. Changes in copyright and patent law could either expand or reduce the extent to which the Celera Genomics group and its customers are able to protect their intellectual property.

The Celera Genomics group's position may depend on its ability to protect trade secrets.

    The Celera Genomics group relies on trade secret protection for its confidential and proprietary information and procedures, including procedures related to sequencing genes and to searching and identifying important regions of genetic information. The Celera Genomics group currently protects its information and procedures as trade secrets. The Celera Genomics group protects its trade secrets through recognized practices, including access control, confidentiality and nonuse agreements with employees, consultants, collaborators, and customers, and other security measures. These confidentiality and nonuse agreements may be breached, however, and the Celera Genomics group may not have adequate remedies for a breach. In addition, the Celera Genomics group's trade secrets may otherwise become known or be independently developed by competitors.

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Public disclosure of genomics sequence data could jeopardize the Celera Genomics group's intellectual property protection and have an adverse effect on the value of its products and services.

    The Celera Genomics group, the federally funded Human Genome Project and others engaged in similar research have made and are expected to continue making available to the public basic human sequence data. Such disclosures might limit the scope of the Celera Genomics group's claims or make subsequent discoveries related to full-length genes unpatentable. While the Celera Genomics group believes that the publication of sequence data will not preclude it or others from being granted patent protection on genes, there can be no assurance that the publication has not affected and will not affect the ability to obtain patent protection. Customers may conclude that uncertainties of that protection decrease the value of the Celera Genomics group's information products and services and as a result, it may be required to reduce the fees it charges for its products and services.

The Celera Genomics group may infringe the intellectual property rights of third parties and may become involved in expensive intellectual property litigation.

    The intellectual property rights of biotechnology companies, including the Celera Genomics group, are generally uncertain and involve complex legal, scientific and factual questions. The Celera Genomics group's success in the functional genomics and drug discovery and development fields may depend, in part, on its ability to operate without infringing on the intellectual property rights of others and to prevent others from infringing on its intellectual property rights.

    There has been substantial litigation regarding patents and other intellectual property rights in the genomics industry. The Celera Genomics group may become a party to patent litigation or proceedings at the United States Patent and Trademark Office to determine its patent rights with respect to third parties, which may include subscribers to the Celera Genomics group's database information services. Interference proceedings may be necessary to establish which party was the first to discover the intellectual property. The Celera Genomics group may become involved in patent litigation against third parties to enforce the Celera Genomics group's patent rights, to invalidate patents held by the third parties, or to defend against these claims. The cost to the Celera Genomics group of any patent litigation or similar proceeding could be substantial, and it may absorb significant management time. If an infringement litigation against the Celera Genomics group is resolved unfavorably to the Celera Genomics group, the Celera Genomics group may be enjoined from manufacturing or selling certain of its products or services without a license from a third party. The Celera Genomics group may not be able to obtain a license on commercially acceptable terms, or at all.

    The United States Patent and Trademark Office has issued several patents to third parties relating to single nucleotide polymorphisms (SNPs). If other important SNPs receive patents, the Celera Genomics group will need to obtain rights to those important SNPs in order to develop, use and sell related assays. Such licenses may not be available to the Celera Genomics group on commercially acceptable terms, or at all.

The Celera Genomics group's business is dependent on the continuous, effective, reliable and secure operation of its computer hardware, software and internet applications and related tools and functions.

    Because the Celera Genomics group's business requires manipulating and analyzing large amounts of data, and communicating the results of the analysis to its internal research personnel and to its customers via the Internet, the Celera Genomics group depends on the continuous, effective, reliable and secure operation of its computer hardware, software, networks, Internet servers and related infrastructure. To the extent that the Celera Genomics group's hardware or software malfunctions and access to the Celera Genomics group's data by the Celera Genomics group's internal research personnel or customers through the Internet is interrupted, its business could suffer. The Celera

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Genomics group's computer and communications hardware is protected through physical and software safeguards. However, it is still vulnerable to fire, storm, flood, power loss, earthquakes, telecommunications failures, physical or software break-ins and similar events. In addition, the Celera Genomics group's database products are complex and sophisticated, and as such, could contain data, design or software errors that could be difficult to detect and correct. Software defects could be found in current or future products. If the Celera Genomics group fails to maintain and further develop the necessary computer capacity and data to support its computational needs and its customers' drug discovery efforts, it could result in loss of or delay in revenues and market acceptance. In addition, any sustained disruption in Internet access provided by third parties could adversely impact the Celera Genomics group's business.

The Celera Genomics group's research and product development depends on access to tissue samples and other biological materials.

    The Celera Genomics group will need access to normal and diseased human and other tissue samples, other biological materials and related clinical and other information, which may be in limited supply. The Celera Genomics group may not be able to obtain or maintain access to these materials and information on acceptable terms. In addition, government regulation in the United States and foreign countries could result in restricted access to, or use of, human and other tissue samples. If the Celera Genomics group loses access to sufficient numbers or sources of tissue samples, or if tighter restrictions are imposed on its use of the information generated from tissue samples, its business may be harmed.

Ethical, legal and social issues related to the use of genetic information and genetic testing may cause less demand for the Celera Genomics group's products.

    Genetic testing has raised issues regarding confidentiality and the appropriate uses of the resulting information. For example, concerns have been expressed towards insurance carriers and employers using these tests to discriminate on the basis of this information, resulting in barriers to the acceptance of these tests by consumers. This could lead to governmental authorities calling for limits on or regulation of the use of genetic testing or prohibit testing for genetic predisposition to certain diseases, particularly those that have no known cure. Any of these scenarios could reduce the potential markets for products of the Celera Genomics group.

Expected rapid growth in the number of its employees could absorb valuable management resources and be disruptive to the development of the Celera Genomics group's business.

    The Celera Genomics group expects to increase its employee base significantly, including the addition of Axys' employees. This growth will require substantial effort to hire new employees and train and integrate them in the Celera Genomics group's business and to develop and implement management information systems, financial controls and facility plans. The Celera Genomics group's inability to manage growth effectively would have a material adverse effect on its future operating results.

The use of the Celera Genomics group's products and services may be subject to government regulation.

    The use of the Celera Genomics group's products by the Celera Genomics group and by pharmaceutical and biotechnology customers may be subject to certain United States Food and Drug Administration or other regulatory approvals. For example, any new drug developed as a result of the use of the Celera Genomics group's databases must undergo an extensive regulatory review process. This process can take many years and require substantial expense. Within the field of personalized health/medicine, current and future patient privacy and health care laws and regulations issued by the United States Food and Drug Administration may limit the use of polymorphism data.

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    To the extent that use of the Celera Genomics group's databases is limited or additional costs are imposed on the Celera Genomics group or its customers due to regulation, the Celera Genomics group's business may be adversely affected.

    Furthermore, the Celera Genomics group may be directly subject to regulations as a provider of diagnostic information. To the extent that these regulations restrict the sale of the Celera Genomics group's products or impose other costs, the Celera Genomics group's business may be materially adversely affected.

Future acquisitions may absorb significant resources and may be unsuccessful.

    As part of the Celera Genomics group's strategy, it expects to pursue acquisitions (in addition to the Axys acquisition), investments and other strategic relationships and alliances. Acquisitions, investments and other strategic relationships and alliances may involve significant cash expenditures, debt incurrence, additional operating losses, dilutive issuances of equity securities, and expenses that could have a material effect on the Celera Genomics group's financial condition and results of operations. For example, to the extent that it elects to pay the purchase price for acquisitions in shares of Celera Genomics common stock, the issuance of additional shares of Celera Genomics common stock may be dilutive to holders of Celera Genomics common stock. Acquisitions involve numerous other risks, including:

    It may be difficult for the Celera Genomics group to complete these transactions quickly and to integrate these businesses efficiently into its current business. Any acquisitions, investments or other strategic relationships and alliances by the Celera Genomics group may ultimately have a negative impact on its business and financial condition.

Celera Genomics common stock price is highly volatile.

    The market price of Celera Genomics common stock has been and may continue to be highly volatile due to the risks and uncertainties described in this section of this proxy statement/prospectus, as well as other factors, including:

    The stock market has from time to time experienced extreme price and volume fluctuations that are unrelated to the operating performance of particular companies. In the past, companies that have experienced volatility have sometimes been the subject of securities class action litigation. If litigation was instituted on this basis, it could result in substantial costs and a diversion of management's attention and resources.

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Applera is subject to a purported class action lawsuit relating to its 2000 offering of shares of Celera Genomics common stock that may be expensive and time consuming.

    Applera and certain of its officers have been served in five lawsuits purportedly on behalf of purchasers of Celera Genomics common stock in Applera's follow-on public offering of Celera Genomics common stock completed on March 6, 2000. In the offering, Applera sold an aggregate of approximately 4.4 million shares of Celera Genomics common stock at a public offering price of $225 per share. The complaints in these lawsuits generally allege that the prospectus used in connection with the offering contained inaccurate and misleading statements in violation of federal securities laws. The complaints seek unspecified damages, rescission, costs and expenses, and other relief as the court deems proper. All of these lawsuits have been consolidated into a single case. Although Applera believes the asserted claims are without merit and intends to defend the case vigorously, the outcome of this or any other litigation is inherently uncertain. The defense of this case will require management attention and resources.

The Celera Genomics group's ability to develop proprietary therapeutics and the Celera Genomics/Applied Biosystems Joint Venture's ability to develop proprietary molecular diagnostic products is unproven.

    The development and commercialization of new drugs based on genomic and proteomic information is unproven. As the Celera Genomics group expands its efforts into this new business area, it faces the difficulties inherent in developing and commercializing therapeutic products, and it has limited experience in operating a commercial research and development program. In addition, Applera has announced the formation of a major initiative in the field of molecular diagnostics and has decided that it will be optimally positioned as a joint venture between the Applied Biosystems group and the Celera Genomics group. The joint venture faces the difficulties inherent in developing and commercializing diagnostic tests and in building and operating a commercial research and development program. Given the Celera Genomics group's unproven ability to develop proprietary therapeutics and the joint venture's unproven ability to develop proprietary molecular diagnostic products, it is possible that the Celera Genomics group's and the joint venture's discovery processes will not result in any commercial products or services. Even if the group or the joint venture is able to develop products and services, it is possible that these products and services may not be commercially viable or successful due to a variety of reasons, including difficulty obtaining regulatory approvals, competitive conditions, the inability to obtain necessary intellectual property protection, the need to build distribution channels, failure to get adequate reimbursement for these products from insurance or government payors, or the inability of the group or the joint venture to recover its development costs in a reasonable period.

Risks Related to a Capital Structure with Two Separate Classes of Common Stock

You will be stockholders of Applera and, therefore, financial effects on either the Celera Genomics group or the Applied Biosystems group could adversely affect the other.

    The Celera Genomics group and the Applied Biosystems group are not separate legal entities. As a result, stockholders will continue to be subject to all of the risks of an investment in Applera, including the Applied Biosystems group. The risks and uncertainties that may affect the operations, performance, development, and results of the Applied Biosystems group's businesses include but are not limited to rapidly changing technology and dependence on new products, dependence of sales on customers' capital spending policies and government-sponsored research, claims for patent infringement, significant overseas operations, integration of acquired technologies as part of future growth strategy, electricity shortages and earthquakes. The assets attributed to the Celera Genomics group could be subject to the liabilities of the Applied Biosystems group, even if these liabilities arise from lawsuits, contracts or indebtedness that are attributed to the Applied Biosystems group. If Applera is unable to satisfy the Applied Biosystems group's liabilities out of the assets attributed to

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that group, Applera may be required to satisfy those liabilities with assets attributed to the Celera Genomics group.

    Financial effects from the Applied Biosystems group that affect Applera's consolidated results of operations or financial condition could, if significant, affect the results of operations or financial condition of the Celera Genomics group and the market price of Celera Genomics common stock. In addition, net losses of the Applied Biosystems group and dividends or distributions on, or repurchases of, Applied Biosystems common stock or repurchases of certain preferred stock will reduce the funds Applera can pay as dividends on Celera Genomics common stock under Delaware law. For these reasons, you should read Applera's consolidated financial information with the financial information it provides for each group.

Holders of Celera Genomics common stock will have limited rights related to the Celera Genomics group.

    Holders of Celera Genomics common stock have only the rights customarily held by common stockholders. They will have only the following rights related to the Celera Genomics group:

    Applera will not hold separate meetings for holders of Celera Genomics common stock and Applied Biosystems common stock.

Limits exist on the voting power of group common stock.

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    Recent cases in Delaware involving tracking stocks have established that decisions by directors or officers involving differing treatment of tracking stocks are judged under the principle known as "the business judgment rule" unless self-interest is shown. In addition, principles of Delaware law established in cases involving differing treatment of two classes of capital common stock or two groups of holders of the same class of capital common stock provide that a board of directors owes an equal duty to all stockholders regardless of class or series. Absent abuse of discretion, a good faith business decision made by a disinterested and adequately informed board of directors, board of directors' committee or officer of Applera with respect to any matter having different effects on holders of Celera Genomics common stock and holders of Applied Biosystems common stock would be a defense to any challenge to the determination made by or on behalf of the holders of either class of common stock.

Stock ownership could cause directors and officers to favor one group over the other.

    As a policy, Applera's board of directors periodically monitors the ownership of shares of Celera Genomics common stock and shares of Applied Biosystems common stock by Applera's directors and senior officers as well as their option holdings and other benefits so that their interests are not misaligned with the two classes of common stock and with their duty to act in the best interests of Applera and its stockholders as a whole. However, because the actual stock market value of their interests in Celera Genomics common stock and Applied Biosystems common stock could vary significantly, it is possible that they could favor one group over the other as a result of their common stock holdings, options and other benefits.

Numerous potential conflicts of interest exist between the classes of common stock that may be difficult to resolve by Applera's board or may be resolved adversely to one of the classes.

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Applera's board of directors may change its management and allocation policies without stockholder approval to the detriment of either group.

    Applera's board of directors may modify or rescind Applera's policies with respect to the allocation of corporate overhead, taxes, debt, interest and other matters, or may adopt additional policies, in its sole discretion without stockholder approval. A decision to modify or rescind these policies, or adopt additional policies, could have different effects on holders of Celera Genomics common stock and holders of Applied Biosystems common stock or could result in a benefit or detriment to one class of stockholders compared to the other class. Applera's board of directors will make any decision in accordance with its good faith business judgment that the decision is in the best interests of Applera and all of its stockholders as a whole.

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Either the Celera Genomics group or the Applied Biosystems group may finance the other group on terms unfavorable to itself.

    From time to time, Applera anticipates that it will transfer cash and other property between groups to finance their business activities. When this occurs, the group providing the financing will be subject to the risks relating to the group receiving the financing. Applera will account for those transfers in one of the following ways:

    Applera's board of directors has not adopted specific criteria for determining when it will account for transfer of cash or other property as a reallocation of pooled debt or preferred stock, a loan or repayment, an increase or decrease in equity interest or a sale of assets. These determinations, including the terms of any transactions accounted for as debt, may be unfavorable to either the group transferring or receiving the cash or other property. Applera's board of directors expects to make these determinations, either in specific instances or by setting generally applicable policies, after considering the financing requirements and objectives of the receiving group, the investment objectives of the transferring group and the availability, cost and time associated with alternative financing sources, prevailing interest rates and general economic conditions.

    Applera cannot assure you that any terms that it fixes for debt will approximate those that could have been obtained by the borrowing group if it were a stand-alone company.

The Celera Genomics group will not be reimbursed for the Applied Biosystems group's use of its future tax benefits and could incur a higher future tax liability than if it were a stand-alone taxpayer.

    Consolidated federal income tax provisions and related tax payments or refunds are allocated between the groups based principally on the taxable income and tax credits directly attributable to each group. Tax benefits that cannot be used by the group generating those benefits but can be used on a consolidated basis are transferred to the group that can utilize the benefits. Tax benefits generated by the Celera Genomics group commencing July 1, 1998, which could be utilized on a consolidated basis, are reimbursed by the Applied Biosystems group to the Celera Genomics group up to a limit of $75 million. The Celera Genomics group has generated cumulative tax benefits in excess of $75 million that have been utilized by the Applied Biosystems group. Amounts utilized by the Applied Biosystems group in excess of the $75 million limit are not reimbursed and are recorded to group equity by the Celera Genomics group. Accordingly, any tax benefits that cannot be used by the Celera Genomics group but can be used by the Applied Biosystems group will not be carried forward to reduce the Celera Genomics group's future tax liability. Use of the tax benefits of the Celera Genomics group by the Applied Biosystems group would result in the Celera Genomics group being charged a greater portion of the total corporate tax liability in the future than would have been the case if the Celera Genomics group were a stand-alone taxpayer.

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Holders of Celera Genomics common stock may receive less consideration upon a sale of assets than if the Celera Genomics group were a separate company.

    Applera's certificate of incorporation provides that if a disposition of all or substantially all of the assets of the Celera Genomics group occurs, Applera must, subject to certain exceptions:

    If the Celera Genomics group were a separate, independent company and its shares were acquired by another person, certain costs of that disposition, including corporate level taxes, might not be payable in connection with that acquisition. As a result, stockholders of the Celera Genomics group as a separate, independent company might receive a greater amount than the net proceeds that would be received by holders of Celera Genomics common stock if the assets of the Celera Genomics group were sold. In addition, Applera cannot assure you that the net proceeds per share of Celera Genomics common stock will be equal to or more than the market value per share of Celera Genomics common stock prior to or after announcement of a disposition.

Applera's capital structure and variable vote per share may discourage acquisitions of the Celera Genomics group or Celera Genomics common stock.

    A potential acquiror could acquire control of Applera by acquiring shares of common stock having a majority of the voting power of all shares of common stock outstanding. Such a majority could be obtained by acquiring a sufficient number of shares of both classes of common stock or, if one class of common stock has a majority of the voting power, only shares of that class. Currently, Applied Biosystems common stock has a substantial majority of the voting power. As a result, it might be possible for an acquiror to obtain control by purchasing only shares of Applied Biosystems common stock.

Decisions by Applera's board of directors and officers that affect market values could adversely affect voting and conversion rights.

    The relative voting power per share of each class of common stock and the number of shares of one class of common stock issuable upon the conversion of the other class of common stock will vary depending upon the relative market values of Celera Genomics common stock and Applied Biosystems common stock. The market value of either or both classes of common stock could be adversely affected by market reaction to decisions by Applera's board of directors or Applera's management that investors perceive as affecting differently one class of common stock compared to the other. These decisions could involve changes to Applera's management and allocation policies, transfers of assets between groups, allocations of corporate opportunities and financing resources between groups and changes in dividend policies.

Investors may not value Celera Genomics common stock based on the Celera Genomics group's financial information and policies.

    Applera cannot assure you that investors will value Celera Genomics common stock based on the reported financial results and prospects of the Celera Genomics group or the dividend policies established by Applera's board of directors with respect to the Celera Genomics group.

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Provisions governing common stock could discourage a change of control and the payment of a premium for stockholders' shares.

    Applera's stockholder rights plan could prevent stockholders from profiting from an increase in the market value of their shares as a result of a change in control of Applera by delaying or preventing a change in control. The existence of two classes of common stock could also present complexities and could, in certain circumstances, pose obstacles, financial and otherwise, to an acquiring person. In addition, certain provisions of Delaware law and Applera's certificate of incorporation and bylaws may also deter hostile takeover attempts.

Legislative proposals could have adverse tax consequences for us or for holders of Celera Genomics common stock and Applied Biosystems common stock.

    The Clinton Administration Budget Proposals in 1999 and 2000 proposed legislation that would have adversely affected holders of tracking stock such as Celera Genomics common stock and Applied Biosystems common stock. Although Congress did not act on either proposal and the recent Bush Administration Budget Proposal does not contain a similar provision, it is impossible to predict whether any proposals relating to tracking stock will be made in the future, and to what extent Congress would act upon any proposals.

    Applera may convert Celera Genomics common stock or Applied Biosystems common stock into shares of the other class without any premium if, based on the legal opinion of its tax counsel, it is more likely than not as a result of the enactment of legislative changes or administrative proposals or changes that Applera or its stockholders will be subject to tax upon issuance of Celera Genomics common stock or Applied Biosystems common stock or that the stock will not be treated as stock of Applera.

Risks Related to Axys

    By not voting in favor of approving and adopting the merger agreement and approving the merger, you will be choosing to continue your ownership of Axys common stock. If the merger is completed, the business operations of Axys will be integrated into the research and development and business operations of the Celera Genomics group. You should carefully consider the following factors before voting on the proposal to approve and adopt the merger agreement and approve the merger.

If Axys does not consummate the merger under the merger agreement, the market value of Axys common stock may decrease and Axys may not be able to locate or consummate a strategic combination with another company on equal or more favorable terms.

    As a result of the proposed merger under the merger agreement, the trading price of Axys common stock includes a premium per share and fluctuates in relation to the trading price of Celera Genomics common stock. However, if Axys does not consummate the merger, the trading price of Axys common stock will no longer be affected by the trading price of Celera Genomics common stock, and the trading price of Axys common stock may decrease if no other third party is offering to purchase Axys common stock at a premium. In addition, Axys may not be able to identify another strategic partner that would be willing to provide Axys' stockholders with a premium over market price equivalent to that offered by Applera. Further, if Axys does not consummate the proposed merger, a third party may determine on that basis that Axys is not an attractive strategic partner.

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If Axys fails to discover or develop or is delayed in the development of pharmaceuticals, its business and results of operations will be adversely affected.

    All of Axys' potential pharmaceutical products are in various stages of research and development and will require significant additional research and development efforts before Axys can sell them. These efforts include extensive preclinical and clinical testing and lengthy regulatory review and approval by the United States Food and Drug Administration. The development of Axys' new pharmaceutical products is highly uncertain and subject to a number of significant risks. To date, Axys has not developed a commercial drug and Axys does not expect any of its pharmaceuticals to be commercially available for a number of years. Pharmaceuticals that appear to be promising at early stages of development may not reach the market for a number of reasons, including the following:

Axys may not be successful in developing a commercial drug.

    Axys is primarily engaged in the earliest stage of drug discovery; namely, the design and systematic evaluation of therapeutic small molecule compounds. Axys' drug discovery programs are unproven. Although Axys has expended, and continues to expend, time and money on internal research and development programs, Axys may be unsuccessful in creating drug candidates that would enable it to form additional collaborations and receive milestone and/or royalty payments. Even if Axys is able to negotiate additional collaborations, Axys may never discover potential drug candidates that ultimately lead to a commercially available drug. Axys has not yet created, or contributed to the creation of, a commercial drug and there can be no assurance that Axys ever will discover, create or contribute to the creation of a commercial drug. Axys does not currently have the internal capability to move potential products through clinical testing, manufacturing and the approval process of the United States Food and Drug Administration.

If the merger is not completed and Axys fails to obtain additional financing to fund its operations, it will be unable to complete its product development efforts.

    The development of Axys' potential drugs will require substantially more money than Axys currently has. That means that if the merger fails to occur, Axys will have to obtain commitments for substantial funds in order to conduct the costly and time-consuming research and preclinical and clinical testing activities necessary to develop its drugs. Axys cannot be certain that any financing will be available when needed. If Axys fails to secure additional financing, as needed, it will have to delay or terminate its drug development programs.

    In April 2000, Axys successfully sold its share of Axys Advanced Technologies (which we refer to in this proxy statement/prospectus as "Advanced Technologies"), now ChemRx Advanced Technologies Inc., to Discovery Partners for 7,425,000 shares of Discovery Partners common stock. As of June 7, 2001, Axys held 7,246,500 shares of Discovery Partners common stock. In December 2000, Axys successfully sold its shares of PPGx, Inc. to DNA Sciences for approximately $15 million in preferred stock of DNA Sciences. Axys' DNA Sciences shares and Discovery Partners shares are subject to contractual restrictions that limit its ability to liquidate its position in a timely manner. DNA

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Sciences is a privately held company and there are limited opportunities to dispose of Axys' interest. There can be no assurance that the businesses in which Axys holds these equity positions will be successful or that Axys will have the ability to sell all or a portion of its equity ownership in these businesses. In addition, there can be no assurance that the amount Axys may receive upon selling its equity ownership interest will provide significant funding so as to postpone for a meaningful time period the need to engage in other capital raising activities.

    If the merger is not completed, even if Axys is successful in obtaining financing from the sale of its interests in Discovery Partners and DNA Sciences, Axys believes it will still need to pursue other financing opportunities to fund its research and development. Axys' future financing needs will depend on many factors, including the following:

    If the merger is not completed, Axys expects that it will need to continue to raise money for a number of years until it achieves, if it ever achieves, substantial product or royalty revenues. Axys expects that it will seek additional funding through new collaborations, the extension of existing collaborations, through sale of its interests in Discovery Partners and DNA Sciences, or through public or private equity or debt financings. Axys cannot be certain that additional funding will be available or that the terms will be acceptable. Existing stockholders will experience dilution of their investment if Axys raises additional funds by issuing equity. If adequate funds are not available, Axys may delay, reduce or eliminate any of its research or development programs. Furthermore, Axys may obtain funds through arrangements with collaborative partners or others that require it to give up rights to technologies or products that it would otherwise seek to develop or commercialize itself.

If the merger is not completed, Axys' increased leverage could affect its ability to service its debt obligations or incur additional debt, which could negatively affect its stock price.

    Axys is and will continue to be leveraged. At March 31, 2001, Axys had total indebtedness of approximately $28.3 million (of which $26 million consisted of its convertible notes and the balance consists of outstanding balances under its capital lease obligations) and stockholders' equity of approximately $71.7 million. Axys' ability to make scheduled payments of principal of, or to pay the interest on, or to refinance, its indebtedness, including the notes, or to fund planned capital expenditures and research and development expenses, will depend on its future performance, which, to a certain extent, is subject to general economic, financial, competitive, legislative, regulatory and other factors that are beyond its control. Axys may need to refinance all or a portion of the principal of the notes on or prior to maturity. If the merger is not completed, there can be no assurance that Axys' business will generate sufficient cash flow from operations or that future borrowings will be available in an amount sufficient to enable it to service its indebtedness, including the notes, or to fund its other liquidity needs. In addition, there can be no assurance that Axys will be able to effect any refinancing on commercially reasonable terms or at all.

    Axys' indebtedness could have significant additional negative consequences, including:

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If the merger is not completed, if Axys continues to incur operating losses for longer than expected, it may be unable to continue operations and its stock price may decline.

    While Axys generated net income of $9.9 million for the year ended December 31, 2000, it generated a net loss of $18 million for the quarter ended March 31, 2001 and Axys may never sustain profitability and does not expect to remain profitable in fiscal year 2001. Axys was profitable for fiscal year 2000 due to the sale, for stock, of two of its non-core subsidiary companies: Advanced Technologies, which was sold to Discovery Partners, and PPGx, which was sold to DNA Sciences. Axys has experienced significant continuing operating losses since it commenced operations. Axys has not generated any pharmaceutical product sales revenue. For the year ended December 31, 2000, Axys generated a net loss from continuing operations of approximately $45.4 million, and as of December 31, 2000, it had an accumulated deficit of approximately $267.4 million. Axys expects that it will continue to incur significant operating losses over at least the next several years as its research and development efforts and preclinical and clinical testing activities continue. Axys' future profitability depends on its ability to complete product development and obtain regulatory approval for its drug candidates. If the merger is not completed, and Axys fails to become profitable or is unable to sustain profitability on a quarterly or annual basis, it may be unable to continue operations and its stock price may decline.

If Axys fails to maintain its existing collaborative relationships and enter into new collaborative relationships, development of its products could be delayed or Axys may need to obtain other sources of revenue if the merger is not completed.

    Axys' strategy for the development, clinical testing, manufacturing and commercialization of most of its pharmaceuticals has included entering into collaborations with corporate partners. Axys relies to a large extent on the activities of its collaborators with respect to the development and commercialization of its pharmaceuticals. All of Axys' collaboration agreements may be canceled under certain circumstances. Some of these agreements contain provisions that might permit the other party to the contract to terminate certain aspects of the contractual relationship relating to research and development if the merger takes place, and there is no assurance these parties will not seek to exercise these termination rights after the merger. In addition, the amount and timing of resources to be devoted to research, development, eventual clinical trials and commercialization activities by Axys' collaborators are not within Axys' control. Axys cannot guarantee that its partners will perform their obligations as expected. If any of Axys' collaborators terminate or elect to cancel their agreements or otherwise fail to conduct their collaborative activities in a timely manner, the development or commercialization of pharmaceuticals may be delayed. If in some cases Axys assumes responsibilities for continuing unpartnered programs after cancellation of a collaboration, Axys may be required to devote additional resources to product development and commercialization or Axys may cancel certain development programs.

    A large portion of Axys' revenues to date have resulted from these collaborations. In the event the merger is not completed, the research funding phase of most of Axys' collaborations will come to an end in the next year unless continued or extended by agreement with Axys' collaborators. In this case, if Axys' collaborations are not extended or Axys does not enter into additional collaborative

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relationships, Axys will have to seek other sources of revenue, including additional financing and/or selling interests in its affiliated businesses. Axys cannot be certain that it will receive any additional revenue from these arrangements beyond the minimum contractual commitments of its partners.

If Axys fails to satisfy United States Food and Drug Administration safety and efficacy requirements in its clinical trails for any pharmaceutical, Axys will be unable to complete the development and commercialization of that pharmaceutical product.

    Either Axys or its collaborators must show through preclinical studies and clinical trials that each of Axys' pharmaceuticals is safe and effective in humans for each indication before obtaining regulatory clearance from the United States Food and Drug Administration for the commercial sale of that pharmaceutical. If Axys fails to adequately show the safety and effectiveness of a pharmaceutical, regulatory approval could be delayed or denied. The results from preclinical studies and early clinical trials are often different than the results that are obtained in large-scale testing. Axys cannot be certain that it will show sufficient safety and effectiveness in its clinical trials to allow it to obtain the needed regulatory approval. A number of companies in the pharmaceutical industry, including biotechnology companies, have suffered significant setbacks in advanced clinical trials, even after promising results in earlier trials.

    Any drug is likely to produce some level of toxicity or undesirable side effects in animals and in humans when administered at sufficiently high doses and/or for a long period of time. Unacceptable toxicities or side effects may occur in the course of toxicity studies or clinical trials. If Axys observes unacceptable toxicities or side effects, Axys, its collaborators or regulatory authorities may interrupt, limit, delay or halt the development of the drug. In addition, these unacceptable toxicities or side effects could prevent approval by the United States Food and Drug Administration or foreign regulatory authorities for any or all indications.

    In the fourth quarter of 2000, Axys completed a Phase II clinical trial on its compound, APC 2059, in ulcerative colitis. Before moving forward to more advanced trials, Axys has recently determined that extensive safety pharmacology and dose-ranging pre-clinical research is necessary. Axys determined that it would not undertake this research and intends to seek a partner who is willing to conduct this research, as well as undertake additional clinical and commercial activities. As these clinical trials are intended to establish safety in humans, Axys cannot be certain that it will be able to initiate or complete necessary future clinical trials successfully. Axys' collaboration partner, Bayer, is moving forward with advanced pre-clinical studies of a compound developed in Axys' collaboration with them for the treatment of asthma that would be taken as a pill. Axys cannot be certain that the clinical trials of this compound will be initiated or completed successfully. Finally, Axys cannot be certain that any other drug candidates which may enter clinical trials will successfully complete those trials or that Axys or its collaborators will be able to show the safety and effectiveness of these drug candidates.

If Axys fails to obtain regulatory approvals to commercially manufacture or sell any of its drugs, or if approval is delayed, Axys will be unable to generate revenue from the sale of its products.

    Axys must obtain regulatory approval before marketing or selling its future drug products. In the United States, Axys must obtain United States Food and Drug Administration approval for each drug that it intends to commercialize. The United States Food and Drug Administration approval process is lengthy and expensive, and approval is never certain. Products distributed abroad are also subject to foreign government regulation. The process of obtaining United States Food and Drug Administration and other required regulatory approvals can vary a great deal based upon the type, complexity and novelty of the products involved. Delays or rejections may be encountered based upon additional government regulation from future legislation or administrative action or changes in United States Food and Drug Administration policy during the period of clinical trials and United States Food and Drug Administration regulatory review. Similar delays also may be encountered in foreign countries.

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    None of Axys' drug candidates has received regulatory approval. If Axys fails to obtain this approval, Axys will be unable to commercially manufacture and sell its drug products. Axys has several drugs in various stages of preclinical development and one drug which recently completed the initial phase of Phase II clinical development. These products are not expected to be available for several more years, if at all. Because of the risks and uncertainties involved in development of drug products, Axys' drug candidates could take significantly longer to gain approval than Axys expects or may never gain approval. If regulatory approval is delayed, the market value of Axys and its operating results could be adversely affected. Even if regulatory approval of a product is granted, Axys cannot be certain that it will be able to obtain the labeling claims necessary or desirable for the successful promotion of those products.

    Even if Axys obtains regulatory approval, it may be required to continue clinical studies even after it has started selling a drug. In addition, identification of certain side effects after a drug is on the market or the occurrence of manufacturing problems could cause subsequent withdrawal of approval, reformulation of a drug, additional preclinical testing or clinical trials and changes in labeling of the product. This could delay or prevent Axys from generating revenues from the sale of that drug or cause Axys' revenues to decline.

If regulatory approval to commercially manufacture or sell any of its drugs is obtained, Axys will also be subject to ongoing existing and future United States Food and Drug Administration regulations and guidelines and continued regulatory review.

    In particular, Axys or any third party that Axys uses to manufacture the drug or Axys' collaborators will be required to adhere to regulations setting forth current good manufacturing practices. The regulations require that Axys manufacture its products and maintain its records in a particular way with respect to manufacturing, testing and quality control activities. Furthermore, Axys or its third party manufacturers or its collaborators must pass a pre-approval inspection of its manufacturing facilities by the United States Food and Drug Administration before obtaining marketing approval.

    Failure to comply with the United States Food and Drug Administration or other relevant regulatory requirements may subject Axys to administrative or legally imposed restrictions. These include: warning letters, civil penalties, injunctions, product seizure or detention, product recalls, total or partial suspension of production and United States Food and Drug Administration refusal to approve pending New Drug Applications (which we refer to in this proxy statement/prospectus as NDAs), or supplements to approved NDAs.

If Axys is unable to effectively protect its intellectual property, it may not be able to compete effectively.

    Axys' success depends in a large part on its ability to obtain patents, maintain trade secrets and operate without infringing the intellectual property rights of others, both in the United States and in other countries.

    Patents may not be issued from any of Axys' pending or future applications. Patent applications in the United States are maintained in secrecy until the patent is issued. As a result, Axys cannot be certain that others have not filed patent applications for technology covered by its pending patent applications or that Axys was the first to invent the technology. In addition, an issued patent may be challenged, invalidated or maneuvered around or it may otherwise not be sufficient to protect Axys' technology. The patent positions of biotechnology and pharmaceutical companies can be highly uncertain and involve complex legal and factual questions. As a result, it is difficult to predict the breadth of claims allowed in biotechnology and pharmaceutical patents or their enforceability.

    Axys' commercial success also depends, in part, on not infringing patents issued to others and not breaching the technology licenses upon which any of its potential products are based. Competitors may

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have filed applications for, or may have received patents and may obtain additional patents and rights relating to, genes, products or processes that block or compete with Axys' patents and rights. A number of third parties have filed patent applications or received patents in the areas of Axys' programs. Some of these applications or patents may limit or hinder Axys' patent applications, or conflict in certain ways with claims made under Axys' issued patents. Furthermore, in the past Axys has been, and may from time to time in the future be, notified of claims that it is infringing patents or other intellectual property rights owned by third parties.

    Axys may have to participate in interference proceedings declared by the United States Patent and Trademark Office. These proceedings determine the priority of invention and the right to a patent for the technology in the United States. In addition, lawsuits may be necessary to enforce any patents issued to Axys or to determine the scope and validity of the rights of third parties. Lawsuits and interference proceedings, even if they are successful, are expensive to pursue, and Axys could use a substantial amount of its limited financial resources in either case. An adverse outcome could subject Axys to significant liabilities to third parties and require Axys to license disputed rights from third parties or to cease using the technology.

    It is also unclear whether Axys' trade secrets will provide useful protection. Axys protects its own technology and processes, in part, by confidentiality agreements with its employees, consultants and certain contractors. However, these agreements may be disregarded or breached, and Axys may not have adequate remedies for any breach. In addition, it is possible that Axys' trade secrets will otherwise become known or be independently discovered by competitors.

    Disputes may arise in the future with regard to the ownership of rights to any technology developed with collaborators. These and other possible disagreements with collaborators could lead to delays in the achievement of milestones or receipt of royalty payments or in research, development and commercialization of Axys' pharmaceuticals. In addition, these disputes could require or result in lawsuits or arbitration. Lawsuits and arbitration are time-consuming and expensive. Even if Axys wins, the cost of these proceedings could adversely affect its business, financial condition and results of operations. Furthermore, these proceedings could adversely affect Axys' stock price or its business reputation and may make the process of entering into additional collaborative relationships more difficult.

Because Axys does not have manufacturing facilities for its proposed drug products or commercial manufacturing experience, Axys could experience manufacturing delays or problems that hurt its product sales.

    Axys has no manufacturing facilities for its proposed drug products, and its potential products have never been commercially manufactured. Axys must currently rely on its collaborators, Merck, Aventis, and Bayer, to manufacture its products. Axys must find contract manufacturers or commit capital to establish United States Food and Drug Administration approved facilities for non-partnered drug candidates. If Axys or its collaborators or third party manufacturers are unable to manufacture or contract with others for a sufficient supply of Axys' compounds on acceptable terms, Axys may have to delay any of the following:

    Any of these delays could adversely affect Axys' financial condition and results of operations.

    Not only Axys, but Axys' collaborators and contract manufacturers must adhere to current Good Manufacturing Practices regulations enforced by the United States Food and Drug Administration

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through its facilities inspection program. If these facilities cannot pass a pre-approval plant inspection, United States Food and Drug Administration approval of Axys' products will not be granted or will be delayed.

If Axys fails to recruit and retain professional staff, Axys' product development programs will be delayed.

    Axys is highly dependent on the senior members of its scientific and management staff. Retaining and attracting qualified personnel, consultants and advisors is critical to Axys' success. If Axys fails to recruit and retain qualified personnel, its product development efforts will be delayed. Axys faces intense competition for qualified individuals from numerous pharmaceutical and biotechnology companies, universities and other research institutions. Axys has experienced high attrition rates in the last several years due in part to restructuring following Axys' 1998 acquisition of Sequana Therapeutics, Inc. Axys is currently seeking to hire additional qualified scientific personnel to perform research and development. In addition, Axys expects that it will need to add management personnel and develop additional expertise by existing management personnel in order to expand product development and clinical testing. Axys cannot be certain that it will be able to attract and retain these individuals on acceptable terms or at all.

    In addition, Axys' collaborators and consultants are not its employees. As a result, Axys has limited control over their activities and can expect that only limited amounts of their time will be dedicated to Axys' activities. Academic collaborators may also have relationships with other commercial entities, some of whom may be Axys' competitors.

Axys' future stock price may be volatile and your investment could suffer a decline in market value.

    Stock prices and trading volumes for biotechnology companies often fluctuate widely for reasons that may be unrelated to their businesses. Axys' stock price could decline as a result of many factors, including:

    In the past, following large price declines in the public market price of a company's securities, securities litigation has often been initiated against that company. Litigation of this type could result in substantial costs and diversion of management's attention and resources. Any adverse determination in litigation could subject Axys to substantial liabilities.

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If product liability claims are brought against Axys, Axys may incur substantial liabilities.

    Axys may be exposed to liability claims resulting from the use of its products in clinical trials, or the manufacturing, marketing and sale of any approved products. These claims may be made directly by consumers, pharmaceutical companies or others. Axys maintains product liability insurance coverage for claims arising from the use of its products that are still in the developmental phase. However, this insurance coverage is becoming increasingly expensive. Axys and its collaborative partners may not be able to obtain and maintain product liability insurance on commercially reasonable terms. Furthermore, even if Axys maintains insurance, the amount may not be enough to protect Axys against losses due to a lawsuit. A successful product liability claim against Axys or series of claims in excess of its insurance could adversely affect its results of operations and result in a need for additional financing.

Anti-takeover provisions under Delaware law and in Axys' charter documents and its stockholders rights plan could make a subsequent acquisition of Axys more difficult.

    In 1998, Axys adopted a stockholder rights plan, which may have the effect of delaying or preventing an unsolicited takeover of Axys. Axys' certificate of incorporation and bylaws state that any action taken by stockholders must be conducted at an annual or special meeting of stockholders and may not be conducted by written consent. Only the board of directors, the Chairman of the Board or the President may call special meetings of the stockholders. In addition, the Axys board of directors has the authority to issue additional shares of preferred stock and to determine the rights of those shares without any further action by the stockholders. Those rights could be senior to those of the common stockholders. The issuance of preferred stock may make it more difficult for a third party to acquire Axys. These and other charter provisions may discourage certain types of transactions involving an actual or potential change in control of Axys. In fact, these provisions may discourage transactions in which the stockholders might otherwise receive a premium for their shares over then current prices, and may limit the stockholders' ability to approve transactions that they think are in their best interests.

    Delaware law also prohibits corporations from engaging in a business combination with any holders of 15% or more of their capital stock until the holder has held the stock for three years unless, among other things, the board approves the transaction. Also, under Delaware law, the Axys board of directors may adopt additional anti-takeover measures in the future.

Axys' senior secured notes are convertible into shares of common stock; there are risks associated with redeeming these notes and their conversion may be dilutive.

    In September 2000, Axys issued $26 million in senior secured convertible notes, which bear interest at 8% per annum and have a conversion price of $7.06 per share. These notes are due in November 2004; however, the holders of the notes may choose to convert the notes at any time into shares of Axys common stock. Upon maturity of these notes, the holders may choose to have the notes repaid in cash or shares of its common stock. If the merger is not completed, in the event that some or all of the note holders request that the notes be repaid in cash upon maturity in November 2004, Axys may not have sufficient cash to satisfy all of its obligations under the notes. The underlying collateral pledged against those notes (approximately 6.7 million shares of Discovery Partners stock owned by Axys) may not be sufficient to satisfy the debt obligation. In addition, conversion of these notes into common stock will be dilutive to the stockholders.

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THE SPECIAL MEETING

    This proxy statement/prospectus is being furnished to stockholders of Axys in connection with the solicitation of proxies by the board of directors of Axys for use at the special meeting of its stockholders.

Date, Time and Place

    The special meeting will be held at Axys' headquarters located at 180 Kimball Way, South San Francisco, California 94080, at 10:00 a.m. Pacific Time, on [            ], 2001.

Purpose of the Special Meeting

    At the special meeting, holders of Axys common stock will be asked to consider and vote upon the approval and adoption of the merger agreement and the approval of the merger and such other matters as may properly be brought before the special meeting.

    The Axys board of directors has, by unanimous vote, approved the merger agreement and the merger and the transactions contemplated thereby, and recommends a vote FOR approval and adoption of the merger agreement and approval of the merger.

Record Date; Stock Entitled to Vote

    Only holders of record of Axys common stock at the close of business on [            ], 2001, the record date for the special meeting, are entitled to receive notice of and to vote at the special meeting. Axys common stock constitutes the only issued and outstanding class of voting securities of Axys.

    On the record date, [            ] shares of Axys common stock were issued and outstanding and were held by [      ] holders of record. Holders of record of shares of Axys common stock on the record date are each entitled to one vote per share on each matter to be considered at the special meeting.

Quorum

    The presence at the special meeting, either in person or by proxy, of a majority of the shares of Axys common stock outstanding on the record date is necessary to constitute a quorum to transact business at the special meeting. If a quorum is not present, it is expected that the special meeting will be adjourned or postponed in order to solicit additional proxies.

    Abstentions and "broker non-votes" will be counted for the purpose of determining whether a quorum is present. Broker non-votes are shares held by brokers or nominees on behalf of customers that are represented at the meeting but with respect to which the broker or nominee has not been instructed how to vote. Brokers holding shares of Axys common stock in street name for customers are prohibited from voting those customers' shares regarding the merger agreement and the merger in the absence of specific instructions from those customers.

Vote Required

    The approval and adoption of the merger agreement and the approval of the merger requires the affirmative vote of holders of a majority of the shares of Axys common stock issued and outstanding and entitled to vote on the record date for the special meeting. If you abstain from voting or do not vote, either in person or by proxy, it will have the same effect of a vote against adoption and approval of the merger agreement and approval of the merger.

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Share Ownership of Management and Others

    At the close of business on the record date, directors and executive officers of Axys and their affiliates beneficially owned and were entitled to vote approximately [            ] shares of Axys common stock, representing approximately [  ]% of the shares of Axys common stock issued and outstanding on the record date. Each of those directors and executive officers has indicated his or her present intention to vote, or cause to be voted, the Axys common stock owned by him FOR the approval and adoption of the merger agreement and approval of the merger.

Voting of Proxies

    Shares represented by all properly executed proxies received in time for the special meeting will be voted at the special meeting in the manner specified by the holders thereof. Except for the broker non-votes, properly executed proxies that do not contain voting instructions will be voted in favor of the approval and adoption of the merger agreement and approval of the merger.

    For voting purposes at the special meeting, only shares affirmatively voted in favor of approval and adoption of the merger agreement and approval of the merger will be counted as favorable votes for the approval and adoption. The failure to submit a proxy (or to vote in person) or the abstention from voting or submission of a broker non-vote with respect to the approval and adoption will have the same effect as a vote against approval and adoption of the merger agreement and approval of the merger.

    It is not expected that any matter other than those referred to in this proxy statement/prospectus will be brought before the special meeting. If, however, other matters are properly presented for a vote, the persons named as proxies will vote in accordance with their judgment with respect to those matters. The persons named as proxies by a holder of Axys common stock may propose and vote for one or more adjournments of the special meeting to permit further solicitations of proxies in favor of approval and adoption of the merger agreement and approval of the merger; however, no proxy which is voted against the approval and adoption of the merger agreement and approval of the merger will be voted in favor of an adjournment.

Revoking Proxies

    Holders of Axys common stock on the record date may revoke their proxies at any time prior to the time their proxies are voted at the special meeting. Proxies may be revoked by written notice, including by telegram or facsimile, to the Secretary of Axys, by a later-dated proxy signed and returned by mail, or by attending the special meeting and voting in person. Attendance at the special meeting will not in and of itself constitute a revocation of a proxy. Any written notice of a revocation of a proxy must be sent so as to be delivered before the taking of the vote at the special meeting as follows:

Proxy Solicitation

    Axys will bear the cost of the solicitation of proxies from its stockholders, except that Applera will pay 75% of the cost of filing, printing and distributing the registration statement and this proxy statement/prospectus and Axys will be responsible for 25% of these costs. In addition to solicitation by mail, the directors, officers and employees of Axys may solicit proxies from stockholders of Axys by telephone or telegram or by other means of communication. Such directors, officers and employees will

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not be additionally compensated but may be reimbursed for reasonable out-of-pocket expenses in connection with the solicitation.

    Axys has retained MacKenzie Partners, Inc. to assist in the solicitation of proxies by Axys. Axys will pay $6,000, plus reimbursement of some out-of-pocket expenses, to MacKenzie Partners for its services. Axys will cause brokerage houses and other custodians, nominees and fiduciaries to forward solicitation materials to the beneficial owners of common stock held of record by those persons. Axys will reimburse any of these custodians, nominees and fiduciaries for their reasonable out-of-pocket expenses in doing so.

    Do not send in any stock certificates with your proxy cards. Applera will instruct its exchange agent to send transmittal forms with instructions for the surrender of certificates representing shares of Axys common stock in exchange for the issuance of certificates representing shares of Celera Genomics common stock to former holders of Axys common stock shortly after the merger is completed.

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THE MERGER

    The following is a description of certain aspects of the proposed merger, including the material terms of the merger agreement. The following summary is qualified in its entirety by reference to the complete merger agreement, which is attached to this proxy statement/prospectus as Annex A, and is incorporated in this proxy statement/prospectus by reference. All stockholders of Axys are urged to read the merger agreement in its entirety.

Background of the Merger

    In January 2000, Axys' management and board of directors concluded that Axys should explore opportunities for a strategic combination with a company in the life sciences industry. Axys was concerned that its limited financial resources and limited access to novel drug targets would constrain Axys' long-term ability to capitalize on its core scientific assets, primarily its highly skilled scientific employee base. In addition, Axys was concerned about its continuing ability to access additional capital in the shorter-term. This concern was heightened by Axys' challenges in realizing near-term value from any of its affiliated businesses. Consequently, Axys engaged Lehman Brothers as its financial advisor and, through Lehman Brothers, Axys held preliminary discussions with various potential strategic parties during the first two quarters of 2000. None of these discussions progressed beyond the preliminary stage, and on or about August 2000, Axys terminated its relationship with Lehman Brothers.

    In addition to exploring the opportunities for strategic combinations during the first half of 2000, Axys also sought additional financing for its operations, and engaged in a series of transactions in 2000 to provide Axys with further funding. In March 2000, Axys raised approximately $31.5 million in gross proceeds through a private placement of Axys common stock. In April 2000, Axys merged its subsidiary Advanced Technologies with Discovery Partners and acquired 7,425,000 shares of Discovery Partners stock. Discovery Partners subsequently went public in July 2000; however, the Discovery Partners shares owned by Axys, which represented approximately 33% of Discovery Partners' outstanding shares, were subject to an underwriters' lock up until January 2001 and continue to be subject to various restrictions on resale. In July 2000, Axys put in place an equity line of credit for up to $50 million and made an initial draw down of $10 million. In September 2000, Axys raised an additional $26 million by selling convertible notes with warrants, which notes were collateralized by most of Axys' Discovery Partners shares. Based on the closing price of Discovery Partners common stock on the Nasdaq National Market on September 1, 2000, Axys' 33% stake in Discovery Partners had a market value in excess of $145 million. In December 2000, Axys agreed to merge its subsidiary PPGx with another private company, DNA Sciences. Although DNA Sciences filed for an initial public offering in January 2001, it has not proceeded with that offering. Axys' other spinout business, Akkadix, sought but failed to secure additional funding in late 2000, and in early 2001, laid off a substantial portion of its workforce and was forced to reduce its operations.

    In Axys' view during late 2000, the following factors were important to its continuing ability to fund its programs for the next several years: (1) the ability to sell its Discovery Partners shares and the amount that could be realized from that sale, since their market value had declined substantially since the convertible note transaction in which $26 million had been borrowed, (2) the ability to sell its shares in privately-held DNA Sciences and the amount that could be realized from that sale, (3) the ability to raise additional funding through the equity line or other sources despite the current difficult biotech funding environment and (4) the entry into additional research and development collaborations to further reduce Axys' operating expenditures.

    In January 2001, Axys received an unsolicited invitation from an interested party in the life sciences industry to discuss a possible strategic combination. In February, in response to the overture from this interested party, Axys requested JPMorgan H&Q, a division of J.P. Morgan Securities Inc. to assist Axys in identifying potential merger partners, exploring other strategic and financial transactions

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for Axys and reviewing publicly available information regarding possible merger partners. JPMorgan H&Q was formally engaged by Axys on May 7, 2001. The discussions with the initial interested party ended at an early stage. During the course of the ensuing months, JPMorgan H&Q and/or Axys engaged in discussions with approximately 10 other potential strategic parties, including Applera, which were potential merger partners for Axys and/or which Axys believed might have the potential to provide Axys with novel targets and other valuable resources.

    On April 2, Paul Hastings, Axys' President and Chief Executive Officer, Dr. Michael Venuti, Senior Vice President, Research and Preclinical Development and Chief Technical Officer and William Newell, Senior Vice President, Corporate & Business Development, met with Dr. Peter Barrett, Chief Business Officer of the Celera Genomics group, to discuss a possible transaction in very general terms. On that same date, Axys and Applera entered into a confidentiality agreement. Executives of both companies, as well as their respective financial advisors, met periodically over the ensuing weeks to explore a potential strategic combination. Commencing in mid-April, Applera began a preliminary due diligence review of Axys' operations.

    On May 2 and 3, a team from the Celera Genomics group led by Dr. Barrett met with Axys management to further discuss the Axys business. After that meeting and throughout the remainder of May, Applera conducted a more thorough due diligence review of Axys' business, scientific, legal and financial affairs and engaged in more in depth discussions with Axys' senior management team. During the month of May, Axys and Applera and their respective financial advisors also commenced preliminary negotiations regarding the possible financial terms for a merger. The board of directors of Axys held meetings on May 14, May 17, May 23 and June 1 with Axys' management and legal advisors and, except with respect to the May 23 meeting, representatives of JPMorgan H&Q, concerning the progress of the Applera negotiations and related matters. During these meetings, the board of directors instructed management and Axys' legal and financial advisors to continue negotiations with Applera.

    Beginning in the week of June 3, the respective financial advisors and legal counsel for Axys and Applera reviewed and negotiated the detailed terms of a definitive merger agreement to govern the strategic combination of the parties and Applera continued to conduct its due diligence review of Axys' business throughout the week. Tony L. White, Applera's Chairman and Chief Executive Officer, and Peter Chambré, Chief Operating Officer of the Celera Genomics group, met with Mr. Hastings on June 7, and Dr. Venuti met with Dr. Craig Venter, President and Chief Scientific Officer of the Celera Genomics group on June 10, to discuss the possible strategic transaction. The board of directors of Axys discussed the proposed terms of the merger, including exchange ratio and other material terms, with legal counsel and representatives from JPMorgan H&Q at special meetings held on the evenings of June 10 and 11. During each of these meetings, members of the law firm of Latham & Watkins, outside counsel to Axys, reviewed with the directors their fiduciary duties. At the conclusion of each meeting, the board of directors instructed management to continue proceeding toward reaching a final definitive agreement with Applera.

    During the period that Axys was providing due diligence materials to Applera, and Applera and Axys were negotiating a potential strategic combination, Axys was also providing due diligence information to another potential strategic party. In addition, Axys and its financial and legal advisors were negotiating the terms for a potential merger with this second party. The status and terms of this alternative merger proposal were reviewed and discussed by the Axys board members during the board meetings held on May 14, May 17, May 23, June 1, June 10 and June 11, and during each of the meetings, the Axys board of directors instructed management to continue to pursue this potential merger transaction concurrently with their discussions with Applera.

    The Axys board of directors believes that Axys' success to date and ongoing value are attributable to Axys' base of highly-qualified and experienced scientific employees. The Axys board of directors had significant concerns regarding Axys' ability to retain these very talented and sought after employees through the closing of a potential merger with this second party, and failing this retention, concerns

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that the potential merger might fail to close. In this regard, Axys was only to be given limited freedom by the second party to offer financial incentives to Axys' employees to ensure that they would remain with Axys through the closing of the transaction. Axys believed that Axys would have an increased ability to retain its employees through the closing of the merger with the Applera affiliate due to the willingness of Applera to permit Axys to provide certain incentives to Axys' employees, as well as the current business practices of the Celera Genomics group, both of which were more compatible with the approach of Axys. In addition, the second party wanted to strictly limit Axys' ability to amend and extend its existing collaboration agreements and enter into similar agreements for non-sponsored research and development programs prior to the closing of a merger. Applera was willing to provide Axys with more flexibility in this regard as continued partnering has been and is expected to be generally consistent with the business practices of the Celera Genomics group. The board of directors noted that Axys' existing and planned collaboration agreements were an integral part of Axys' financial planning, and the elimination of these initiatives would meaningfully reduce Axys' sources of revenue and liquidity. The board of directors concluded that if the merger with this second party failed to close due to a failure to retain employees or some other reason, Axys' ability to continue its operations would be hampered significantly if it could not pursue its collaboration initiatives during the pre-closing period. Concerns about the certainty of closing the merger, in addition to concerns about the ongoing financial strength of Axys in the event the merger did not close, led the board of directors to conclude in its June 11 meeting that the Applera transaction, which offered Axys greater flexibility in these areas of concern, was superior to the proposal from the second party. Immediately following the board meeting on June 11, and again during the afternoon and evening of June 12, Axys and its financial advisor invited the second party to revise its proposal to address these and other concerns. As of the evening of June 12, 2001, Axys had not received a new proposal from the second party that addressed the board of directors' concerns.

    At a special meeting of the board of directors of Applera held by telephone on the afternoon of June 12, 2001 and attended by Morgan Stanley & Co. Incorporated, financial advisor to Applera, and Applera's legal counsel, Simpson Thacher & Bartlett, the board of directors reviewed and discussed the proposed terms of the merger transaction with Axys. The Applera board of directors approved the terms of the merger and delegated authority to certain members of senior management to finalize and enter into a definitive merger agreement.

    At a special meeting of the Axys board of directors held on the evening of June 12, 2001 and attended by JPMorgan H&Q and Axys' legal counsel, Latham & Watkins and Richards, Layton & Finger, the board of directors reviewed and discussed the final definitive Applera merger agreement. Axys' legal counsel reviewed with the members of the Axys board of directors their fiduciary duties relating to the proposed transaction with Applera. Also at this meeting, JPMorgan H&Q reviewed its financial analysis of the exchange ratio provided for in the transaction and delivered to the Axys board of directors its oral opinion (which opinion was confirmed by a written opinion dated June 12, 2001) to the effect that, as of the date provided in the opinion, and based on and subject to the matters described in the opinion, the exchange ratio provided for in the transaction was fair, from a financial point of view, to holders of Axys' common stock. See "The Merger—Opinion of the Financial Advisor to the Axys Board of Directors" in this proxy statement/prospectus for more information about the opinion delivered by JPMorgan H&Q. The opinion is attached as Annex B to this proxy statement/prospectus. JPMorgan H&Q expressed no opinion as to the fairness of the offer from the second party nor did it make a recommendation to pursue one transaction over any other. At the conclusion of the meeting, the board of directors unanimously determined that the Applera merger was fair to and in the best interests of Axys' stockholders and approved the definitive merger agreement. The merger agreement was executed later that night, and the transaction was announced in a joint press release on the morning of June 13, 2001.

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    The Axys board of directors, in consultation with its financial and legal advisors, carefully considered the terms and conditions of the merger agreement and the proposed merger. The Axys board of directors unanimously determined that the merger of Axys pursuant to the terms of the merger agreement is in the best interests of Axys' stockholders, unanimously approved the merger agreement and the merger and unanimously recommended that the stockholders of Axys vote to approve and adopt the merger agreement and approve the merger.

    In reaching its unanimous decision to approve the merger agreement, the Axys board of directors considered a number of positive factors, including the following:

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    The Axys board of directors also considered a number of potentially negative factors in its deliberations concerning the merger, including:

    The Axys board of directors believes that these negative risks are outweighed by the potential benefits to be gained by the merger.

    The foregoing discussion of the information and factors considered by the board of directors of Axys is not intended to be exhaustive. In view of the wide variety of the factors considered by the board of directors in evaluating the merger and the complexity of these matters, the board of directors of Axys did not find it practicable to, and did not, quantify or otherwise attempt to assign any relative weight to the various factors considered. In considering the factors described above, individual members of the board of directors of Axys may have given different weight to different factors.

Recommendation of the Axys Board of Directors

    After careful consideration, and in light of the factors described under the heading "—Reasons for the Merger—Axys," the Axys board of directors has unanimously determined that the merger agreement is advisable, and that the merger and the consideration to be paid to the holders of Axys' common stock in the merger are fair to, and in the best interests of, the holders of Axys' common stock. Accordingly, the Axys board of directors has unanimously approved the merger agreement and the merger, and unanimously recommends that the holders of Axys' common stock entitled to vote at

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the special meeting vote FOR the proposal to approve and adopt the merger agreement and approve the merger.

Reasons of Applera for the Merger

    In evaluating the proposed merger, the Applera board of directors reviewed presentations from its management and advisors, including the advice of its financial advisor, Morgan Stanley and Co. Incorporated. In reaching its determination to approve the merger agreement and the transactions contemplated thereby, the Applera board of directors considered a number of factors, including the factors listed below.

    None of the foregoing factors or groups of factors had particular prominence in the decision of the Applera board of directors to approve the merger agreement and the transactions contemplated thereby, and none was assigned any specific or relative weight.

Opinion of the Financial Advisor to the Axys Board of Directors

    The board of directors of Axys retained JPMorgan H&Q, a division of J.P. Morgan Securities Inc., as its financial advisor in connection with the proposed merger.

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    The full text of the definitive written JPMorgan H&Q opinion, dated June 12, 2001, which sets forth the assumptions made, the procedures followed, the matters considered and the limitations on the scope of the review undertaken by JPMorgan H&Q in rendering its opinion is attached as Annex B to this proxy statement/prospectus. Holders of Axys common stock are urged to read the JPMorgan H&Q opinion carefully and in its entirety. The JPMorgan H&Q opinion only addresses the fairness of the exchange ratio provided in the merger agreement, from a financial point of view, to the holders of common stock of Axys as of the date of the JPMorgan H&Q opinion, and does not constitute a recommendation to any stockholder of Axys as to how the stockholder should vote at the special meeting.

    At the meeting of the board of directors of Axys on June 12, 2001, JPMorgan H&Q rendered its oral opinion to the board of directors of Axys that, as of such date, the exchange ratio provided in the merger agreement, as defined in the merger agreement, was fair, from a financial point of view, to the holders of common stock of Axys. JPMorgan H&Q has confirmed its June 12, 2001 oral opinion by delivering its written opinion, dated June 12, 2001, to the board of directors of Axys, that, as of such date, the exchange ratio provided in the merger agreement was fair, from a financial point of view, to the holders of common stock of Axys. No limitations were imposed by the board of directors of Axys upon JPMorgan H&Q with respect to the investigations made or procedures followed by it in rendering its opinion.

    In arriving at its opinion, JPMorgan H&Q (1) reviewed a draft of the merger agreement, dated June 11, 2001; (2) reviewed certain publicly available business and financial information concerning Axys and the Celera Genomics group, and the industries in which they operate; (3) compared the proposed financial terms of the merger with the publicly available financial terms of certain transactions involving companies JPMorgan H&Q deemed relevant and the consideration received for such companies; (4) compared the financial and operating performance of Axys and the Celera Genomics group with publicly available information concerning certain other companies it deemed relevant and reviewed the current and historical market prices of the common stock of Axys and Celera Genomics common stock and certain publicly traded securities of such other companies; (5) reviewed certain internal financial analyses and forecasts prepared by the management of Axys relating to its business; and (6) performed such other financial studies and analyses and considered such other information as it deemed appropriate for the purposes of its opinion.

    In giving its opinion, JPMorgan H&Q relied upon and assumed, without independent verification, the accuracy and completeness of all information that was publicly available or was furnished to it by Axys and Applera or otherwise reviewed by it, and JPMorgan H&Q has not assumed any responsibility or liability therefor. JPMorgan H&Q has not conducted any valuation or appraisal of any assets or liabilities, nor have any such valuations or appraisals been provided to it. In relying on financial analyses and forecasts provided to it, JPMorgan H&Q has assumed that they have been reasonably prepared based on assumptions reflecting the best currently available estimates and judgments by management and its representatives as to the expected future results of operations and financial condition of Axys and the Celera Genomics group to which such analyses or forecasts relate. JPMorgan H&Q has also assumed that the merger will qualify as a tax-free reorganization for United States federal income tax purposes, that the merger will be accounted for as a purchase, and that the other transactions contemplated by the merger agreement will be consummated as described in the merger agreement. JPMorgan H&Q has relied as to all legal matters relevant to rendering its opinion upon the advice of counsel. JPMorgan H&Q has also assumed that the definitive merger agreement did not differ in any material respects from the draft thereof furnished to it. JPMorgan H&Q has further assumed that all material governmental, regulatory or other consents and approvals necessary for the consummation of the merger will be obtained without any adverse effect on Axys, the Celera Genomics group or the Applera or on the contemplated benefits of the merger.

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    JPMorgan H&Q also held discussions with certain members of the management of Axys with respect to certain aspects of the merger, and the past and current business operations of Axys and the Celera Genomics group, the financial condition and future prospects and operations of Axys and the Celera Genomics group, the effects of the merger on the financial condition and future prospects of Axys and the Celera Genomics group, and certain other matters it believed necessary or appropriate to its inquiry.

    The opinion of JPMorgan H&Q is necessarily based on economic, market and other conditions as in effect on, and the information made available to it as of June 12, 2001. It should be understood that subsequent developments may affect this opinion and that JPMorgan H&Q does not have any obligation to update, revise, or reaffirm this opinion. For purposes of its opinion, JPMorgan H&Q was not asked to consider, and its opinion does not address, the relative merits of the merger as compared to any alternative business strategy that might exist for Axys or of the effect of any other business combinations in which Axys might engage. The opinion of JPMorgan H&Q is limited to the fairness, from a financial point of view, to the holders of common stock of Axys of the exchange ratio in the proposed merger, based upon the trading price of Celera Genomics common stock as of June 11, 2001, and it expresses no opinion as to the underlying decision by Axys to engage in the merger. JPMorgan H&Q expressed no opinion therein as to the price at which Celera Genomics common stock will trade at any future time.

    The projections furnished to JPMorgan H&Q for Axys were prepared by the management of Axys. Axys does not publicly disclose internal management projections of the type provided to JPMorgan H&Q in connection with JPMorgan H&Q's analysis of the transaction, and such projections were not prepared with a view toward public disclosure. These projections were based on numerous variables and assumptions that are inherently uncertain and may be beyond the control of management, including, without limitation, factors related to general economic and competitive conditions and prevailing interest rates. Accordingly, actual results could vary significantly from those set forth in such projections.

    In accordance with customary investment banking practice, JPMorgan H&Q employed generally accepted valuation methods in reaching its opinion. The following is a summary of the material financial analyses utilized by JPMorgan H&Q in connection with providing its opinion.

    Historical Price and Premium Analysis.  JPMorgan H&Q calculated the implied premium over the closing price of the common stock of Axys as of June 11, 2001 of the consideration to be paid in the proposed merger.

Period of Sales Price Comparison

  Implied Premium at $4.65
 
June 11, 2001   42.6 %
5 Day Average   38.6 %
10 Day Average   41.5 %
20 Day Average   41.0 %
60 Day Average   50.2 %
90 Day Average   28.2 %

    Premiums Paid Analysis.  JPMorgan H&Q compared the implied premium as of June 11, 2001 of the consideration to be paid in the proposed merger to implied premiums paid in certain comparable transactions. The transactions used for this analysis were:

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    Applying the median premiums paid to the corresponding closing price of the common stock of Axys as of June 11, 2001, JPMorgan H&Q calculated the following implied equity values per share.

Period of Price Comparison

  Median
Premium Paid

  Implied Equity
Value per share

One day prior spot price   27.5 % $ 4.16
10 day trailing average   31.9 % $ 4.33
30 day trailing average   35.4 % $ 4.43

    JPMorgan H&Q compared the range from $4.16 to $4.43 to the offer price in the proposed merger, as of June 11, 2001, of $4.65.

    Exchange Ratio Analysis.  JPMorgan H&Q reviewed the ratios of the closing prices of the common stock of Axys to the corresponding closing prices of the common stock of the Celera Genomics group over various periods ending June 11, 2001. The resulting ratios are referred to as average exchange ratios.

Period Ending June 11, 2001

  Average Implied Exchange Ratio
90 Day   0.0932x
60 Day   0.0831x
20 Day   0.0749x
10 Day   0.0719x
5 Day   0.0699x
1 Day   0.0710x

    JPMorgan H&Q compared these ratios with the implied natural exchange ratio of 0.1012x as of June 11, 2001.

    Public Trading Multiples.  Using publicly available information, JPMorgan H&Q compared selected employee data of Axys with similar data for comparable companies which JPMorgan H&Q judged to be of a similar employee business to Axys. The companies selected by JPMorgan H&Q were Array BioPharma, Inc., Medichem Life Sciences, Inc. and Albany Molecular Research, Inc. These

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companies were selected, among other reasons, because of their operational and organizational similarities with Axys. For each comparable company, JPMorgan H&Q determined the number of chemists and Ph.D.'s as of June 2001. JPMorgan H&Q calculated the multiples of enterprise value (enterprise value equals market value plus net debt) to the number of chemists and Ph.D.'s at each comparable company. These resulting median multiples were then applied to Axys' number of chemists and Ph.D.'s, yielding implied enterprise values that were then used to calculate implied equity values per share for Axys. JPMorgan H&Q, in its judgment, used the following results of such calculations:

Metric

  Multiples
  Implied Equity Value
Per Share for Axys

Chemists   1.6x   $ 3.52
Ph.D.'s   2.7x   $ 5.36

    JPMorgan H&Q compared the range from $3.52 to $5.36 to the offer price in the proposed merger, as of June 11, 2001, of $4.65.

    Discounted Future Value Analysis.  Using publicly available information, JPMorgan H&Q compared selected financial data of Axys with similar data for selected publicly traded healthcare companies with near-term sales engaged in businesses which JPMorgan H&Q judged to be similar to Axys' business. The companies selected by JPMorgan H&Q were Aviron, ImClone Systems Incorporated, The Medicines Company, Praecis Pharmaceuticals Incorporated and Scios Inc. These companies were selected, among other reasons, because of their operational, organizational and overall business similarities with Axys and because each company is expected to have near-term sales. For each comparable company, Wall Street projections for CY2002 and CY2003 revenues were measured as well as current equity values. JPMorgan H&Q calculated the current enterprise values for each company and used such values to calculate multiples of enterprise value to CY2002 and CY2003 revenues. JPMorgan H&Q selected the applicable median multiple and applied it to the projected CY2007 and CY2008 revenues for Axys as provided by management of Axys in order to calculate the future enterprise value of Axys. The resulting enterprise values were discounted back to the current year. JPMorgan H&Q then calculated equity values per share for Axys. JPMorgan H&Q, in its judgment, used the following results of such calculations:

 
  Multiple
  Implied Equity Value per
Share for Axys

CY2007   9.7x   $ 4.15
CY2008   7.3x   $ 4.25

    JPMorgan H&Q then calculated the average of such implied equity values per share as $4.20.

    JPMorgan H&Q also compared selected financial data of Axys with similar data for selected publicly traded healthcare companies with current sales engaged in businesses which JPMorgan H&Q judged to be similar to Axys' business. The companies selected by JPMorgan H&Q were Celgene, Cephalon, COR Therapeutics and QLT Inc. These companies were selected, among other reasons, because of their operational, organizational and overall business similarities with Axys and because each company has current sales. For each comparable company, Wall Street projections for CY2001 and CY2002 revenues were measured as well as current equity values. JPMorgan H&Q calculated the current enterprise values for each company and used such values to calculate multiples of enterprise value to CY2001 and CY2002 revenues. JPMorgan H&Q selected the applicable median multiple and applied it to the projected CY2008 and CY2009 revenues for Axys as provided by management of Axys in order to calculate the future enterprise value of Axys. The resulting enterprise values were

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discounted back to the current year. JPMorgan H&Q then calculated equity values per share for Axys. JPMorgan H&Q, in its judgment, used the following results of such calculations:

 
  Multiple
  Implied Equity Value per
Share for Axys

CY2008   16.1x   $ 4.87
CY2009   9.9x   $ 4.27

    JPMorgan H&Q then calculated the average of such implied equity values per share as $4.57. JPMorgan H&Q then observed that the range of average implied equity values per share for Axys based on the near-term sales comparable companies and current sales comparable companies was $4.20 to $4.57, which compared to the offer price in the proposed merger, as of June 11, 2001, of $4.65.

    Historical Trading Price Analysis.  JPMorgan H&Q reviewed and analyzed the historical closing prices for the common stock of Axys for the 12 month period ending June 11, 2001. JPMorgan H&Q observed the following values for the trading price of the common stock of Axys:

Metric

  Price
Period High   $ 8.06
Period Low   $ 2.19

    JPMorgan H&Q compared the range from $2.19 to $8.06 to the offer price in the proposed merger, as of June 11, 2001, of $4.65. JPMorgan H&Q also considered in its analysis the historical closing prices for the common stock of Axys for the six months ended June 11, 2001. JPMorgan H&Q compared the six month range of $2.19 to $6.47 to the offer price in the proposed merger, as of June 11, 2001, of $4.65.

    The summary set forth above does not purport to be a complete description of the analyses or data presented by JPMorgan H&Q. The preparation of a fairness opinion is a complex process and is not necessarily susceptible to partial analysis or summary description. JPMorgan H&Q believes that the summary set forth above and its analyses must be considered as a whole and that selecting portions thereof, without considering all of its analyses, could create an incomplete view of the processes underlying its analyses and opinion. JPMorgan H&Q based its analyses on assumptions that it deemed reasonable, including assumptions concerning general business and economic conditions and industry-specific factors. The other principal assumptions upon which JPMorgan H&Q based its analyses are set forth above under the description of each such analysis. JPMorgan H&Q's analyses are not necessarily indicative of actual values or actual future results that might be achieved, which values may be higher or lower than those indicated. Moreover, JPMorgan H&Q's analyses are not and do not purport to be appraisals or otherwise reflective of the prices at which businesses actually could be bought or sold.

    As a part of its investment banking business, JPMorgan H&Q and its affiliates are continually engaged in the valuation of businesses and their securities in connection with mergers and acquisitions, investments for passive and control purposes, negotiated underwritings, secondary distributions of listed and unlisted securities, private placements, and valuations for estate, corporate and other purposes. JPMorgan H&Q was selected to advise the board of directors of Axys with respect to the merger on the basis of such experience and its familiarity with Axys.

    For services rendered in connection with the merger, Axys has agreed to pay JPMorgan H&Q a customary fee. In addition, Axys has agreed to reimburse JPMorgan H&Q for its expenses incurred in connection with its services, including the fees and disbursements of counsel, and will indemnify JPMorgan H&Q against certain liabilities, including liabilities arising under the federal securities laws. Previously, JPMorgan H&Q has provided investment banking and other financial advisory services to Axys, including as a manager in a public offering of securities in 1996, and has received fees for rendering these services.

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    In the ordinary course of their businesses, JPMorgan H&Q and its affiliates may actively trade the debt and equity securities of Axys, or Applera for their own accounts or for the accounts of customers and, accordingly, they may at any time hold long or short positions in such securities.

Structure of the Merger

    If all conditions to the merger are satisfied or waived in accordance with the merger agreement, Angel Acquisition, a direct, wholly owned subsidiary of Applera, will merge with and into Axys, with Axys continuing as the surviving corporation. Following the merger, Axys will be a wholly owned subsidiary of Applera. After the merger, Axys will be integrated into the research and development and business operations of the Celera Genomics group.

Closing Matters

    Closing.  The closing of the merger will take place on the second business day after all closing conditions have been satisfied or waived, unless the merger agreement has been terminated or another time or date is agreed to in writing by the parties. See "—Conditions to the Merger" for a more complete description of the conditions that must be satisfied prior to closing.

    Effective Time.  On the closing date of the merger, Applera and Axys will file a certificate of merger agreement in accordance with the Delaware General Corporation Law and make all other required filings or recordings. The merger will become effective when the certificate of merger is duly filed or at such later time as is permissible in accordance with the Delaware General Corporation Law and as Axys and Applera agree and specify in the certificate of merger.

    Certificate of Incorporation and Bylaws.  The merger agreement provides that the restated certificate of incorporation of Axys will be the certificate of incorporation of the surviving corporation, and the bylaws of Angel Acquisition will be the bylaws of the surviving corporation.

    Directors and Officers.  The merger agreement provides that the directors of Angel Acquisition at the effective time of the merger will be the directors of the surviving corporation, and that the officers of Axys at the effective time will be the officers of the surviving corporation.

Consideration to Be Received in the Merger

    The merger agreement provides that, at the effective time of the merger, each share of Axys common stock will be exchanged for a fraction of a share of Celera Genomics common stock and associated rights. This number is referred to as the "exchange ratio." The exchange ratio will be determined as follows:

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    The merger agreement also provides that, at the effective time of the merger, each share of Axys common stock held in the treasury of Axys or owned by Applera or Angel Acquisition will be canceled and retired without any cash or other consideration delivered with respect to such share.

    At the time of the special meeting, Axys stockholders will not necessarily know the exact number or the exact market price of the Celera Genomics common stock that will be issued in connection with the merger. The number of shares of Celera Genomics common stock that will be received for each share of Axys common stock will be calculated using the exchange ratio formula described above, and will vary accordingly based on the trading price of Celera Genomics common stock after the special meeting. Stockholders of Axys are urged to obtain current market quotations for Celera Genomics common stock prior to the date of the special meeting. No assurance can be given as to the market price of Celera Genomics common stock at any time prior to or on the effective date of the merger.

Treatment of Axys Stock Options

    The merger agreement provides that, after the effective time of the merger, each outstanding option to purchase Axys common stock granted prior to the effective time of the merger under Axys' stock option plans, whether vested or unvested, will be assumed by Applera at the effective time and converted into an option to purchase shares of Celera Genomics common stock under the same terms and conditions as were applicable to the options as granted under the option plan and form of option agreement under which it was issued. To the extent permitted by law, Applera will comply with the terms of the relevant Axys stock option plans applicable to the options and will ensure that the stock options which qualified as incentive stock options prior to the effective time of the merger continue to qualify as incentive stock options after the merger.

    The number of shares of Celera Genomics common stock that each converted option will be exercisable for will be equal to the number of shares of Axys common stock subject to such options prior to the merger multiplied by the exchange ratio, rounded down to the nearest whole share, and the exercise price for each share under the option will be a price per share equal to the exercise price per share prior to the merger divided by the exchange ratio, rounded up to the nearest whole cent, provided that in no event will the option exercise price for options held by Axys employees or consultants be higher than the closing price of a share of Celera Genomics common stock on the date immediately prior to the closing of the merger. Within 10 business days after the effective time of the merger, Applera will deliver notices to the holders of Axys stock options, stating that the option has been converted pursuant to the merger and setting forth the number of shares of Celera Genomics common stock for which such converted options shall be exercisable, as well as the applicable exercise price for such converted options.

    For a further discussion of the treatment of Axys stock options and the Axys employee benefit plans under the merger agreement, see "—Effect on Employee Benefits, Stock Plan and Stock Options" in this proxy statement/prospectus.

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Exchange of Certificates in the Merger

    BankBoston, N.A., in its capacity as exchange agent of Celera Genomics common stock, will handle the exchange of Axys stock certificates for stock certificates of Celera Genomics common stock and the payment of cash for fractional shares. Soon after the closing of the merger, the exchange agent will send a letter of transmittal, which is to be used to exchange Axys stock certificates for stock certificates of Celera Genomics common stock, to each former Axys stockholder. The letter of transmittal will contain instructions explaining the procedure for surrendering Axys stock certificates. You should not return certificates with the enclosed proxy card.

    Axys stockholders who surrender their stock certificates, together with a properly completed letter of transmittal, will receive stock certificates representing the shares of Celera Genomics common stock into which their shares of Axys common stock were converted in the merger. After the merger, each certificate previously representing shares of Axys common stock will only represent the right to receive the shares of Celera Genomics common stock into which those shares of Axys common stock have been converted (and cash in lieu of fractional shares).

    Applera will not pay dividends or make any other distributions with respect to Celera Genomics common stock to holders of any Axys stock certificates until the Axys stock certificates are surrendered. However, once those certificates are surrendered, Applera will pay to the holder, without interest, any dividends or other distributions that may have been declared after the effective time of the merger on the shares of Celera Genomics common stock into which those Axys shares have been converted. After the effective time of the merger, Axys will not register any transfers of shares of Axys common stock.

Fractional Shares

    No fractional shares of Celera Genomics common stock will be issued in the merger. Instead, Applera will deposit with BankBoston, N.A., the exchange agent, any cash payable in lieu of fractional shares of Celera Genomics common stock. From the deposited funds, the exchange agent will pay each of those former Axys stockholders who would have otherwise been entitled to a fractional share of Celera Genomics common stock an amount in cash determined by multiplying the fractional share interest to which the holder would otherwise be entitled by the average of the closing prices of a share of Celera Genomics common stock on the New York Stock Exchange Composite Transactions Tape on each of the 10 consecutive trading days immediately preceding (but excluding) the second trading day prior to the closing date of the merger.

Effect on Axys Convertible Notes and Warrants

    Applera has agreed to become jointly and severally liable with Axys for the payment and performance by Axys of all of its obligations under the convertible notes issued by Axys and the related indenture and note purchase agreements and warrants to purchase Axys common stock. After the merger, each convertible note outstanding at the effective time of the merger will become convertible into the number of shares of Celera Genomics common stock that would have been received for the note if the note had been converted immediately prior to the merger.

    The merger agreement provides that at the effective time of the merger, subject to limited exceptions, each outstanding unexercised warrant to purchase Axys common stock will be converted into a warrant to purchase shares of Celera Genomics common stock under the same terms and conditions as applied to the Axys warrant. Each warrant shall be exercisable for the number of shares of Celera Genomics common stock the holder of the warrant would have been entitled to receive in the merger if the warrant had been exercised immediately prior to the merger. The exercise price under the warrant will be a price per share equal to the total exercise price for all shares of Axys common stock that were purchasable under the warrant immediately prior to the merger divided by the

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number of full shares of Celera Genomics common stock that are purchasable under the warrant immediately after the merger.

Representations and Warranties

    The merger agreement contains substantially reciprocal customary representations and warranties made by each of Applera and Axys to the other. These representations and warranties relate to, among other things:

    The merger agreement also contains representations and warranties of Axys relating to:

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    The merger agreement also contains representations and warranties of Applera that relate to operations of Angel Acquisition prior to closing.

    The representations and warranties contained in the merger agreement do not survive the effective time of the merger.

Covenants

    Axys and Applera have each undertaken certain covenants in the merger agreement. The following summarizes the most significant of these covenants.

    Conduct of Business by Axys Pending Closing.  Axys and its subsidiaries have undertaken a covenant that places restrictions on the conduct of their businesses until either the effective time of the merger or the termination of the merger agreement. In general, Axys and its subsidiaries are required to carry on their businesses in the ordinary course of business consistent with past practice and use their reasonable best efforts to preserve substantially intact their current business organizations, keep available the services of their current officers and employees and preserve their relationships with third parties. Axys and its subsidiaries have agreed to some specific restrictions that prohibit them from taking any of the following actions unless otherwise expressly provided in the merger agreement:

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    Axys has also agreed to notify Applera if any employee at or above a specified level of seniority gives Axys notice of his or her intention to terminate his or her employment with Axys, so that Applera may meet with the employee.

    Conduct of Business by Applera Pending Closing.  Until the closing of the merger (or the termination of the merger agreement prior to the closing of the merger), Applera has agreed not to declare or pay any dividend on or split, combine or reclassify any Celera Genomics common stock prior to the effective time of the merger or issue or authorize the issuance of any equity interest in substitution for shares of Celera Genomics common stock.

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    Additional Reciprocal Covenants Relating to Conduct of Business Pending the Merger.  Both Axys and Applera have agreed to some specific restrictions that prohibit them from:

    Recommendation of Axys Board of Directors.  The Axys board of directors has agreed to recommend that its stockholders approve and adopt the merger agreement and approve the merger. The Axys board of directors may withdraw or modify its recommendation of the merger in a manner adverse to Applera only if Axys receives a "superior proposal" as described below under "—No Solicitation" in this proxy statement/prospectus.

    No Solicitation.  Axys has agreed that it will not (whether directly or indirectly through advisors, agents or other intermediaries), nor will it or its subsidiaries authorize or permit any of their officers, directors, agents, representatives, advisors or subsidiaries, to:

    A "transaction proposal" is any proposal or offer, other than the transactions contemplated by the merger agreement, with respect to:


    In the event a third party has made a bona fide transaction proposal that could result in a "superior proposal" of the type described below and the Axys board of directors concludes in good

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faith, upon consultation with outside counsel, that the failure to take such action would violate the fiduciary duties of the board of directors of Axys to its stockholders, then Axys may:

    A "superior proposal" is any proposal, other than the transactions contemplated by the merger agreement, with respect to:

if, in each case, the board of directors of Axys has concluded in good faith, after consultation with its outside legal counsel and its financial advisor(s), that the proposal is reasonably capable of being completed and represents a financially superior transaction for holders of Axys common stock compared to the merger under the merger agreement.

    The merger agreement requires Axys to promptly inform Applera of all material terms and conditions of any transaction proposal (including any superior proposal) it receives and to keep Applera informed on a prompt and current basis of the status, terms and content of any discussions regarding any transaction proposal.

    Rights Agreement.  The Axys board of directors has agreed to take all action necessary in order to render its stockholder rights agreement inapplicable to the merger and other transactions contemplated by the merger agreement. Further, the Axys board of directors has agreed not to otherwise amend the rights agreement or take any action with respect to, or make any determination under, the rights agreement without the prior written consent of Applera.

    Reasonable Best Efforts.  Applera and Axys have agreed to cooperate with each other and to use their reasonable best efforts to take all actions and do all things advisable or necessary under applicable laws to complete the merger and the other transactions contemplated by the merger agreement. This cooperation includes obtaining all regulatory consents and approvals necessary to complete the merger and defending any lawsuits or other proceedings challenging the merger agreement. However, Applera and Axys will not be required to make any disposition of or enter into any agreement to hold separate any subsidiary, assets or business, or take any other action that Applera determines could significantly reduce the value of Axys or the benefits that Applera expects to derive from the merger and Axys and its subsidiaries have agreed not to take any of these actions without Applera's prior written consent. Additionally, Axys and its subsidiaries will not agree to take any of the above actions without the prior written consent of Applera.

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    Accountants Letter.  Axys will also use its reasonable best efforts to deliver to Applera a comfort letter from Ernst & Young LLP in a form and substance reasonably satisfactory to Applera prior to the effective date of the Form S-4.

    Access to Information; Confidentiality.  Axys will provide Applera and its representatives reasonable access during normal business hours to Axys' properties, books, contracts, commitments, personnel and records, and will provide Applera with all information concerning its business, properties, financial condition, operations and personnel and a copy of each report, schedule, registration statement or other document filed by it as Applera may reasonably request. Applera and Axys will keep all non-public information confidential.

Conditions to the Merger

    Axys' and Applera's respective obligations to complete the merger are subject to the satisfaction or, to the extent permissible, the waiver of various conditions that include, in addition to other customary closing conditions:

    In addition, each party's obligation to complete the merger is subject to the satisfaction of the following conditions:

    Additionally, Applera's obligation to effect the merger and the other transactions contemplated by the merger agreement is conditioned upon:

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Stock Exchange Listings

    Applera has agreed to use all reasonable efforts to cause the Celera Genomics common stock to be issued in the merger and upon the exercise or conversion of the stock options, warrants and convertible notes granted or issued by Axys prior to the closing of the merger to be approved for listing on the New York Stock Exchange.

Regulatory Approvals Required

    The Hart-Scott-Rodino Antitrust Improvements Act of 1976 prohibits Axys and Applera from completing the merger until after we have filed the required notification and report forms and furnished any additional information and materials requested by the Antitrust Division of the United States Department of Justice and the United States Federal Trade Commission, if requested, and the required waiting period has expired or terminated. The required notification and report forms under the Hart-Scott-Rodino Act were filed by Axys and Applera with the Antitrust Division of the United States Department of Justice and the United States Federal Trade Commission on June 29, 2001. Accordingly, the waiting period under the Hart-Scott-Rodino Act will expire on July 30, 2001 unless, on or prior to that date, either the Antitrust Division or the Federal Trade Commission requests additional information or documentary material from Applera or Axys. There can be no assurance that a challenge to the merger on antitrust grounds will not be made or, if a challenge is made, that it would not be successful. A challenge could be brought by governmental or private parties, and could seek to enjoin consummation of the merger or to compel the divestiture of businesses conducted by Axys or Applera.

Termination of the Merger Agreement

    Right to Terminate.  Axys and Applera may mutually agree to terminate the merger agreement at any time. In addition, either of Axys or Applera may terminate the merger agreement if specified events do or do not occur. These include:

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    The merger agreement may also be terminated by Applera if Axys or its board of directors:

    In addition, Axys may terminate the merger agreement, after it receives a superior proposal and complying with its obligations under the merger agreement with respect to the superior proposal, if its board of directors concludes in good faith, upon consultation with outside counsel, that in order to avoid violating the fiduciary duties of the board of directors of Axys to the stockholders of Axys under the General Corporation Law of the State of Delaware, that the board of directors must not make or must withdraw or modify its recommendation that the stockholders of Axys approve the merger and the merger agreement.

    Effect of Termination.  Under the terms of the merger agreement, if the merger agreement is terminated it will become void and have no effect, and neither Applera nor Axys will have any liability to the other, except that:

    Termination Fee.  Axys will pay to Applera $5.6 million plus out-of-pocket fees and expenses incurred by Applera not exceeding $900,000 if any of the following events occur:

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Amendment and Waiver of the Merger Agreement

    The merger agreement may be amended by the parties at any time before or after approval of the merger agreement by the holders of Axys common stock, except that after that stockholder approval is obtained, there will be no amendment that by law requires further approval by the stockholders without further approval of the stockholders. All amendments to the merger agreement must be in a writing signed by Applera, Axys and Angel Acquisition.

    At any time prior to the effective time of the merger, the parties to the merger agreement may, to the extent legally allowed:

    All extensions and waivers must be in writing and signed by the party against whom the waiver is to be effective.

Expenses

    Axys and Applera have agreed that all costs and expenses incurred in connection with the merger, including the parties' respective brokers fees, will be paid by the party incurring the expenses, except that Applera will pay 75% of the cost of filing, printing and distributing the registration statement and this proxy statement/prospectus and Axys will pay 25% of the cost. In addition, Axys may be required to pay Applera a termination fee and reimburse Applera for certain expenses in the event the merger agreement is terminated under circumstances described in detail under "—Termination of the Merger Agreement—Termination Fee" in this proxy statement/prospectus.

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Effect on Employee Benefits and Related Agreements

    Benefit Plans.  Applera has agreed that following the effective time of the merger until July 1, 2002, employees of Axys will participate in the employment benefits plans maintained by Applera or the surviving corporation providing benefits no less favorable in the aggregate than those benefits currently provided by Axys, excluding any stock compensation plans or programs and arrangements. Applera has also agreed to waive limitations as to pre-existing conditions, exclusions and waiting periods with respect to participation and coverage requirements applying to Axys' employees in Applera benefit plans following the effective time of the merger and to provide credit for amounts paid by Axys employees prior to the effective time of the merger in satisfying deductible or out-of-pocket requirements under Applera's welfare plans. Applera will give employees of Axys at the effective time of the merger who remain employees thereafter full credit, under each Applera employee benefit plan in which the employee may participate, for service under each comparable Axys employee benefit plan maintained by Axys immediately before the effective time of the merger for purposes of eligibility and vesting and entitlement to vacation and vacation pay, but not for purposes of benefit accrual under any employee pension benefit plan.

    Extension of Stock Options.  If Applera or any of its subsidiaries terminate any Axys employee without cause within 90 days after the effective time, Applera has agreed to cause the employees' vested stock options that were converted from Axys stock options to be amended to provide that the exercise period for these vested options will be extended so as to permit their exercise by the terminated employee for a period of 12 months after the date of his or her termination. However, in the case of any employee holding an option intended to qualify as an incentive stock option under Section 421 of the Internal Revenue Code, the extension will be made only with the consent of the terminated employee. Mr. Hastings has indicated that he will not consent to any extension of his options in the event his employment is terminated.

Material United States Federal Income Tax Consequences

    The following discussion sets forth the material United States federal income tax consequences of the merger to United States holders (as defined below) of Axys common stock. This discussion is based upon the Internal Revenue Code of 1986, as amended, Treasury regulations and court and administrative rulings and decisions in effect on the date of this proxy statement/prospectus. These laws may change, possibly retroactively, and any change could affect the continuing validity of this discussion. This discussion does not address any tax consequences arising under the laws of any state, locality or foreign jurisdiction.

    For purposes of this discussion, we use the term "United States holder" to mean:

    This discussion assumes that you hold your shares of Axys common stock as a capital asset and does not address the tax consequences that may be relevant to you in light of your particular circumstances. In addition, it does not present a description of the United States federal income tax

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laws applicable to you if you are subject to special treatment under the United States federal income tax laws, including if you are:

    Applera and Axys have not and will not seek any ruling from the Internal Revenue Service regarding any matters relating to the merger. The Internal Revenue Service has announced that it will not issue advance rulings on the classification of an instrument similar to Celera Genomics common stock that has certain voting and liquidation rights in an issuing corporation but whose dividend rights are determined by reference to a segregated portion of the issuing corporation's assets, including assets held by a subsidiary. In addition, there are no court decisions or other authorities bearing directly on the classification of instruments with characteristics similar to those of Celera Genomics common stock.

    It is a condition to the closing of the merger that each of Applera and Axys receive an opinion from its tax counsel that the merger qualifies as a reorganization within the meaning of Section 368(a) of the Internal Revenue Code of 1986, as amended. The opinions will be based on customary assumptions and factual representations and will assume that the merger will be completed according to the terms of the merger agreement. An opinion of counsel represents counsel's best legal judgment and is not binding on the Internal Revenue Service or any court. The following discussion of United States federal income tax consequences of the merger assumes that, if completed, the merger will qualify as a reorganization within the meaning of Section 368(a) of the Internal Revenue Code of 1986, as amended for United States federal income tax purposes. Based upon the above assumptions and qualifications, the merger will generally result in the following United States federal income tax consequences:

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    Backup Withholding.  If you are a noncorporate holder of Axys common stock, you may be subject to backup withholding on any cash payments received in lieu of a fractional share interest in Celera Genomics common stock. You will not be subject to backup withholding, however, if you:

    Any amounts withheld under the backup withholding rules will be allowed as a refund or credit against your United States federal income tax liability, provided you furnish the required information to the Internal Revenue Service.

    Tax matters are very complicated, and the tax consequences of the merger to you will depend upon your particular tax situation. We encourage you to consult your own tax advisors regarding the specific tax consequences of the merger, including tax return reporting requirements, the applicability of federal, state, local and foreign tax laws and the effect of any proposed change in the tax laws.

Accounting Treatment

    For accounting and financial reporting purposes, the merger will be treated as a purchase by Applera under generally accepted accounting principles.

Interests of Certain Persons in the Merger

    In considering the recommendation of the Axys board of directors with respect to the merger agreement and the merger, you should be aware that some of Axys' directors and executive officers have interests in the merger that may be different from, or in addition to, your interests as a stockholder. The Axys board of directors was aware of these differing interests and considered them, among other matters, in recommending that you approve and adopt the merger agreement and approve the merger. These interests are summarized below.

    Axys has entered into employment agreements with its executive officers: Mr. Hastings; Daniel F. Hoth, M.D., Senior Vice President and Chief Medical Officer of Axys; Mr. Newell; David E. Riggs, Senior Vice President and Chief Financial Officer of Axys; Dr. Venuti; and Douglas H. Altschuler, Vice President and General Counsel of Axys; and director John H. Walker. These agreements may, under the circumstances set forth below, entitle the officer to severance or termination pay or accelerate stock option vesting in connection with the transactions contemplated by the merger agreement.

    Executive Employment Agreement of Mr. Hastings dated as of January 23, 2001.  Mr. Hastings became President and Chief Executive Officer of Axys in January 2001. Mr. Hastings' employment agreement provides for an annualized base salary equal to $400,000 (subject to review each year) and

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eligibility for an annual bonus up to fifty percent of his then current base salary upon achievement of reasonable goals set by the Axys board of directors. Under the terms of the agreement, Axys loaned Mr. Hastings $300,000 and Mr. Hastings issued a full-recourse promissory note, secured by any shares of Axys common stock received by him in connection with any stock option exercise, to Axys on January 2, 2001. The note bears interest at a rate of 5.61% per annum and is payable in full on the earlier of thirty days following Mr. Hastings' termination of employment (other than as set forth below) or January 2, 2004. So long as Mr. Hastings continues to render services to Axys, one thirty-sixth of the principal amount of the note and any interest accrued thereon will be forgiven on the first day of each calendar month. The agreement also provides that Mr. Hastings will receive medical and dental coverage and other standard benefits from time to time provided by Axys to its executives or other employees in general.

    If Mr. Hastings is terminated for any reason other than death, disability, change of control, voluntarily without good reason, or for cause, he will receive one year's base salary (currently $400,000) and his yearly target bonus (currently $200,000) paid in twelve monthly installments, together with forgiveness of all remaining principal and interest due to Axys under the note. Mr. Hastings' options to purchase Axys' common stock that would have vested had he remained in employment an additional twelve months will immediately vest. Axys will also continue to pay the costs associated with his health care benefits for up to twelve months or until he acquires comparable benefits. In the event that Mr. Hastings is terminated, including a voluntary termination by Mr. Hastings for good reason, upon a change of control, he will within seven days receive a lump sum payment equal to eighteen months of his base salary plus a pro rata share of his bonus for the calendar year in which the termination occurs, plus an additional eighteen months of his target bonus. Mr. Hastings will also receive eighteen months of continued health benefits (unless comparable benefits become available to him during that time). All of Mr. Hastings' outstanding options to purchase Axys' common stock shall become fully vested and exercisable immediately upon his termination. In order to obtain these lump sum payments, accelerated vesting and health care benefits in the case of any provided for termination scenario, Mr. Hastings must sign a release of all claims against Axys. Although Mr. Hastings may be able to voluntarily terminate his employment with good reason following the merger, Mr. Hastings has agreed not to do so for a period of six months. In addition, the Celera Genomics group has agreed to recommend to the Management Resources Committee of the Applera board of directors that Mr. Hastings receive an incentive package in consideration of his efforts in integrating Axys and the Celera Genomics group following the merger.

    Executive Employment Agreement of Dr. Hoth dated as of March 30, 2001.  Dr. Hoth's employment agreement provides for an annualized base salary equal to $305,000 (subject to review) and eligibility for an annual bonus up to thirty percent of his then current base salary upon achievement of reasonable goals set by the Axys board of directors. The agreement also provides that Dr. Hoth will receive the standard benefits from time to time provided by Axys to its executive employees generally.

    If Dr. Hoth is terminated involuntarily without cause at any time or voluntarily for good reason after a change of control, he will receive his annual salary and bonus accrued but unpaid as of that date plus health benefits for one year. Specifically, within thirty days following the effectiveness of a release of all claims against Axys, Dr. Hoth will receive a lump sum payment equal to one year's base salary (currently $305,000) plus one year's target bonus (currently $91,500). If Dr. Hoth's termination is within eighteen months following a change of control, 100% of his options to purchase shares of Axys' common stock will immediately vest and become exercisable. In order to obtain the lump sum payment and accelerated vesting benefits, Dr. Hoth must sign a release of all claims against Axys.

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    Amended and Restated Executive Employment Agreement of Mr. Newell dated as of March 27, 2001.   Mr. Newell's employment agreement provides for an annualized base salary equal to $275,000 (subject to review) and eligibility for an annual bonus up to thirty percent of his then current base salary upon achievement of reasonable goals set by the Axys board of directors. The agreement also provides that Mr. Newell will receive the standard benefits from time to time provided by Axys to its executive employees generally.

    This agreement provides that if Mr. Newell is terminated involuntarily without cause at any time or voluntarily for good reason after a change of control, he will receive his annual salary and bonus accrued but unpaid as of that date plus health benefits for one year. Specifically, within thirty days following the effectiveness of a release of all claims against Axys, Mr. Newell will receive a lump sum payment equal to one year's base salary (currently $275,000) plus one year's target bonus (currently $82,500). If Mr. Newell's termination is within eighteen months following a change of control, 100% of his options to purchase shares of Axys' common stock will immediately vest and become exercisable. In order to obtain the lump sum payment and accelerated vesting benefits, Mr. Newell must sign a release of all claims against Axys.

    Amended and Restated Executive Employment Agreement of Mr. Riggs dated as of March 27, 2001.  This agreement provides that if Mr. Riggs is terminated involuntarily without cause at any time or voluntarily for good reason after a change of control, he will receive his annual salary and bonus accrued but unpaid as of that date plus health benefits for one year. Specifically, within thirty days following the effectiveness of a release of all claims against Axys, Mr. Riggs will receive a lump sum payment equal to one year's base salary (currently $235,000) plus one year's target bonus (currently $70,500). If Mr. Riggs' termination is within eighteen months following a change of control, 100% of his options to purchase shares of Axys' common stock will immediately vest and become exercisable. In order to obtain the lump sum payment and accelerated vesting benefits, Mr. Riggs must sign a release of all claims against Axys.

    Amended and Restated Executive Employment Agreement of Dr. Venuti dated as of March 28, 2001.   Dr. Venuti's employment agreement provides for an annualized base salary equal to $290,000 (subject to review) and eligibility for an annual bonus up to thirty percent of his then current base salary upon achievement of reasonable goals set by the Axys board of directors. Dr. Venuti was obligated to pay Axys principal and accrued interest under a $300,000 promissory note issued to Axys as of August 14, 2000; the agreement provides that (other than as set forth below), so long as he continues to render services to Axys through such dates, Axys will forgive $60,000 of the indebtedness on August 14, 2001 and each August 14 through 2005. The agreement also provides that Dr. Venuti will receive the standard benefits from time to time provided by Axys to its executive employees generally.

    This agreement provides that if Dr. Venuti is terminated involuntarily without cause at any time or voluntarily for "good reason" after a change of control, he will receive his annual salary and bonus accrued but unpaid as of that date plus health benefits for one year. Specifically, within thirty days following the effectiveness of a release of all claims against Axys, Dr. Venuti will receive a lump sum payment equal to one year's base salary (currently $290,000) plus one year's target bonus (currently $87,000). If the termination is within eighteen months following a change of control, 100% of Dr. Venuti's options to purchase shares of Axys' common stock will immediately vest and become exercisable and principal and accrued interest amounts outstanding under the Note shall be forgiven as of the date of his termination. In order to obtain the lump sum payment, accelerated vesting and debt forgiveness benefits, Dr. Venuti must sign a release of all claims against Axys.

    Dr. Venuti has signed an additional amendment to his employment agreement waiving certain rights that may arise upon consummation of the transactions contemplated by the merger agreement, and in particular specifying that the completion of the merger and the fact that Dr. Venuti will be

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working for a subsidiary of Applera and may report to an officer of Applera or one of its subsidiaries will not constitute "good reason" for Dr. Venuti to voluntarily terminate his employment.

    Executive Employment Agreement of Mr. Altschuler dated as of December 14, 2000.  This agreement provides that if Mr. Altschuler is terminated involuntarily without cause at any time or voluntarily for good reason after a change of control, he will receive his annual salary and bonus accrued but unpaid as of that date plus health benefits for one year. Specifically, within thirty days following the effectiveness of a release of all claims against Axys, Mr. Altschuler will receive a lump sum payment equal to one year's base salary (currently $230,000) plus one year's target bonus (currently $57,500). If Mr. Altschuler's termination is within eighteen months following a change of control, 100% of his options to purchase shares of Axys' common stock will immediately vest and become exercisable. In order to obtain the lump sum payment and accelerated vesting benefits, Mr. Altschuler must sign a release of all claims against Axys.

    Amended and Restated Employment Agreement of Mr. Walker dated as of December 14, 2000.   Mr. Walker's agreement provides for an annualized base salary equal to $212,500 each year commencing on January 1, 2001 and terminating on December 31, 2003. On the date of the agreement, Mr. Walker was obligated to pay Axys principal in the amount of $400,000 and accrued interest in the amount of $94,611.04 in connection with a promissory note issued by Mr. Walker to Axys. Effective as of such date and under the terms of the agreement, Axys forgave all outstanding principal and interest due under the note and agreed to pay Mr. Walker a tax gross-up payment of $160,000. The agreement provides that Axys will, at its sole expense, provide Mr. Walker and his eligible dependents with medical and dental plan benefits, which benefits will be provided without regard to whether Mr. Walker continues to render services to Axys. Additionally, so long as Mr. Walker continues to render services to Axys, Axys will maintain a split-dollar life insurance policy in Mr. Walker's name to which Axys made premium payments while Mr. Walker was the Chief Executive Officer of Axys and which includes a collateral assignment in favor of Axys. Mr. Walker is also entitled to all other rights and benefits that Axys from time to time provides to its executive employees generally.

    If Mr. Walker is terminated other than for cause or good reason, he will receive in a lump sum an amount equal to his base salary ($212,500) for each of the calendar years 2001, 2002 and 2003 (less any amount he has already been paid). In addition, any options to purchase common stock of Axys that are unvested immediately prior to the termination of his employment will immediately vest and become exercisable as of that date. In order to obtain the lump sum payment and accelerated vesting benefits, Mr. Walker must sign a release of all claims against Axys.

    Certain other Axys employees are also party to employment agreements with Axys containing similar provisions relating to the effects of a change of control. Some of these employees have entered into agreements with Applera specifying that the completion of the merger and the fact that the employees will be working for a subsidiary of Applera will not constitute "good reason" for the employees to voluntarily terminate their employment under the terms of their employment agreements. For other Axys employees, including those described above other than Mr. Hastings and Dr. Venuti, these post-merger changes may constitute good reason for voluntary termination of employment.

    Axys' equity-based compensation plans, other than Axys' Non-Employee Directors' Stock Option Plan established in 1994, do not provide for the acceleration of outstanding options upon a change in control in which options are assumed. As of the record date, Axys' directors and executive officers held vested and unvested options to acquire an aggregate of 88,229 shares of Axys common stock with a weighted average exercise price of $6.55 per share. Under the merger agreement, upon the consummation of the merger, each of these options, whether vested or unvested, will be converted into an option to acquire a number of shares of Celera Genomics common stock equal to the number of

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shares subject to the Axys option multiplied by the exchange ratio, rounded down, at an exercise price equal to the exercise price of the Axys option divided by the exchange ratio, rounded up. In no event, however, will the exercise price for options held by employees of or consultants to Axys exceed the closing price of a share of Celera Genomics common stock on the date immediately prior to the closing of the merger.

    In addition, in the event that Applera or any of its subsidiaries terminates the employment of an employee of Axys without cause within 90 days of the consummation of the merger, the exercise period for any vested options then held by the terminated employee will be extended to a total of 12 months following the termination. However, in the case of any employee holding an option intended to qualify as an incentive stock option under Section 421 of the Internal Revenue Code, the extension will be made only with the consent of the terminated employee. Mr. Hastings has indicated that he will not consent to any extension of his options in the event his employment is terminated.

    Under the Axys Non-Employee Directors' Stock Option Plan established in 1994, non-employee directors of Axys receive annual automatic stock option grants. Options granted under the plan generally vest at a rate of 25% per year for four years. In the event of a change-in-control of Axys, such as the proposed merger, the vesting of these options will accelerate and the options expire if not exercised prior to the change-in-control. As a result, the non-employee directors will be able to exercise options to purchase 88,750 shares of Axys common stock at an average exercise price of $6.50. If the non-employee directors do not exercise these options prior to the completion of the merger, all options to purchase these shares of Axys common stock will expire. For more information about this stock option plan, see "Management of Axys—Compensation of Non-Employee Directors of Axys" in this proxy statement/prospectus.

    Pre-Existing Indemnification and Insurance.  Axys has entered into separate indemnification agreements with each of its directors and officers which require Axys, among other things, to indemnify them against liabilities arising from their status as directors or officers to the fullest extent permitted by Axys' amended and restated bylaws and Delaware law. In addition, Axys' amended and restated bylaws provide that Axys will indemnify its directors and officers to the fullest extent permitted by Delaware law, including in circumstances in which indemnification is otherwise discretionary under Delaware law. Axys also maintains directors' and officer's liability insurance.

    Additional Indemnification and Insurance.  The merger agreement provides that Applera and the surviving corporation of the merger will, to the fullest extent permitted by law, indemnify and hold harmless each of Axys' present and former directors and officers against any costs or expenses arising out of or pertaining to the transactions contemplated by the merger agreement, or for any actions or omissions at or prior to the effective time of the merger, in each case to the same extent provided in Axys' amended and restated certificate of incorporation, Axys' amended and restated bylaws or any pre-existing indemnification contract with the present or former director or officer. The surviving corporation of the merger must maintain policies of directors' and officers' liability insurance containing terms and conditions which are not less advantageous than policies maintained by Axys prior to the effective time of the merger for a period of six years following the closing of the merger (provided that the surviving corporation of the merger is not required to pay an annual premium for any policy in excess of 200% of the annual premiums currently paid by Axys).

Resale of Celera Genomics Common Stock

    The shares of Celera Genomics common stock to be issued to stockholders of Axys pursuant to the merger have been registered under the Securities Act, so these shares may generally be freely traded without restriction by people who will not be "affiliates" of Applera after the merger and who

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were not "affiliates" of Axys on the date of the Axys special meeting for purposes of Rule 145 under the Securities Act. All directors and certain officers of Axys may be deemed to have been "affiliates" of Axys within the meaning of such rule. Those people may resell Celera Genomics common stock received by them in the merger only if the shares are registered for resale under the Securities Act or an exemption from such registration under the Securities Act is available. Those people may be permitted to effect resales under the safe harbor provisions of Rule 145 under the Securities Act (or Rule 144 in the case of such persons who become "affiliates" of Applera) or as otherwise permitted under the Securities Act. People who may be deemed to be affiliates of Axys or Applera generally include individuals or entities that control, are controlled by, or are under common control with, Axys or Applera, as applicable, and may include certain officers and directors of such party as well as principal stockholders of Axys or Applera, as applicable. It is recommended that any such person obtain advice of securities counsel prior to effecting any resales.

    This proxy statement/prospectus does not cover resales of Celera Genomics common stock received by any person, including any person who may be deemed to be an affiliate of Applera or Axys.

Dissenters' Rights

    Under Delaware law, stockholders of Axys will not be entitled to exercise dissenters' appraisal rights or to demand payment for their shares in connection with the merger.

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INFORMATION ABOUT AXYS

Business

Overview

    Axys is a biopharmaceutical company focused on the discovery, design and development of therapeutic small molecules that address significant markets with major unmet medical needs. Axys collaborates with large pharmaceutical companies in discovering therapeutics for chronic diseases for which there are large markets. Axys also selectively focuses its own resources on discovering and developing therapeutics for the treatment of various types of cancer and other specialty therapeutic opportunities. Axys has on-going programs in the treatment of autoimmune diseases, inflammatory diseases, and cancer. Axys' drug design platform integrates advanced biology, chemistry, biophysics and information technologies to optimize the potency, selectivity and physical properties of new drugs, making the drug discovery process more efficient and productive.

    Currently, Axys has significant collaborations with Aventis Pharmaceuticals Products, Inc. (a subsidiary of Aventis S.A.), Merck & Co. and Bayer A.G. These collaborations provide Axys with financial support and collaborative resources for these research programs. Axys' partners are also responsible for developing Axys' clinical drug candidates and commercializing Axys' products in broad medical markets in the event Axys' products are approved by the United States Food & Drug Administration. Axys believes that several of its partnered programs are positioned to advance into human clinical testing over the next few years, which Axys expects will generate increased milestone payments and eventual royalty streams. Axys has additional research programs underway, both proprietary and in collaboration with other life science companies, and Axys believes that novel drug candidates will enter clinical studies within the next 12 to 18 months. At the present time, Axys aims to establish additional partnerships with major pharmaceutical companies in order to obtain the funding and collaborative research support needed to expand its discovery efforts in cancer and other areas.

    Axys believes that advances in genomic research represent a major opportunity for drug discovery directed at novel biological targets. Axys seeks to exploit this opportunity by combining medicinal chemistry and molecular biology, through collaborations and internally, to identify possible drug candidates for a drug target or group of drug targets. Over the next few years, Axys expects to continue its research and development efforts and to bring drug candidates into clinical development. Axys also seeks to license and acquire technologies, resources and products that have the potential to strengthen its drug discovery platform and product pipeline.

    During the year 2000, Axys reported gains of $61.2 million on the sale of two of Axys' three non-core affiliated companies. In April 2000, Axys sold Advanced Technologies to Discovery Partners. Discovery Partners completed an initial public offering of common stock in July 2000. In consideration of the sale of Advanced Technologies, Axys received 7,425,000 shares of Discovery Partners common stock with a carrying value of $40.4 million on December 31, 2000. In December 2000, Axys also sold its interest in PPGx, Axys' pharmacogenomics subsidiary, to DNA Sciences for 1,478,550 shares of Series D Preferred Stock and 108 shares of common stock in DNA Sciences, valued in the aggregate at $15 million as of December 31, 2001. In addition, at December 31, 2000, Axys owned 23% of Akkadix. In March 2001, Axys' ownership interest increased to 44% in connection with the exercise of contractual put options held by third party investors in Akkadix (see note 3 in the financial statements of Axys that appear commencing on page F-1 of this proxy statement/prospectus).

What Gives Axys an Edge in Drug Discovery and Development?

    The entire drug discovery process runs from target identification and validation to lead identification to preclinical development to clinical development. The following sections describe each part of this process and the technologies that Axys employs in drug discovery.

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    In recent years, the advent of new drug discovery technologies, including genomics, bioinformatics, computational sciences, structure-based drug design, combinatorial chemistry and high throughput screening, has offered great potential for streamlining the lengthy and expensive process of drug discovery. Axys has assembled a premier platform for drug discovery by combining and integrating these new technologies with the traditional pharmaceutical sciences, including medicinal chemistry and pharmacology. Axys' capabilities in this area, which include assay development, compound screening, lead optimization, pharmacology and preclinical development, are instrumental in increasing the speed and efficiency of Axys' drug candidate identification efforts. In addition, Axys has functional genomics capabilities, which it is using to select and validate targets for Axys' cancer research.

    As a biopharmaceutical company, Axys' core strengths lie in the portion of the drug discovery continuum spanning from selection of leads from hits in primary screens, through lead optimization using structure-based drug design and combinatorial chemistry, to preclinical development and pharmacology. In this regard, Axys believes it is among the few biotechnology companies having an in-house medicinal chemistry group of Axys' size and scope.

    Target identification and validation is the process of identifying and validating those genetic-based targets that are the most promising for therapeutic intervention by small molecules. There are numerous potential targets, which may apply to all manner of diseases. As described below, Axys is currently focusing its target identification and validation efforts on discovering new biochemical pathways in cancer.

    The human genome is the collection of all the genetic information of a human being. Scientifically defined, the human genome consists of 23 pairs of chromosomes that contain the 40,000 or so genes that define every human's make-up. Genes are made up of DNA (deoxyribonucleic acid). In humans, a DNA molecule resembles a twisted ladder and consists of two strands—a double helix—whose carbohydrate-like sides are connected by pairs of nitrogen-containing chemicals called bases, which form the rungs of the ladder. The particular order of the bases is called the DNA sequence. In total, there are approximately 3 billion base pairs of DNA comprising all of the chromosomes in the human genome. Much effort has been devoted by various governments, research institutions and companies to mapping out the exact location of each gene on each chromosome in order to determine the complete DNA sequence of the 3 billion DNA bases. Detailed knowledge of the human genome is now available, either through public databases or through commercially available databases. Through 1999, Axys had applied the technology generally known as positional cloning to disease gene identification. This technology depended on securing DNA samples from donor populations with a known disease incidence, followed by high throughput genotyping and DNA sequencing to establish a linkage between the disease and a particular chromosome or specific gene.

    However, knowing the sequence of a gene is really only the beginning of the drug discovery process. The next step is the determination of the biological processes in which the gene plays a role. The term "functional genomics" refers to a variety of scientific disciplines that examine gene function and identify disease pathways resulting from a gene or genes that are not functioning properly. The job of determining the functions of a gene—and its protein products—requires testing in systems that approximate human systems, such as the C. elegans (nematode worm) system.

    Although Axys was a pioneer in genomics research using positional cloning techniques in many different disease areas, Axys concluded in 1999 that many of its genomics programs were at too early a stage and too far removed from product development to justify the sizeable investment that Axys was making. So, during the last half of 1999, Axys wound down its genomics research programs which were based on positional cloning technology. Axys continues to utilize its genomics capabilities as part of its cancer research programs. Axys has integrated these capabilities with its functional genomics

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capabilities to create a directed set of target identification and validation tools, which include bioinformatics, a sophisticated antisense knock-out technology, expression array technology and C. elegans nematode biology, all of which Axys uses to discover new biochemical pathways in cancer.

    Axys makes use of both proprietary and licensed bioinformatics software to enable the discovery of new genes and the identification of known genes and species homologs (sister genes) in its efforts in target identification and validation. When new gene sequences are identified, Axys is able to rapidly access both public and proprietary databases through these software tools. When the function of a gene needs to be determined, especially in the case when it might play a pivotal role in a biochemical process, Axys can use antisense knock-out technology, either in well-characterized functional systems, such as the nematode worm, or in mammalian systems. For most applications of antisense, as applied to specific new targets, Axys has licensed the technology from Atugen. Axys also employs sophisticated gene expression array technology, licensed from Molecular Dynamics-Amersham. Using this technology, very small arrays are custom built on glass slides to study the expression levels of thousands of genes at the same time. With the information generated from these arrays, Axys can compare differences in gene expression between normal and diseased or genetically manipulated cells. Finally, another technology Axys uses is C. elegans, a microscopic multicellular round worm that is the most thoroughly understood multicellular animal in terms of cellular development, anatomy and genetic content. C. elegans is useful as a research tool because as many as 70% of the currently known human disease genes possess a highly significant homolog in the nematode.

    By combining gene expression data and Axys' antisense results with information about genetic relationships gained from model systems and Axys' bioinformatics capabilities, Axys is better able to identify points in biological pathways that may be the best point of intervention for a potential therapeutic. For a description of some of Axys' more significant target validation and identification activities in cancer in 2000 and the first half of 2001, see the section below entitled "What Does Axys' Non-Partnered Research and Development Franchise Look Like?"

    Once a biological point of intervention or target is identified and validated, Axys has the capability to rapidly identify chemical compounds that regulate the protein product of the relevant gene. Axys has generated such lead compounds for new biological targets at a rapid pace by making use of a broad range of technologies in dual discovery tracks: (1) structure-based drug design driven by X-ray crystallography and computational modeling, and (2) high throughput screening combined with chemical compound diversity.

    Axys uses a broad range of scientific capabilities to study the basic structure of molecules (X-ray crystallography) and advanced chemistry that uses the knowledge gained from crystallography and structural biology. These technologies can speed research by enabling an understanding of the precise three-dimensional structure of a target associated with a disease. Then, Axys brings additional computational science capabilities into play. Axys has a rapid, flexible molecular docking model that can be used to find a natural or synthetic "inhibitor" that can bind to the molecule and change the way it will perform in the body. By using structure-based design, Axys has the ability to rapidly create lead compounds that are less likely to cause side effects or be toxic.

    Axys' medicinal chemists also play an important role in Axys' lead identification efforts. The chemists obtain iterative structural information from X-ray crystallography and molecular modeling, complemented by powerful computational resources and coupled with production-level protein expression and purification, all of which enables them to develop and refine target compound families. Axys' particular strength is in the determination of serine and cysteine protease protein structures, and the design of small molecules with potency and specificity among these closely related protein family members. Proteases are enzymes, which play a critical role in virtually every biological process. Axys

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believes the ability to develop inhibitors of proteases may give Axys important advantages in its drug discovery activities.

    Axys' combinatorial chemistry expertise compliments its structure-based design activities. Combinatorial chemistry capabilities are particularly useful where there is little known structural information. Axys has created compound diversity libraries, originally through Axys' former subsidiary Advanced Technologies, which has synthesized and delivered to Axys approximately 530,000 individual compounds to date. Axys may develop additional compound diversity libraries or purchase additional compounds from Discovery Partners. Axys projects to have received an aggregate of approximately 600,000 such compounds, encompassing over 140 distinct sub-libraries, by year-end 2001. Axys' medicinal and combinatorial chemists are able to generate a wide variety of diversity or lead optimization libraries, depending on Axys' needs. Assays for high throughput screening are adapted for automation and validated for screening against diverse chemical structures to provide data with a low false positive hit rate. Screening hits are rapidly confirmed or eliminated based on follow-up assays, and are qualified for further library expansion and medicinal chemistry based on novelty, potency and selectivity criteria.

    To screen these libraries, Axys uses automated robotics systems. These robots test the binding activity of thousands of compounds against a disease target, usually a protein. This binding activity is a measure of the compound's ability to inhibit or potentiate the activity of the protein. The primary role of the technology is to detect active compounds and supply directions for their optimization using other techniques. Given the variety and size of chemical libraries available today, and the need to compare the results from multiple screens, data collection and management of information are critical elements of high throughput screening. Axys maintains databases of structures, assays performed, screening results and other similar information in relational databases, which can be queried from any number of research parameters.

    Once a lead candidate has been identified, the most resource-intensive stage of Axys' drug discovery process begins. This is the process of identification of a preclinical candidate with the desired pharmaceutical product profile. It requires directed medicinal chemistry efforts coupled closely with pharmacokinetics, drug metabolism and efficacy studies in pharmacology. Axys' experience in such programs partnered with major pharmaceutical companies during the last several years has resulted in an integration of effort by Axys' medicinal chemists and Axys' pharmacology group.

    Axys believes that it is one of the few biotechnology companies having an in-house medicinal chemistry group of its size and scope. Axys has approximately 55 medicinal chemists. Axys uses its medicinal chemistry capabilities to improve the potency, selectivity (won't bind to wrong target), oral bioavailability (compound can be absorbed by the body when taken orally as a pill), metabolic stability (how rapidly the body breaks down the compound), and biological half-life (how long the effects of the drug will last) of a drug candidate.

    Axys is building a new 43,500 square foot building dedicated to medicinal chemistry on the Axys research campus in South San Francisco, California. The facility will house medicinal chemistry, X-ray crystallography and computational chemistry. This facility will be able to accommodate approximately 80 chemists upon completion in the latter half of 2001, allowing for future growth.

    Before qualifying for evaluation in human trials, chemical compounds must pass extensive safety and effectiveness tests. In such tests, Axys uses cell-based and animal-based models of human disease to provide important information on the duration of action of a potential drug, as well as how it is absorbed by the body or metabolized. On-site studies take advantage of advanced technologies, such as mass spectrometry (a sensitive analytical method to identify a compound and the products into which it is broken down), to evaluate hundreds of samples, indicating not only drug concentrations but also the

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pharmacodynamic (what the drug does to the body) and the pharmacokinetic (what the body does to the drug) characteristics of compounds nearing human clinical trials.

    Finally, while some of Axys' collaborative partners currently provide clinical development expertise, Axys also has an in-house clinical development group with the capability to manage clinical trials, satisfy regulatory requirements, and ensure manufacturing quality control and quality assurance. This group is responsible for taking Axys' products forward into human testing.

What Drug Discovery Partnerships with Pharmaceutical Companies Does Axys Have?

Partnered Pipeline—Preclinical

    Merck—Osteoporosis (Cathepsin K)

    Aventis—Inflammation (Cathepsin S)

    Bayer—Asthma (Tryptase)

    In November 1996, Axys entered into a research and development collaboration with Merck to develop small molecule inhibitors of cathepsin K for the treatment of osteoporosis. Osteoporosis is a disease of the bones that results in weakened bones which leads to pain, difficulty in moving, deformity and fractures. This condition mainly affects post-menopausal women.

    Cathepsin K belongs to a class of enzymes called cysteine proteases. It is known to be secreted in excessive amounts by osteoclasts. In the healthy human body, osteoblast cells are responsible for bone-building while osteoclasts are responsible for bone degradation. By maintaining a careful balance in each type of cell's activity, normal bone remodeling and skeletal integrity is achieved. However, when the rate at which bone is destroyed by the osteoclasts exceeds the rate at which new bone is produced by osteoblasts, the result is excessive bone degradation (bone resorption)—a condition that results in brittle bones and is characteristic of osteoporosis.

    In February 1997, Axys announced the first-ever solution of the three-dimensional crystal structure of cathepsin K that has enabled Axys to design potent and selective inhibitors of cathepsin K. In December 1999, Axys announced the successful testing of a specific, selective cathepsin K inhibitor compound in an animal efficacy model, which triggered a milestone payment to Axys. In addition, although the research and development relationship was originally scheduled to end after two years and had already been extended for one additional year, Axys agreed with Merck in December 1999 to extend this collaboration for another additional year until early November 2000. In November 2000, Axys and Merck extended their osteoporosis collaboration for a fifth year to develop additional analog compounds to those previously provided. In February 2001, Axys received $1.5 million payment from Merck for an important milestone attained in the cathepsin K inhibition program. Axys expects IND-enabling studies to be completed in 2001, with phase I clinical trials initiated during the first quarter of 2002.

    In December 1998, Axys entered into a collaborative research and development agreement with Aventis (successor to Rhone-Poulenc Rorer). The objective of the collaboration is the discovery and development of small molecule therapeutics that inhibit cathepsin S, a human cysteine protease associated with certain inflammatory diseases.

    Cathepsin S is a cysteine protease found in antigen-presenting cells of the immune system. Unlike many other proteases, it is rarely found in other types of cells. Cathepsin S is believed to function in a pathway that regulates the body's ability to fight off these foreign antigens, leading to an inflammatory

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reaction. As a result, it may be possible to use inhibitors of cathepsin S to block the pathway and consequently protect the body from certain inflammatory diseases and perhaps autoimmune disorders. Axys' researchers were the first to solve the three-dimensional X-ray crystal structure of cathepsin S, as reported in June 1998 in Protein Science, which allowed Axys to design potent and selective inhibitor drug candidates.

    Cathepsin S is associated with some inflammatory diseases, including arthritis, asthma, atherosclerosis and a variety of autoimmune diseases. Under the terms of the agreement, Aventis has exclusive development and marketing rights to cathepsin S protease inhibitors for respiratory diseases, atherosclerosis and related conditions, rheumatoid arthritis, and multiple sclerosis. Rheumatoid arthritis affects approximately 2.5 million Americans. Coronary heart disease is caused by the atherosclerotic narrowing of the coronary arteries and is the number one cause of death in United States with approximately 500,000 deaths occurring annually. Approximately 350,000 people have been diagnosed with multiple sclerosis.

    In November 1999, Axys announced the successful testing of a potent, selective cathepsin S inhibitor compound in an animal efficacy model of asthma and received a milestone payment. In addition, current in vivo proof-of-concept studies are underway and planned for rheumatoid arthritis and atherosclerosis. In October 2000, Axys announced that on the basis of data from an in vivo efficacy model of asthma, Aventis qualified a collaboration compound for pre-clinical advancement. Upon successful completion of this work, Axys expects Aventis to initiate IND-enabling studies of a lead cathepsin S compound in late 2001.

    In 1994, Axys entered into an agreement with Bayer for the research and development of tryptase inhibitors for the treatment of asthma. Tryptase is a serine protease that has been shown to regulate inflammation. Tryptase is released by mast cells as part of an immune response to allergens such as pollen, mold or grasses and contributes to several biological events that result in inflammation. Axys' tryptase inhibitors are designed to slow or halt the inflammatory process at an early stage, in an attempt to provide safe and effective therapies for the treatment of the underlying cause of disease, rather than the symptoms. The most significant indication for tryptase inhibitors is allergic asthma, as a replacement for inhaled steroid therapies.

    Asthma is characterized by generalized airway inflammation and tightness in the lungs (bronchoconstriction) that makes breathing difficult. Five percent of the United States population, or approximately 13 million people, are estimated to suffer from some form of asthma. The exact causes of asthma are not well understood, and current treatments for asthma include controlling inflammation through the use of inhaled steroids, treating airway constriction through the use of bronchodilators and prevention of asthma attacks through the daily use of oral leukotriene inhibitors.

    In Axys' collaboration with Bayer, Axys has established human proof-of-concept for tryptase as a drug target. This was achieved in previous Phase II clinical studies of APC 366, an inhaled peptide tryptase inhibitor, which showed that inhibiting tryptase resulted in improved breathing (reduction in late airway response) in asthmatics. Bayer is currently in preclinical studies with a later generation small molecule tryptase inhibitor with high oral bioavailability and circulating half-life, with the goal of developing a once-a-day oral therapeutic for the prevention and chronic treatment of asthma.

    In September 1995, Axys signed a collaboration agreement with the predecessor to Pharmacia Corporation to develop oral therapeutics for blood clotting disorders, such as deep vein thrombosis, stroke, and myocardial infarction. More specifically, Axys had been performing research on inhibitors of Factors Xa and VIIa and thrombin, all of which are serine proteases involved in the blood clotting

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process. These proteases have been acknowledged as targets for a host of disorders related to abnormal clotting. Annually, more than 2 million people are hospitalized in the United States for deep vein thrombosis, acute myocardial infarction and unstable angina.

    In July 1998 the research support for this collaboration ended and in February 1999 Axys formally agreed to end this collaboration. Axys is currently continuing its research efforts with a focus on Factor VIIa and is actively seeking a new partner for the Factor VIIa program. At the present time, Axys is continuing to work on potent and selective compounds, which could result in the nomination of a clinical candidate.

What Does Axys' Non-Partnered Research and Development Franchise Look Like?

Proprietary Pipeline—Oncology & Specialty Therapeutic Areas

 
  Screening/
Proof of
Concept

  Preclinical
  IND
  Phase I
Clinical
Trials

  Phase II
Clinical
Trials

 
Urokinase—Angiogenesis/metastasis       X              
SERM-b—Selective estrogen receptor modulators (Beta)       X              
Apoptosis inducers   X                  
Prostate Specific Antigen—Prostate cancer   X                  
Cathepsin V   X                  
APC 2059—Ulcerative Colitis                   X(1 )
APC 2059—Asthma           X(1 )        

(1)
Additional trials require further preclinical testing as described below.

    In early 1999, Axys implemented an initiative to focus its unpartnered resources on the development of small molecule therapeutics for the treatment of cancer. Axys believes that there is a significant market opportunity to meet current and future medical needs associated with many different types of cancer. One of the factors contributing to this growth is the aging of the world's population. As people live longer, their chances of developing cancer increase.

    Axys' decision to focus its resources on cancer therapeutics was also partly based on the improving regulatory environment for approval of cancer therapeutics. In recent years, the Food & Drug Administration has established a regulatory "fast track" for some cancer therapeutics approved reviews. In addition, surrogate markers such as tumor shrinkage have been increasingly accepted as research endpoints. The use of surrogate markers may substantially shorten the length of the necessary clinical research studies.

    Further, Axys believes that protease inhibition may provide a treatment method for many cancers, resulting in orally delivered small molecule therapeutics. These include antiangiogenesis, hypoxia and metastasis inhibition. Angiogenesis is the process by which blood vessels are formed. Blood vessel formation and growth is necessary for tumor growth. Antiangiogenesis drugs are believed to be able to cut off blood vessel growth and thereby reduce the size of tumors and potentially interfere with their growth. Hypoxia is the deprivation of oxygen to tumor cells, which can lead to the inhibition of tumor cell proliferation. Metastasis is the process by which cancer spreads. Drugs that discourage metastasis are believed to be able to stop cancer from spreading throughout the body.

    Axys has had research programs underway that range from a preclinical program in antiangiogenesis to screening and proof-of-concept programs in solid tumor metastasis and prostate cancer, to cancer target identification and validation research programs.

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    Urokinase.  One of Axys' most advanced oncology programs involves the development of inhibitors of the protease urokinase to interfere with angiogenesis and metastasis processes. Utilizing a broad range of scientific capabilities including crystallography and structural biology, Axys' scientists have extensively analyzed urokinase to identify sites on the molecule best suited for drug interaction. Using Axys' medicinal chemistry and structure-based drug design capabilities, a series of drug-like compounds have been screened to identify potential drugs and select a candidate for preclinical development.

    Axys' lead series of urokinase inhibition drug candidates have been shown in preclinical testing to be potent and specific which may reduce the chance of unwanted side effects. The results to date of Axys' tests in animal models show that urokinase may be required for tumor metastasis, and preclinical studies have shown activity of a urokinase inhibitor in animal models. Axys plans to select an IND candidate from the urokinase inhibition program later in 2001, if the results obtained in animal studies in pancreatic cancer, in collaboration with the Arizona Cancer Center, are successful.

    SERM-b.  Axys' first in-licensed program in oncology comes from Celgene (formerly Signal Pharmaceuticals). In October 1999, Celgene granted Axys exclusive rights to their selective estrogen receptor-beta modulators (SERM-b) for the treatment of cancer. SERM-b compounds are small molecules that selectively modulate the activity of the newly discovered beta estrogen receptor found in tumors and certain hormonally sensitive tissues. Preclinical studies in animal models of prostate cancer are expected to continue throughout 2001.

    Apoptosis Inducers.  In early 2000, Axys entered into a collaborative agreement with Cytovia, Inc. (later acquired by Maxim Pharmaceuticals, Inc.) to discover and develop inducers of apoptosis (programmed cell death) as anticancer drugs. During 2000, the research involved the screening of Axys diversity libraries (approximately 400,000 compounds) through Maxim's proprietary assay systems designed to identify potential drug candidates. Lead compounds are expected to advance into animal studies in cancer models during 2001.

    Screening/Proof-of-Concept.  Particular areas of emphasis in Axys' early-stage research include hypoxia and angiogenesis. Biological targets identified in these pathways can be validated as small-molecule drug targets through additional molecular biology and eventual screening. In 2000, six oncology targets—histone deactylase, methionine aminopeptidase-2, MT1-MMP, HIF1-(Greek alpha), rho kinase and CAAX protease—were entered into high throughput screening by this process. Some of these targets are no longer being pursued and other replacement targets will be entered into high throughput screening. Two additional protease targets, prostate-specific antigen (PSA) and cathepsin V, are being validated in vivo using antisense and chemical inhibitor approaches.

    In addition to these programs, Axys is continuing to actively seek to license potential cancer treatment compounds from other biotechnology or pharmaceutical companies with an emphasis on early stage clinical product opportunities, as well as advanced pre-clinical compounds.

    Tryptase Inhibitors/Inflammatory Ulcerative Colitis/Clinical Phase II).  In July 1997, Axys modified its 1994 research and development agreement with Bayer to re-acquire the rights to develop tryptase inhibitors for the treatment of inflammatory bowel disease and psoriasis, which, like asthma, is another mast cell regulated inflammatory disease. In December 2000, Axys amended its collaborative agreement with Bayer to return exclusive rights to develop a specific tryptase inhibitor, APC 2059, for non-oral applications. Axys is investigating development of the compound as a potential inhaled therapy for asthma and as an injectable treatment for ulcerative colitis. Axys' collaboration with Bayer to develop oral tryptase inhibitors is unaffected by this amendment. The January 2001 amended agreement provided for an up front payment to Bayer and future royalty payments, based on net sales, upon commercialization.

    In the fourth quarter of 2000, Axys completed a Phase II clinical trial on Axys' compound, APC 2059, in ulcerative colitis. Before moving forward to more advanced trials, Axys has recently

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determined that extensive safety pharmacology and dose-ranging pre-clinical research is necessary. Axys determined that it would not undertake this research and intends to seek a partner who is willing to conduct this research, as well as undertake additional clinical and commercial activities. As these clinical trials are intended to establish safety in humans, Axys cannot be certain that it will be able to initiate or complete necessary future clinical trials successfully. Axys' collaboration partner, Bayer, is moving forward with advanced pre-clinical studies of a compound developed in Axys' collaboration with them for the treatment of asthma that would be taken as a pill. Axys cannot be certain that the clinical trials of this compound will be initiated or completed successfully. Finally, Axys cannot be certain that any other drug candidates which may enter clinical trials will successfully complete those trials or that Axys or its collaborators will be able to show the safety and effectiveness of these drug candidates.

    Axys is currently evaluating further development of APC 2059. To enable longer term dosing required for chronic disease therapies, Axys is currently in the process of planning additional dose-ranging safety pharmacology studies. Axys expects further human clinical testing, if any, to be delayed until these safety pharmacology studies are completed and results evaluated.

Why and How Has Axys Leveraged its Technology Platform?

    If the merger is not consummated, Axys will need additional capital in order to continue its research and development efforts. One way Axys has attempted to raise additional capital is by creating new stand-alone companies using Axys' non-core technologies for purposes other than drug discovery, obtaining third party funding for these companies and eventually selling its equity interest. Axys has created three such businesses: Advanced Technologies in combinatorial chemistry, PPGx, in pharmacogenomics, and Akkadix in agricultural biotechnology. At the same time, Axys retains the right to use Axys' intellectual property that these businesses utilize for its' own drug discovery and development purposes.

    Axys has sought out third parties to invest additional capital for these businesses, but retained equity ownership positions. In 2000, Axys sold its equity position in two of these businesses: Advanced Technologies, which Axys sold to Discovery Partners, and PPGx, which Axys sold to DNA Sciences.

    While Axys believes that it will be successful in realizing meaningful value from these affiliated businesses, Axys' ability to do so will depend on the success these companies have in executing their business strategies. Axys currently owns 7,246,500 shares of Discovery Partners common stock, 1,478,550 of Series D Preferred Stock of DNA Sciences and 108 shares of DNA Sciences common stock. Axys' Discovery Partners shares are subject to certain contractual restrictions that limit Axys' ability to liquidate its position. DNA Sciences is a privately held company and there are limited opportunities to dispose of Axys' interest. There can be no assurance that the businesses in which Axys holds these equity positions will be successful or that Axys will have the ability to sell all or a portion of its equity ownership in these businesses. In addition, there can be no assurance that the amount Axys may receive upon selling its equity ownership interest will provide significant funding so as to postpone for a meaningful time period the need to engage in other capital raising activities.

Competition

    Axys faces intense competition in the different market segments it is pursuing. There are many companies that have or are developing capabilities in drug discovery, particularly in structure-based drug design and high throughput screening, to identify new products. In addition, there are many companies focused on the development of drugs for chronic disease, such as osteoperosis, asthma, rheumatoid arthritis, ulcerative colitis, and for cancer in general. Many biotechnology companies are expanding their capabilities, using a variety of techniques, to determine gene function and to develop products based on gene function. Axys' potential competitors in the field are numerous and include

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major pharmaceutical and agricultural companies, diagnostic companies, specialized biotechnology companies, genomics companies and academic institutions and universities.

    Many of Axys' potential competitors have significantly more financial, technical and other resources than it does, which may allow them to have a competitive advantage. Axys is aware that there are many companies focused specifically on other proprietary technologies directed at identifying product targets. In addition, pharmaceutical, biotechnology and genomics companies and academic institutions are conducting work in this field. In the future, Axys expects the field to become more competitive with companies and academic institutions seeking to develop competing technologies.

    Any products that Axys may develop or discover through application of its technologies will compete in highly competitive markets. Many of Axys' potential competitors in these markets have substantially greater financial, technical and personnel resources than Axys does, and Axys cannot assure you that they will not succeed in developing technologies and products that may render Axys' technologies and products and those of Axys' collaborators obsolete or noncompetitive. In addition, many of Axys' competitors have significantly greater experience than Axys does in their respective fields.

Patents and Proprietary Rights

    Axys holds 27 issued United States patents and 28 issued foreign patents relating to compositions of matter, methods of treating disease, combinatorial chemistry and computational technologies. Most of Axys' patents in combinatorial chemistry diversity library processes and compositions of matter have been assigned to Discovery Partners as part of the sale of Advanced Technologies completed in 2000. These patents expire at various dates starting in year 2013 up to the year 2018. In addition, Axys has filed and there are now pending patent applications relating to compositions of matter, methods of treating disease, assay techniques, computational technologies and novel technology for the discovery of novel protease inhibitors. Axys intends to file additional patent applications, when appropriate, relating to Axys' technology and to specific products it develops.

    Axys strategically files selected patent applications to protect technology, inventions and improvements that are important to the development of Axys' business. That is Axys' policy, as well as Axys' practice. Axys also relies upon trade secrets, know-how, continuing technological innovations and licensing opportunities to develop and maintain its competitive position. Axys maintains a policy that it does not and will not knowingly violate valid claims of patents issued by the United States Patent and Trademark Office.

    The patent positions of pharmaceutical and biotechnology firms, including Axys, are uncertain and involve complex legal and factual questions. In addition, the scope of the claims in a patent application can be significantly modified before the patent is issued. As a result, Axys does not know whether any of its applications will result in the issuance of patents, or if any of its issued patents will provide significant protection. Axys also does not know whether any of its issued patents will be invalidated. Since patent applications in the United States are maintained in secrecy until patents issue, and since publication of discoveries in the scientific or patent literature often lag behind actual discoveries, Axys cannot even be certain that it was the first creator of inventions covered by its pending patent applications or that it was the first to file patent applications for such inventions.

    In addition, Axys may have to participate in interference proceedings declared by the United States Patent and Trademark Office. These proceedings determine the priority of invention and the right to a patent for the technology in the United States. Such proceedings could result in substantial costs to Axys, even if Axys wins.

    There can be no assurance that Axys' pending patent applications, if issued, or Axys' existing patents, will not be invalidated. An adverse outcome could subject Axys to significant liabilities to third

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parties, require disputed rights to be licensed from third parties or require Axys to stop or modify its use of such technology.

    The development of therapeutic products for applications in the product fields Axys is pursuing is intensely competitive. A number of pharmaceutical companies, biotechnology companies, universities and research institutions have filed patent applications or received patents in the areas in which Axys is conducting research. In addition, patent applications filed by others relating to Axys' potential products or technologies may currently be pending. Some of these applications or patents may limit or hinder Axys' freedom to practice and could result in a significant reduction of the coverage of Axys' patents, or potential patents. Axys is aware of pending patent applications that have been filed by other companies that may pertain to certain of Axys' technologies. If patents are issued to these or other companies containing incompatible or conflicting claims, and such claims are ultimately determined to be valid, Axys may be required to obtain licenses to these patents or to develop or obtain alternative technology.

    Furthermore, Axys has in the past been, and may again be, notified of claims that it may be infringing patents or other intellectual property rights owned by third parties. Axys has obtained licenses under several patents held by third parties. If necessary or desirable, Axys may seek additional licenses under other patents or intellectual property rights. There can be no assurance, however, that Axys will be able to obtain a license it seeks on reasonable terms or even at all. As an alternative, Axys could decide to resort to litigation to challenge a patent or patents. Such challenges can be extremely expensive and time consuming. Consequently, they could have a material adverse effect on Axys' business, financial condition and results of operations.

    Much of the unpatentable know-how important to Axys' technology and many of its processes depends upon the knowledge, experience and skills of key scientific and technical personnel. To protect Axys' rights to this know-how and technology, all employees, consultants, advisors and collaborators are required to enter into confidentiality agreements with Axys that prohibit the disclosure of confidential information to any third party and require disclosure to Axys of ideas, developments, discoveries and inventions made by these individuals. There can be no assurance that these agreements will effectively prevent disclosure of Axys' confidential information or that these agreements will provide meaningful protection for Axys' confidential information if there is unauthorized use or disclosure. Axys' business could be adversely affected by competitors who develop substantially equivalent technology.

    In connection with certain research, Axys entered into sponsored research agreements with various researchers and universities. Generally, under these agreements Axys funds the research of investigators in exchange for the right or an option to a license to any patentable inventions that may result in designated areas. Axys is obligated to make certain payments during the terms of certain of the agreements, to pay royalties on net sales of any licensed products and, in some cases, to negotiate in good faith the business terms of any license executed upon exercise of licensing options. There can be no assurance that these agreements will not be breached or that Axys would have adequate remedies for any breach.

Government Regulation

    The manufacturing and marketing of Axys' proposed products and Axys' research and development activities are subject to regulation for safety, effectiveness and quality by many governmental authorities in the United States and other countries. In the United States, drugs are subject to stringent regulation by the United States Food and Drug Administration. The Federal Food, Drug and Cosmetic Act and Food and Drug Administration regulations, as well as other federal and state laws and regulations, govern the testing, manufacture, safety, effectiveness, package labeling, storage, record keeping, approval, advertising and promotion of Axys' proposed products. Product development and approval takes a long time and involves the expenditure of a lot of money. If Axys fails to comply with certain

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regulatory requirements, Axys could be subject to sanctions, such as warning letters, penalties, criminal prosecution, injunctions, product seizure, product recalls, total or partial suspension of production, and Food and Drug Administration refusal to approve pending NDAs or costly supplements to approved applications.

    The steps required before a drug may be marketed in the United States include (1) preclinical laboratory tests, in vivo (animal model) preclinical studies and formulation studies, (2) the submission to the Food and Drug Administration of an application for human clinical testing, known as an Investigational New Drug Application (which we refer to in this proxy statement/prospectus as INDs), which must be accepted by the Food and Drug Administration before human clinical trials are started, (3) adequate and well-controlled human clinical trials to establish the safety and effectiveness of the drug, (4) the submission of an NDA to the Food and Drug Administration, and (5) Food and Drug Administration approval of the NDA prior to any commercial sale or shipment of the drug. In addition to obtaining Food and Drug Administration approval for each product, each domestic drug manufacturing establishment must be registered with the Food and Drug Administration. Domestic drug manufacturing establishments are subject to inspections twice a year by the Food and Drug Administration and must comply with Good Manufacturing Practices. To supply products for use in the United States, foreign manufacturers must comply with Good Manufacturing Practices and are subject to periodic inspection by the Food and Drug Administration or by corresponding regulatory agencies in their country. Drug product manufacturers located in California also must be licensed by the State of California.

    Preclinical tests include laboratory evaluation of what is in the product and how it was made, as well as animal studies to assess the potential safety and effectiveness of the product. Preclinical safety tests must be conducted by laboratories that comply with Food and Drug Administration regulations regarding Good Laboratory Practices. The results of the preclinical tests are submitted to the Food and Drug Administration as part of an IND and reviewed by the Food and Drug Administration prior to the start of human clinical trials. Unless the Food and Drug Administration objects, the IND will become effective 30 days following its receipt by the Food and Drug Administration. There can be no assurance that submission of an IND will result in Food and Drug Administration authorization to start clinical trials. Clinical trials involve giving the investigational new drug to healthy volunteers and to patients, under the supervision of qualified investigators. Clinical trials are conducted in agreement with Good Clinical Practices under instructions that detail the objectives of the study, the limits to be used to monitor safety and the effectiveness criteria to be evaluated. Instructions must be submitted to the Food and Drug Administration as part of the IND. Further, each clinical study must be conducted under the power of an independent institutional review board at the site where the study will be conducted. The institutional review board will consider, among other things, ethical factors, the safety of human subjects and the possible liability of the site.

    Clinical trials are typically conducted in three phases that go in order, but the phases may overlap. In Phase I, in which Axys usually gives the drug to healthy subjects, the drug is tested to determine its metabolism (how the drug is absorbed by the body), pharmacokinetics (what the body does to the drug) and pharmacological actions (biological effects) in humans, the side effects associated with increasing doses and early evidence of how effective the drug is, if possible. Phase II involves studies in a limited patient population to (1) determine the effectiveness of the drug for specific, targeted indications, (2) determine what amount of the drug works best and how much of the drug can be tolerated, and (3) identify possible adverse effects and safety risks. If a compound is found to be effective and to have an acceptable safety profile in Phase II evaluations, Phase III trials further evaluate the effectiveness of the drug and further test for safety in a larger group of people at many different locations.

    There can be no assurance that Phase I, Phase II or Phase III testing will be completed successfully within any specific time period, if at all, for any of Axys' proposed products. Furthermore, the Food and Drug Administration or Axys may suspend or cancel clinical trials at any time if it is felt

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that the patients are being exposed to an unacceptable health risk or the Food and Drug Administration finds errors or incorrect information in the IND or due to the conduct of the investigation. Further, Food and Drug Administration regulations state that sponsors of clinical investigations must meet numerous regulatory requirements, including, selection of qualified investigators, proper monitoring of the investigations, recordkeeping and record retention, and ensuring that Food and Drug Administration and all investigators are promptly informed of significant new adverse effects or risks with respect to the drug.

    The results of the drug development, preclinical studies and clinical studies are submitted to the Food and Drug Administration in the form of an NDA, which, if accepted, would clear the way for marketing and commercial shipment of the drug. There can be no assurance that any approval will be granted by the Food and Drug Administration at all or, if granted, will be granted on a timely basis. The Food and Drug Administration may deny an NDA if certain regulatory criteria are not satisfied, may require additional testing or information, or may require post-marketing testing and surveillance to monitor the safety of Axys' products if the Food and Drug Administration does not view the NDA as containing enough evidence of the safety and effectiveness of the drug. Even if Axys submits additional data, the Food and Drug Administration may still decide that the application does not satisfy its regulatory criteria for approval. In addition, even if regulatory clearance of a drug is granted, such approval may limit the uses for which it may be marketed. Finally, product approvals may be taken away if regulatory standards are not maintained or if problems occur following initial marketing.

    Among the typical conditions for NDA approval is the requirement that the proposed manufacturer's quality control and manufacturing procedures conform to Good Manufacturing Practices, which must be followed at all times. To comply with these standards, Axys will have to spend a large amount of time, money and effort in the area of production and quality control to ensure full technical compliance.

    In addition to regulations enforced by the Food and Drug Administration, Axys will also be subject to regulation under the Occupational Safety and Health Act, the Environmental Protection Act, the Toxic Substances Control Act, the Resource Conservation and Recovery Act and other present and potential future federal, state or local regulations. Axys' research and development involves the controlled use of hazardous materials, chemicals and various radioactive compounds, all of which are regulated. Although Axys believes that Axys' safety procedures for handling and disposing of these materials comply with the standards set by state and federal regulations, the risk of accidental contamination or injury from these materials is possible. In the event of an accident, Axys could be sued for any damages that result and any such lawsuit could exceed the insurance and resources of Axys.

    For clinical investigation and marketing outside the United States, Axys is also subject to foreign regulatory requirements governing human clinical trials and marketing approval for drugs. These requirements governing the conduct of clinical trials, product licensing, pricing and reimbursement vary widely for European countries both within, and outside, the European Union. Axys plans to comply with the European regulatory process by identifying and using clinical investigators in the member states of the European Union and other European countries to conduct clinical studies. Further, Axys intends to design Axys' studies to meet Food and Drug Administration, European Union and other European countries' standards.

    Within the European Union, while marketing authorizations must be supported by clinical trial data of a type and to the extent set out by European Union directives and guidelines, the approval process for the commencement of clinical trials is not currently harmonized by European Union law and varies from country to country. As far as possible, Axys intends to design Axys' studies so as to develop a regulatory package sufficient for multi-country approval in Axys' European target markets, without the need to duplicate studies for individual country approvals.

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    Outside the United States, Axys' ability to market a product is based upon receiving a marketing authorization from the appropriate regulatory authority. Currently, foreign marketing authorizations are applied for at a national level, although within the European Union certain registration procedures are available to companies wishing to market the product in more than one European Union member state. If the regulatory authority is satisfied that enough evidence of safety, quality and effectiveness has been presented, a marketing authorization will be granted. The system for obtaining marketing authorizations within the European Union changed on January 1, 1995. The current European Union registration system is a dual one in which certain products, such as biotechnology and high technology products and those containing new active substances, will have access to a central regulatory system that provides registration throughout the entire European Union. Other products will be registered by national authorities in individual European Union member states, operating on a principle of mutual recognition. This foreign regulatory approval process includes all of the same risks involved in the Food and Drug Administration approval process described above.

Employees

    As of May 31, 2001, Axys employed 161 individuals, of whom 57 held Ph.D. or M.D. degrees and 39 held other advanced degrees. Approximately 130 of Axys' employees are involved in research and development activities, including a variety of disciplines within the areas of molecular biology and other biological sciences, medicinal chemistry, bioinformatics, computer sciences pharmacology, safety assessment and clinical development. Approximately 31 of Axys' employees are employed in finance, business development and general administrative activities. None of Axys' employees are covered by collective bargaining agreements, and Axys' management considers relations with its employees to be good. Axys also enters into consulting arrangements with experienced, professional scientists and managers to supplement Axys' work force.

Recent Developments

    In November 2000, the Financial Accounting Standards Board issued Emerging Issues Task Force Issue No. 00-27, "Application of EITF Issue No. 98-5, Accounting for Convertible Securities with Beneficial Conversion Features or Contingently Adjustable Conversion Ratios, to Certain Convertible Instruments". This established new accounting rules that were applicable immediately to Axys' $26 million convertible debt instrument Axys issued in September 2000. The new accounting rule required Axys to record a $4 million beneficial conversion feature charge during the fourth quarter of fiscal 2000.

    On March 8, 2001, Axys issued a press release that announced Axys' unaudited financial results for the fiscal year ended December 31, 2000. Axys' March 8, 2001 reported results did not recognize the entire $4 million non-cash charge for the beneficial conversion feature as Axys was amortizing the beneficial conversion feature over the four year term of the debt. The immediate charge resulting from this accounting rule, which applies to transactions entered into prior to November 16, 2000, does not impact Axys' reported operating loss, but results in a one-time, non-cash charge to interest expense in connection with the issuance of the convertible debt. As a result, Axys reported in the press release, for the fiscal year ended December 31, 2000, basic and diluted net loss per share from continuing operations and basic and diluted net (loss) income per share of ($1.18) and $0.39, respectively. After recognizing the entire $4 million beneficial conversion feature, Axys' basic and diluted net loss per share from continuing operations and basic and diluted net (loss) income per share, for the fiscal year ended December 31, 2000, was ($1.29) and $0.28, respectively. Axys does not believe that this change will have any material impact on Axys' operations or financial condition.

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Properties

    Axys currently leases approximately 170,000 square feet and occupies approximately 111,000 square feet of laboratory, support and administrative space in South San Francisco, California. Leases expire on these facilities on November 30, 2003 with respect to approximately 52,000 square feet; on July 31, 2005 on approximately 33,000 square feet; on August 4, 2006 on approximately 83,000 square feet and on a month to month arrangement on approximately 2,000 square feet. Most of these leases have additional options for extensions. In 2000, Axys converted a warehouse lease into a ground lease for 25 years with options to extend for two additional 10-year periods. Axys is constructing a medicinal chemistry building on this lot that will include approximately 43,500 square feet of laboratory and office space. Construction is expected to be completed in the second half of 2001. Axys is subleasing approximately 33,000 square feet to an unrelated third party, with the lease and sublease expiring on July 31, 2005. In addition, Axys is subleasing approximately 25,000 square feet to Discovery Partners, with the lease and sublease expiring on November 30, 2003. Axys expects to sublease 52,000 square feet of adjacent space to Discovery Partners when Axys occupies the new medicinal chemistry facility. Discovery Partners also has the right of first refusal to sublease the remainder of that 52,000 square foot facility or approximately 25,000 square feet upon the opening of the new medicinal chemistry facility. Axys' existing and planned facilities are believed to be adequate to meet Axys' present requirements, and Axys currently believes that suitable additional space will be available to Axys, when needed, on commercially reasonable terms.

Legal Proceedings

    From time to time, Axys is subject to legal proceedings or claims arising in the ordinary course of its business. While the outcome of any such proceedings or claims cannot be predicted with certainty, Axys' management does not believe that the outcome of any of these legal matters will have a material adverse effect on Axys' results of operations or financial position.

Selected Financial Data

    Selected financial data of Axys appears on page 17 of this proxy statement/prospectus. The data should be read in conjunction with "—Management's Discussion and Analysis of Financial Condition and Results of Operations" which is included beginning on page 94 of this proxy statement/prospectus.

Axys Management's Discussion and Analysis of Financial Condition and Results of Operations

    You should read the following discussion of the financial condition and results of operations in conjunction with Axys' financial statements and its notes located elsewhere in this proxy statement/prospectus. The following discussion contains both historical information and forward-looking statements that involve risks and uncertainties. Forward-looking statements include projections and other statements of events that may occur at some point in the future. Axys' actual results could differ significantly from those described in the forward-looking statements. Factors that could cause or contribute to such differences include, but are not limited to, those discussed in this section as well as under "Information About Axys" and "Risk Factors" in this proxy statement/prospectus.

Overview

    Axys is a biopharmaceutical company focused on the discovery, design and development of therapeutic small molecules that address significant markets with major unmet medical needs. Axys collaborates with large pharmaceutical companies in discovering therapeutics for chronic diseases for which there are large markets. Axys also selectively focuses its resources on discovering and developing therapeutics for the treatment of various types of cancer and other specialty market therapeutics. Axys has on-going programs in the treatment of autoimmune, inflammatory diseases, and cancer. Axys' drug

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design platform integrates advanced biology, chemistry, biophysics and information technologies to optimize the potency, selectivity and physical properties of new drugs, making the drug discovery process more efficient and productive.

    In February 2001, Axys received a research milestone payment from Merck & Co. for meeting a pre-agreed milestone in the development of a compound being studied for use in the treatment of osteoporosis, a disease that affects an estimated 40 percent of women over the age of 50. The compound selected by Merck is a potent and selective inhibitor of Cathepsin K, a cysteine protease that has been demonstrated to play a key role in bone resorption.

    In March 2001, Axys recorded revenue from a research milestone from Aventis, for successfully completing a pivotal in vivo proof-of-concept study that confirmed the mechanism of action for orally administered inhibitors of Cathepsin S, another human cysteine protease. The collaboration with Aventis is focused on development of Cathepsin S inhibitors for potential applications in treating inflammation and autoimmune disease, including rheumatoid arthritis, asthma, atherosclerosis, COPD and rhinitis.

    Also in March 2001, two investors in Akkadix Corporation exercised options, extended to them by Axys, to exchange their 2.7 million shares of Series A Preferred Stock of Akkadix for approximately 2.5 million shares of Axys common stock. The fair market value of Axys' common stock exchanged for Akkadix preferred stock was approximately $9.0 million. As a result of the exercise of these options, Axys' ownership of Akkadix voting stock increased from 31% to approximately 44%. During the first quarter of 2001, Akkadix sharply reduced its operations because of diminished financial resources. A substantial percentage of its employees were terminated and Akkadix vacated its office/laboratory space. Axys has concluded that the future viability of the Akkadix business is highly uncertain. Accordingly, in conformance with the equity method of accounting, Axys incurred a non-cash charge of $9.0 million during the quarter recognizing an impairment in the value of our investment in Akkadix. Axys does not anticipate any future benefit from this investment.

    To date, Axys has not generated any product revenue from our drug discovery programs and does not expect to generate product revenue for at least several years. As of March 31, 2001, Axys had an accumulated deficit of $285 million. Axys expects that losses will fluctuate from quarter to quarter, that such fluctuations may be substantial, and that results from prior quarters may not be indicative of future operating results. Included Axys' accumulated deficit at March 31, 2001 was approximately $147 million of acquired in-process research and development from the acquisitions of Khepri Pharmaceuticals, Inc. in 1995 and Sequana Therapeutics, Inc. in January 1998. Axys expects its sources of revenue, if any, for the next several years to consist of payments under corporate partnerships. The process of developing its products will require significant additional research and development, preclinical testing and clinical trials, as well as regulatory approval. These activities, together with our general and administrative expenses are expected to result in significant operating losses for the foreseeable future. Axys will not receive product revenues or royalties from its collaborative partners before completing clinical trials and successfully commercializing these products.

    Axys is subject to risks common to biopharmaceutical companies, including risks inherent in its research and development efforts and clinical trials, reliance on collaborative partners, enforcement of patent and proprietary rights, the need for future capital, potential competition and uncertainty of regulatory approvals. In order for a product to be commercialized, it will be necessary for Axys, and in some cases, its collaborators, to conduct preclinical tests and clinical trials to demonstrate the efficacy and safety of its product candidates, obtain regulatory clearances and enter into manufacturing, distribution and marketing arrangements as well as obtain market acceptance. There can be no assurance that Axys will generate revenues or achieve and sustain profitability in the future.

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Results of Operations

Three Months ended March 31, 2001 and March 31, 2000

    Axys' collaboration and licensing revenues were $3.1 million for the three months ended March 31, 2001, compared to $1.4 million for the same period in 2000. The increase was primarily due to milestones earned from corporate collaborations with both Merck and Aventis.

    Axys' research and development expenses were $8.9 million for the three months ended March 31, 2001, compared to $7.9 million for the same period in 2000. The overall increase for the first three months of 2001 was primarily due to clinical development expenses incurred in connection with clinical studies for APC 2059.

    Axys' general and administrative expenses were $3.2 million for the three months ended March 31, 2001, compared to $2.8 million for the same period in 2000. The increase was primarily due to upgrading Axys' information systems and network infrastructure.

    Axys recorded non-cash compensation income of $1.1 million for the three months ended March 31, 2001, relating to its 1999 Key Personnel Stock Option Plan. Axys recorded a credit as a result of the decline in fair value of the company's liability under the Key Stock Option Employee Plan. Under this plan, certain employees of Axys have been granted contractual options to purchase shares of our investment of Discovery Partners International, Inc.

    Interest income was $531,000 for the three months ended March 31, 2001, compared to $141,000 for the same period in 2000. The increase was primarily due to the increase in average cash investment balances during the first quarter of 2001, compared to the first quarter of 2000. Interest expense was $1,474,000 for the three months ended March 31, 2001, compared to $176,000 for the same period in 2000. The increase in the first quarter was primarily due to the interest expense on the subordinated notes payable. Interest expense on these notes consists of the 8% face value interest rate and the amortization of debt issuance costs.

    Axys recorded a $9.1 million loss in connection with its equity method investees during the three months ended March 31, 2001. This loss reflects Axys' pro rata share loss from its investments in Discovery Partners and the write off of Axys' remaining investment in Akkadix.

    Other expense was $978,000 for the three months ended March 31, 2001, compared to none for the same period in 2000. The amount represents the change in fair value of the warrants received as part of Axys' investment in Discovery Partners in conformity with Statement of Financial Accounting Standards No. 133, "Accounting for Derivative Instruments and Hedging Activities" adopted in January 2001.

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Years Ended December 31, 2000 and 1999

    In December 1999, Axys closed its La Jolla operations, which primarily represented the Sequana business acquired in 1998, and relocated Axys' oncology genomics research activities to its South San Francisco headquarters. As a result of this action, a one-time restructuring charge of $5.2 million was recorded in 1999. At the time of the Sequana acquisition, the following research programs were in progress: Asthma, partnered with Boehringer Ingelheim GmbH; Osteoporosis, partnered with Corange International Ltd. (currently F. Hoffmann—La Roche Ltd.); Non-Insulin Dependent Diabetes Mellitus, partnered with GlaxoWellcome (currently Glaxo SmithKline, Inc.); Schizophrenia/Bipolar, partnered with Parke-Davis (currently Pfizer, Inc.) Pharmaceutical Research division of Warner-Lambert Company; and the unpartnered programs in Obesity, Alzheimer's and Pharmacogenomics. As of December 31, 1999, the Schizophrenia/Bipolar program was transferred to Parke-Davis and the Pharmacogenomics program was spun off into the PPGx subsidiary with PPD. All other programs have ended.

    In September 1999, Akkadix completed its acquisition of Global Agro, Inc. The acquisition resulted in Axys' equity ownership interest in Akkadix falling below 50% and thereafter Akkadix is accounted for under the equity method.

    In February 1999, Axys formed a majority owned subsidiary, PPGx, which was engaged in the business of providing pharmacogenomic (the science of how genetic variations among individuals affects drug safety and efficacy) products and services to the pharmaceutical industry. In connection with the formation of PPGx, Axys contributed certain assets and technology in exchange for an 82% ownership interest in PPGx. PPD, Inc. acquired an 18% equity interest in PPGx, in exchange for contributing certain assets, technology, cash and loan guarantees and the exclusive, worldwide right to market the pharmacogenomic products and services of PPGx.

    During 2000, Axys completed the sale of two of its three non-core subsidiary businesses created several years ago from Axys' technology. Axys obtained equity from the acquiring companies in consideration for the sale of these entities. Axys plans to liquidate these equity shares over time to fund Axys' future research and development. The transactions involved are:

    Akkadix (formerly known as Xyris) focuses its business on agricultural biotechnology. In 1999, The Bay City Capital Fund I, L.P. and an affiliated fund, North American Nutrition & Agribusiness Fund, L.P., became a primary source of funding for Akkadix. In 2000, Axys and Bay City Capital each provided Akkadix with bridge loan financing of $2.5 million, which Axys subsequently increased by another $100,000. In accordance with the equity method of accounting, Axys recorded a charge of approximately $2.8 million in 2000, representing Axys' share of Akkadix's losses and substantially all of Axys' investment in Akkadix.

    In March 2001, Bay City Capital and North American Nutrition & Agribusiness Fund each exercised its option to exchange its shares of Akkadix preferred stock for shares of Axys common stock. These option exercises increased Axys' ownership interest in Akkadix from 23% at December 31, 2000

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to 44% in March 2001. Axys does not expect to receive any future value, nor is it planning to make future investments in Akkadix and its future viability as a business is very uncertain. As a result of Axys' ownership interest in Akkadix, Axys recorded a non-cash charge of $9 million in the first quarter of 2001.

    Axys' collaborative research programs generally contain one or more of the following sources of revenue to Axys:

    Axys' collaboration and licensing revenues decreased to $7.0 million for the year ended December 31, 2000, from $24.1 million in 1999. Collaboration and licensing revenues (which generally consist of research support and license fees), for the year ended December 31, 2000 were attributable to collaborative research agreements with:

    Revenues in 2000 decreased when compared to 1999 as the following collaborative research programs were concluded:

    Axys' research and development expenses decreased to $36.6 million for the year ended December 31, 2000, from $55.2 million in 1999. The decrease was primarily due to lower expenses as a result of the 1999 shutdown of Axys' La Jolla operation and lower headcount in 2000 from 1999 levels.

    Axys' general and administrative expenses were $10.0 million for the year ended December 31, 2000, compared to $10.9 million in 1999. The decrease was primarily due to lower expenses as a result of the shut down of Axys' La Jolla operation in 1999.

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    Interest income decreased to $1.8 million for the year ended December 31, 2000, from $2.3 million in 1999. The decrease was primarily due to the decrease in average cash and investment balances between the periods. Interest expense increased to $5.9 million for the year ended December 31, 2000, from $2.0 in 1999. The increase was due primarily to an embedded beneficial conversion charge of $4 million recorded in the fourth quarter of 2000.

    Equity in losses of equity-method investee increased to $3.2 million for the year ended December 31, 2000 as compared to $0.8 million in 1999. The increase was primarily due to Axys expensing its $2.8 million investment in Akkadix during the fourth quarter of 2000.

    In December 1999, Axys completed the closing of Axys' La Jolla operations and relocated the oncology genomics research activities to the South San Francisco headquarters. At December 31, 1999, $1.9 million remained in an accrual relating to this restructuring charge. During 2000, Axys revised its restructuring charge and reversed approximately $592,000 of this accrual as a result of assigning the La Jolla facility lease to a third party.

    For the year 2000, Axys reported $0.9 million in other income related to the gain on sale of a portion of the common stock held as short term marketable investments. This is an increase of $1.7 million from the $0.9 million other expenses that Axys reported in 1999 that was due to the write-off of Axys' 50% interest in Genos Biosciences.

Years Ended December 31, 1999 And 1998

    Axys' collaboration and licensing revenues decreased to $24.1 million for the year ended December 31, 1999, from $35.8 million in 1998. Collaboration and licensing revenues (which generally consist of research support and license fees), for the year ended December 31, 1999 were attributable to the collaborative research agreements with: Parke-Davis in the gene identification program in schizophrenia and bipolar disorder; Bristol-Myers Squibb for the development of protease inhibitors involved in hepatitis C infection; Aventis for the development of small molecule therapeutics that inhibit cathepsin S, associated with certain inflammatory diseases; and Merck for the development of small molecule inhibitors of proteases involved in osteoporosis. 1999 revenues decreased when compared to 1998 due to lower revenues recognized under the following agreements: the end of research support in June 1999 under the Boehringer Ingelheim International GmbH agreement for the gene identification program in asthma; the winding-down of the Parke-Davis gene identification program for schizophrenia and bipolar disorder; and the conclusion in mid-1998 of the Pharmacia Corporation agreement for the development of inhibitors of Factor Xa.

    Axys' research and development expenses decreased to $55.2 million for the year ended December 31, 1999, from $57.5 million in 1998. The decrease is primarily due to reduced headcount in 1999. Research and development expenses in 1999 reflect a partial year of Akkadix activity.

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    Axys' general and administrative expenses decreased to $10.9 million for the year ended December 31, 1999, from $13.4 million in 1998. The decrease is primarily due to lower expenses as a result of the winding down of activities in Axys' La Jolla operation in 1999.

    Interest income decreased to $2.3 million for the year ended December 31, 1999, from $4.7 million in 1998. The decrease was primarily due to the decrease in average cash and investment balances between the periods. Interest expense decreased to $2.0 million for the year ended December 31, 1999, from $2.4 million in 1998. The decrease was primarily due to the lower debt balances from Axys' lines of credit and existing leasing arrangements in 1999.

    Equity in losses of equity method investee decreased to $0.8 million for the year ended December 31, 1999 as compared to $2.4 million in 1998, and was due to the decrease in the loss for Genos Biosciences, Inc, Axys' joint venture with Memorial Sloan Kettering Cancer Center. This amount represents Axys' 50% portion of Genos Biosciences' loss for 1999. The decrease is primarily due to the winding down of operations of Genos Biosciences in May 1999. In the third quarter of 1999, Axys wrote off the balance of the investment in Genos Biosciences.

    In December 1999, Axys completed the closing of its La Jolla operations and relocated its oncology genomics research activities to its South San Francisco headquarters. As a result of this action, a one-time charge of $7.0 million was taken during the third quarter of 1999, of which $2.2 million related to severance and other employee-related costs, $1.7 million related to facilities costs, $1.8 million related to the disposal of assets, and $1.3 million related to other costs associated with the restructuring. In the fourth quarter of 1999, the restructuring charge was reduced by $1.8 million, to $5.2 million due to a change in estimates resulting from the additional subleases of the La Jolla facility, and from proceeds from the disposal of equipment and other assets associated with closing down the La Jolla facility. The facilities costs include lease payments in La Jolla net of proceeds from existing subleases. As a result of closing the facility, Axys eliminated 120 positions of which 93 were included in the severance calculation and 27 positions were eliminated through attrition and cancellation of open requisitions. At December 31, 1999, the remaining accrual relating to the restructuring was approximately $1.9 million.

    Other expense reported in 1999 was $0.9 million compared to none reported in 1998. The difference is primarily due to the write-off of Axys' 50% interest in Genos Biosystems.

Recent Accounting Pronouncements

    In June 1998, the Financial Accounting Standards Board issued Statement of Financial Accounting Standard No. 133, "Accounting for Derivative Instruments and Hedging Activities," which was required to be adopted in years beginning after June 15, 2000. Axys adopted the new Statement effective January 1, 2001. The Statement requires Axys to recognize all derivatives on the balance sheet at fair value. Derivatives that are not hedges must be adjusted to fair value through income. If the derivative is a hedge, depending on the nature of the hedge, changes in the fair value of derivatives will either be offset against the change in fair value of the hedged assets, liabilities, or firm commitments through

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earnings or recognized in other comprehensive income until the hedged item is recognized in earnings. The ineffective portion of a derivative's change in fair value will be immediately recognized in earnings.

    Based on Axys' derivative positions at December 31, 2000, which are limited to warrants to purchase common shares of Discovery Partners stock (see Note 2 to Axys' financial statements commencing on page F-1 of the proxy statement/prospectus) and certain key employee contracts to acquire investments held by Axys (see Note 11 to Axys' financial statements commencing on page F-1 of this proxy statement/prospectus), Axys recorded a cumulative effect of an accounting change of approximately $972,000 recognized in the statement of operations in the first quarter of 2001.

Liquidity And Capital Resources

    Axys has financed its operations since inception primarily through private and public offerings of capital stock, through corporate collaborative research and from a secured convertible note. As of March 31, 2001, Axys had accumulated, approximately $229 million in net proceeds from offerings of our capital stock. In addition, Axys has accumulated approximately $183 million from our collaborative research agreements.

    Our principal sources of liquidity are Axys' cash and investments, which totaled $29.4 million on March 31, 2001. Included in our investments on March 31, 2001 were 35,450 shares of common stock., which are subject to a lock-up agreement that restricts its ability to sell the securities. The lock up expires in June 2001.

    In 2000, Axys sold its Advanced Technologies subsidiary to Discovery Partners for approximately 7.4 million shares of Discovery Partners' common stock. Later in 2000, Axys sold its interest in PPGx, Inc., to DNA Sciences, Inc. for approximately 1.5 million shares of Series D Preferred Stock.

    Axys used cash and cash equivalents of $10.9 million in its operations during the first quarter of 2001 compared to $11.9 million in the same period in 2000.

    Axys purchased approximately $2.1 million of property and equipment during the first quarter of 2001. Axys expects to acquire or lease additional equipment in connection with future research and development activities. Axys is also expending cash in the construction of its new 43,500 square foot medicinal chemistry building adjacent to its principal offices and laboratory buildings in South San Francisco. Axys expects the building to be completed in the second half of 2001 and to relocate some of its employees from its off-campus medicinal chemistry building to the new building. At March 31, 2001, Axys has incurred expenses of approximately $2.9 million on the construction and has commitments totaling approximately $5.0 million. In June 2001, Axys secured a building construction loan for $11.0 million at an interest rate of prime plus one percent with a final maturity date not to exceed 15 months in order to finance the completion of construction of this building.

    The drug development process is expensive and will require that Axys raise money in the future until it begins to generate substantial product or royalty revenues, if ever. Axys believes that existing cash, short-term investments, revenues from existing collaborations, potential proceeds from the liquidation of our long-term equity investments in Discovery Partners and DNA Sciences, and potential additional licensing revenues will enable Axys to continue current and planned operations for 18 to 24 months. Axys continues to actively pursue a variety of financing alternatives. There can be no assurances that Axys can liquidate its investments in a timely manner, or that the proceeds from these investments will be adequate to meet its requirements to fund operations. Finally, the senior secured convertible notes are collateralized by approximately 6.7 million shares of the Discovery Partners stock Axys owns; accordingly, at such time that the Discovery Partners shares are liquidated, a substantial portion of the proceeds may be used to retire the debt.

    In July 2000, Axys completed a sale of $10 million of its common stock, under a shelf registration relating to the offer and sale of up to $50 million of its common stock. The shares of common stock

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were sold at a discounted weighted average price of $6.10 to Acqua Wellington North American Equities Fund, Ltd.. Under the agreement with Acqua Wellington, Axys may, after additional SEC filings in accordance with federal securities laws, and at Axys' discretion, issue and sell to Acqua Wellington up to an additional $40 million of common stock, at a price per share based on the daily volume weighted average price. In addition, Axys may also grant to Acqua Wellington a right to purchase additional shares up to an amount equal to the number of shares Axys elect to sell during that period.

    If the merger is not completed, Axys expects that it will need to continue to raise money for a number of years until it achieves, if it ever achieves, substantial product or royalty revenues. If the merger is not completed, Axys expects to seek additional funding through new collaborations, the extension of existing collaborations, through sale of its interests in Discovery Partners and DNA Sciences, or through public or private equity or debt financings. Axys cannot be certain that additional funding will be available or that the terms will be acceptable. Existing stockholders will experience dilution of their investment if the merger is not completed and Axys raises additional funds by issuing equity. If adequate funds are not available, Axys may delay, reduce or eliminate any of its research or development programs. Furthermore, Axys may obtain funds through arrangements with collaborative partners or others that require Axys to give up rights to technologies or products that it would otherwise seek to develop or commercialize itself.

Quantitative and Qualitative Disclosures About Market Risk

    Axys' exposure to market risk is principally limited to Axys' cash equivalents and investments that have maturities of less than one year and equity investments in public and private companies. Axys maintains an investment portfolio of investment grade, liquid securities that limit the amount of credit exposure to any one issue, issuer or type of instrument. The securities in Axys' investment portfolio are not leveraged, are classified as available-for-sale and are therefore subject to interest rate risk. Axys currently does not hedge interest rate exposure. If market interest rates were to increase by 100 basis points, or 1%, from December 31, 2000 levels, the fair value of Axys' portfolio would decline by approximately $50,000. The modeling technique used measures the change in fair values arising from an immediate hypothetical shift in market interest rates and assumes ending fair values include principal plus accrued interest.

Holders

    As of June 30, 2001 there were approximately 517 stockholders of record of Axys' common stock.

Dividends

    Since inception, Axys has not paid dividends on Axys' common stock. Axys currently intends to retain all future earnings, if any, for use in Axys' business and currently does not plan to pay any cash dividends in the foreseeable future. Any future determination to pay dividends will be at the discretion of the Axys board of directors.

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MANAGEMENT OF AXYS

Executive Officers Of Axys

    Listed below is biographical information on executive officers of Axys as of June 1, 2001.

Name

  Age
  Position With Axys
Paul J. Hastings   41   President and Chief Executive Officer, and a member of the Board of Directors
Daniel F. Hoth, M.D.   55   Senior Vice President, Chief Medical Officer
William J. Newell   43   Senior Vice President, Corporate and Business Development and Secretary
David E. Riggs   49   Senior Vice President, Chief Financial Officer
Michael C. Venuti, Ph.D.   47   Senior Vice President, Research and Preclinical Development, and Chief Technical Officer
Douglas H. Altschuler   44   Vice President, General Counsel and Assistant Secretary

PAUL J. HASTINGS

    Mr. Hastings joined Axys in January 2001, from Chiron Corporation of Emeryville, CA where he was President of Chiron Bio-Pharmaceuticals from 1999-2000. Before Chiron, from 1998-1999, Mr. Hastings served as the President and Chief Executive Officer of LXR Biotechnology, a company focused on the role of apoptosis in cardiovascular disease and oncology. From 1994-1998, Mr. Hastings held a series of management positions at Genzyme Corporation of Cambridge, MA, the last of which was President of Genzyme Therapeutics worldwide. From 1989-1994, Mr. Hastings was at Synergen, in Boulder, CO, as Vice President of Marketing and Sales and General Manager, Synergen Europe, and from 1984-1989, was with Hoffmann-La Roche, Nutley, NJ, in marketing and sales management positions. Mr. Hastings holds a B.S. in Pharmacy from the University of Rhode Island.

DANIEL F. HOTH, M.D.

    Dr. Hoth joined Axys in June 1999 as Senior Vice President and Chief Medical Officer. Prior to joining Axys, Dr. Hoth was principal of an independent consulting practice to pharmaceutical and life science firms, and the National Institutes of Health. Previously, from 1993 to 1997, Dr. Hoth served as Senior Vice President and Chief Medical Officer at Cell Genesys, where he was responsible for trials of gene therapy in cancer and HIV. From 1987 to 1993, he was Director, Division of Acquired Immunodeficiency Syndrome at the NIH, heading all activities under the NIAID's AIDS program. Dr. Hoth's tenure at the National Cancer Institute (1980 to 1987) included Chief of the Investigational Drug Branch, as well as the head of the Cancer Therapy Evaluation Program. Dr. Hoth also served as an instructor and Assistant Professor of Medicine at Georgetown University School of Medicine. He received his medical degree at Georgetown University School of Medicine, and completed his fellowship in medical oncology at Georgetown University Hospital.

WILLIAM J. NEWELL

    Mr. Newell joined Axys in August 1998. He has responsibility for all of Axys' corporate development and business development activities. He was previously responsible for Axys' legal affairs. Previously, Mr. Newell practiced at the firm of McCutchen, Doyle, Brown & Enersen, LLP (Palo Alto office) where he had been a partner since 1990. He received his J.D. from the University of Michigan Law School and holds an A.B. from Dartmouth College.

DAVID E. RIGGS

    Mr. Riggs joined Axys in September 2000 from Unimed Pharmaceuticals, Inc. where he was Senior Vice President, Business Operations from September 1999 to September 2000, and Chief Financial

103


Officer from 1992 to September 1999. At Unimed from 1992-1999, Mr. Riggs was responsible both for building Unimed's commercial platform, its integration as a specialty drug company, product licensing and acquisition activities as well as the financial management of Unimed. While at Unimed, Mr. Riggs concurrently held the CFO position at NeoPharm, Inc. He has a B.S. in Accounting from the University of Illinois, and a M.B.A. in finance and quantitative methods from DePaul University in Chicago, IL.

MICHAEL C. VENUTI, PH.D.

    Dr. Venuti has been Axys' Senior Vice President, Research and Preclinical Development since November 1998, and had previously served as Senior Vice President, Research, South San Francisco, Vice President, Research and Chief Technical Officer since January 1998, February 1997 and July 1996, respectively. Dr. Venuti joined Axys in November 1994 as Director of Chemistry and was promoted to Vice President of Chemistry in July 1995, where he served until February 1997. From 1993 until he joined Axys, he was at Parnassus Pharmaceuticals, a start-up biotechnology company where he was Vice President, Chief Scientific Officer and a founder. From 1988 to 1993, Dr. Venuti was at Genentech, Inc., a biotechnology company, where he was Director of Bioorganic Chemistry, a program that he helped establish. From 1979 to 1988, Dr. Venuti was employed at Syntex as a chemistry group leader. Dr. Venuti received an A.B. in chemistry from Dartmouth College, a Ph.D. in organic chemistry from the Massachusetts Institute of Technology and was a postdoctoral fellow at the Syntex Institute of Organic Chemistry.

DOUGLAS H. ALTSCHULER

    Mr. Altschuler joined Axys in December 2000 from Mentor Corporation where he was Vice President/General Counsel and Compliance Officer from 1996 to 2000. At Mentor, Mr. Altschuler was responsible for all aspects of Mentor's legal and compliance issues. Previously, from 1994 to 1996, Mr. Altschuler was an attorney with the law firm of Bleecher & Collins; from 1988 to 1993, he was an attorney in the Los Angeles office of Jones, Day, Reavis & Pogue. Mr. Altschuler received his J.D. from the University of Arizona School of Law and a B.S. in Chemistry and Biology from the University of Arizona.

Compensation of Executive Officers

    The following table sets forth certain information regarding the annual and long-term compensation for services in all capacities to Axys for the fiscal years ended December 31, 1998, December 31, 1999 and December 31, 2000 of those persons who were either (1) the chief executive officer of Axys during the fiscal year ended December 31, 2000, (2) up to four most highly compensated executive officers of Axys whose annual salary and bonuses exceeded $100,000 who were serving as an executive officer at December 31, 2000 or (3) up to two other executive officers who would have qualified under sections (1) or (2) of this paragraph but for the fact that the individual was not serving as an executive officer of Axys at the end of the 2000 fiscal year.

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SUMMARY COMPENSATION TABLE

 
   
   
   
   
  Long-Term Compensation Awards
   
 
 
  Annual Compensation
  All Other
Annual
Compensation
($)(2)

 
Name and Principal Position

  Restricted
Stock
Awards($)

  Securities
Underlying
Options(#)(1)

 
  Year
  Salary($)
  Bonus($)
  Other($)
 
John P. Walker(3)
Chairman and Chief Executive Officer
  2000
1999
1998
  425,015
410,000
390,000
  138,125

135,000
  909,540
247,250
261,252
(4)
(7)
(7)


  268,322
85,000
435,000
(5)

(8)
19,927
7,979
6,150
(6)

Michael C. Venuti, Ph.D.
Senior Vice President, Research and Preclinical Development, Chief Technical Officer
  2000
1999
1998
  262,510
250,000
235,000
  57,093

47,000
 

 
112,375

(11)
246,823
103,000
197,000
(9)

(8)
911
1,188
696
(10)

Daniel F. Hoth, M.D.(12)
Senior Vice President, Clinical Development, Chief Medical Officer
  2000
1999
  288,503
151,666
  62,748
 
 
76,125

(11)
209,323
150,000
(13)
6,335
5,327
(14)
William J. Newell(15)
Senior Vice President, Corporate and Business Development, General Counsel & Secretary
  2000
1999
1998
  255,000
238,417
102,404
  61,200

22,559
 

 
88,812

(11)
211,823
115,000
75,000
(16)

414
5,703
(17)


(1)
Includes options to acquire Axys' common stock and options to acquire capital stock of certain of Axys' affiliated companies under the 1999 Key Personnel Stock Option Plan.

(2)
Consists of Company matching contributions under Axys' 401(k) retirement plan and life insurance premiums.

(3)
Mr. Walker was Chief Executive Officer of Axys until December 31, 2000 and chairman of the board of directors until May 14, 2001. Mr. Hastings became the President and Chief Executive Officer of Axys on January 2, 2001. See "The Merger—Interests of Certain Persons in the Merger" in this proxy statement/prospectus for a description of Mr. Hastings employment agreement.

(4)
Consists of the forgiveness of principal and interest due on one promissory note in the aggregate amount of $685,540 and a tax gross-up in the aggregate amount of $224,000 under Mr. Walker's amended and restated employment agreement. See "The Merger—Interests of Certain Persons in the Merger" in this proxy statement/prospectus for a description of Mr. Walkers' amended and restated employment agreement.

(5)
Includes options to acquire 100,000 shares of Axys' common stock and the following options to acquire stock in Axys' affiliated companies granted to Mr. Walker under the 1999 Key Personnel Stock Option Plan: (i) options to acquire 50,000 shares of preferred stock of Akkadix at an exercise price of $3.33 per share, (ii) options to acquire 114,800 shares of series A preferred stock of PPGx at an exercise price of $6.11 per share (following the acquisition of PPGx by DNA Sciences in December 2000 these options became fully vested options to acquire 33,947 shares of series D preferred stock of DNA Sciences at an exercise price of $20.66 per share, which options to acquire preferred stock of DNA Sciences are included above) and (iii) options to acquire 112,500 shares of common stock of Advanced Technologies at an exercise price of $1.00 (following the acquisition of Advanced Technologies by Discovery Partners in April 2000 these options became fully vested options to acquire 84,375 shares of common stock of Discovery Partners at an exercise price of $1.33 per share, which options to acquire common stock of Discovery Partners are included above).

(6)
In 2000, Axys paid a total of $14,677 in life insurance premiums for Mr. Walker and $5,250 in matching contributions to Mr. Walker's 401(k) retirement plan.

(7)
Consists of the forgiveness of principal and interest due and an interest rate reduction under one promissory note.

(8)
Includes stock options which were canceled and regranted in connection with Axys' stock option repricing in 1998, as follows: Mr. Walker, 375,000 shares; and Dr. Venuti, 147,000 shares.

(9)
Includes options to acquire 110,000 shares of Axys' common stock and the following options to acquire stock in Axys' affiliated companies granted to Dr. Venuti under the 1999 Key Personnel Stock Option Plan: (i) options to acquire 40,000 shares of preferred stock of Akkadix at an exercise price of $3.33 per share, (ii) options to acquire 73,800 shares of series A preferred stock of PPGx at an exercise price of $6.11 per share (following the acquisition of PPGx. Inc. by DNA Sciences in December 2000 these options became fully vested options to acquire 21,823 shares of series D preferred stock of DNA

105


(10)
In 2000, Axys paid a total of $911 in life insurance premiums for Dr. Venuti.

(11)
Fair market value of restricted stock bonus at the time of grant was $7.25 per share of common stock. These officers voluntarily agreed to receive restricted shares, which may not be sold for one year after grant except in limited circumstances, in lieu of a cash bonus that they otherwise would have been entitled to receive. Dr. Hoth received 10,500 shares, Mr. Newell received 12,250 shares and Dr. Venuti received 15,500 shares.

(12)
Dr. Hoth joined Axys in June 1999.

(13)
Includes options to acquire 110,000 shares of Axys' common stock and the following options to acquire stock in Axys' affiliated companies granted to Dr. Hoth under the 1999 Key Personnel Stock Option Plan: (i) options to acquire 40,000 shares of preferred stock of Akkadix at an exercise price of $3.33 per share, (ii) options to acquire 73,800 shares of series A preferred stock of PPGx at an exercise price of $6.11 per share (following the acquisition of PPGx. Inc. by DNA Sciences in December 2000 these options became fully vested options to acquire 21,823 shares of series D preferred stock of DNA Sciences at an exercise price of $20.66 per share, which options to acquire preferred stock of DNA Sciences are included above) and (iii) options to acquire 50,000 shares of common stock of Advanced Technologies at an exercise price of $1.00 (following the acquisition of Advanced Technologies by Discovery Partners in April 2000 these options became fully vested options to acquire 37,500 shares of common stock of Discovery Partners at an exercise price of $1.33 per share, which options to acquire common stock of Discovery Partners are included above).

(14)
In 2000, Axys paid a total of $1,091 in life insurance premiums for Dr. Hoth and $5,250 in matching contributions to Dr. Hoth's 401(k) retirement plan.

(15)
Mr. Newell joined Axys in July 1998. Mr. Altschuler became General Counsel of Axys in December 2000.

(16)
Includes options to acquire 75,000 shares of Axys' common stock and the following options to acquire stock in Axys' affiliated companies granted to Mr. Newell under the 1999 Key Personnel Stock Option Plan: (i) options to acquire 40,000 shares of preferred stock of Akkadix at an exercise price of $3.33 per share, (ii) options to acquire 73,800 shares of series A preferred stock of PPGx at an exercise price of $6.11 per share (following the acquisition of PPGx. Inc. by DNA Sciences in December 2000 these options became fully vested options to acquire 21,823 shares of series D preferred stock of DNA Sciences at an exercise price of $20.66 per share, which options to acquire preferred stock of DNA Sciences are included above) and (iii) options to acquire 100,000 shares of common stock of Advanced Technologies at an exercise price of $1.00 (following the acquisition of Advanced Technologies by Discovery Partners in April 2000 these options became fully vested options to acquire 75,000 shares of common stock of Discovery Partners at an exercise price of $1.33 per share, which options to acquire common stock of Discovery Partners are included above).

(17)
In 2000, Axys paid a total of $414 in life insurance premiums for Mr. Newell.

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    The following table sets forth certain information with respect to grants of stock options during fiscal 2000 to the Axys executive officers under Axys' 1997 Equity Incentive Plan, as amended, and the 1999 Key Personnel Option Plan.


Option Grants In Last Fiscal Year

 
   
   
   
   
  Potential Realizable Value
at Assumed Annual Rates
of Stock Price
Appreciation for Option
Term(1)

 
   
  Percentage of
Total Options
Granted to
Employees in
Fiscal
Year(2)

   
   
 
  Number of
Securities
Underlying
Options
Granted

   
   
 
  Per Share
Exercise
Price
(3)(4)

   
Name

  Expiration
Date

  5%
  10%
John P. Walker   100,000 (5) 4.5 % $ 7.25   01/28/10   $ 455,949   $ 1,155,463
    50,000 (7) 20.0     3.33   12/14/10     104,711     265,358
    84,375 (8) 22.5     1.33   2/11/10     70,574     178,848
    33,947 (9) 28.0     20.66   12/14/10     441,072     1,117,763

Michael C. Venuti, Ph.D.

 

50,000

(5)

2.3

 

 

7.25

 

01/28/10

 

 

227,974

 

 

577,732
    60,000 (5) 2.7     4.875   12/14/10     183,952     466,170
    40,000 (7) 16.0     3.33   12/14/10     83,769     212,286
    75,000 (8) 20.0     1.33   2/11/10     62,732     158,976
    21,823 (9) 18.0     20.66   12/14/10     283,545     718,560

Daniel F. Hoth, M.D.

 

50,000

(6)

2.3

 

 

7.25

 

01/28/10

 

 

227,974

 

 

577,732
    60,000 (6) 2.7     4.875   12/14/10     183,952     466,170
    40,000 (7) 16.0     3.33   12/14/10     83,769     212,286
    37,500 (8) 10.0     1.33   2/11/10     31,366     79,488
    21,823 (9) 18.0     20.66   12/14/10     283,545     718,560

William J. Newell

 

25,000

(5)

1.1

 

 

7.25

 

01/28/10

 

 

113,987

 

 

288,866
    50,000 (5) 2.3     4.875   12/14/10     153,293     388,475
    40,000 (7) 16.0     3.33   12/14/10     83,769     212,286
    75,000 (8) 20.0     1.33   2/11/10     62,732     158,976
    21,823 (9) 18.0     20.66   12/14/10     283,545     718,560

(1)
Potential realizable value is based on the assumption that the common stock of Axys or the capital stock of the affiliated companies appreciates at the annual rate shown (compounded annually) from the date of grant until the expiration of the ten-year option term. The 5% and 10% assumed rates of appreciation are mandated by the rules of the Securities and Exchange Commission and do not reflect Axys' estimate or projection of the future stock prices.

(2)
For options to acquire shares of Axys' common stock, the percentage refers to the percentage of the total options to acquire Axys' common stock granted to employees in 2000. For options to acquire shares of capital stock of certain of Axys' affiliated companies, the percentage refers to the percentage of the total options to acquire the capital stock of each respective affiliated company granted to employees in 2000.

(3)
Options to acquire shares of Axys' common stock were granted at a price equal to the fair market value of Axys' common stock on the date of grant. Fair market value is determined by reference to the closing sale price of the common stock on the Nasdaq National Market.

(4)
Options to acquire capital stock of certain of Axys' affiliated companies at a price equal to the fair market value of capital stock of the respective affiliated companies on the date of grant. Fair market value was determined by the board of directors at the time of grant.

107


(5)
Options to acquire shares of Axys' common stock that vest in equal monthly installments over four years from the date of grant.

(6)
Options to acquire shares of Axys' common stock. One-eighth of the shares vest after six months, the remaining shares vest in equal monthly installments over the following three and one half years.

(7)
Options to acquire shares of preferred stock of Akkadix that vest in equal monthly installments over four years from the date of grant.

(8)
Fully vested options to acquire shares of common stock of Discovery Partners. At the time of grant, these were options to acquire shares of common stock of Axys' subsidiary Advanced Technologies. Following the acquisition of Advanced Technologies, these became fully vested options to acquire shares of common stock of Discovery Partners.

(9)
Fully vested options to acquire shares of preferred stock of DNA Sciences. At the time of grant, these were options to acquire shares of preferred stock of Axys' subsidiary, PPGx. Following the acquisition of PPGx by DNA Sciences, these became fully vested options to acquire shares of preferred stock of DNA Sciences.

    The following table sets forth certain information with respect to options exercised during fiscal 2000 and exercisable and unexercisable options held by the Axys executive officers as of December 31, 2000.


Aggregated Option Exercises In Last Fiscal Year
And Year-End Option Value

 
   
   
  Number of Securities
Underlying Unexercised Options
at Fiscal Year End

  Value of Unexercised
In-The-Money Options at
Fiscal Year End(1)

 
  Shares
Acquired on
Exercise

  Value
Realized

 
  Exercisable
  Unexercisable
  Exercisable
  Unexercisable
John P. Walker       348,409 (2) 211,591   $ 218,042   $ 101,333
        0 (3) 50,000         0
        84,375 (4) 0     910,828    
        33,947 (5) 0     0    

Michael C. Venuti, Ph.D.

 


 


 

162,748

(2)

212,752

 

 

117,432

 

 

202,093
        0 (3) 40,000         0
        75,000 (4) 0     809,625    
        21,823 (5) 0     0    

Daniel F. Hoth, M.D.

 


 


 

77,333

(2)

193,167

 

 

115,988

 

 

238,313
        0 (3) 40,000         0
        37,500 (4) 0     404,813    
        21,823 (5) 0     0    

William J. Newell

 


 


 

99,353

(2)

177,897

 

 

56,996

 

 

175,155
        0 (3) 40,000         0
        75,000 (4) 0     809,625    
        21,823 (5) 0     0    

(1)
Based on the fair market value of the securities underlying the option on December 31, 2000, minus the exercise price of the option, multiplied by the number of shares to which the option relates. The fair market value of Axys' common stock is based on the closing price of the common

108


(2)
Options to acquire shares of Axys' common stock.

(3)
Options to acquire shares of preferred stock of Akkadix.

(4)
Options to acquire shares of common stock of Discovery Partners.

(5)
Options to acquire shares of preferred stock of DNA Sciences

Management Agreements

    Certain officers of Axys have employment agreement with Axys. For a description of the terms of Axys' employment agreements with Mr. Hastings, Mr. Newell, Dr. Venuti, Dr. Hoth, Mr. Altschuler and Mr. Walker, see "The Merger—Interests of Certain Persons in the Merger."

Stock Ownership Of Beneficial Owners, Directors And Management

    The following table sets forth, as of February 28, 2001, the amount and percentage of the outstanding shares of Axys common stock which, according to the information supplied to Axys, are beneficially owned by (1) each person or entity who, to the knowledge of Axys, is the beneficial owner of more than 5% of the outstanding common stock, (2) each person who is currently a director of Axys, (3) each Axys executive officer and (4) all current directors and executive officers of Axys as a group. Except to the extent indicated in the footnotes to the following table, the person or entity listed has sole voting or dispositive power with respect to the shares that are deemed beneficially owned by such person or entity.

    The information in the table is based on reports that have been filed with the Securities and Exchange Commission pursuant to the Exchange Act, and information furnished to Axys by certain holders of Axys common stock. As of February 28, 2001, there were 37,389,307 shares of Axys common stock outstanding. In accordance with regulations promulgated by the Securities and Exchange Commission, the table reflects for each beneficial owner the exercise of warrants or options or the conversion of convertible securities (exercisable or convertible within 60 days after February 28, 2001) owned by such beneficial owner, but, in determining the percentage ownership and general voting power of such person, does not assume the exercise of warrants or options or the conversion of securities owned by any other person.

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Name and Address of
Beneficial Owner

  Outstanding
Common Stock

  Options/Warrants
Exercisable
Within 60 Days

  Total
Outstanding
Common Stock
Beneficially
Owned

  Percent of
Outstanding
Shares of
Common
Stock

 
Directors and Named Executive Officers                  
Ann M. Arvin, M.D.   0   26,250   26,250   *  
Paul J. Hastings(1)   0   0   0   *  
Daniel F. Hoth, M.D.   12,940 (2) 89,375   102,315   *  
Vaughn M. Kailian   2,500 (4) 29,074   31,574   *  
Irwin Lerner   69,225 (3) 40,833   110,058   *  
Alan C. Mendelson   5,329 (4) 24,896   30,225   *  
William J. Newell   26,124 (5) 110,209   136,333   *  
J. Leighton Read, M.D.   3,000   26,250   29,250   *  
Michael C. Venuti, Ph.D.   26,632 (6) 177,293   203,925   *  
John P. Walker   248,563 (7) 385,958   634,521   1.7 %
All directors and executive officers as a group (12 persons)(8)   394,313   942,637   1,336,884   3.5 %

5% Beneficial Holders

 

 

 

 

 

 

 

 

 
Wellington Management Company, LLP(9)
75 State Street
Boston, Massachusetts 02109
  3,385,400   0   3,835,400   10.3 %

Bay City Capital(10)
750 Battery Street
San Francisco, CA 94111

 

0

 

2,482,758

 

2,482,758

 

6.2

%

*
Less than one percent.

(1)
Mr. Hastings became a Director of Axys in December 2000 and the President and Chief Executive Officer of Axys in January 2001.

(2)
Includes 10,500 shares acquired pursuant to a restricted stock grant.

(3)
Includes 1,350 shares beneficially owned by Mr. Lerner's wife and 1,500 shares acquired as consideration for services provided on Axys' Chief Executive Officer Search Committee.

(4)
Includes 2,500 shares acquired as consideration for services provided on Axys' Chief Executive Officer Search Committee.

(5)
Includes 12,250 shares acquired pursuant to a restricted stock grant.

(6)
Includes 15,500 shares acquired pursuant to a restricted stock grant.

(7)
Includes 26,123 shares held in the Walker Living Trust and 8,574 shares beneficially owned by Mr. Walker's wife as trustee of educational trusts for his children.

(8)
Includes David E. Riggs who became the Senior Vice President and Chief Financial Officer of Axys in September 2000 and Douglas H. Altschuler who became the Vice President and General Counsel of Axys in December 2000.

(9)
Information regarding the ownership of common stock by Wellington Management Company, LLP was obtained from a Schedule 13G, dated February 28, 2001. Wellington Management reports shared dispositive power for all 3,835,400 shares and shared voting power over 3,029,100 shares.

(10)
Subsequent to February 28, 2001, Bay City Capital, acting through two of its funds, exercised its options to acquire 2,482,758 shares of Axys common stock.

110


    Compensation.  In 2000, compensation for non-employee members of the Axys board of directors was $15,000 per year, plus reimbursement of expenses. In addition, Mr. Lerner achieved an additional $30,000 as compensation for consulting services he provided to Axys during 2000. Mr. Walker, who was an employee of Axys during 2000, received no compensation for his services during 2000 as a director of Axys. Mr. Hastings was appointed to the Axys board of directors in December 2000 and became an employee in January 2001. Mr. Hastings received no compensation for his services on the Axys board of directors in 2000. Directors of Axys do not receive any additional compensation for their services on committees.

    Stock Options.  Under the Axys Non-Employee Directors' Stock Option Plan established in 1994, non-employee directors of Axys receive annual automatic stock option grants. The terms of the Non-Employee Directors' Stock Option Plan provide that each non-employee elected for the first time to the Axys board of directors will be granted an option to purchase 30,000 shares of common stock upon the date of his or her initial election or appointment. On the date of each annual meeting, each non-employee member of the Axys board of directors who has served for at least three months, and is re-elected to the Axys board of directors, is automatically granted a non-qualified stock option to purchase 5,000 shares of Axys common stock. No other options may be granted at any time under this plan. The exercise price of the options that are granted is 100% of the fair market value of the common stock on the date of the option grant. Options granted under the plan generally vest at a rate of 25% per year for four years. The term of the options is ten years. In the event of a change-in-control of Axys, such as a merger with or into another corporation or a consolidation, the unvested options will accelerate and become fully-vested immediately prior to consummation of the change of control. At that time, the holders of these options may exercise the options to purchase shares of Axys common stock, and the options will expire if not exercised prior to consummation of the change-in-control. Following their election at the 2000 annual meeting, Dr. Arvin, Dr. Kennedy, Dr. Read, Mr. Mendelson, Mr. Kailian, and Mr. Lerner each received options to acquire 5,000 shares of common stock at an exercise price of $4.063 per share. As of June 30, 2001, none of the options granted under the plan had been exercised. Following their election at the 2001 annual meeting, Dr. Arvin, Dr. Read, Mr. Mendeson, Mr. Kailian and Mr. Lerner each received options to acquire 5,000 shares of common stock at an exercise price of $3.14.

    Stock Grants.  In December 2000, the Axys board of directors resolved to make grants of common stock to Mr. Kailian, Mr. Lerner and Mr. Mendelson in the amounts of 2,500 shares, 1,500 shares and 2,500 shares, respectively. These stock grants were made for service on the Chief Executive Officer Search Committee of the Axys board of directors by Mr. Kailian, Mr. Lerner and Mr. Mendelson following Mr. Walker's announcement of his intent to resign as the Chief Executive Officer of Axys upon the appointment of his successor. Mr. Walker resigned from the positions of Chief Executive Officer of Axys on January 1, 2001 and Chairman of the Board on May 14, 2001.

Relationships And Transactions You Should Know About

    In 1997, Axys advanced $750,000 in a note receivable to Mr. Walker. The note, when it was outstanding, bore interest at the rate of 6.02% per year until 1999 when the interest rate was reduced to 4.71% per year. The note was full recourse and secured by shares of Axys common stock owned by Mr. Walker. In December 2000, Axys amended its employment agreement with Mr. Walker. Under the terms of the agreement, Mr. Walker will receive approximately one-half of his former salary and bonus, forgiveness of his note receivable plus accrued interest at December 31, 2000, in exchange for three years of continued service and an agreement not to compete. The agreement is in effect through December 31, 2003. Axys charged compensation expense in 2000 for the forgiveness of the note receivable.

111


    In August 2000, Axys advanced $300,000 in a note receivable to Dr. Venuti for housing assistance. The note earns interest at 6.37% per year and interest is due annually. The note plus accrued interest is forgivable over five years, subject to Dr. Venuti's continued employment with Axys.

    In January 2000, Axys advanced $300,000 in a note receivable to Mr. Hastings. The note earns interest at 5.61% per annum. The note is due and payable on January 2, 2004, is full-recourse and is secured by shares of common stock that Mr. Hastings acquires upon the exercise of any stock options. The entire note will be forgiven by Axys if Mr. Hastings continues to provide his services to Axys through January 2, 2004.

    For a more detailed discussion of the employment agreements of Mr. Walker, Dr. Venuti and Mr. Hastings with Axys, see the section of this proxy statement/prospectus entitled "The Merger—Interests of Certain Persons in the Merger."

112



INFORMATION ABOUT APPLERA AND ANGEL ACQUISITION

Applera

    Applera was incorporated in Delaware in 1998 and succeeded by recapitalization to the business of PE Corporation (NY) (formerly The Perkin-Elmer Corporation) in May 1999. Applera conducts its business through two operating groups: the Celera Genomics group and Applied Biosystems group. Applera has two classes of common stock, Celera Genomics common stock and Applied Biosystems common stock, that are intended to reflect the relative performance of these groups. For more information about the capital stock of Applera, see "Description of Applera Capital Stock" and "Risk Factors—Risks Related to a Capital Structure with Two Separate Classes of Common Stock" in this proxy statement/prospectus.

    The Celera Genomics group is engaged principally in the generation, sale, and support of genomic information and enabling data management and analysis software. The Celera Genomics group's customers use this information for commercial applications in the pharmaceutical and life sciences industries in the specific areas of target identification, drug discovery, and drug development. The Celera Genomics group also provides gene discovery, genotyping, and related genomics services. The Celera Genomics group has recently expanded its business into the emerging fields of functional genomics, in particular, proteomics and personalized health/medicine. The Celera Genomics group intends to leverage its industrialized approach to biology to develop platforms for enabling diagnostic and therapeutic discoveries both for its own internal product development and for its customers, including its collaboration partners.

    The Applied Biosystems group is a world leader in the development, manufacture, sale, and service of instrument systems and associated consumable products for life science research and related applications. Its products are used in various applications including the synthesis, amplification, purification, isolation, analysis, and sequencing of nucleic acids, proteins, and other biological molecules.

    Applera's principal executive offices are located at 301 Merrit 7, Norwalk, Connecticut 06851-1070 and its telephone number is (203) 840-2000.

Angel Acquisition

    Angel Acquisition is a wholly owned subsidiary of Applera, which was incorporated in Delaware for the sole purpose of effecting the merger by merging with and into Axys. It engages in no other business. Its principal executive offices are c/o Applera Corporation at 301 Merrit 7, Norwalk, Connecticut 06851-1070 and its telephone number is (203) 840-2000.

Management Following the Acquisition

    Following the merger, Axys will continue its operations as a wholly owned subsidiary of Applera. At the effective time of the merger, the current officers of Axys will remain the officers of Axys. See "Management of Axys" in this proxy statement/prospectus for information about the current officers of Axys. Following the merger, the board of directors of Axys will consist of one or more officers of Applera.

113



UNAUDITED PRO FORMA CONDENSED CONSOLIDATED AND
COMBINED FINANCIAL STATEMENTS

    The following unaudited pro forma condensed consolidated and combined financial statements are presented to illustrate the effects of the merger on the historical financial position and operating results of Applera and Axys and the Celera Genomics group and Axys. Because Applera and the Celera Genomics group have different fiscal years than Axys, and the combined company will adopt the fiscal year-end of Applera and the Celera Genomics group, pro forma operating results are presented on a June 30 fiscal-year basis.

    The following unaudited pro forma condensed consolidated and combined balance sheets of Applera and the Celera Genomics group at March 31, 2001 give effect to the merger as if it occurred as of that date. The pro forma condensed consolidated and combined statements of operations of Applera and the Celera Genomics group for the nine months ended March 31, 2001 and the year ended June 30, 2000 give effect to the merger as if it occurred as of July 1, 1999.

    The pro forma condensed combined financial statements have been derived from, and should be read in conjunction with, the historical consolidated and combined financial statements, including the notes thereto, of Applera, the Celera Genomics group, and Axys. For Applera and the Celera Genomics group, those financial statements are included in Applera's Quarterly Report on Form 10-Q for the quarter ended March 31, 2001, and the Applera (formerly PE Corporation) Annual Report on Form 10-K for the year ended June 30, 2000, which are incorporated in this proxy statement/prospectus by reference. For Axys, those financial statements are included in this proxy statement/prospectus beginning on page F-1.

    The pro forma condensed consolidated and combined financial statements are presented for informational purposes only and are not necessarily indicative of the financial position or results of operations of Applera and the Celera Genomics group that would have occurred had the merger been consummated as of the dates indicated. In addition, the pro forma condensed consolidated and combined financial statements are not necessarily indicative of the future financial condition or operating results of Applera and the Celera Genomics group.

    For accounting purposes, Applera will be deemed to be the surviving corporation in the merger and the cost of the acquisition as well as the net assets and operations of Axys will be allocated to the Celera Genomics group. The pro forma adjustments are based upon currently available information and upon assumptions that management believes are reasonable. Applera will account for the merger based upon the estimated fair market values of the net tangible and identifiable intangible assets acquired and liabilities assumed at the date of acquisition. The adjustments included in the unaudited pro forma condensed consolidated and combined financial statements represent the preliminary determination of these adjustments based upon available information. Applera cannot assure you that the actual adjustments will not differ from the pro forma adjustments reflected in the pro forma financial information.

    The merger is structured so that holders of Axys common stock will receive shares of Celera Genomics common stock as consideration in the merger, as described under the "The Merger—Consideration to be Received in the Merger" in this proxy statement/prospectus. Under the terms of the transaction, the number of shares of Celera Genomics common stock to be received for each share of Axys common stock is determined by an exchange ratio, which is subject to a maximum and a minimum as described under "The Merger—Consideration to be Received in the Merger" in this proxy statement/prospectus. For the purposes of the condensed consolidated and combined pro forma financial statements, it has been assumed that each share of Axys common stock would receive the equivalent of $4.65 in Celera Genomics common stock. It has also been assumed that the same exchange ratio would apply with respect to warrants and stock options exercisable for shares of Axys common stock. The exchange ratio provided for in the merger agreement was determined through arm's length negotiations.

114


    Using these assumptions, the consideration to be paid by Applera in connection with the merger is approximately $220.0 million, consisting of the following:

    The merger will be accounted for by Applera and the Celera Genomics group as an acquisition of Axys under the purchase method of accounting for business combinations, and accordingly, the purchase price will be allocated to the tangible and identifiable intangible assets of Axys acquired by Applera and liabilities of Axys assumed by Applera on the basis of their fair values on the acquisition date. The Celera Genomics group is in the process of obtaining an independent valuation of Axys. The preliminary allocation of the purchase price could be subject to significant change depending upon the outcome of that independent valuation. For pro forma purposes, the Celera Genomics group has assumed that the historical carrying amounts of such assets and liabilities approximated their fair values. The remaining purchase price over the fair value of the assets acquired and liabilities assumed has preliminarily been allocated to workforce, other intangible assets, deferred tax assets and goodwill. The workforce allocation is approximately $6.6 million; the other intangible assets allocation, including patents and technology, is approximately $33.0 million; and the deferred tax asset allocation is approximately $49.9 million. The remaining portion of purchase price in excess of tangible and intangible assets, estimated at $58.9 million, has been allocated to goodwill. These amounts will vary based upon the valuation of the securities issued at consummation and the final outcome of the independent valuation. Such independent valuation will likely include an allocation of a portion of the purchase price to "in process research and development" which would be required to be expensed immediately upon acquisition. Goodwill and other intangible assets will be amortized over their expected period of benefit, which is initially estimated as five years for other intangible assets and goodwill, and two years for workforce.

    The exchange ratio assumed for the pro forma financial statements was 0.1220 shares of Celera Genomics common stock for each share of Axys common stock, which is the exchange ratio that would have been applied had the merger occurred on July 9, 2001. Once the final exchange ratio under the merger agreement has been determined, the amounts assumed in the following pro forma financial statements will change. For example, if the average closing price of Celera Genomics common stock is 20% lower than the price of Celera Genomics common stock assumed in the pro forma financial statements, the equivalent per share price of Axys common stock would be $4.13 per share and the total purchase price would be $195.4 million. The final changes in the purchase price and the allocation of the purchase price would also impact the calculated pro forma earnings per share, based on the differing amounts of goodwill and other specifically identifiable intangible asset amortization.

    No pro forma adjustments are necessary to reflect the merger of Applera into a separate wholly owned subsidiary of Applera because Applera's net assets will be recorded at their historical cost basis.

Accounting Changes

    It is expected that the Financial Accounting Standards Board will issue two new statements resulting from its project on Business Combinations that would require a change in accounting for goodwill effective July 1, 2001. If these statements are issued as expected, goodwill from acquisitions occurring after July 1, 2001 would not be amortized, and for goodwill existing prior to June 30, 2000,

115


Applera and the Celera Genomics group may choose to adopt the nonamortization provisions of the statement either July 1, 2001 or July 1, 2002. Goodwill for which the nonamortization provisions are being applied will be required to be reviewed for impairment on an annual basis. If an impairment is found to exist, a charge will be taken against operations. We cannot currently determine the amount of an impairment charge, if any, that would be recorded upon adoption.

    Accounting for Employee Stock Options.  In March 2000, the Financial Accounting Standards Board issued FASB Interpretation No. 44, Accounting for Certain Transactions involving Stock Compensation, which contains rules designed to clarify the application of APB Opinion No. 25, Accounting for Stock Issued to Employees. FASB Interpretation No. 44 has been effective since July 1, 2000.

    Among other matters, the provisions of FASB Interpretation No. 44 changed the accounting for an exchange of unvested employee stock options in a purchase business combination. The new rules require the intrinsic value of the unvested awards to be allocated to unearned compensation and recognized as noncash compensation cost over the remaining future vesting period. The ultimate amount to be allocated to unearned compensation will be based on the stock price of Celera Genomics common stock and the number of Axys' unvested employee stock options and restricted stock awards on the date the merger is completed. Based on the market price of Celera Genomics common stock and the number of Axys' unvested employee stock options, it is estimated that these new provisions would have an immaterial net effect on pro forma net income of Applera and pro forma net loss of the Celera Genomics group for the nine months ended March 31, 2001 and the year ended June 30, 2000.

116


APPLERA CORPORATION

UNAUDITED PRO FORMA CONDENSED CONSOLIDATED BALANCE SHEET

March 31, 2001

(amounts in thousands)

 
  Applera
  Axys
  Pro Forma
Adjustments

  Pro Forma
Applera

Assets                        
Current assets                        
Cash and cash equivalents   $ 825,917   $ 29,191   $   $ 855,108
Short-term investments     548,934     239           549,173
Accounts receivable, net     427,652     750           428,402
Inventories, net     171,874                 171,874
Prepaid expenses and other current assets     107,259     3,160           110,419
   
 
 
 
Total current assets     2,081,636     33,340           2,114,976

Property, plant and equipment, net

 

 

417,639

 

 

11,780

 

 

 

 

 

429,419
Investment in equity-method investee           42,828     (42,828 )(2)    
Other investments           15,007     (15,007 )(2)    
Other long-term assets     526,589     7,755     206,166  (1)(2)   740,510
   
 
 
 
Total Assets   $ 3,025,864   $ 110,710   $ 148,331   $ 3,284,905
   
 
 
 
Liabilities and Stockholders' Equity                        
Current liabilities                        
Loans payable   $ 20,415   $   $   $ 20,415
Accounts payable     199,434     3,544           202,978
Accrued salaries and wages     70,977     1,535           72,512
Deferred revenues           362     (362 )(2)    
Accrued taxes on income     113,224                 113,224
Current portion of capital lease and notes           1,047           1,047
Other accrued expenses     219,768     2,346     11,062  (1)(2)   233,176
   
 
 
 
Total current liabilities     623,818     8,834     10,700     643,352

Long-term debt

 

 

30,715

 

 

26,000

 

 

 

 

 

56,715
Capital lease obligations, noncurrent           2,300           2,300
Other long-term liabilities     154,102     1,919           156,021
   
 
 
 
Total Liabilities     808,635     39,053     10,700     858,388

Stockholders' Equity

 

 

2,217,229

 

 

71,657

 

 

137,631

 (1)

 

2,426,517
   
 
 
 
Total Liabilities and Stockholders' Equity   $ 3,025,864   $ 110,710   $ 148,331   $ 3,284,905
   
 
 
 

See accompanying notes.

117


CELERA GENOMICS GROUP

UNAUDITED PRO FORMA CONDENSED COMBINED BALANCE SHEET

March 31, 2001

(amounts in thousands)

 
  Celera
Genomics

  Axys
  Pro Forma
Adjustments

  Pro Forma
Celera
Genomics

Assets                        
Current assets                        
Cash and cash equivalents   $ 486,122   $ 29,191   $   $ 515,313
Short-term investments     548,934     239           549,173
Accounts receivable, net     22,275     750           23,025
Inventories, net     4,699                 4,699
Prepaid expenses and other current assets     6,552     3,160           9,712
   
 
 
 
Total current assets     1,068,582     33,340           1,101,922

Property, plant and equipment, net

 

 

117,138

 

 

11,780

 

 

 

 

 

128,918
Investment in equity-method investee           42,828     (42,828 )(2)    
Other investments           15,007     (15,007 )(2)    
Other long-term assets     137,930     7,755     206,166  (1)(2)   351,851
   
 
 
 
Total Assets   $ 1,323,650   $ 110,710   $ 148,331   $ 1,582,691
   
 
 
 
Liabilities and Group Equity                        
Current liabilities                        
Accounts payable   $ 27,985   $ 3,544   $   $ 31,529
Accrued salaries and wages     14,756     1,535           16,291
Deferred revenues     31,889     362           32,251
Current portion of capital lease and notes           1,047           1,047
Other accrued expenses     8,519     2,346     10,700  (1)   21,565
   
 
 
 
Total current liabilities     83,149     8,834     10,700     102,683

Long-term debt (subordinated notes)

 

 

 

 

 

26,000

 

 

 

 

 

26,000
Capital lease obligations, noncurrent           2,300           2,300
Other long-term liabilities     25,672     1,919           27,591
   
 
 
 
Total Liabilities     108,821     39,053     10,700     158,574

Group Equity

 

 

1,214,829

 

 

71,657

 

 

137,631

 (1)

 

1,424,117
   
 
 
 
Total Liabilities and Group Equity   $ 1,323,650   $ 110,710   $ 148,331   $ 1,582,691
   
 
 
 

See accompanying notes.

118


APPLERA CORPORATION

UNAUDITED PRO FORMA CONSOLIDATED STATEMENT OF OPERATIONS

Nine Months Ended March 31, 2001

(Dollar amounts in thousands except per share amounts)

 
  Applera
  Axys
  Pro Forma
Adjustments

  Pro Forma
Applera

 
Net Revenues   $ 1,227,765   $ 7,138   $   $ 1,234,903  
Cost of sales     557,129                 557,129  
   
 
 
 
 
Gross Margin     670,636     7,138         677,774  
Selling, general and administrative     331,474     9,626     (347 )(2)   340,753  
Research, development and engineering     257,022     27,499     (704 )(2)   283,817  
Non-cash compensation (income)           (1,051 )   1,051  (2)      
Amortization of goodwill and intangibles     32,965           16,252 (3)   49,217  
Other special charges           31           31  
   
 
 
 
 
Operating Income (Loss)     49,175     (28,967 )   (16,252 )   3,956  
Gain on investments     14,985                 14,985  
Interest expense     1,678     7,073           8,751  
Interest income     63,185     1,583           64,768  
Other expense, net     (4,331 )   (166 )         (4,497 )
Loss from equity method investee           (12,267 )         (12,267 )
   
 
 
 
 
Income (Loss) Before Income Taxes     121,336     (46,890 )   (16,252 )   58,194  
Provision (benefit) for income taxes     41,080           (19,010 )(4)   22,070  
   
 
 
 
 
Income (Loss) From Continuing Operations   $ 80,256   $ (46,890 ) $ 2,758   $ 36,124  
   
 
 
 
 
Applied Biosystems Group                          
Net Income   $ 164,767               $ 164,767  
  Basic per share   $ 0.78               $ 0.78  
  Diluted per share   $ 0.74               $ 0.74  
Weighted Average Common Shares                          
  Basic     209,925                 209,925  
  Diluted     221,696                 221,696  

Celera Genomics Group

 

 

 

 

 

 

 

 

 

 

 

 

 
Loss From Continuing Operations   $ (84,480 )             $ (128,612 )
  Basic and diluted per share   $ (1.40 )             $ (1.97 )
Weighted Average Common Shares                          
  Basic and diluted     60,480                 65,366  

Axys Pharmaceuticals, inc.

 

 

 

 

 

 

 

 

 

 

 

 

 
Loss From Continuing Operations         $ (46,890 )            
  Basic and diluted per share         $ (1.27 )            
Weighted Average Common Shares                          
  Basic and diluted           37,038              

See accompanying notes.

119


APPLERA CORPORATION

UNAUDITED PRO FORMA CONSOLIDATED STATEMENT OF OPERATIONS

Twelve Months Ended June 30, 2000

(Dollar amounts in thousands except per share amounts)

 
  Applera
  Axys
  Pro Forma
Adjustments

  Pro Forma
Applera

 
Net Revenues   $ 1,371,035   $ 13,601   $   $ 1,384,636  
Cost of sales     609,054                 609,054  
   
 
 
 
 
Gross Margin     761,981     13,601         775,582  
Selling, general and administrative     436,911     8,578           445,489  
Research, development and engineering     274,796     41,663     (4,166 )(3)   312,293  
Amortization of goodwill and intangibles                 25,835  (3)   25,835  
Other special charges     2,142     4,552           6,694  
   
 
 
 
 
Operating Income (Loss)     48,132     (41,192 )   (21,669 )   (14,729 )
Gain on investments     48,603                 48,603  
Interest expense     3,501     1,280           4,781  
Interest income     39,428     1,368           40,796  
Other income (expense), net     3,446     (856 )         2,590  
Loss from equity method investee           (836 )         (836 )
   
 
 
 
 
Income (Loss) Before Income Taxes     136,108     (42,796 )   (21,669 )   71,643  
Provision (benefit) for income taxes     40,612           (18,443 )(4)   22,169  
   
 
 
 
 
Income (Loss) From Continuing Operations   $ 95,496   $ (42,796 ) $ (3,226 ) $ 49,474  
   
 
 
 
 
Applied Biosystems Group                          
Net Income   $ 186,247               $ 186,247  
  Basic per share   $ 0.90               $ 0.90  
  Diluted per share   $ 0.86               $ 0.86  
Weighted Average Common Shares                          
  Basic     207,010                 207,010  
  Diluted     217,016                 217,016  

Celera Genomics Group

 

 

 

 

 

 

 

 

 

 

 

 

 
Loss From Continuing Operations   $ (92,737 )             $ (138,759 )
  Basic and diluted per share   $ (1.73 )             $ (2.37 )
Weighted Average Common Shares                          
  Basic and diluted     53,725                 58,611  

Axys Pharmaceuticals, inc.

 

 

 

 

 

 

 

 

 

 

 

 

 
Loss From Continuing Operations         $ (42,796 )            
  Basic and diluted per share         $ (1.33 )            
Weighted Average Common Shares                          
  Basic and diluted           32,232              

See accompanying notes.

120


CELERA GENOMICS GROUP

UNAUDITED PRO FORMA COMBINED STATEMENT OF OPERATIONS

Nine Months Ended March 31, 2001

(Dollar amounts in thousands)

 
  Celera
Genomics

  Axys
  Pro Forma
Adjustments

  Pro Forma
Celera
Genomics

 
Net Revenues   $ 61,947   $ 7,138   $   $ 69,085  

Costs and Expenses

 

 

 

 

 

 

 

 

 

 

 

 

 
Research and development     151,663     27,499     (704 )(2)   178,458  
Selling, general and administrative     42,538     9,626     (347 )(2)   51,817  
Non-cash compensation (income)           (1,051 )   1,051  (2)      
Amortization of goodwill and intangibles     32,965           16,252  (3)   49,217  
Other special charges           31           31  
   
 
 
 
 
Operating Loss     (165,219 )   (28,967 )   (16,252 )   (210,438 )
Interest expense     829     7,073           7,902  
Interest income     50,568     1,583           52,151  
Other expense, net     (246 )   (166 )         (412 )
Loss from equity method investee           (12,267 )         (12,267 )
   
 
 
 
 
Loss Before Income Taxes     (115,726 )   (46,890 )   (16,252 )   (178,868 )
Benefit for income taxes     31,246           19,010  (4)   50,256  
   
 
 
 
 
Loss From Continuing Operations   $ (84,480 ) $ (46,890 ) $ 2,758   $ (128,612 )
   
 
 
 
 

See accompanying notes.

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CELERA GENOMICS GROUP

UNAUDITED PRO FORMA COMBINED STATEMENT OF OPERATIONS

Twelve Months Ended June 30, 2000

(Dollar amounts in thousands)

 
  Celera Genomics
  Axys
  Pro Forma
Adjustments

  Pro Forma
Celera
Genomics

 
Net Revenues   $ 42,747   $ 13,601   $   $ 56,348  
Costs and Expenses                          
Research and development     167,831     41,663     (4,166 )(3)   205,328  
Selling, general and administrative     43,022     8,578           51,600  
Amortization of goodwill and intangibles                 25,835  (3)   25,835  
Other special charges           4,552           4,552  
   
 
 
 
 
Operating Loss     (168,106 )   (41,192 )   (21,669 )   (230,967 )
Interest expense     2,115     1,280           3,395  
Interest income     27,548     1,368           28,916  
Other expense, net           (856 )         (856 )
Loss from equity method investee           (836 )         (836 )
   
 
 
 
 
Loss Before Income Taxes     (142,673 )   (42,796 )   (21,669 )   (207,138 )
Benefit for income taxes     49,936           18,443  (4)   68,379  
   
 
 
 
 
Loss From Continuing Operations   $ (92,737 ) $ (42,796 ) $ (3,226 ) $ (138,759 )
   
 
 
 
 

See accompanying notes.

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Notes to Unaudited Pro Forma Financial Statements

    1.  Reflects the proposed acquisition by Applera and the Celera Genomics group of Axys as follows:

    2.  To make the following reclassifications to conform Axys' classification to that of Applera and the Celera Genomics group: Axys' non-cash compensation of $1.0 million allocated to research and development expenses ($.3 million) and general and administrative expenses ($.7 million) in the pro forma consolidated and combined statements of operations for the nine months ended March 31, 2001 and the year ended June 30, 2000; Axys' investment in equity—method investee of $42.8 million and other investments of $15.0 million to other long-term assets in the pro forma condensed consolidated and combined balance sheets and Axys' deferred revenues of $.4 million to other accrued expenses in the pro forma condensed consolidated balance sheet.

    3.  To reflect amortization expense of goodwill and intangible assets in the pro forma statements of operations for the nine months ended March 31, 2001 and for the year ended June 30, 2000 resulting from the allocation of the excess purchase price over the estimated net assets assumed. The total values assigned to goodwill and intangible assets in millions and the related estimated useful lives in years are as follows:

Description

  Useful Life
  Amount
Goodwill   5   $ 58.9
Workforce   2   $ 6.6
Other intangible assets   5   $ 33.0

    The pro forma statement of operations for the year ended June 30, 2000 also includes a reclassification of amortization of goodwill and intangibles of $4.2 million from research and development expenses for Applera and the Celera Genomics Group.

    4.  To record income tax benefits provided on Axys' losses inclusive of amortization of certain specific identifiable intangible assets at a 35% rate. Goodwill amortization is excluded from the losses as it is not deductible for tax purposes. Reference should be made to the risk factors related to the Celera Genomics group's tax benefits on page 35 of this proxy statement/prospectus, as well as to

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Note 1, "Accounting Policies and Practices—Allocation of Federal and State Income Taxes," in the Notes to Combined Financial Statements of the Celera Genomics group in the Applera (formerly PE Corporation) Annual Report for the year ended June 30, 2000 (which is incorporated by reference) for a description of Applera's tax policies.


DESCRIPTION OF APPLERA CAPITAL STOCK

    The following is a description of the terms of the capital stock of Applera. This description does not purport to be complete and is qualified in its entirety by reference to Applera's certificate of incorporation that has been incorporated by reference as an exhibit to the registration statement of which this proxy statement/prospectus is a part.

General

    Applera's certificate of incorporation authorizes it to issue 1,235,000,000 shares of stock as follows: 1,000,000,000 shares of a class of common stock, designated as Applera Corporation-Applied Biosystems Group Common Stock, 225,000,000 shares of a class of common stock, designated as Applera Corporation-Celera Genomics Group Common Stock, and 10,000,000 shares of preferred stock. Shares of each class of stock have a par value of $.01 per share. Applera is able to issue shares of preferred stock in series, without stockholder approval. Of the 10,000,000 authorized shares of preferred stock, Applera's board of directors has designated a total of 80,000 shares of two series of participating junior preferred stock for use in connection with Applera's stockholder rights plan. See "—Rights Agreement."

    As of June 28, 2001, there were no shares of preferred stock, 61,609,868 shares of Celera Genomics common stock and 211,293,240 shares of Applied Biosystems common stock issued and outstanding.

Celera Genomics Common Stock

    Dividends on Celera Genomics common stock will be limited to an amount not greater than the "Available Dividend Amount" for the Celera Genomics group. The Available Dividend Amount for the Celera Genomics group is intended to be similar to the amount that would be legally available for the payment of dividends on Celera Genomics common stock if the group were a separate company. In calculating the Available Dividend Amount for the Celera Genomics group, the amount of net income or loss of Applera that is attributed to the Celera Genomics group in accordance with generally accepted accounting principles will be reduced by any unused federal tax benefits in excess of $75 million generated by the Celera Genomics group since July 1, 1998.

    Delaware law limits the amount of distributions on Applera's capital stock to its legally available funds, which are determined on the basis of the entire company, and not only the respective groups. As a result, the amount of legally available funds will reflect the amount of any net losses of each group, any distributions on Celera Genomics common stock, Applied Biosystems common stock or any preferred stock, and any repurchases of Celera Genomics common stock, Applied Biosystems common stock or certain preferred stock. Dividend payments on Celera Genomics common stock could be precluded because legally available funds of Applera are not available under Delaware law, even though the Available Dividend Amount test for the Celera Genomics group was met. Applera cannot assure you that there will be an Available Dividend Amount for the Celera Genomics group or, if met, that Applera will have available funds to pay such a dividend.

    Subject to the prior payment of dividends on any outstanding shares of preferred stock and the limitations described above, Applera's board of directors is able, in its sole discretion, to declare and pay dividends exclusively on Applied Biosystems common stock, exclusively on Celera Genomics

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common stock or on both, in equal or unequal amounts. In making its dividend decisions, Applera's board of directors is not required to take into account the relative available dividend amounts for the two groups, the amount of prior dividends declared on either class, the respective voting or liquidation rights of either class or any other factor.

    Mandatory Dividend, Redemption or Conversion of Common Stock if Disposition of Celera Genomics Group Assets Occurs.  If Applera sells, transfers, assigns or otherwise disposes of, in one transaction or a series of related transactions, all or substantially all of the properties and assets attributed to the Celera Genomics group (a "disposition"), Applera is required, except as described below, to:

    Applera may only pay a dividend or redeem shares of Celera Genomics common stock as set forth above if it has legally available funds under Delaware law and the amount to be paid to holders is less than or equal to the Available Dividend Amount for the Celera Genomics group. Applera is required to pay such dividend or complete such redemption or conversion on or prior to the 95th trading day following the disposition.

    For purposes of determining whether a disposition has occurred, "substantially all of the properties and assets" attributed to the Celera Genomics group means a portion of such properties and assets:

    The "net proceeds" of a disposition means an amount equal to what remains of the gross proceeds of the disposition after any payment of, or reasonable provision is made as determined by Applera's board of directors for:

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    Applera may elect to pay the dividend or redemption price in connection with a disposition either in the same form as the proceeds of the disposition were received or in any other combination of cash, securities or other property that Applera's board of directors or, in the case of securities that have not been publicly traded for a period of at least 15 months, an independent investment banking firm, determines will have an aggregate market value of not less than the fair value of the net proceeds.

    The following illustration demonstrates the provisions requiring a mandatory dividend, redemption or conversion if a disposition occurs. If:


net proceeds        

  =    
number of outstanding shares
of Celera Genomics common stock
       

$500 million

 

 

 

 

  =   $10 per share
50 million shares        

net proceeds        

  =    
average market value
of Celera Genomics common stock
       

$500 million

 

 

 

 

  =   10,000,000 shares
$50 per share        

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    average market value of Celera
Genomics common stock
       
1.1x  
  =    
    average market value
of Applied Biosystems common stock
       

 

 

$50 per share

 

 

 

 
1.1x  
  =   1.3750 shares
    $40 per share        

    Exceptions to the Dividend, Redemption or Conversion Requirement if a Disposition Occurs.  Applera is not required to take any of the above actions for any disposition of all or substantially all of the properties and assets attributed to the Celera Genomics group in a transaction or series of related transactions that results in Applera's receiving for such properties and assets primarily equity securities of any entity which:

    The purpose of this exception is to enable Applera technically to "dispose" of properties or assets of the Celera Genomics group to other entities engaged or proposing to engage in businesses similar or complementary to those of the Celera Genomics group without requiring a dividend on, or a conversion or redemption of, Celera Genomics common stock, so long as Applera holds an equity interest in that entity. A joint venture in which Applera owns a direct or indirect equity interest is an example of such an acquirer. Applera is not required to control that entity, whether by ownership or contract provisions.

    Applera is also not required to effect a dividend, redemption or conversion if the disposition is:

    Notices if Disposition of Celera Genomics Group or Applied Biosystems Group Assets Occurs.  Not later than the 20th trading day after the consummation of a disposition, Applera will announce publicly by press release:

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    Not earlier than the 36th trading day and not later than the 40th trading day after the consummation of the disposition, Applera will announce publicly by press release whether it will pay a dividend or redeem shares of common stock with the net proceeds of the disposition or convert the shares of Celera Genomics common stock into Applied Biosystems common stock.

    Applera is required to cause to be mailed to each holder of shares of Celera Genomics common stock the additional notices and other information required by Applera certificate of incorporation.

    Conversion of Celera Genomics Common Stock at Applera's Option at Any Time.  Applera's board of directors may at any time convert each share of Celera Genomics common stock into a number of shares of Applied Biosystems common stock equal to 110% of the ratio of the average market values of Celera Genomics common stock to Applied Biosystems common stock over a 20-trading day period. Applera will calculate the ratio as of the fifth trading day prior to the date it mails the conversion notice to holders. However, if a Tax Event occurs at any time, a factor of 100% rather than 110% will be applied to the ratio of the average market values. This means that the holders of Celera Genomics common stock will not receive any premium in such conversion.

    "Tax Event" means the receipt by Applera of an opinion of its tax counsel that, as a result of:

it is more likely than not that for United States federal income tax purposes:

    For purposes of rendering such an opinion, tax counsel will assume that any legislative or administrative proposals will be adopted or enacted as proposed.

    These provisions allow Applera the flexibility to recapitalize the two classes of common stock into one class of common stock that would, after such recapitalization, represent an equity interest in all of Applera's businesses. The optional conversion or redemption could be exercised at any future time if Applera's board of directors determines that, under the facts and circumstances then existing, an equity structure consisting of two classes of common stock was no longer in the best interests of all of Applera's stockholders. Such exchange could be exercised, however, at a time that is disadvantageous to the holders of one of the classes of common stock. See "Risk Factors—Stockholders may not have any remedies for breach of fiduciary duties if any action by directors and officers has a disadvantageous effect on either class of common stock" and "—Numerous potential conflicts of interest exist between the classes of common stock that may be difficult to resolve by Applera's board of directors or may be resolved adversely to one of the classes."

    Many factors could affect the market values of Celera Genomics common stock or Applied Biosystems common stock, including Applera's results of operations and those of each of the groups, trading volume and general economic and market conditions. Market values could also be affected by decisions by Applera's board of directors or its management that investors perceive to affect differently one class of common stock compared to the other. These decisions could include changes to Applera's

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management and allocation policies, transfers of assets between groups, allocations of corporate opportunities and financing resources between the groups and changes in dividend policies.

    The following illustration demonstrates the calculation of the number of shares issuable upon conversion of Celera Genomics common stock into shares of Applied Biosystems common stock at Applera's option. If:

    $50 per share        
1.1x  
  =   1.3750 shares
    $40 per share        

    Redemption in Exchange for Stock of Subsidiary.  Applera's board of directors may redeem on a pro rata basis all of the outstanding shares of Celera Genomics common stock for shares of the common stock of one or more of Applera's wholly owned subsidiaries which own all of the assets and liabilities attributed to the Celera Genomics group. Applera may redeem shares of common stock for subsidiary stock only if it has legally available funds under Delaware law.

    These provisions are intended to give Applera increased flexibility with respect to splitting-off the assets of the Celera Genomics group by transferring the assets of that group to one or more wholly-owned subsidiaries and redeeming the shares of Celera Genomics common stock in exchange for stock of such subsidiary or subsidiaries. As a result of any such redemption, or a redemption of Applied Biosystems common stock under a similar provision for that stock, holders of each class of common stock would hold securities of separate legal entities operating in distinct lines of business. Such a redemption could be authorized by Applera's board of directors at any time in the future if it determines that, under the facts and circumstances then existing, an equity structure comprised of Celera Genomics common stock and Applied Biosystems common stock is no longer in the best interests of all of Applera's stockholders as a whole.

    Selection of Shares for Redemption.  If less than all of the outstanding shares of Celera Genomics common stock are to be redeemed, Applera will redeem such shares proportionately from among the holders of outstanding shares of Celera Genomics common stock or by such method as may be determined by Applera's board of directors to be equitable.

    Fractional Interests; Transfer Taxes.  Applera will not be required to issue fractional shares of any capital stock or any fractional securities to any holder of Celera Genomics common stock upon any conversion, redemption, dividend or other distribution described above. If a fraction is not issued to a holder, Applera will pay cash instead of such fraction.

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    Applera will pay all documentary, stamp or similar issue or transfer taxes that may be payable in respect of the issue or delivery of any shares of capital stock and/or other securities on conversion or redemption of shares.

    The entire voting power of Applera's stockholders is vested in the holders of common stock, who are entitled to vote on any matter on which Applera's stockholders are entitled to vote, except as otherwise required by Applera's board of directors or provided by law or stock exchange rules, by the terms of any outstanding preferred stock or by any provision of Applera's certificate of incorporation restricting the power to vote on a specified matter to other stockholders.

    Holders of Celera Genomics common stock and Applied Biosystems common stock vote as a single class on each matter on which holders of common stock are generally entitled to vote.

    On all matters as to which both Celera Genomics common stock and Applied Biosystems common stock vote together as a single class, each share of Celera Genomics common stock has a number of votes equal to the quotient of the average market value of a share of Celera Genomics common stock over the 20-trading day period ending on the 10th trading day prior to the record date for determining the holders of common stock entitled to vote, divided by the average market value of a share of Applied Biosystems common stock over the same period, while each share of Applied Biosystems common stock has one vote.

    Accordingly, the relative per share voting rights of Applied Biosystems common stock and Celera Genomics common stock will fluctuate depending on changes in the relative market values of shares of such classes of common stock. Applied Biosystems common stock currently has a substantial majority of the voting power because the aggregate market value of the outstanding shares of Applied Biosystems common stock is substantially greater than the aggregate market value of the outstanding shares of Celera Genomics common stock.

    Applera sets forth the number of outstanding shares of Applied Biosystems common stock and Celera Genomics common stock in its Annual Report on Form 10-K and its Quarterly Reports on Form 10-Q filed under the Securities Exchange Act of 1934. Applera also discloses in any proxy statement for a stockholders' meeting the number of outstanding shares and per share voting rights of Celera Genomics common stock.

    If only shares of Celera Genomics common stock are outstanding, each share will have one vote. If Celera Genomics common stock is entitled to vote as a separate class with respect to any matter, each share will, for purpose of such vote, have one vote on such matter.

    Fluctuations in the relative voting rights of Celera Genomics common stock and Applied Biosystems common stock could influence an investor interested in acquiring and maintaining a fixed percentage of the voting power of Applera stock to acquire such percentage of both classes of common stock, and would limit the ability of investors in one class to acquire for the same consideration relatively more or less votes per share than investors in the other class.

    The holders of Celera Genomics common stock and Applied Biosystems common stock do not have any rights to vote separately as a class on any matter coming before Applera's stockholders, except for certain limited class voting rights provided under Delaware law. In addition to the approval of the holders of a majority of the voting power of all shares of common stock voting together as a single class, the approval of a majority of the outstanding shares of Celera Genomics common stock or Applied Biosystems common stock, voting as a separate class, would be required under Delaware law to approve any amendment to Applera's certificate of incorporation that would change the par value of the shares of the class or alter or change the powers, preferences or special rights of the shares of such class so as to affect them adversely. As permitted by Delaware law, Applera's certificate of

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incorporation provides that an amendment to Applera's certificate of incorporation that increases or decreases the number of authorized shares of Celera Genomics common stock or Applied Biosystems common stock will only require the approval of the holders of a majority of the voting power of all shares of common stock, voting together as a single class, and will not require the approval of the holders of the class of common stock affected by such amendment, voting as a separate class.

    The following illustration demonstrates the calculation of the number of votes each share of Celera Genomics common stock would be entitled on all matters on which holders of Celera Genomics common stock and Applied Biosystems common stock vote as a single class. If the average market value for the 20-trading day valuation period was $50 for Celera Genomics common stock and $40 for Applied Biosystems common stock, each share of Applied Biosystems common stock would have one vote and each share of Celera Genomics common stock would have 1.250 votes based on the following calculation:

$50
$40
  =   1.250 votes

    Assuming 200 million shares of Applied Biosystems common stock and 50 million shares of Celera Genomics common stock were outstanding, the shares of Applied Biosystems common stock would represent approximately 76% of Applera's total voting power and the shares of Celera Genomics common stock would represent approximately 24% of Applera's total voting power.

    Under Applera's certificate of incorporation, in the event of its dissolution, liquidation or winding up, after payment or provision for payment of the debts and other liabilities and full preferential amounts to which holders of any preferred stock are entitled, regardless of the group to which such shares of preferred stock were attributed, the holders of Celera Genomics common stock and Applied Biosystems common stock will be entitled to receive Applera assets remaining for distribution to holders of common stock on a per share basis in proportion to the liquidation units per share of such class. Each share of Celera Genomics common stock has .0725 liquidation units and each share of Applied Biosystems common stock has 0.25 liquidation units.

    The number of liquidation units to which each share of Celera Genomics common stock is entitled will not be changed without the approval of holders of the class of common stock adversely affected except as described below. As a result, the liquidation rights of the holders of the respective classes of common stock may not bear any relationship to the relative market values or the relative voting rights of the two classes.

    No holder of Applied Biosystems common stock will have any special right to receive specific assets of the Applied Biosystems group and no holder of Celera Genomics common stock will have any special right to receive specific assets of the Celera Genomics group in the case of Applera's dissolution, liquidation or winding up.

    Neither a merger nor consolidation of Applera into or with any other corporation, nor any sale, transfer or lease of all or any part of Applera's assets, will, alone, be deemed a liquidation or winding up of Applera, or cause the dissolution of Applera for purposes of these liquidation provisions.

    Any determinations made in good faith by Applera's board of directors under any provision described above and any determinations with respect to any group or the rights of holders of shares of Celera Genomics common stock or Applied Biosystems common stock, will be final and binding on all

131


of Applera's stockholders, subject to the rights of stockholders under applicable Delaware law and under the federal securities laws.

    The holders of Celera Genomics common stock will not have any preemptive rights or any rights to convert their shares into any other securities of Applera.

Celera Genomics Designated Shares

    The Applied Biosystems group may hold in the future an equity interest in the Celera Genomics group in the form of "Celera Genomics Designated Shares" as a result of future contributions of cash or property to the Celera Genomics group described below. The Applera board of directors could create Celera Genomics Designated Shares if it determines that, among other things,

    Celera Genomics Designated Shares are authorized shares of Celera Genomics common stock that are not issued and outstanding, but which Applera's board of directors, pursuant to management and allocation policies, may from time to time issue without allocating the proceeds or other benefits of such issuance to the Celera Genomics group. The Celera Genomics Designated Shares are not eligible to receive dividends and cannot be voted.

    The number of Celera Genomics Designated Shares is currently zero but from time to time will be:



Applied Biosystems Common Stock

    Dividends on Applied Biosystems common stock are limited to an amount not greater than the Available Dividend Amount for the Applied Biosystems group. The Available Dividend Amount for the

132


Applied Biosystems group is intended to be similar to the amount that would be legally available for the payment of dividends on Applied Biosystems common stock if the group were a separate company. In calculating the Available Dividend Amount for the Applied Biosystems group, the amount of net income or loss of Applera that is attributed to the Applied Biosystems group in accordance with generally accepted accounting principals will be increased by any federal tax benefits in excess of $75 million generated but not used by the Celera Genomics group from July 1, 1998 and used by the Applied Biosystems group.

    The holders of shares of Applied Biosystems common stock have conversion and redemption rights similar to those described above under "—Celera Genomics Common Stock-Conversion and Redemption," except as noted below.

    Redemption for Stock of a Subsidiary.  As discussed above, Applera's board of directors may redeem on a pro rata basis all of the outstanding shares of Applied Biosystems common stock or Celera Genomics common stock for shares of common stock of one or more of Applera's wholly-owned subsidiaries which own all of the assets or liabilities attributed to the relevant group. If at the time of any such redemption of Applied Biosystems common stock, the Applied Biosystems group is entitled to Celera Genomics Designated Shares, Applera will also issue an equal number of shares of Celera Genomics common stock either to

    The holders of shares of Applied Biosystems common stock have the voting rights described above under the caption "—Celera Genomics Common Stock-Voting Rights," except that each share of Applied Biosystems common stock has one vote on all matters as to which both classes of common stock vote together as a single class.

    In the event of Applera's liquidation, dissolution or termination, the holders of shares of Applied Biosystems common stock are entitled to receive funds in the amounts described above under "—Celera Genomics Common Stock-Liquidation," except that each share of Applied Biosystems common stock will have 0.25 liquidation units.

Rights Agreement

    Applera has issued participating preferred stock purchase rights (the "existing rights") to all holders of Celera Genomics common stock and Applied Biosystems common stock under Applera's rights agreement dated as of April 28, 1999, with Applera's rights agent, BankBoston, N.A. Each existing right entitles the holder to purchase shares of participating junior preferred stock as follows:

    Applera refers to the Applied Biosystems Rights and the Celera Genomics Rights as the "Rights."

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    A "distribution date" will occur upon the earlier of:


    Until the distribution date, the Rights will be transferred only with the common stock.

    Following the distribution date, holders of Rights will be entitled to purchase from Applera:

    If any person or group becomes an acquiring person:

    In certain circumstances after the Rights have been triggered, Applera may exchange the Rights, other than Rights owned by an acquiring person, at an exchange ratio of one share of Applied Biosystems common stock per Applied Biosystems Right and one share of Celera Genomics common stock per Celera Genomics Right.

    If, following the time a person becomes an acquiring person:

then each Applied Biosystems Right and each Celera Genomics Right will entitle its holder to purchase, for the Series A Purchase Price or Series B Purchase Price, as applicable, a number of shares of common stock of the surviving entity in any such merger, consolidation or other business combination or the purchaser in any such sale or transfer with a market value equal to twice the Series A Purchase Price or Series B Purchase Price, as applicable.

    The Rights will expire on April 28, 2009 unless extended or terminated as described below.

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    At any time until a person becomes an acquiring person, Applera's board of directors may redeem all of the Rights at a price of $.01 per Right. On the redemption date, the right to exercise the Rights will terminate and the only right of the holders of Rights will be to receive this price.

    A holder of a Right will not have any rights as a stockholder of Applera, including the right to vote or to receive dividends, until a Right is exercised.

    At any time prior to the time that any person becomes an acquiring person, Applera may, without the approval of any holders of Rights, supplement or amend any provision of the rights agreement in any manner, whether or not such supplement or amendment is adverse to any holders of the Rights. From and after the time a person becomes an acquiring person, Applera may, without the approval of any holders of Rights, supplement or amend the rights agreement:

    Applera's rights agreement contains provisions designed to prevent the inadvertent triggering of the Rights. For example, it gives a person who has inadvertently acquired 15% or more of the outstanding shares of a class of common stock and does not have any intention of changing or influencing the control of Applera the opportunity to sell a sufficient number of shares so that such acquisition would not trigger the Rights. In addition, the Rights will not be triggered and a divestiture of shares will not be required by Applera's repurchase of shares of common stock outstanding which could raise the proportion of shares held by a person to over the applicable 15% threshold. However, any person who exceeds such threshold as a result of Applera's stock repurchases will trigger the Rights if such person subsequently acquires any additional shares of common stock.

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COMPARISON OF STOCKHOLDER RIGHTS

    If the merger is completed, all holders of Axys common stock will become holders of shares of Celera Genomics common stock. The rights of a holder of Celera Genomics common stock are similar in some respects and different in other respects from the rights of a holder of Axys common stock. The rights of Applera stockholders are currently governed by the Delaware General Corporation Law and the certificate of incorporation and bylaws of Applera. The rights of holders of Axys common stock are currently governed by the Delaware General Corporation Law and the certificate of incorporation and bylaws of Axys. The following are summaries of the material differences between the current rights of holders of Axys common stock and the rights they will have as holders of Celera Genomics common stock following the merger.

    The following comparison of stockholders' rights is necessarily a summary, is not intended to be complete or to identify all differences that may, under given situations, be material to stockholders and is subject, in all respects, and is qualified by reference, to the Delaware General Corporation Law, the Applera certificate of incorporation, the Applera bylaws, the Axys certificate of incorporation and the Axys bylaws.

 
  Celera Genomic Stockholder Rights
  Axys Stockholder Rights

Authorized Shares

 

The total number of authorized shares of capital stock of Applera is 1,235,000,000, consisting of 1,000,000,000 shares of Applied Biosystems common stock, 225,000,000 shares of Celera Genomics common stock and 10,000,000 shares of Applera preferred stock, each having a par value of $.01 per share. Applera's certificate of incorporation authorizes the Applera board of directors to issue shares of preferred stock in one or more series, the terms of which will be determined by the board of directors, as well as Applied Biosystems common stock and Celera Genomics common stock.

 

The total number of authorized shares of capital stock of Axys is 110,000,000, consisting of 100,000,000 shares of common stock, and 10,000,000 shares of preferred stock, each having a par value of $.001. Axys' certificate of incorporation authorizes the Axys board of directors to issue shares of preferred stock in one or more series, the terms of which will be determined by the board, as well as Axys common stock.

Number of Directors

 

The Applera certificate of incorporation provides that the number of directors on the Applera board will be fixed by the board of directors but will not be less than three and not more than thirteen.

 

The Axys bylaws provide that the number of directors on the Axys board will be nine, unless modified by resolution of the board of directors. The board of directors has set the number of directors at seven.

136



Classification of Board of Directors

 

The Applera board of directors is not divided into separate classes but consists of a single class elected annually.

 

The Axys board of directors also consists of a single class elected annually.

Quorum for Meeting of Directors

 

Under the Applera bylaws, the presence of a majority of the directors then in office constitutes a quorum for the transaction of business by the Applera board.

 

Under the Axys bylaws, the presence of a majority of the total authorized number of directors constitutes a quorum for the transaction of business by the Axys board.

Removal of Directors

 

Under Delaware law and the Applera bylaws, stockholders may remove any director, with or without cause, by the vote of the holders entitled to cast a majority of the votes entitled to be cast by all outstanding shares entitled to vote at an election of directors.

 

Under Delaware law and the Axys bylaws, no director may be removed without cause; the board of directors or any individual director may be removed with cause by the holders of a majority of the then-outstanding shares entitled to vote at an election of directors.

Filling Newly Created Directorships and Vacancies

 

Under Delaware law and the Applera bylaws, a majority of the directors then in office, even if less than a quorum, may fill vacancies and newly created directorships. Applera stockholders may fill a vacancy in the board of directors caused by the removal of a director by the vote of the holders entitled to cast a majority of the votes entitled to be cast for the removal of the director.

 

Under Delaware law and the Axys certificate of incorporation, vacancies on the board of directors may be filled by a majority of the remaining directors, though less than a quorum, or by a sole remaining director.

Amendments to Certificate of Incorporation

 

Under Delaware law, the board of directors must propose an amendment to the certificate of incorporation and then a majority of all outstanding shares entitled to vote must approve it.

 

Under Delaware law and the Axys certificate of incorporation, the corporation reserves the right to amend the certificate of incorporation in the manner prescribed by law.

137



Amendment of Bylaws

 

Under Delaware law and the Applera certificate of incorporation and bylaws, the Applera bylaws can be amended or repealed by the affirmative vote of either:

 

Under Delaware law and the Axys certificate of incorporation and bylaws provide, the Axys bylaws may be amended or repealed by the affirmative vote of either:

 

 

• holders of a majority of the outstanding shares of capital stock entitled to vote and present in person or by proxy at the meeting, or

 

• holders of at least 662/3% of the voting power of all of the then outstanding shares of the voting stock, or

 

 

• a majority of the members of the Applera board of directors.

 

• a majority of the members of the Axys board of directors.

Special Meetings of Stockholders

 

Under the Applera certificate of incorporation and bylaws, only the Applera board of directors or its chairman, president or secretary may call a special meeting of the stockholders.

 

Under the Axys certificate of incorporation a special meeting of stockholders may be called by the chairman of the board, the chief executive officer or the board of directors pursuant to a resolution adopted by a majority of the total number of authorized directors, whether or not any vacancies exist.

Notices of Stockholder
Meetings

 

Under the Applera bylaws, Applera must give personally or by mail, not less than ten and not more than sixty days before the date of any meeting of stockholders, to each stockholder entitled to vote at such meeting, written notice stating the place, date, hour and purpose or purposes of the meeting. Any and all notices of a meeting may be waived by a stockholder by submitting a signed waiver either before or after the meeting. The attendance of any stockholder at a meeting, in person or by proxy, without protesting prior to the conclusion of the meeting the lack of notice of such meeting, will constitute a waiver of notice.

 

Under the Axys bylaws, Axys must give personally or by mail or by telegraphic or other written communication, not less than ten and not more than sixty days before the date of the meeting, written notice stating the place, date, hour and purpose or purposes of the meeting. Any and all notices of a meeting may be waived by a stockholder by submitting a signed waiver either before or after the meeting. The attendance of any stockholder at a meeting, in person or by proxy, without protesting prior to the conclusion of the meeting the lack of notice of such meeting, will constitute a waiver of notice.

138



Stockholders Necessary to Constitute a Quorum

 

Under the Applera bylaws, the holders of record of shares of Celera Genomics common stock and Applied Biosystems common stock entitled to cast a majority of the votes entitled to be cast by the holders of all outstanding shares of capital stock entitled to vote at such meeting, whether present in person or represented by proxy, constitutes a quorum for the purposes of transacting business at any stockholder meeting.

 

Under the Axys bylaws, the presence in person or by proxy of the holders of record of a majority of shares entitled to vote at a meeting of stockholders constitutes a quorum for the transaction of business at such meeting.

Stockholder Action Without a Meeting.

 

Under Delaware law, unless a corporation's certificate of incorporation states otherwise, stockholders may take action without a meeting if such action is authorized by the written consents of stockholders having not less than the minimum number of votes necessary to take such action at a meeting at which all shares were present and voting.

 

Under Axys' certificate of incorporation, no action can be taken by the stockholders by written consent.

 

 

Under Applera's certificate of incorporation, the written consent of all stockholders entitled to vote on an action must be obtained for the consent to be effective.

 

 

Stockholder Rights Plans

 

Each share of Celera Genomics common stock has attached to it the right to purchase preferred shares issued pursuant to the Applera rights plan.

 

Each share of Axys common stock has attached to it the right to purchase preferred shares issued pursuant to the Axys rights plan. Axys has taken all action necessary to ensure that the rights issued under the plan agreement do not apply to the merger.

139



EXPERTS

    The consolidated financial statements of Applera, the combined financial statements of the Applied Biosystems group and the combined financial statements of the Celera Genomics group incorporated in this proxy statement/prospectus by reference to the PE Corporation Annual Report on Form 10-K for the year ended June 30, 2000 have been so incorporated in reliance on the reports of PricewaterhouseCoopers LLP, independent accountants, given on the authority of said firm as experts in auditing and accounting.

    The financial statements of Axys and Discovery Partners at December 31, 2000 and 1999, and for each of the three years in the period ended December 31, 2000, which are included in and made a part of this proxy statement/prospectus and registration statement, have been audited by Ernst & Young LLP, independent auditors, as set forth in their reports appearing elsewhere herein, and are included in reliance upon such reports given on the authority of such firm as experts in accounting and auditing.

    It is not anticipated that representatives of Ernst & Young LLP or PricewaterhouseCoopers LLP will attend the special meeting.


LEGAL OPINIONS

    The validity of the shares of Celera Genomics common stock to be issued to holders of shares of Axys common stock pursuant to the merger will be passed upon for Applera by Simpson Thacher & Bartlett, Palo Alto, California.

    Certain federal income tax matters related to the merger will be passed upon for Applera by Simpson Thacher & Bartlett, New York, New York, and for Axys by Latham & Watkins, Menlo Park, California. Alan Mendelson, a partner of Latham & Watkins, is a member of the Axys board of directors and beneficially owns 5,329 shares of Axys common stock as of the date of this proxy statement/prospectus.


SUBMISSION OF STOCKHOLDER PROPOSALS

    If the merger and the merger agreement are approved and adopted by holders of Axys common stock and the merger is completed, Axys will not hold a 2002 annual meeting of stockholders. If the merger agreement and the merger are not approved and adopted by holders of Axys common stock or the merger is not completed for any other reason, the Axys board of directors requests that any stockholder proposals intended for presentation at the 2002 annual meeting be submitted to the corporate secretary of Axys in writing by December 19, 2001 for consideration for inclusion in Axys' proxy materials for such meeting.

    In addition, under Axys' bylaws, stockholders must comply with specified procedures to nominate directors or introduce an item of business at the 2002 annual meeting. Nominations or an item of business to be introduced at an annual meeting must be submitted in writing. To be in proper written form, a stockholder's notice must contain the specific information required by Axys' bylaws. A copy of the bylaws that describes the advance notice procedures can be obtained from the corporate secretary of Axys.


SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS

    This proxy statement/prospectus includes "forward-looking statements" within the meaning of Section 27A of the Securities Act and Section 21E of the Securities Exchange Act of 1934, as amended. Such statements are identified by the use of forward-looking words or phrases including, but not limited to, "intended," "expects," "expected," "plans," "anticipates" and "anticipated." These forward- looking statements are based on current expectations of Applera or Axys, as the case may be. All statements other than statements of historical facts included in this proxy statement/prospectus,

140


including those regarding the financial position, results of operations, cash flows, business strategy, projected costs, growth opportunities for existing products, benefits from new technology, strategic and other benefits of the merger, cost savings and plans and objectives of management for future operations of Applera or Axys, as the case may be, are forward-looking statements. Although Applera or Axys believes that the expectations of Applera or Axys, as the case may be, reflected in such forward-looking statements are reasonable, there can be no assurance that such expectations will prove to have been correct. Because forward-looking statements involve risks and uncertainties, the actual results of Applera and Axys, as the case may be, could differ materially. Important factors that could cause actual results to differ materially from the expectations of Applera or Axys, as the case may be, are the cautionary statements disclosed under "Risks Related to the Merger," "Risks Related to the Celera Genomics Group," "Risks Related to a Capital Structure with Two Separate Classes of Common Stock," "Reasons for the Merger" and elsewhere in this proxy statement/prospectus and in Applera's and Axys' Securities and Exchange Commission filings listed below. These forward-looking statements represent the judgment of Applera or Axys, as the case may be, as of the date of this proxy statement/prospectus. All subsequent written and oral forward-looking statements attributable to Applera or Axys or persons acting on behalf of Applera or Axys are expressly qualified in their entirety by the cautionary statements. Applera and Axys disclaim, however, any intent or obligation to update their respective forward-looking statements.


WHERE YOU CAN FIND MORE INFORMATION

    Applera and Axys file annual, quarterly and special reports, proxy statements and other information with the Securities and Exchange Commission. You may read and copy any reports, statements or other information we file at the Public Reference Room of the Securities and Exchange Commission at 450 Fifth Street, N.W., Washington, D.C. 20549 and the Securities and Exchange Commission's regional offices at 7 World Trade Center, New York, New York 10048 and Northwestern Atrium Center, 500 West Madison Street, Suite 1400, Chicago, Illinois 60661. Please call the Securities and Exchange Commission at 1-800-SEC-0330 for further information on the public reference rooms. These filings are also available to the public from commercial document retrieval services and at the world wide web site maintained by the Securities and Exchange Commission at http://www.sec.gov.

    Applera has filed a Form S-4 to register with the Securities and Exchange Commission Celera Genomics common stock to be issued to holders of Axys common stock in the merger. This document is a part of the Form S-4 and constitutes a prospectus of Applera in addition to being a proxy statement for the Axys special meeting. As allowed by Securities and Exchange Commission rules, this document does not contain all the information you can find in the Form S-4 or the exhibits to the Form S-4.

    The Securities and Exchange Commission allows Applera to "incorporate by reference" information into this document, which means that Applera can disclose important information to you by referring you to another document filed separately with the Securities and Exchange Commission. The information incorporated by reference is deemed to be part of this document, except for any information superseded by information in this document. Applera incorporates by reference its documents listed below and any future filings it makes with the Securities and Exchange Commission under Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act, prior to the termination of this offering:

141


    If you are a stockholder of Axys, Applera may have sent you some of the documents incorporated by reference, but you can obtain any of them through us or the Securities and Exchange Commission. Documents incorporated by reference are available from Applera without charge, excluding all exhibits unless Applera has specifically incorporated by reference an exhibit in this document. Stockholders of Axys may obtain documents incorporated by reference in this document by requesting them in writing or by telephone from Applera at the following address:

    If you would like to request documents from Applera, please do so by [      ], 2001, to receive them prior to the special meeting.

    You should rely only on the information contained or incorporated by reference in this document to vote on the proposals included in this document. Applera has not authorized anyone to provide you with information that is different from what is contained in this document. This document is dated [      ], 2001. You should not assume that the information contained in this document is accurate as of any date other than such date, and neither the mailing of this document to stockholders of Axys nor the issuance of Celera Genomics common stock in the merger will create any implication to the contrary.

Information on Applera's Web Site

    Information on any Applera Internet web site or the web site of any business of Applera is not part of this document, and you should not rely on that information in deciding whether to adopt the merger agreement unless that information is also in this document or in a document that is incorporated by reference into this proxy statement/prospectus.

Information on Axys' Web Site

    Information on any Axys Internet web site or the web site of any subsidiary of Axys is not part of this document, and you should not rely on that information in deciding whether to adopt the merger agreement unless that information is also in this document or in a document that is incorporated by reference into this proxy statement/prospectus.

142



INDEX TO FINANCIAL STATEMENTS

 
  Page
AXYS PHARMACEUTICALS, INC.    
AUDITED FINANCIAL STATEMENTS FOR THE YEARS ENDED DECEMBER 31, 2000, 1999 AND 1998    
Report of Ernst & Young LLP, Independent Auditors   F-2
Balance Sheets   F-3
Statements of Operations   F-4
Statement of Stockholders' Equity   F-5
Statements of Cash Flows   F-6
Notes to Financial Statements   F-7

UNAUDITED CONDENSED FINANCIAL STATEMENTS

 

 
Condensed Balance Sheet as of March 31, 2001 and December 31, 2000   F-26
Condensed Statements of Operations for the three months ended March 31, 2001 and 2000   F-27
Condensed Statements of Cash Flows for the three months ended March 31, 2001 and 2000   F-28
Notes to Condensed Financial Statements   F-29

DISCOVERY PARTNERS INTERNATIONAL, INC.

 

 
AUDITED FINANCIAL STATEMENTS FOR THE YEARS ENDED DECEMBER 31, 2000, 1999 AND 1998    
Report of Ernst & Young LLP, Independent Auditors   F-32
Consolidated Balance Sheets   F-33
Consolidated Statements of Operations   F-34
Consolidated Statements of Stockholders' Equity (Deficit)   F-35
Consolidated Statements of Cash Flows.   F-36
Notes to Consolidated Financial Statements   F-37

F–1



REPORT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS

Board of Directors and Stockholders
Axys Pharmaceuticals, Inc.

    We have audited the accompanying balance sheets of Axys Pharmaceuticals, Inc. as of December 31, 2000 and 1999, and the related statements of operations, stockholders' equity and cash flows for each of the three years in the period ended December 31, 2000. These financial statements are the responsibility of the Company's management. Our responsibility is to express an opinion on these financial statements based on our audits.

    We conducted our audits in accordance with auditing standards generally accepted in the United States. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.

    In our opinion, the financial statements referred to above present fairly, in all material respects, the financial position of Axys Pharmaceuticals, Inc. at December 31, 2000 and 1999, and the results of its operations and its cash flows for each of the three years in the period ended December 31, 2000, in conformity with accounting principles generally accepted in the United States.

Palo Alto, California
March 2, 2001

F–2


AXYS PHARMACEUTICALS, INC.

BALANCE SHEETS
(In thousands, except share and per share amounts)

 
  December 31,
 
 
  2000
  1999
 
ASSETS  
Current assets:              
  Cash and cash equivalents   $ 41,247   $ 23,577  
  Marketable securities     529     3,080  
  Accounts receivable, trade         4,786  
  Inventories         2,258  
  Prepaid expenses and other current assets     2,890     1,524  
   
 
 
      Total current assets     44,666     35,225  
Property and equipment, net     10,983     18,873  
Investment in equity-method investee     40,367      
Other investments     15,007      
Notes receivable from employees     365     715  
Debt issuance costs, net     6,753      
Other assets     555     921  
   
 
 
    $ 118,696   $ 55,734  
   
 
 

LIABILITIES AND STOCKHOLDERS' EQUITY

 
Current liabilities:              
  Accounts payable   $ 5,406   $ 4,563  
  Accrued compensation     2,154     2,980  
  Other accrued liabilities     2,503     5,284  
  Deferred revenue     229     2,083  
  Current portion of capital lease and debt obligations     950     23,646  
   
 
 
      Total current liabilities     11,242     38,556  

Capital lease obligations, noncurrent

 

 

1,889

 

 

57

 
Subordinated notes     26,000      
Minority interest         3,074  
Commitments              
Stockholders' equity:              
  Preferred stock, $0.001 par value, 10,000,000 shares authorized, none issued or outstanding          
  Common stock, $0.001 par value, 50,000,000 shares authorized, 37,270,144 and 30,471,281 shares issued and outstanding at December 31, 2000 and 1999, respectively     347,444     291,328  
  Accumulated other comprehensive loss     (524 )   (70 )
  Accumulated deficit     (267,355 )   (277,211 )
   
 
 
      Total stockholders' equity     79,565     14,047  
   
 
 
    $ 118,696   $ 55,734  
   
 
 

See accompanying notes.

F–3


AXYS PHARMACEUTICALS, INC.

STATEMENTS OF OPERATIONS
(In thousands, except per share amounts)

 
  Year Ended December 31,
 
 
  2000
  1999
  1998
 
Collaboration and license revenue   $ 6,990   $ 24,084   $ 35,760  
Operating expenses:                    
  Research and development     36,575     55,174     57,502  
  General and administrative     9,999     10,872     13,411  
  Restructuring charge     (592 )   5,175      
  Acquired in-process research and development             124,888  
   
 
 
 
      Total operating expenses     45,982     71,221     195,801  
   
 
 
 
Operating loss     (38,992 )   (47,137 )   (160,041 )
Interest income     1,780     2,346     4,720  
Interest expense     (5,885 )   (2,005 )   (2,403 )
Equity in losses of equity-method investees     (3,208 )   (836 )   (2,393 )
Other income (expense)     889     (852 )    
   
 
 
 
Loss from continuing operations     (45,416 )   (48,484 )   (160,117 )
Discontinued operations:                    
  (Loss) income from operations of a discontinued segment     (5,941 )   (279 )   3,993  
  Gain on disposal of segment     61,213          
   
 
 
 
Net income (loss)   $ 9,856   $ (48,763 ) $ (156,124 )
   
 
 
 
Basic and diluted net loss per share from continuing operations   $ (1.29 ) $ (1.59 ) $ (5.38 )
Basic and diluted net income (loss) per share from discontinued segments   $ 1.57   $ (0.01 ) $ 0.13  
   
 
 
 
Basic and diluted net income (loss) per share   $ 0.28   $ (1.60 ) $ (5.25 )
   
 
 
 
Shares used in computing basic and diluted net loss per share     35,281     30,385     29,758  
   
 
 
 

See accompanying notes.

F–4


AXYS PHARMACEUTICALS, INC.

STATEMENTS OF STOCKHOLDERS' EQUITY
(In thousands, except share and per share amounts)

 
   
   
   
  Accumulated
Other
Comprehensive
Income
(Loss)

   
   
 
 
  Common Stock
  Note
Receivable
From
Officer

   
   
 
 
  Accumulated
Deficit

  Total
Stockholders'
Equity

 
 
  Shares
  Amount
 
Balances at January 1, 1998   15,203,089   $ 117,786   $ (125 ) $   $ (73,771 ) $ 43,890  
Exercise of options and warrants to purchase common stock   91,649     621                 621  
Issuance of common stock for cash   132,254     1,063                 1,063  
Issuance of common stock in connection with the ESPP   189,145     1,091                 1,091  
Issuance of common stock in connection with the acquisition of Sequana Therapeutics, Inc.   14,618,013     169,730                 169,730  
Forgiveness of note receivable           125             125  
Net loss                   (156,124 )   (156,124 )
Unrealized gain on securities               116         116  
                               
 
Comprehensive loss                                 (156,008 )
   
 
 
 
 
 
 
Balances at December 31, 1998   30,234,150     290,291         116     (229,895 )   60,512  
   
 
 
 
 
 
 
Exercise of options and warrants to purchase common stock   34,874     132                 132  
Issuance of common stock in connection with the ESPP   202,257     905                 905  
Deconsolidation of Akkadix Corporation                   1,447     1,447  
Net loss                   (48,763 )   (48,763 )
Unrealized loss on securities               (186 )       (186 )
                               
 
Comprehensive loss                                 (48,949 )
   
 
 
 
 
 
 
Balances at December 31, 1999   30,471,281     291,328         (70 )   (277,211 )   14,047  
   
 
 
 
 
 
 
Exercise of options and warrants to purchase common stock   1,364,760     5,778                 5,778  
Embedded beneficial conversion associated with convertible debt issuance       4,058                 4,058  
Issuance of warrants in connection with convertible debentures       5,699                 5,699  
Compensation expense related to options and warrants granted to consultants       339                 339  
Issuance of common stock in connection with the ESPP   176,247     613                 613  
Issuance of common stock in connection with a private placement, net of offering costs of $1,934   3,497,778     29,547                 29,547  
Issuance of common stock in connection with an equity line of credit, net of offering costs of $385   1,639,344     9,615                 9,615  
Issuance of common stock for interest due on convertible debt   120,734     467                 467  
Net income                   9,856     9,856  
Unrealized loss on securities               (454 )       (454 )
                               
 
Comprehensive income                                 9,402  
   
 
 
 
 
 
 
Balance at December 31, 2000   37,270,144   $ 347,444       $ (524 ) $ (267,355 ) $ 79,565  
   
 
 
 
 
 
 

See accompanying notes.

F–5


AXYS PHARMACEUTICALS, INC.

STATEMENTS OF CASH FLOW
(In thousands)

 
  Year Ended December 31,
 
 
  2000
  1999
  1998
 
Cash Flows From Operating Activities                    
Net income (loss)   $ 9,856   $ (48,763 ) $ (156,124 )
Adjustments to reconcile net income (loss) to net cash used in operating activities:                    
  Non-cash restructure charge         1,598      
  Forgiveness of notes receivable from officers     350     160     155  
  Beneficial Conversion and other non-cash charges     4,611          
  Depreciation and amortization     6,378     11,135     10,156  
  Gain on disposal of segments     (61,213 )        
  (Gain) loss on disposal of fixed assets         (176 )   44  
  Equity in losses of equity method investees     3,208     836     2,393  
  Acquired in-process research and development             124,888  
  Minority interest     (3,074 )   1,879     388  
  Changes in assets and liabilities:                    
      Accounts receivable     4,786     (2,646 )   (839 )
      Inventories     2,258     (1,823 )   (435 )
      Prepaid expenses and other assets     (1,366 )   3,297     (1,833 )
      Accounts payable     843     775     (5,818 )
      Accrued compensation     (826 )   (1,252 )   2,440  
      Other accrued liabilities     (2,781 )   2,328     808  
      Deferred revenue     (1,854 )   (6,615 )   (3,382 )
   
 
 
 
          Net cash and cash equivalents used in operating activities     (38,824 )   (39,267 )   (27,159 )
   
 
 
 
Cash Flows From Investing Activities                    
Available for-sale-securities:                    
  Purchases     (11,061 )   (77,003 )   (56,065 )
  Maturities     13,612     110,193     92,105  
Investment in subsidiaries and joint ventures         (25 )   (2,000 )
Acquisition, net of cash received             13,270  
Change in investment in consolidated subsidiaries and affiliates         3,351      
Proceeds from sale of PPGx stock     5,900          
Proceeds from sale of property and equipment         877     119  
Expenditures for property and equipment     (3,990 )   (8,862 )   (8,263 )
   
 
 
 
          Net cash and cash equivalents provided by investing activities     4,461     28,531     39,166  
   
 
 
 
Cash Flows From Financing Activities                    
Net proceeds from issuance of common stock     45,553     1,037     2,775  
Proceeds from issuance of note payable and capital lease obligations, net of issuance costs     27,400     53,292     6,174  
Principal payments on note payable and capital lease obligations     (20,920 )   (56,277 )   (7,633 )
   
 
 
 
          Net cash and cash equivalents provided by (used in) by financing activities     52,033     (1,948 )   1,316  
   
 
 
 
Net increase (decrease) in cash and cash equivalents     17,670     (12,684 )   13,323  
Cash and cash equivalents, beginning of year     23,577     36,261     22,938  
   
 
 
 
Cash and cash equivalents, end of year   $ 41,247   $ 23,577   $ 36,261  
   
 
 
 
Supplemental disclosure of cash flows information:                    
Cash paid during the year for interest   $ 2,684   $ 2,130   $ 2,284  
   
 
 
 
Supplemental Schedule of Non-Cash Investing and Financing Activities:                    
Issuance of common stock and value of options and warrants issued in acquisitions   $   $   $ 169,730  
   
 
 
 
Value of options and warrants issued in connection with convertible debt   $ 9,757   $   $  
   
 
 
 

See accompanying notes.

F–6


AXYS PHARMACEUTICALS, INC.

NOTES TO FINANCIAL STATEMENTS

1.  ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

    Axys Pharmaceuticals, Inc., a Delaware corporation ("Axys" or the "Company"), is a biopharmaceutical company focused on the discovery, design and development of therapeutic small molecules that address significant markets with major unmet medical needs. Axys collaborates with large pharmaceutical companies in discovering therapeutics for chronic diseases for which there are large markets. The Company also selectively focuses its own resources on discovering and developing therapeutics for the treatment of various types of cancer and other specialty market therapeutics. The Company has on-going programs in the treatment of autoimmune, inflammatory diseases, and cancers. Axys' drug design platform integrates advanced biology, chemistry, biophysics and information technologies to optimize the potency, selectivity and physical properties of new drugs, making the drug discovery process more efficient and productive.

    At December 31, 2000, the Company owns approximately 23% of Akkadix Corporation ("Akkadix"), formerly known as Xyris Corporation (see notes 3 and 14) and approximately 31% of Discovery Partners International, Inc. ("DPI") (see notes 2 and 3). These investments are accounted for under the equity method.

    The preparation of financial statements in conformity with accounting principles generally accepted in the United States requires management to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. Actual results could differ from those estimates, and such differences could be material.

    During 2000, the Company completed the sale of its former subsidiaries Axys Advanced Technologies ("AAT") and PPGx, Inc. ("PPGx"). The statements of operations are reclassified for the years ended December 31, 1999 and 1998 to reflect the results of AAT and PPGx as discontinued operations, in accordance with Accounting Principles Board Opinion No. 30.

    The Company considers all highly liquid investments with maturities of three months or less at the date of purchase to be cash equivalents. Investments with maturities greater than three months and less than one year are classified as marketable investments. Investments with maturities greater than one year are classified as long-term investments.

    The Company considers all its marketable investment securities as available-for-sale. Available-for-sale securities are reported at estimated fair market value with the related unrealized gains and losses included in stockholders' equity. Realized gains and losses, and declines in value judged to be other than temporary are included in interest income and expense. Realized gains and losses have been immaterial. The cost of securities sold is based on the specific identification method.

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    Investments in affiliated entities in which the Company has the ability to exercise significant influence, but not control, of an investee, generally an ownership interest of the voting stock of between 20% and 50%, are accounted for under the equity method of accounting. Under the equity method of accounting, the Company's share of the investee's earnings or losses are included in the statements of operations. The Company records its investments in equity-method investees on the balance sheets as "Investments in equity-method investees" and its share of the investees' earnings or losses in "Equity in losses of equity-method investee."

    All other investments, which consist of investments for which the Company does not have the ability to exercise significant influence, are accounted for under the cost method of accounting. Dividends and other distributions of earnings from other investees, if any, are included in income when declared. The Company periodically evaluates the carrying value of its investments accounted for under the cost method of accounting to determine whether a decrease in value of the cost of the investment has occurred which is other than temporary.

    Inventories (relating to the Company's former AAT subsidiary) are stated at the lower of cost (first-in, first-out) or market and consisted of the following at December 31, 1999 (in thousands):

Raw materials   $ 156
Finished goods     2,102
   
Total     2,258
   

    Property and equipment is recorded at cost. Depreciation is provided using the straight-line method over the estimated useful lives of the respective assets. Machinery and equipment have estimated useful lives ranging from 3 to 5 years and furniture and office equipment has an estimated useful life of 5 years. Purchased computer software is amortized over 3 years. Leasehold improvements are amortized over the term of the lease or economic useful life, whichever is shorter.

    The Company's collaborative research programs contain one or more of the following sources of revenue:

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    Research and development expenses consist of costs incurred for independent and collaborative research and development. These costs include direct costs and research-related overhead expenses. Research and development expenses under the collaborative research agreements approximate the research support revenue recognized under the agreements of $5,443,000, $16,649,000 and $24,804,000, in 2000, 1999 and 1998 respectively.

    The Company grants stock options for a fixed number of shares to employees with an exercise price equal to the fair value of the shares at the date of grant. The Company accounts for stock option grants in accordance with Accounting Principles Board Opinion No. 25, Accounting for Stock Issued to Employees ("APB 25") and related interpretations because the Company believes the alternative fair value accounting provided for under Financial Accounting Standards Board Statement No. 123, Accounting for Stock-Based Compensation, ("FAS 123") requires the use of option valuation models that were not developed for use in valuing employee stock options. Under APB 25, because the exercise price of the Company's employee stock options equals the market price of the underlying stock on the date of grant, no compensation expense is recorded. Stock based compensation arrangements to non-employees are accounted for in accordance with FAS 123 and EITF 96-18, using a fair value approach, and the compensation cost of such arrangements are subject to remeasurement over their vesting terms, as earned.

    Basic earnings per share is computed based on the weighted average number of shares of the Company's common stock outstanding, less shares subject to repurchase, if any. In addition, there were other dilutive securities in the form of options and warrants to purchase 7,311,844, 4,876,824, and 5,050,026 shares of common stock outstanding at December 31, 2000, 1999, and 1998, respectively. These shares, which would normally be included in the computation of dilutive earnings per share, were not included in that computation because the effect would be antidilutive.

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    Major customers, responsible for 10% or more of revenues include drug discovery partners and pharmaceutical companies. The percentages of collaboration and license revenue earned from these major customers to total revenue for the years ended December 31 were as follows:

 
  2000
  1999
  1998
Customer A   51%   16%   14%
Customer B   39%   13%   8%
Customer C     23%   26%
Customer D     21%   13%
All others   10%   27%   39%
   
 
 
    100%   100%   100%
   
 
 

    In June 1998, the Financial Accounting Standards Board issued Statement No. 133, Accounting for Derivative Instruments and Hedging Activities, which is required to be adopted in years beginning after June 15, 2000. The Company expects to adopt the new Statement effective January 1, 2001. The Statement will require the Company to recognize all derivatives on the balance sheet at fair value. Derivatives that are not hedges must be adjusted to fair value through income. If the derivative is a hedge, depending on the nature of the hedge, changes in the fair value of derivatives will either be offset against the change in fair value of the hedged assets, liabilities, or firm commitments through earnings or recognized in other comprehensive income until the hedged item is recognized in earnings. The ineffective portion of a derivative's change in fair value will be immediately recognized in earnings.

    Based on the Company's derivative positions at December 31, 2000, which are limited to warrants to purchase common shares of DPI stock (See Note 2 to our Financial Statements) and certain key employee contracts to acquire investments held by the Company (see Note 11 to our Financial Statements), management estimates that upon adoption the Company will record a cumulative effect of an accounting change of approximately $900,000 recognized in the statement of operations in the first quarter of 2001.

    Certain prior year balances have been reclassified to conform to the current year presentation.

2.  DISCONTINUED OPERATIONS

    During 2000, the Company sold two of its affiliated businesses: PPGx, Inc. ("PPGx") and Axys Advanced Technologies, Inc. ("AAT"). As a result, the operating results previously reported for the years ended December 31, 1999 and 1998 are reclassified in accordance with Accounting Principles Board Opinion No. 30.

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    On December 22, 2000, the Company completed the sale of PPGx to a privately held company—DNA Sciences, Inc. ("DNAS"). PPGx was previously a majority-owned subsidiary (82%) of Axys and performed genetic testing and contract research services for biotechnology and pharmaceutical companies. In conjunction with the sale, Axys received 1,478,550 shares of DNAS Series D Preferred Stock and 108 shares of DNAS common stock. The fair value of the Series D Preferred Stock and Common Stock received was approximately $15 million. Immediately prior to this transaction, Pharmaceutical Product Development, Inc. ("PPD"), the minority owner of PPGx, exercised its right to purchase 50% of the outstanding shares of PPGx. As a result of this exercise, Axys received $5.9 million from PPD for 32% of the outstanding PPGx shares held by Axys. Prior to consummation of the sale of PPGx, the carrying value of Axys' interest in the common stock of PPGx was $5.5 million. Accordingly, a $26 million gain (representing the difference between the fair value of securities received and the carry value, less estimated expenses) was recorded in connection with the transaction. At December 31, 2000, Axys owned approximately 5% of DNAS outstanding stock and accounts for its investment under the cost method.

    On April 28, 2000, the Company completed the sale of its combinatorial chemistry business, Axys Advanced Technologies, Inc. ("AAT") to Discovery Partners International, Inc. ("DPI"). Under the terms of the agreement, AAT was merged with a subsidiary of DPI and Axys received as consideration 7,425,000 shares of common stock in DPI, $50,000 in cash, a $550,000 note receivable, and a warrant to purchase 200,000 additional shares of DPI at $8 per share. The shares held by Axys represented an ownership interest in DPI of approximately 31% at December 31, 2000. Accordingly, a portion of the gain recognized on the transaction is deferred and will be recognized as Axys' ownership in DPI is reduced. The total gain realized from the sale of AAT through December 31, 2000 was approximately $54 million, of which $34.8 million was realized and recorded during 2000. The Company accounts for its investment in DPI under the equity method of accounting.

    A summary of the discontinued operations described above for the year ended 2000 follows:

 
  PPGx
  AAT
  Total
 
(Loss) income from operations of a discontinued segment   $ (7,089 ) $ 1,148   $ (5,941 )
Gain on disposal of segment     26,432     34,781     61,213  
   
 
 
 
    $ 19,343   $ 35,929   $ 55,272  
   
 
 
 

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    The results of operations and net income (loss) of AAT and PPGx reflected in the financial statements of Axys for the years ended 2000, 1999, and 1998 are summarized as follows:

 
  2000
  1999
  1998
 
  Revenue
  Net Income/
(Loss)

  Revenue
  Net Income/
(Loss)

  Revenue
  Net Income/
(Loss)

Axys Advanced Technologies   $ 5,071   $ 1,148   $ 13,287   $ 4,776   $ 11,662   $ 3,993
PPGx     1,719     (7,089 )   886     (5,055 )      
   
 
 
 
 
 
    $ 6,790   $ (5,941 ) $ 14,173   $ (279 ) $ 11,662   $ 3,993
   
 
 
 
 
 

3.  INVESTMENTS IN UNCONSOLIDATED AFFILIATES AND NON-MARKETABLE SECURITIES

    The following is a summary of the Company's investments in equity method investees and investments in non-marketable securities.

    At December 31, 2000, the Company's only equity-method investment with a carry value was a 31% ownership interest in DPI. DPI is a provider of drug discovery products, services and bio-information to pharmaceutical and biotechnology companies. The Company received shares in DPI as a result of the sale of AAT (see Note 2) in April 2000.

    In July 2000, DPI completed its initial public offering (IPO) of its common stock. Prior to the IPO, Axys owned 7,425,000 shares of DPI common stock, which represented approximately 43% of the outstanding shares. DPI sold 5,000,000 shares of common stock in its IPO at a price of approximately $18 per share. The IPO reduced Axys' original ownership percentage in DPI to its current ownership of approximately 31%. As of December 31, 2000, DPI was the only publicly held equity-method investee of the Company. The market value of the Company's DPI common stock was approximately $90 million as of December 31, 2000. The DPI shares are subject to restrictions that may limit the Company's ability to liquidate its position in a timely manner.

    Summarized balance sheet information as of December 31, 2000 of DPI is as follows (in thousands):

Current assets   $ 118,600
Non-current assets     61,400
Current liabilities     11,600
Non-current liabilities     1,600

    Summarized statement of operations information of DPI for the year ended December 31, 2000, is as follows (in thousands):

Net revenue   $ 36,300
Gross profit     17,900
Net loss     11,700

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    In May 1998, the Company formed a majority owned subsidiary, Akkadix Corporation ("Akkadix", formerly known as Xyris Corporation), which was established to leverage Axys' existing pharmaceutical technology in the agricultural biotechnology market. In connection with the formation of Akkadix, Axys contributed certain technology rights for use in the field of agriculture in exchange for an 82% ownership interest at the formation date. Axys' ownership in Akkadix was diluted as a result of various financings in 1999 (as discussed below) and acquisitions. The Company's ownership in Akkadix was 82% at December 31, 1998, 38% at December 31, 1999, and 23% at December 31, 2000. The carrying value of Axys' investment in Akkadix is zero as of December 31, 2000 and 1999 due to its pro rata share of losses in Akkadix from inception. Axys does not guarantee any funding for Akkadix and continues to account for this investment under the equity method of accounting.

    In 1999, Akkadix completed various financings in which it raised approximately $10 million from third parties. Under the terms of these financings, the Company granted certain third parties the right (the "Put Option") to require Axys to purchase all third party interests in Akkadix in exchange for additional shares of Axys' common stock. The Put Options granted in connection with $9 million of that funding were extended from February 2001 to August 2001 pursuant to an agreement reached between the Company and the holders of such options (see Note 14).

    During the fourth quarter of 2000, Axys advanced a $2.5 million bridge loan to Akkadix. The loan to Akkadix resulted in the Company recognizing an adjusted basis for allocation of its pro rata share of losses of Akkadix. As of December 31, 2000, the adjusted basis was charged to "Equity in losses of equity-method investees" as the Company recorded its pro rata share of losses in the fourth quarter and the carrying value was again reduced to zero.

    At December 31, 2000, "Other investments" includes $15 million of Series D Preferred Stock and 108 shares of common stock of DNAS accounted for under the cost method. The investments represent the value of the stock received from DNAS from the sale of PPGx (See Note 2).

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4.  FAIR VALUE OF FINANCIAL INSTRUMENTS

    Securities classified as available-for-sale at December 31, 2000 and 1999 are summarized below. Estimated fair value is based on quoted market prices for these investments (in thousands).

 
  Amortized Cost
  Gross Unrealized
Losses

  Estimated Fair
Value

At December 31, 2000:                  
Money market account   $ 41,247   $   $ 41,247
Equity securities     1,053     (524 )   529
   
 
 
    $ 42,300   $ (524 ) $ 41,776
   
 
 
At December 31, 1999:                  
Commercial paper of U.S. corporations   $ 8,599   $   $ 8,599
U.S. treasury securities     5,000         5,000
Certificate of deposit     28         28
Securities of foreign corporations     2,148     (56 )   2,092
U.S. agency securities     10,952     (14 )   10,938
   
 
 
    $ 26,727   $ (70 ) $ 26,657
   
 
 
Balance sheet classification:                  
At December 31, 2000:                  
Cash and cash equivalents   $ 41,247   $   $ 41,247
Marketable securities     1,053     (524 )   529
   
 
 
    $ 42,300   $ (524 ) $ 41,776
   
 
 
At December 31, 1999:                  
Cash and cash equivalents   $ 23,577   $   $ 23,577
Marketable securities     3,150     (70 )   3,080
   
 
 
    $ 26,727   $ (70 ) $ 26,657
   
 
 

    The carrying value of the debt obligations of $26 million approximates its fair value at December 31, 2000. The fair value of the debt obligations was estimated based on a discounted cash flow. The carrying values of all other financial instruments approximate their fair values.

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5.  PROPERTY & EQUIPMENT

    Property and equipment is recorded at cost and consists of the following (in thousands):

 
  December 31,
 
 
  2000
  1999
 
Machinery and equipment   $ 17,471   $ 29,119  
Purchased software     1,833     1,946  
Furniture and office equipment     8,253     2,702  
Leasehold improvements     10,547     14,614  
Construction in progress     1,710     227  
   
 
 
      39,814     48,608  
Less accumulated depreciation and amortization     (28,831 )   (29,735 )
   
 
 
    $ 10,983   $ 18,873  
   
 
 

    Property and equipment includes approximately $3,621,000 and $14,168,000 recorded under capital leases at December 31, 2000 and 1999, respectively. Accumulated amortization of equipment under capital leases was approximately $1,289,000 and $13,891,000 at December 31, 2000 and 1999, respectively. Depreciation expenses was approximately $5,627,000, $10,310,000 and $8,883,000 for the years ended 2000, 1999, and 1998, respectively.

6.  CONVERTIBLE DEBT SECURITIES

    On September 22, 2000, the Company issued $26 million of 8% Senior secured convertible notes. After placement agent fees of $1.4 million and other offering costs, total net proceeds raised from the offering was approximately $24.6 million. The notes mature on October 1, 2004 and interest is payable quarterly. Principal is payable in lump sum at maturity. The Company may, at its option, pay interest in shares of its common stock in lieu of cash if certain requirements are satisfied. The notes are convertible at any time into 3,682,720 shares of our common stock at a conversion price of $7.06. The notes are senior obligations to the Company and rank pari passu in right of payment with all our existing and future senior indebtedness and senior to all our existing and future subordinated indebtedness, and are secured by 6,682,500 shares, or approximately 90%, of our holding of DPI common stock.

    The holders of notes shall have the right to require the Company to repurchase all or a portion of the notes at a price equal to 100% of the outstanding principal amount plus accrued and unpaid interest, upon the occurrence of certain repurchase events. The Company cannot redeem the notes prior to their maturity.

    The notes were issued with Class A and Class B detachable warrants that entitle the note holders to purchase a total of 1,841,360 shares of the Company's common stock at an exercise price of $8.82 and $10.59, respectively. All Class A and Class B warrants expire on October 1, 2004. A portion of the proceeds from the offering were allocated to the warrants and capitalized as debt issuance costs. The value of the warrants were determined using Black Scholes option pricing model and estimated to be approximately $5.7 million and will be amortized over the life of the notes. Total amortized debt issuance costs were $498,000 for the year ended 2000.

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    In November 2000, the FASB issued Emerging Issues Task Force Issue No. 00-27, "Application of EITF Issue No. 98-5, Accounting for Convertible Securities with Beneficial Conversion Features or Contingently Adjustable Conversion Ratios, to Certain Convertible Instruments" ("EITF 00-27") which is effective for all such instruments. EITF 00-27 clarifies the accounting for instruments with beneficial conversion features or contingently adjustable conversion ratios. According to the new accounting principle, the beneficial conversion feature should be calculated by first allocating the proceeds received from the financing among the convertible instrument and the detachable warrants and then, measuring the beneficial conversion feature between the stated conversion price of the convertible instrument and the effective conversion price based on the allocated proceeds. Previously, the beneficial conversion feature calculation was based on the difference between the stated conversion price of the convertible instrument and the fair value of the company's stock price on the closing date of the financing. As a result of the new accounting principle, the Company recognized a beneficial conversion feature of approximately $4 million.

    Any recorded beneficial conversion feature resulting from the allocation of proceeds is recognized as interest expense over the minimum period from the date of issuance to the earliest date the debt holder can exercise its conversion option. As a result, the Company recognized the entire beneficial conversion option of $4 million as interest expense in the fourth quarter of 2000.

7.  RESTRUCTURING CHARGE

    In December 1999, the Company completed the closing of its San Diego, CA, operations and relocated its oncology genomics activities to its South San Francisco headquarters. As a result of this action, a one-time charge of $5.2 million was recorded in 1999, of which $2.2 million related to severance and other employee-related costs, $1.1 million related to facilities costs, $500,000 related to the disposal of assets, and $1.4 in other costs associated with the restructuring. During 2000, the Company successfully transferred the lease facility to a third party who assumed all of the liabilities associated with the facility, including the transfer of subleases. As a result of the lease transfer, we did not realize all of the expected restructuring charges as previously estimated at December 31, 1999 and, accordingly, the Company revised its restructuring charge estimate during 2000. The net change in estimate resulting from our successful lease transfer was approximately $592,000.

    The following table summarizes the Company's 2000 restructuring charge activity for the twelve months ended December 31, 2000 (in thousands):

Description

  Cash/ Non-Cash
  Reserve Balance at 12/31/99
  Payments Made
  Changes in Estimate
  Reserve Balance at 12/31/00
Severance and benefits   Cash   $ (1,095 ) $ 1,095   $   $
Facilities   Cash/Non-Cash     (748 )   156     592    
Contractual Research Commitments   Cash     (81 )   81        
       
 
 
 
        $ (1,924 ) $ 1,332   $ 592   $
       
 
 
 

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AXYS PHARMACEUTICALS, INC.

NOTES TO FINANCIAL STATEMENTS (Continued)

8.  STOCKHOLDERS EQUITY

    At December 31, 2000 and 1999 common stock was reserved for issuance as follows (in thousands):

 
  2000
  1999
Stock options   5,369   5,234
Warrants   1,899   679
Employee stock purchase plan   383   558
   
 
    7,651   6,471
   
 

    On July 21, 2000, the Company completed the sale of $10 million of its common stock, par value $0.001 per share. Net proceeds resulting from the sale of 1,639,344 shares of common stock at a price of $6.10 per share were approximately $9.6 million. Pursuant to a common stock purchase agreement, the Company may, at its own discretion, issue and sell an additional $40 million of common stock at an average price as determined over a period of 30 days prior to the financing.

    As of December 31, 2000, the Company had issued and outstanding warrants to purchase a total of 1,899,234 shares of the Company's common stock at prices ranging from $4.06 to $10.59 per share. These warrants expire at various dates from 2004 through 2005.

    The Company has various equity incentive plans under which it issues stock options to employees, consultants and members of the Board of Directors. The Company's plans include the 1997 Equity Incentive Plan under which incentive stock options or non-qualified stock options may be granted, or restricted stock may be issued, at the discretion of the Board of Directors to employees, directors and consultants to purchase the Company's common stock; the 1997 Non-Officer Equity Incentive Plan, under which non-officer employees and consultants may be granted non-qualified stock options to purchase the Company's common stock; and the 1994 Non-Employee Directors' Stock Option Plan, whereby nonqualified stock options are automatically granted to non-employee directors to purchase the Company's common stock.

    The Company also had a 1989 Stock Option Plan, under which directors, officers, employees, and consultants may be issued restricted stock, or granted incentive stock options or nonqualified stock options to purchase the Company's common stock, at the discretion of the Board of Directors. This Plan expired in 1999 eliminating approximately 700,000 shares available for grant at December 31, 1999, but continues to have options outstanding that will expire ten years from the date of original grant.

    All options granted under these Plans become exercisable pursuant to the applicable terms of the grant. For options granted after December 31, 1997, the exercise price is equal to the market value of

F–17


the Company's common stock on the date of grant. Generally options vest ratably over four years and expire ten years from the date of grant.

    In October 1998, the Company offered its employees the right to exchange their then outstanding options to purchase shares of common stock with exercise prices ranging from $4.31 to $15.59, for new options to purchase shares with exercise prices of $4.00 per share for non-officer employees and $5.00 per share for executive officer employees. Under this program, options to purchase 3,643,387 shares were exchanged resulting in a decrease in aggregate purchase price from $34,254,046 to $15,560,548. All new options had an additional year of vesting added to the original vesting term.

    In May, 2000, the stockholders approved an additional 1,500,000 shares of common stock under the Company's 1997 Equity Incentive Plan.

    Transactions under all of the above equity incentive plans are as follows:

 
  Outstanding Stock Options
   
 
  Shares Available
  Number of Shares
  Weighted Average
Exercise Price

Balances at January 1, 1998   1,380,234   1,999,624   $ 11.06
  Shares reserved   2,850,000        
  Options granted   (7,080,180 ) 7,080,180   $ 5.86
  Options exercised     (226,193 ) $ 3.23
  Options canceled   4,433,158   (4,433,158 ) $ 9.28
   
 
     

Balances at December 31, 1998

 

1,583,212

 

4,420,453

 

$

4.80
   
 
     
  Shares reserved          
  Options granted   (1,699,539 ) 1,699,539   $ 4.31
  Options exercised     (34,643 ) $ 3.38
  Options canceled   1,886,403   (1,886,403 ) $ 4.57
  Options expired   (735,135 )    
   
 
     

Balances at December 31, 1999

 

1,034,941

 

4,198,946

 

$

4.72
   
 
     
  Shares reserved   1,500,000      
  Options granted   (2,237,317 ) 2,237,317   $ 6.03
  Options exercised     (1,145,445 ) $ 4.34
  Options cancelled   651,924   (651,924 ) $ 4.58
  Options expired   (219,204 )    
   
 
     

Balances at December 31, 2000

 

730,344

 

4,638,894

 

$

5.45
   
 
     

    The weighted average fair value of stock options granted under the plans were approximately $12.2 million, $3.4 million, and $14.8 million in 2000, 1999, and 1998, respectively.

F–18


    Options outstanding and exercisable by price range at December 31, 2000:

 
  Options Outstanding

  Options Exercisable

Range of Exercise
Prices

  Options
Outstanding
(Shares)

  Weighted-Average
Remaining
Contractual Life
(in Years)

  Weighted-
Average
Exercise Price

  Options
Exercisable
(Shares)

  Weighted-Average
Exercise Price

$0.07 — $ 3.94   447,249   8.58   $ 3.40   151,157   $ 3.15
$3.97 — $ 4.00   659,766   2.89   $ 4.00   324,252   $ 4.00
$4.06 — $ 5.00   1,784,687   7.28   $ 4.77   582,353   $ 4.84
$5.13 — $ 8.13   1,541,982   8.77   $ 6.65   348,880   $ 6.70
$8.38 — $17.75   205,210   6.68   $ 11.61   140,238   $ 11.97
   
           
     
    4,638,894   7.45   $ 5.45   1,546,880   $ 5.56
   
           
     

    In October 1993, the Company adopted the 1993 Employee Stock Purchase Plan (the "Purchase Plan") under which employees who meet certain minimum employment criteria are eligible to participate. Eligible employees may purchase common stock of the Company at a purchase price of 85% of the lower of the fair market value of the stock at the offering commencement date or purchase date, within a two-year offering period. In 1999, the Board of Directors approved an additional 500,000 common shares to be reserved under the Purchase Plan. Under the Purchase Plan, 176,247, 202,257, and 189,145 shares were issued in 2000, 1999, and 1998, respectively. There are 383,158 shares available to purchase in the plan at December 31, 2000.

    On October 8, 1998, the Board of Directors adopted a Preferred Share Purchase Rights Plan (the "Plan") designed to enable all stockholders to realize the full value of their investment and to provide for fair and equal treatment for all stockholders in the event an unsolicited attempt were made to acquire the Company. In connection with the Plan, the Board declared a dividend of one preferred share purchase right (a "Right") for each share of common stock of the Company outstanding on October 28, 1998 and further directed the issuance of one such right with respect to each share of the Company's common stock that is issued after October 28, 1998. If a person, entity or group of affiliated or associated persons acquires beneficial ownership of 15% or more of the Company's common stock, or announces a tender offer for 15% or more of the Company's common stock, the rights will be distributed. Each Right entitles the registered holder to purchase from the Company one one-hundredth of a share of Series A Junior Participating Preferred Stock, at a price of $35.00 per one one-hundredth of a Preferred Share subject to adjustment. The Rights are redeemable prior to any person's acquisition of more than 15% of the Company's common stock and will expire on October 7, 2008.

    The Company has elected to follow APB 25 and related interpretations in accounting for its stock-based compensation plans because, as discussed below, the alternative fair value accounting provided

F–19


for under SFAS 123 requires use of option valuation models that were not developed for use in valuing employee stock options and employee stock-based awards. Under APB Opinion No. 25, if the exercise price of the Company's stock options is equal to the market price of the underlying stock on the date of grant, no compensation expense is recognized.

    Pro forma information regarding net loss and net loss per share is required by FAS 123, and has been determined as if the Company had accounted for its stock-based awards under the fair value method of FAS 123. The fair value for these stock-based awards was estimated at the date of grant using a Black-Scholes option-pricing model. The Black-Scholes option valuation model was developed for use in estimating the fair value of traded options, which have no vesting restrictions and are fully transferable. In addition, option valuation models require the input of highly subjective assumptions including the expected stock price volatility.

    The fair value of the Company's stock-based awards to employees was estimated assuming no expected dividends and the following weighted-average assumptions:

 
  Options
 
 
  2000
  1999
  1998
 
Expected life (years)   3.0   3.0   3.0  
Expected volatility   1.41   0.92   0.65  
Risk-free interest rate   5.73 % 5.58 % 5.13 %

    For purposes of pro forma disclosures, the estimated fair value of the stock-based awards are amortized to pro forma net loss over the option's vesting period and the purchase plan's six-month purchase period. The Company's as reported and pro forma information follows (in thousands, except for net loss per share information):

 
  Year Ended December 31,
 
 
  2000
  1999
  1998
 
Net income (loss)                    
  As reported   $ 9,856   $ (48,763 ) $ (156,124 )
  Pro forma   $ 5,491   $ (52,757 ) $ (163,470 )
Net income (loss) per share — basic and diluted                    
  As reported   $ 0.28   $ (1.60 ) $ (5.25 )
  Pro forma   $ 0.16   $ (1.74 ) $ (5.49 )

    For pro forma purposes in accordance with FAS 123, the repricing of employee stock options during 1998 is treated as a modification of the stock-based award, with the original options being repurchased and new options granted. Any additional compensation arising from the modification is recognized over the remaining vesting period of the new grant.

F–20


9.  BUSINESS COMBINATIONS AND OTHER JOINT VENTURES

    The Company completed the following business combinations and joint venture transactions during 1999 and 1998. There were no business purchases or joint venture transactions entered into during 2000.

    On January 8, 1998, the Company acquired all of the outstanding capital stock of Sequana, a genomics company that used industrial-scale gene discovery technology and functional genomics to discover and characterize genes that cause certain common diseases. The Company issued shares of Axys common stock in exchange for all the outstanding common stock of Sequana, on the basis of 1.35 shares of Axys' common stock for one share of Sequana common stock. The purchase price of $174,070,000 consisted of (i) the issuance of 14,618,013 shares of Company common stock valued at $168,107,000, in exchange for all outstanding Sequana capital stock, (ii) the issuance of Company warrants valued at $1,623,000 in exchange for all of the outstanding Sequana warrants, and (iii) transaction costs totaling $4,340,000.

    The allocation of the purchase price was determined as follows (in thousands):

Net tangible assets acquired   $ 45,882
Assembled workforce of Sequana     3,300
Acquired in-process research and development     124,888
   
  Total   $ 174,070
   

    The acquisition was accounted for as a purchase and accordingly, the original purchase price was allocated to acquired assets and assumed liabilities based upon their estimated fair values at the date of acquisition, and to the estimated fair value of in-process research and development ("IPR&D") was charged as an expense in the statement of operations during 1998 such acquired IPR&D had not reached technological feasibility. The unamortized balance at September 30, 1999 of $1.3 million for the assembled work force was written off in connection with the Company's September 30, 1999 restructuring charge.

    The value allocated to purchased IPR&D was determined by estimating the costs to develop the purchased in-process technology into viable products, estimating the resulting net cash flows from such projects, and discounting the net cash flows back to their present value. The discount rate included a factor that takes into account the Company's weighted average cost of capital and the uncertainty surrounding the successful development of the purchased in-process technology.

    The acquired in-process research and development projects in the Sequana acquisition consisted of eight significant research and development projects. As of December 31, 1999, the schizophrenia/bipolar program was transferred to Parke-Davis (currently Pfizer, Inc.) and the pharmacogenomics program was spun off into the PPGx subsidiary. All other programs have been terminated.

    The operating results of Sequana from January 1, 1998 to December 31, 1998 have been included in the Company's consolidated results of operations. The operating results of Sequana from January 1, 1998 to January 8, 1998 (date of acquisition) are considered immaterial.

F–21


    In 1997, Sequana formed Genos with Memorial Sloan-Kettering Cancer Center to focus on research and identification of genes and related genetic information of values in the prognosis, diagnosis and positive treatment of certain common cancers. Sequana invested $5.2 million and licensed certain of its technology to Genos and has contracted with Genos to conduct research and provide certain other services to the joint venture.

    In May 1999, the Board of Directors of Genos decided to suspend its research activities and wind up its affairs. Genos is currently a non-operating entity holding the technology developed during its operations. As a result of the cancellation of Genos activities, the Company recorded a one-time charge of $1.1 million during 1999, representing the total carrying value of the investment in Genos.

10.  RELATED PARTY TRANSACTIONS

    In December 2000, the Company amended the 1999 employment agreement with the Company's former Chief Executive Officer. Under the terms of the agreement, the former executive will receive approximately one-half of his former salary and bonus, forgiveness of his $560,000 note receivable plus accrued interest at December 31, 2000, in exchange for three years of continued service and an agreement not to compete. The agreement is in effect through December 31, 2003. The Company charged compensation expense in 2000 for the forgiveness of the note receivable.

    In August 2000, the Company advanced $300,000 in a note receivable to an officer for housing assistance. The note earns interest at 6.37% and is due annually. The note plus accrued interest is forgivable over five years.

    In April 2000, in connection with the sale of AAT to DPI, the Company entered into a sublease arrangement for approximately 25,000 square feet of facility space. DPI has the right of first refusal on the remainder of the 52,000 square foot building upon the Company's move into the new facility. The sublease provides for rental income equal to the underlying lease expense and expires in November 2003, unless extended in accordance with its terms. Total income recognized in 2000 from this lease was approximately $285,000.

    In April 2000, in connection with the sale of AAT to DPI, the Company entered into a Compound Purchase Agreement, by which the Company will purchase a minimum number of compounds equal to $250,000, $500,000 and $3,350,000 by April 1, 2001, 2002 and 2003, respectively. The Company purchased $2.6 million of compounds during 2000 under this agreement.

11.  EMPLOYEE BENEFIT PLANS AND OTHER COMPENSATION ARRANGEMENTS

    The Company maintains a 401(k) retirement savings plan for all of its eligible employees. Each participant in the plan may elect to contribute 1% to 20% of his or her annual salary to the plan, subject to statutory limitations. The Company matches 50% of the first 6% of the salary contributed by the employee. The Company's match is done with the Company's stock. The expense charged to operations under this plan for fiscal 2000, 1999 and 1998 was $251,108, $458,253, and $295,180, respectively.

F–22


    During 2000, the Board approved the 1999 Key Personnel Option Plan. The plan is intended to award certain eligible key executives when the Company realizes appreciation generated from the sale of certain affiliated business. The plan gives certain employees rights to purchase a fixed and determinable amount of common stock investment shares held by Axys at a set exercise price. Shares currently subject to this arrangement include 375,000 and 121,239 shares of DPI and DNAS, respectively. Total charges recognized during the year ended 2000 associated with this plan approximate $2.9 million. This charge is included as a component of the gain on disposal of segment.

    The Key Personnel Option Plan meets the definition of a derivative under Statement No. 133, Accounting for Derivative Instruments and Hedging Activities (FAS 133). As such, the contract will be marked to market as a liability effective January 1, 2001 and changes in the market value will be recorded in earnings.

12.  COMMITMENTS

    The Company leases office and laboratory facilities and equipment. Rent expense for the years ended December 31, 2000, 1999, and 1998 was approximately $2,179,000, $2,168,000, and $3,293,000, respectively.

    Future minimum lease payments under non-cancelable leases and related sublease income over the next five years are as follows:

 
  Capital Leases
  Operating
Leases

  Sublease
Income

 
  (in thousands)

2001   $ 1,134   $ 2,206   1,072
2002     1,125     2,112   1,133
2003     940     2,265   1,240
2004     18     1,713   1,243
2005         1,436   549
Thereafter         594  
   
 
 
Total minimum lease payments     3,217   $ 10,326   5,237
   
 
 
Less amount representing interest     (430 )        
   
         
Present value of future lease payments     2,787          
Less current portion     (898 )        
   
         
Non-current portion of capital lease obligations   $ 1,889          
   
         

    The Company has a $30 million revolving line of credit with Foothill Capital Corporation. There were no draws on this line during December 31, 2000, and the line of credit was terminated in February 2001 as the collateral requirements made it difficult to utilize.

F–23


    In February 1997, the Company entered into a lending arrangement with one of its facility lessors for tenant improvements. The loan amount was $350,000, with interest accruing at 9% per annum. Principal and interest are due monthly through July 1, 2001. Total outstanding principal at December 31, 2000 approximated $52,000.

    In September 2000, the Company entered into a financing agreement with a lease financing company under which Axys has the ability to finance up to $8.0 million of purchases of lab equipment. At December 31, 2000, Axys borrowed approximately $2.8 million under this financing line, which bears interest of 9.52%.

13.  INCOME TAXES

    As of December 31, 2000, the Company had federal and state net operating loss carryforwards of approximately $92,300,000 and $16,500,000, respectively. The Company also had federal and California research and other tax credit carryforwards of approximately $7,900,000 and $5,200,000, respectively. The federal net operating loss and credit carryforwards will expire at various dates beginning in the year 2001 through 2020, if not utilized. The state of California net operating losses will expire at various dates beginning in 2001 through 2010, if not utilized.

    The utilization of the net operating losses and credits may be subject to a substantial annual limitation due to the "change in ownership" provisions of the Internal Revenue Code of 1986 and similar state provisions. The annual limitation may result in the expiration of net operating losses and credits before utilization.

    Significant components of the Company's deferred tax assets for federal and state income taxes as of December 31 are as follows (in thousands):

 
  2000
  1999
 
Deferred tax assets:              
  Net operating loss carryforwards   $ 32,400   $ 39,600  
  Research and other credit     11,700     8,600  
  Capitalized research expenses     34,700     26,500  
  Fixed asset depreciation     2,800     3,200  
  Gain on sale of AAT     5,300      
  Other     2,800     4,500  
   
 
 
      Total deferred tax assets     89,700     82,400  
Valuation allowance     (84,000 )   (82,400 )
Deferred tax liability:              
  Other     (5,700 )    
   
 
 
  Net Deferred Taxes   $   $  
   
 
 

    Realization of deferred tax assets is dependent upon future earnings, if any, the timing and amount of which are uncertain. Accordingly, the net deferred tax assets have been fully offset by a valuation allowance. The net valuation allowance increased by approximately $1,600,000 and $19,700,000 during the years ended December 31, 2000 and 1999, respectively.

F–24


    Approximately $4,200,000 of the valuation allowance for deferred tax assets relates to benefits of stock options deductions which, when recognized, will be allocated directly to contributed capital.

14.  SUBSEQUENT EVENT (UNAUDITED)

    On March 15, 2001, certain third party investors (see Note 3) exercised their Put Option to acquire a total of 2,482,758 shares of Axys common stock. As a result of the exercise of these options, Axys acquired an additional 2,702,702 shares of Series A Preferred Stock of Akkadix Corporation, increasing Axys' ownership percentage in Akkadix voting stock to approximately 44%. The Company expects to record a charge of approximately $9.0 million in the first quarter resulting from the Put Option.

15.  QUARTERLY FINANCIAL DATA (UNAUDITED)

 
  First
Quarter(1)

  Second
Quarter(1)

  Third
Quarter(1)

  Fourth
Quarter(2)

  Total Year
 
2000                                
Revenue   $ 1,414   $ 1,508   $ 2,611   $ 1,457   $ 6,990  
Operating loss     (8,713 )   (9,362 )   (7,154 )   (13,763 )   (38,992 )
Loss from continuing operations     (8,748 )   (8,808 )   (6,834 )   (21,026 )   (45,416 )
Net (loss) income     (8,492 )   21,395     (6,718 )   3,671     9,856  
Basic and diluted net (loss) income per share:                                
  Loss from continuing operations   $ (0.27 ) $ (0.25 ) $ (0.19 ) $ (0.57 ) $ (1.29 )
  Net (loss) income   $ (0.26 ) $ 0.61   $ (0.18 ) $ 0.10   $ 0.28  
1999                                
Revenue   $ 8,329   $ 4,734   $ 4,493   $ 6,528   $ 24,084  
Operating loss     (8,346 )   (13,080 )   (18,690 )   (7,021 )   (47,137 )
Loss from continuing operations     (8,518 )   (13,049 )   (20,008 )   (6,909 )   (48,484 )
Net loss     (7,748 )   (13,214 )   (19,940 )   (7,861 )   (48,763 )
Basic and diluted net loss per share:                                
  Loss from continuing operations   $ (0.27 ) $ (0.41 ) $ (0.66 ) $ (0.23 ) $ (1.59 )
  Net loss   $ (0.26 ) $ (0.44 ) $ (0.66 ) $ (0.26 ) $ (1.60 )

(1)
Results have been reclassified in accordance with APB 30-Results of Discontinued Operations.

(2)
Significant fourth quarter events include a $4.0 million beneficial conversion charge resulting from the issuance of convertible debt, $2.8 million charge in connection with the loan to Akkadix and approximately $2.0 million charge related to other contractual arrangements.

F–25


AXYS PHARMACEUTICALS, INC.

CONDENSED BALANCE SHEETS
(In thousands)

 
  March 31,
2001

  December 31,
2000(1)

 
 
  (unaudited)

   
 
ASSETS  
Current              
  Cash and cash equivalents   $ 29,191   $ 41,247  
  Marketable investments     239     529  
  Accounts receivable     750      
  Prepaid expenses and other current assets     3,160     2,890  
   
 
 
      Total current assets     33,340     44,666  
  Property and equipment, net     11,780     10,983  
  Investment in equity-method investee     42,828     40,367  
  Other investments     15,007     15,007  
  Notes receivable from employees     652     365  
  Debt issuance costs, net     6,299     6,753  
  Other assets     804     555  
   
 
 
      Total Assets   $ 110,710   $ 118,696  
   
 
 

LIABILITIES AND STOCKHOLDERS

 
Current              
  Accounts payable   $ 3,544   $ 5,406  
  Accrued compensation     1,535     2,154  
  Other accrued liabilities     2,346     2,503  
  Deferred revenue     362     229  
  Current portion of capital lease and notes     1,047     950  
   
 
 
      Total current liabilities     8,834     11,242  
Capital lease obligations, noncurrent     2,300     1,889  
Subordinated notes     26,000     26,000  
Other liabilities     1,919      

Stockholders' equity:

 

 

 

 

 

 

 
  Common stock     357,582     347,444  
  Accumulated other comprehensive loss     (512 )   (524 )
  Accumulated deficit     (285,413 )   (267,355 )
   
 
 
      Total stockholders' equity     71,657     79,565  
   
 
 
      Total Liabilities and Stockholders' Equity   $ 110,710   $ 118,696  
   
 
 

(1)
The balance sheet at December 31, 2000 has been derived from the audited financial statement at that date but does not include all of the information and footnotes required by generally accepted accounting principles for complete financial statements.

See accompanying notes.

F–26


AXYS PHARMACEUTICALS, INC.

CONDENSED STATEMENTS OF OPERATIONS
(Unaudited)
(In thousands, except per share amounts)

 
  Three Months Ended March 31,
 
 
  2001
  2000
 
Collaboration and license revenue   $ 3,070   $ 1,414  

Operating expenses:

 

 

 

 

 

 

 
  Research and development     8,929     7,858  
  General and administrative     3,242     2,814  
  Non-cash compensation income     (1,051 )    
  Restructuring charge         (545 )
   
 
 
      Total operating expenses     11,120     10,127  
   
 
 
Operating loss     (8,050 )   (8,713 )
Interest income     531     141  
Interest expense     (1,474 )   (176 )
Equity interest in loss of equity-method investee     (9,059 )    
Other expense     (978 )    
   
 
 
Loss from continuing operations     (19,030 )   (8,748 )
Cumulative effect of change in accounting principle     972      
Income from operations of discontinued segments         256  
   
 
 
Net loss   $ (18,058 ) $ (8,492 )
   
 
 
Basic and diluted net loss per share from continuing operations   $ (0.51 ) $ (0.27 )
Basic and diluted net income per share from cumulative effect     0.03      
Basic and diluted net income per share from discontinued segments         0.01  
   
 
 
Basic and diluted net income per share   $ (0.48 ) $ (0.26 )
   
 
 
Shares used in computing basic and diluted net (loss) income per share     37,345     32,067  
   
 
 

See accompanying notes.

F–27


AXYS PHARMACEUTICALS, INC.

CONDENSED STATEMENTS OF CASH FLOWS
(Unaudited)
(In thousands)

 
  Three Months Ended March 31,
 
 
  2001
  2000
 
CASH FLOWS FROM OPERATING ACTIVITIES:              
Net loss   $ (18,058 ) $ (8,492 )
Adjustments to reconcile net loss to net cash and cash equivalents used in operating activities:              
  Non-cash restructuring charge         (545 )
  Non-cash compensation income     (1,051 )    
  Cumulative effect of a change in accounting principle     (972 )    
  Other expense     978      
  Interest expense on convertible debt     519      
  Depreciation and amortization     1,712     1,952  
  Options and warrants issued to consultants     161      
  Equity interest in loss of equity-method investee     9,059      
  Forgiveness of note receivable from employees     13     191  
  Changes in assets and liabilities:              
    Accounts receivable     (750 )   (75 )
    Inventory         186  
    Prepaid expenses and other current assets     (270 )   (716 )
    Other assets     296     16  
    Accounts payable     (1,862 )   (2,226 )
    Accrued compensation     (619 )   (323 )
    Other accrued liabilities     (156 )   (1,147 )
    Deferred revenue     133     (756 )
   
 
 
      Net cash and cash equivalents used in operating activities     (10,867 )   (11,935 )
   
 
 

CASH FLOWS FROM INVESTING ACTIVITIES:

 

 

 

 

 

 

 
Maturities of available-for-sale securities     202     3,080  
Minority interest         (409 )
Transaction costs on disposal of segment         (1,500 )
Net purchase of property and equipment     (2,055 )   (1,333 )
Loan to officer     (300 )    
   
 
 
      Net cash and cash equivalents used in investing activities     (2,153 )   (162 )
   
 
 
CASH FLOWS FROM FINANCING ACTIVITIES:              
Net proceeds from issuance of common stock     457     34,273  
Proceeds from notes payable and capital lease financing     703     20,000  
Principal payments on notes payable and capital leases     (196 )   (17,269 )
   
 
 
      Net cash and cash equivalents provided by financing activities     964     37,004  
   
 
 
Net (decrease) increase in cash and cash equivalents     (12,056 )   24,907  
Cash and cash equivalents, beginning of period     41,247     23,577  
   
 
 
Cash and cash equivalents, end of period   $ 29,191   $ 48,484  
   
 
 

See accompanying notes.

F–28


AXYS PHARMACEUTICALS, INC.

NOTES TO CONDENSED FINANCIAL STATEMENTS
March 31, 2001
(Unaudited)

1.  SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

    The unaudited financial statements included herein have been prepared by Axys Pharmaceuticals, Inc. ("Axys" or the "Company") according to the rules and regulations of the Securities and Exchange Commission. Certain information and footnote disclosures normally included in complete financial statements prepared in accordance with generally accepted accounting principles have been condensed or omitted pursuant to such rules and regulations. The financial statements reflect, in the opinion of management, all adjustments (which include only normal recurring adjustments) necessary to state fairly the financial position and results of operations as of and for the periods indicated. The results of operations for the three months ended March 31, 2001 are not necessarily indicative of the results to be expected for subsequent quarters or the full fiscal year.

    On April 28, and December 22, 2000, respectively, the Company completed the sale of two of its subsidiaries: its combinatorial chemistry business, Axys Advanced Technologies, Inc. ("AAT"), to Discovery Partners International, Inc. (Nasdaq: DPII "DPI") and its pharmacogenomics subsidiary PPGx, Inc. to DNA Sciences, Inc. The Company reclassified operating results previously reported for the three months ended March 31, 2000 to reflect the results of these subsidiaries as discontinued operations, in accordance with Accounting Principles Board Opinion No. 30 (APB 30).

    These financial statements should be read in conjunction with the audited financial statements and the notes thereto included in the Company's 2000 Annual Report on Form 10-K filed with the Securities and Exchange Commission.

    Certain prior period amounts have been reclassified to conform to the March 31, 2001 presentations.

    The preparation of financial statements in conformity with accounting principles generally accepted in the United States requires management to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. Actual results could differ from those estimates, and such differences could be material.

    In June 1998, the Financial Accounting Standards Board issued Statement No. 133 Accounting for Derivative Instruments and Hedging Activities (FAS 133), which is required to be adopted in years beginning after June 15, 2000. The Statement requires the recognition of all derivative instruments on the balance sheet to be recorded at fair market value. The accounting for changes in the fair value (i.e., gains or losses) of a derivative instrument depends on whether it has been designated and qualifies as part of a hedging relationship and further, on the type of hedging relationship. We have not designated our derivative instruments as hedges, therefore, all changes in the fair value of our derivative instruments are recorded in earnings. The adoption of FAS 133 on January 1, 2001 resulted in the cumulative effect of an accounting change of $972,000 being recognized in the statement of operations.

F–29


    At March 31, 2001, the Company had two derivative instruments: (1) A warrant held in connection with the DPI investment; and (2) A stock option plan covering a portion of the Company's investment in DPI, in which the Company has granted certain employees options to acquire common stock in this investment (See Note 2). During the first quarter of 2001 the Company recorded a charge of $978,000 in connection with the warrant to reflect the change in fair value and a credit of approximately $1.1 million in connection with the stock option plan to reflect the changes in fair value of these derivative instruments.

2.  INVESTMENT IN EQUITY-METHOD INVESTEE

    Investment in equity-method investee consists of the Company's investment in DPI as a result of the merger agreement between DPI and the Company for the sale of AAT in April 2000. The Company accounts for its investment in DPI under the equity method of accounting.

    At March 31, 2001 the Company owned 7,425,000 shares of DPI common stock, which represented approximately 31% ownership of the outstanding shares of DPI.

    The Company adopted a Key Personnel Stock Option Plan, whereby key personnel have been granted options to purchase shares of stock in Axys' affiliated companies. The participants in the plan have the right to purchase up to 5% of the Company's equity holdings in the affiliated companies. The financial statements reflect a credit of $1.1 million related to the change in fair value associated with the Plan.

    The market value of DPI stock held by Axys as of March 31, 2001 was approximately $47.3 million.

    Summarized statement of operations information of DPI for the three month periods ended March 31, 2001 and 2000 was as follows (in thousands):

 
  Three Months Ended March 31,
 
 
  2001
  2000
 
Net sales   $ 9,524   $ 5,173  
Loss from operations     (3,455 )   (437 )
Net loss     (2,201 )   (1,630 )

3.  INVESTMENT IN AKKADIX

    On March 15, 2001, two third party investors of Akkadix Corporation exercised a contractual option extended to them by the Company to exchange their approximately 2.7 million shares of Akkadix's Series A preferred stock for approximately 2.5 million shares of the Company's common stock. The fair market value of Axys common stock exchanged for Akkadix preferred stock was approximately $9.0 million on the date of the option exercise. The conversion of shares will result in an increase in the Company's equity ownership of Akkadix from approximately 31% to 44% (as of March 31, 2001).

F–30


    Changing conditions in private equity markets during the first quarter forced Akkadix to sharply reduce operations as the company was unable to secure planned new equity funding. A substantial percentage of their employees were terminated and Akkadix vacated their office/laboratory space. The Company has concluded that the future viability of the Akkadix business is highly uncertain. Accordingly, in conformance with the equity method of accounting, we incurred a non-cash charge of $9.0 million during the first quarter of 2001, recognizing a permanent impairment in the value of the Company's investment in Akkadix. The Company does not anticipate any future benefit from this investment.

4.  COMPREHENSIVE LOSS

    Comprehensive loss is comprised of net loss and unrealized holding gains and losses on available-for-sale securities. Components of comprehensive loss are as follows:

 
  Three Months
Ended March 31,

 
 
  2001
  2000
 
Net loss   $ (18,058 ) $ (8,492 )
Other comprehensive income (loss)     12     (1 )
   
 
 
Comprehensive loss   $ (18,046 ) $ (8,493 )
   
 
 

F–31



REPORT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS

The Board of Directors and Stockholders
Discovery Partners International, Inc.

    We have audited the accompanying consolidated balance sheets of Discovery Partners International, Inc. as of December 31, 2000 and 1999 and the related consolidated statements of operations, stockholders' equity (deficit), and cash flows for each of the three years in the period ended December 31, 2000. These financial statements are the responsibility of the Company's management. Our responsibility is to express an opinion on these financial statements based on our audits.

    We conducted our audits in accordance with auditing standards generally accepted in the United States. Those standards require that we plan and perform the audits to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.

    In our opinion, the financial statements referred to above present fairly, in all material respects the consolidated financial position of Discovery Partners International, Inc. at December 31, 2000 and 1999, and the consolidated results of its operations and its cash flows for each of the three years in the period ended December 31, 2000 in conformity with accounting principles generally accepted in the United States.

San Diego, California
February 15, 2001

F–32


DISCOVERY PARTNERS INTERNATIONAL, INC.

CONSOLIDATED BALANCE SHEETS

 
  December 31,
 
 
  2000
  1999
 
ASSETS  
Current assets:              
  Cash and cash equivalents   $ 97,690,236   $ 2,884,639  
  Accounts receivable     9,395,097     2,785,618  
  Inventories     9,787,005     1,517,297  
  Prepaid and other current assets     1,685,914     201,284  
   
 
 
      Total current assets     118,558,252     7,388,838  
Property and equipment, net     9,567,871     4,655,227  
Restricted cash and cash equivalents and other assets     1,996,157     2,264,200  
Patent and license rights, net     3,121,074     1,137,625  
Other assets, net     1,382,443      
Goodwill, net     45,154,516     6,205,830  
   
 
 
      Total assets   $ 179,780,313   $ 21,651,720  
   
 
 

LIABILITIES AND STOCKHOLDERS' EQUITY (DEFICIT)

 
Current liabilities:              
  Accounts payable and accrued expenses   $ 3,574,534   $ 2,133,625  
  Accrued compensation     1,231,503     214,601  
  Deferred business acquisition payment     931,335     1,721,775  
  Current portion of obligations under capital leases, equipment notes payable, line of credit and promissory notes     661,160     1,184,921  
  Deferred revenue     5,172,475     1,935,249  
  Notes payable to stockholders         3,861,920  
   
 
 
      Total current liabilities     11,571,007     11,052,091  
Obligations under capital leases, equipment notes payable, and promissory notes less current portion     944,123     1,910,177  
Deferred rent     74,583     51,906  
Minority interest in Structural Proteomics     628,383      
Commitments              
  Redeemable convertible preferred stock, $.001 par value, none and 7,333,333 shares authorized at December 31, 2000 and 1999, respectively; none and 6,562,278 issued and outstanding at December 31, 2000 and 1999, respectively         27,906,717  
Stockholders' equity (deficit):              
  Common stock, $0.001 par value, 99,000,000 shares authorized, 23,931,237 and 1,611,763 issued and outstanding at December 31, 2000 and 1999, respectively     23,931     1,612  
  Preferred stock, $0.001 par value, 1,000,000 shares authorized, no shares issued and outstanding at December 31, 2000 and 1999, respectively          
  Additional paid-in capital     200,184,929     1,399,376  
  Deferred compensation     (2,032,378 )   (642,282 )
  Note receivable from stockholder     (240,000 )   (240,000 )
  Accumulated other comprehensive income (loss)     54,903     (55,448 )
  Accumulated deficit     (31,429,168 )   (19,732,429 )
   
 
 
      Total stockholders' equity (deficit)     166,562,217     (19,269,171 )
   
 
 
      Total liabilities and stockholders' equity   $ 179,780,313   $ 21,651,720  
   
 
 

See accompanying notes.

F–33


DISCOVERY PARTNERS INTERNATIONAL, INC.

CONSOLIDATED STATEMENTS OF OPERATIONS

 
  Years ended December 31,
 
 
  2000
  1999
  1998
 
Revenues:                    
  Sales to third parties   $ 33,898,886   $ 13,075,835   $ 6,213,736  
  Sales to Axys Pharmaceuticals, Inc.     2,364,764          
   
 
 
 
      Total revenues     36,263,650     13,075,835     6,213,736  
Cost of revenues (exclusive of $17,992 and $7,238 in 2000 and 1999, respectively, of stock-based compensation)     18,342,688     8,234,858     2,785,514  
   
 
 
 
  Gross margin     17,920,962     4,840,977     3,428,222  
Cost and expenses:                    
  Research and development (exclusive of $575,914 and $65,828 in 2000 and 1999, respectively, of stock-based compensation)     8,934,059     3,537,651     5,057,851  
  Selling, general and administrative (exclusive of $781,933 and $238,322 in 2000 and 1999, respectively, of stock-based compensation)     8,413,848     4,439,021     4,984,645  
  Amortization of stock-based compensation and other non-cash compensation charges     1,375,839     311,388      
  Amortization of goodwill     3,379,009          
  Write-off of in-process research and development     9,000,000          
   
 
 
 
      Total operating expenses     31,102,755     8,288,060     10,042,496  
   
 
 
 
Loss from operations     (13,181,793 )   (3,447,083 )   (6,614,274 )
Interest income     2,776,620     270,645     386,058  
Interest expense     (1,529,578 )   (60,003 )   (112,698 )
Foreign currency gains (losses)     133,062     (133,923 )   63,401  
Minority interest in Structural Proteomics     104,950          
   
 
 
 
Net loss   $ (11,696,739 ) $ (3,370,364 ) $ (6,277,513 )
   
 
 
 
Net loss per share, basic and diluted   $ (0.89 ) $ (3.00 ) $ (8.20 )
   
 
 
 
Shares used in calculating net loss per share, basic and diluted     13,176,576     1,125,040     765,263  
   
 
 
 

See accompanying notes.

F–34


DISCOVERY PARTNERS INTERNATIONAL, INC.
CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (DEFICIT)

 
  Common stock
   
   
  Notes
receivable
from
stockholder

   
   
   
 
 
  Additional
Paid-in capital

  Deferred
compensation

  Accumulated other
Comprehensive
Income (loss)

   
  Total stockholders'
equity (deficit)

 
 
  Shares
  Amount
  Accumulated deficit
 
Balance at December 31, 1997   956,731   $ 957   $ 48,367   $   $   $   $ (10,084,552 ) $ (10,035,228 )
  Exercise of options to purchase common stock   34,242     34     14,447                     14,481  
  Issuance of common stock in exchange for a promissory note   430,000     430     171,570         (172,000 )            
          Net loss                           (6,277,513 )   (6,277,513 )
   
 
 
 
 
 
 
 
 
Balance at December 31, 1998   1,420,973     1,421     234,384         (172,000 )       (16,362,065 )   (16,298,260 )
  Exercise of options to purchase common stock   20,790     21     5,412                     5,433  
  Issuance of common stock in exchange for a promissory note   170,000     170     67,830         (68,000 )            
  Issuance of warrants to purchase preferred stock           138,080                     138,080  
  Deferred compensation related to stock options and restricted stock           953,670     (953,670 )                
  Amortization of deferred compensation               311,388                 311,388  
  Comprehensive loss:                                                
      Foreign currency translation adjustment                       (55,448 )       (55,448 )
      Net loss                           (3,370,364 )   (3,370,364 )
                                           
 
  Comprehensive loss                                             (3,425,812 )
   
 
 
 
 
 
 
 
 
Balance at December 31, 1999   1,611,763     1,612     1,399,376     (642,282 )   (240,000 )   (55,448 )   (19,732,429 )   (19,269,171 )
  Common stock issued and options assumed for acquisitions   7,579,641     7,580     60,151,916                     60,159,496  
  Common stock issued for cash   5,750,000     5,750     94,588,039                     94,593,789  
  Exercise of options and warrants to purchase common stock   973,421     973     343,373                     344,346  
  Issuance of warrants to purchase common stock           1,915,766                     1,915,766  
  Conversion of preferred stock into common stock   8,016,412     8,016     39,020,526                     39,028,542  
  Deferred compensation related to stock options and restricted stock           2,724,672     (2,724,672 )                
  Amortization of deferred compensation and other non-cash compensation charges           41,261     1,334,576                 1,375,837  
  Comprehensive loss:                                                
      Foreign currency translation adjustment                       110,351         110,351  
      Net loss                           (11,696,739 )   (11,696,739 )
                                           
 
  Comprehensive loss                                             (11,586,388 )
   
 
 
 
 
 
 
 
 
Balance at December 31, 2000   23,931,237   $ 23,931   $ 200,184,929   $ (2,032,378 ) $ (240,000 ) $ 54,903   $ (31,429,168 ) $ 166,562,217  
   
 
 
 
 
 
 
 
 

See accompanying notes.

F–35


DISCOVERY PARTNERS INTERNATIONAL, INC.

CONSOLIDATED STATEMENTS OF CASH FLOWS

 
  Years ended December 31,
 
 
  2000
  1999
  1998
 
Operating activities                    
Net loss   $ (11,696,739 ) $ (3,370,364 ) $ (6,277,513 )
  Adjustments to reconcile net loss to cash provided by (used in) operating activities:                    
  Depreciation     2,966,335     360,322     561,049  
  Amortization     5,480,244     311,388      
  Non-cash interest expense for warrants issued     1,243,847          
  Write-off of in-process research and development     9,000,000          
Change in operating assets and liabilities:                    
  Accounts receivable     (4,804,972 )   (444,341 )   (334,487 )
  Inventories     (1,415,559 )   (357,037 )   (423,365 )
  Other current assets     (1,373,796 )   130,727     (65,907 )
  Accounts payable and accrued expenses     481,058     (567,171 )   1,395,725  
  Deferred revenue     2,309,449     (774,987 )   1,871,400  
  Deferred rent     22,677     (23,918 )   6,069  
  Restricted cash and cash equivalents and other assets     1,252,200     (1,000,000 )    
   
 
 
 
Net cash provide by (used in) operating activities     3,464,744     (5,735,381 )   (3,267,029 )
Investing activities                    
Purchases of property and equipment     (4,067,670 )   (1,112,191 )   (848,202 )
Deposits and other assets     (870,347 )   181,313     (7,331 )
Purchase of patents and license rights     (143,673 )       (1,212,497 )
Purchase of other assets     (1,800,536 )   (4,963,444 )    
Additional cash consideration for acquisition of Discovery Technologies     (1,721,775 )        
Purchase of Axys Advanced Technologies     (600,334 )        
   
 
 
 
Net cash used in investing activities     (9,204,335 )   (5,894,322 )   (2,068,030 )
Financing activities                    
Proceeds from equipment lease line     1,484,859          
Principal payments on capital leases, equipment notes payable, line of credit, and promissory notes     (2,974,674 )   (205,980 )   (262,165 )
Net proceeds from issuance of preferred stock     5,004,801         13,568,346  
Net proceeds from issuance of common stock     94,938,135     5,433     14,481  
Proceeds from convertible notes payable     2,000,000     4,000,000     2,448,395  
   
 
 
 
Net cash provided by financing activities     100,453,121     3,799,453     15,769,057  
Effect of exchange rate changes     92,067          
   
 
 
 
Net increase (decrease) in cash and cash equivalents     94,805,597     (7,830,250 )   10,433,998  
Cash and cash equivalents at beginning of period     2,884,639     10,714,889     280,891  
   
 
 
 
Cash and cash equivalents at end of period   $ 97,690,236   $ 2,884,639   $ 10,714,889  
   
 
 
 
Supplemental disclosure of cash flow information                    
Interest paid   $ 285,731   $ 60,004   $ 112,697  
   
 
 
 
Supplemental schedule of non-cash investing and financing activities                    
Conversion of convertible notes payable to preferred stock   $ 6,000,000   $   $ 2,448,395  
   
 
 
 
Issuance of common stock for promissory note   $   $ 68,000   $ 172,000  
   
 
 
 
Issuance of warrant to purchase preferred stock   $ 1,105,767   $ 138,080   $  
   
 
 
 
Non-cash consideration for purchase of AAT   $ 59,769,495   $   $  
   
 
 
 
Non-cash consideration for purchase of SPI   $ 1,200,000   $   $  
   
 
 
 
Deferred acquisition payment for DTL   $ 931,335   $ 1,721,775   $  
   
 
 
 

See accompanying notes.

F–36


DISCOVERY PARTNERS INTERNATIONAL, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

1.  ORGANIZATION AND BASIS OF PRESENTATION

    Discovery Partners International, Inc. (the "Company" or "DPI") was incorporated in California on March 22, 1995, under the name IRORI. The Company develops and offers libraries of drug-like compounds, proprietary instruments, consumables, drug discovery services and computational tools to generate compound libraries, and test, screen and optimize potential drugs. In 1998, the Company changed its name to Discovery Partners International, Inc. In July 2000, the Company reincorporated in Delaware.

    The consolidated financial statements include all the accounts of the Company and its wholly owned subsidiaries, IRORI Europe, Ltd., Discovery Technologies Ltd. ("DTL"), ChemRx Advanced Technologies, Inc. and its majority owned subsidiary, Structural Proteomics, Inc. ("SPI"). All intercompany accounts and transactions have been eliminated.

2.  SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

    The preparation of financial statements in conformity with generally accepted accounting principles requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates.

    Certain prior year balances have been reclassified to conform to the 2000 presentation.

    The Company considers all highly liquid investments with a remaining maturity of less than three months when purchased to be cash equivalents. At December 31, 2000 and 1999, the cost of cash equivalents was the same as the market value. Accordingly, there were no unrealized gains and losses. The Company evaluates the financial strength of institutions at which significant investments are made and believes the related credit risk is limited to an acceptable level.

    In accordance with SFAS No. 121, Accounting for the Impairment of Long-Lived Assets and for Long-Lived Assets to be Disposed Of, if indicators of impairment exist, the Company assesses the recoverability of the affected long-lived assets by determining whether the carrying value of such assets can be recovered through undiscounted future operating cash flows. If impairment is indicated, the Company measures the future cash flows associated with the use of the asset and records the asset at fair value. While the Company's current and historical operating and cash flow losses are indicators of impairment, the Company believes the future cash flows to be received from the long-lived assets will exceed the assets' carrying value, and accordingly, the Company has not recognized any impairment losses through December 31, 2000.

F–37


    Inventories are recorded at the lower of weighted average cost (approximates first-in first-out) or market. Inventories consist of the following:

 
  December 31,
 
 
  2000
  1999
 
Raw materials   $ 1,646,779   $ 588,048  
Work-in process     1,787,383     601,432  
Finished goods     13,179,138     412,006  
   
 
 
      16,613,300     1,601,486  
   
 
 
Less reserves     (6,826,295 )   (84,189 )
   
 
 
    $ 9,787,005   $ 1,517,297  
   
 
 

    Chemical compound libraries accounted for approximately $6.1 million of the total net inventory value at December 31, 2000.

    Property and equipment consists of the following:

 
  December 31,
 
 
  2000
  1999
 
Furniture and equipment   $ 12,501,966   $ 4,821,335  
Software     790,389     362,108  
Leasehold improvements     4,446,021     633,387  
   
 
 
      17,738,376     5,816,830  
Less accumulated depreciation and amortization     (8,170,505 )   (1,161,603 )
   
 
 
    $ 9,567,871   $ 4,655,227  
   
 
 

    Property and equipment, including equipment under capital leases and equipment notes payable, are stated at cost and depreciated over the estimated useful lives of the assets (three to seven years) or the term of the related lease, using the straight-line method. Amortization of assets acquired under capital leases is included in depreciation expense.

    The Company has purchased patents and license rights for the labeling of chemical libraries and related to products for sale and in development. The purchased patents and license rights are amortized ratably over a period of ten years.

F–38


    Other assets consists of chemical compounds purchased by DTL for its screening services. The compounds are stated at cost and depreciated over the estimated useful lives of the assets (three to five years) using the straight line method.

    Product sales, which include the sale of combinatorial chemistry instruments and proprietary libraries, are recorded as products are shipped. Development contract revenues and high-throughput screening service revenues are recognized on a percentage of completion basis. Advances received under these development contracts and high-throughput screening service agreements are recorded as deferred revenue and recognized as costs are incurred over the term of the contract. Revenue from chemistry service agreements is recognized on a monthly basis and is based upon the number of full time equivalent ("FTE") employees that actually worked on each agreement and the agreed-upon rate per FTE per month.

    The Company does not have a history of significant returns of its products nor does it allow its customers the right to return its products.

    Costs incurred in connection with research and development is charged to operations as incurred.

    As permitted by SFAS No. 123, Accounting for Stock-Based Compensation, the Company accounts for common stock options granted, and restricted stock sold, to employees, founders and directors using the intrinsic value method and, thus, recognizes no compensation expense for options granted, or restricted stock sold, with exercise prices equal to or greater than the fair value of the Company's common stock on the date of the grant. The Company has recorded deferred stock compensation related to certain stock options which were granted with exercise prices below estimated fair value (see Note 7), which is being amortized on an accelerated amortization methodology in accordance with Financial Accounting Standards Board Interpretation No. 28 ("FIN 28").

    Deferred compensation for options granted, and restricted stock sold, to consultants has been determined in accordance with SFAS No. 123 and EITF 96-18 as the fair value of the consideration received or the fair value of the equity instruments issued, whichever is more reliably measured. Deferred charges for options granted, and restricted stock sold, to consultants are periodically remeasured until the underlying options vest.

    SFAS No. 130, Reporting Comprehensive Income, requires the Company to report in the consolidated financial statements, in addition to net income, comprehensive income (loss) and its components including foreign currency items and unrealized gains and losses on certain investments in debt and equity securities. For the years ended December 31, 2000 and 1999, the Company has disclosed comprehensive loss as a component of stockholders' equity. Comprehensive loss was the same as net loss for the year ended December 31, 1998.

F–39


    Basic and diluted net loss per common share are presented in conformity with SFAS No. 128, Earnings per Share, and SAB 98, for all periods presented. Under the provisions of SAB 98, common stock and redeemable convertible preferred stock that has been issued or granted for nominal consideration prior to the anticipated effective date of the initial public offering must be included in the calculation of basic and diluted net loss per common share as if these shares had been outstanding for all periods presented. To date, the Company has not issued or granted shares for nominal consideration.

    In accordance with SFAS No. 128, basic and diluted net loss per share has been computed using the weighted average number of shares of common stock outstanding during the period, less shares subject to repurchase. The Company has excluded all convertible preferred stock, outstanding stock options and warrants, and shares subject to repurchase from the calculation of diluted net loss per common share because all such securities are anti-dilutive for all applicable periods presented. The weighted average number of shares excluded from the calculation of diluted net loss per share for outstanding convertible preferred stock were 4,374,471, 6,603,780 and 5,665,232 for the years ended December 31, 2000, 1999 and 1998, respectively. The total number of shares excluded from the calculations of diluted net loss per share for options and warrants were 1,292,362, 383,396, and 1,437,691 for the years ended December 31, 2000, 1999 and 1998, respectively. The effect of such securities had they been dilutive, would have been included in the computation of diluted net loss per share using the treasury stock method.

    Pro forma basic and diluted net loss per common share of $(0.67), $(0.44), and $(0.98) for the years ended December 31, 2000, 1999 and 1998, respectively, gives effect to the assumed conversion of preferred stock, which automatically converted to common stock upon the completion of the Company's initial public offering (using the "as-if converted" method) from the original date of issuance.

    The Company has determined that it operates in only one segment.

    Financial instruments which potentially subject the Company to concentrations of credit risk consist primarily of cash, cash equivalents and short-term investments. The Company limits its exposure to credit loss by placing its cash, cash equivalents and investments with high credit quality financial institutions.

    SFAS No. 133, Accounting for Derivative Instruments and Hedging Activities, was effective January 1, 2001. This statement establishes accounting and reporting standards requiring that every derivative instrument, including certain derivative instruments imbedded in other contracts, be recorded in the balance sheet as either an asset or liability measured at its fair value. The statement also requires that changes in the derivative's fair value be recognized in earnings unless specific hedge accounting criteria are met. The Company believes the adoption of SFAS No. 133 will not have an

F–40


effect on the financial statements because the Company does not engage in derivative or hedging activities.

    In March 2000, the Financial Accounting Standards Board issued Financial Interpretation No. 44, or FIN 44, "Accounting for Certain Transactions Involving Stock Compensation—an interpretation of APB Opinion No. 25". FIN 44 clarifies the definition of employees for purposes of applying Accounting Practice Board Opinion No. 25, "Accounting for Stock Issued to Employees", the criteria for determining whether a plan qualifies as a non-compensatory plan, the accounting consequence of various modifications to the terms of a previously fixed stock option or award, and the accounting for an exchange of stock compensation awards in a business combination. FIN 44 became effective on July 1, 2000, but certain conclusions in FIN 44 cover specific events that occur after either December 15, 1998 or January 12, 2000. The adoption of FIN 44 has not had a material impact on the Company.

    The financial statements of IRORI Europe, Ltd. are measured using the U.S. dollar as the functional currency. The financial statements of Discovery Technologies Ltd. are measured using the local currency as the functional currency. Assets and liabilities of the Company are translated at the rates of exchange at the balance sheet date. Income and expense items are translated at the average rate of exchange during the reporting period. The resulting foreign currency gains (losses) for IRORI Europe, Ltd. are included in the consolidated statement of operations. The resulting translation adjustments for Discovery Technologies Ltd. are unrealized and included as a separate component of other comprehensive income (loss). Transactions denominated in currencies other than the local currency are recorded based on exchange rates at the time such transactions arise. Subsequent changes in exchange rates result in transaction gains and losses which are reflected in income as unrealized (based on period-end translations) or realized upon settlement of these transactions.

3.  ACQUISITIONS

    On April 28, 2000, the Company acquired Axys Advanced Technologies, Inc. ("AAT"), a wholly owned subsidiary of Axys Pharmaceuticals, Inc. The acquisition was accounted for as a purchase in accordance with the provisions of Accounting Principles Board Opinion No. 16 ("APB 16").

    The Company obtained a report from Houlihan Valuation Advisors, an independent valuation firm, and performed other procedures necessary to complete the purchase price allocation.

F–41


    A summary of the AAT acquisition costs and allocation to the assets acquired and liabilities assumed is as follows:

Total acquisition costs:        
Cash paid at acquisition   $ 50,000  
Issuance of promissory note     550,334  
Issuance of common stock, warrant and stock options     59,769,495  
Acquisition related expenses     345,099  
   
 
    $ 60,714,928  
   
 
Allocated to assets and liabilities as follows:        
Tangible assets acquired   $ 12,252,068  
Assumed liabilities     (2,581,167 )
In-process research and development     9,000,000  
Assembled workforce     1,344,067  
Below market value lease     1,221,105  
Goodwill     39,478,855  
   
 
    $ 60,714,928  
   
 

    The goodwill will be amortized on a straight-line basis over a period of ten years from the date of acquisition. The assembled workforce and below market lease intangible assets will be amortized on a straight-line basis over periods of three and four years, respectively, from the date of acquisition.

    The valuation of the in-process research and development was determined based on a discounted cash flow analysis of projected future earnings for each project. The revenue stream from each research and development project was estimated based upon its stage of completion as of the acquisition date. The discount rates used for the analysis were adjusted based on the stage of completion to give effect to uncertainties in meeting the projected cash flows. The discount rates used ranged from 20% to 40%.

    Assuming that the acquisition of AAT had occurred on the first day of the Company's fiscal year ended December 31, 1999, pro forma condensed consolidated financial information would be as follows:

 
  Years Ended December 31,
 
 
  2000
  1999
 
 
  (Unaudited)

 
Revenues   $ 41,334,000   $ 27,050,000  
Net loss     (3,543,000 )   (4,170,000 )
Net loss per share, basic and diluted   $ (0.27 ) $ (3.71 )

    This pro forma information is not necessarily indicative of the actual results that would have been achieved had AAT been acquired the first day of the Company's fiscal year ended December 31, 1999, nor is it necessarily indicative of future results. The above pro forma condensed consolidated information does not include the $9.0 million write-off of in-process research and development that occurred in the Company's accounting for its acquisition of AAT in 2000.

F–42


    On May 5, 2000, the Company acquired 75% of the outstanding shares of SPI in exchange for $1,000,000 in cash and 150,000 shares of DPI common stock. The acquisition was accounted for as a purchase in accordance with the provisions of APB No. 16, resulting in a total purchase price of $2.2 million and recognition of goodwill of $1.9 million. The pro forma results of operations for the years ended December 31, 2000 and 1999 as if the acquisition of SPI had occurred on the first day of the Company's fiscal year ended December 31, 1999 are not materially different than the reported net loss.

4.  DEBT

    At December 31, 2000, obligations under equipment notes totaled $1,794,328 payable in monthly installments through the year 2004 with a weighted-average interest rate of 9.77% and secured by the assets of the Company. In March 2000, the Company signed two equipment notes payable totaling $747,150, payable in monthly installments through the year 2003 with a weighted-average interest rate of 13.82% and secured by assets of the Company. In November 2000, the Company signed 3 additional equipment notes payable totaling $737,709, payable in monthly installments through the year 2004 with a weighted-average interest rate of 7.27% and secured by assets of the Company.

    On December 10, 1999, the Company borrowed $4.0 million from certain of its principal investors. The notes accrued interest at 8% per annum and were due and payable on the earlier of the closing of a preferred stock financing round or February 10, 2000. Subsequent to December 31, 1999, the noteholders informally extended the maturity of the notes until the closing of the redeemable convertible Series E preferred stock sale. The notes plus accrued interest were converted into redeemable convertible Series E preferred stock on April 7, 2000 (see Note 6 and 7).

    On March 9, 2000, the Company borrowed $2.0 million from one of its principal investors. The promissory note accrued interest at 8% per annum and was due and payable upon the earlier of the closing of a preferred stock financing round or June 9, 2000. In connection with the note, the Company issued warrants to purchase a variable number of shares of redeemable convertible preferred stock at a purchase price of $5.00 per share. The note plus accrued interest was converted into redeemable convertible Series E preferred stock on April 7, 2000 (see Note 6 and 7).

5.  COMMITMENTS

    The Company leases a facility in San Diego under an operating lease agreement that expires on August 31, 2006, and a second facility in South San Francisco under an operating lease agreement that expires on November 30, 2003. Rent expense was $908,036, $648,788 and $829,343 for the years ended December 31, 2000, 1999 and 1998, respectively. Additionally, the Company leases certain equipment under operating leases with initial terms in excess of one year.

F–43


    Annual future minimum lease obligations under the Company's operating and capital leases as of December 31, 2000 are as follows:

 
  Operating Leases
  Equipment Notes Payable and Capital Leases
 
2001   $ 971,741   $ 774,589  
2002     990,966     691,136  
2003     969,074     321,163  
2004     674,240     19,889  
2005     690,856      
Thereafter     467,955      
   
 
 
Total minimum lease payments   $ 4,764,832     1,806,777  
   
 
 
Less amount representing interest           (201,494 )
         
 
Total present value of minimum payments           1,605,283  
Less current portion           (661,160 )
         
 
Non-current portion         $ 944,123  
         
 

    At December 31, 2000, cost and accumulated amortization of property and equipment under capital leases was $2,472,228 and $523,050, respectively. At December 31, 1999, cost and accumulated amortization of property and equipment under capital leases was $624,947 and $170,183, respectively.

    The Company signed a standby letter of credit for $700,000 required under the terms of the Company's lease of its facilities. The Company pledged $1.0 million of cash equivalents as collateral for the letter of credit. The amount is included in restricted cash and cash equivalents as of December 31, 2000 and 1999. The letter of credit expires in fiscal 2004.

6.  REDEEMABLE CONVERTIBLE PREFERRED STOCK

    In April 2000, the Company issued 1,392,503 shares of redeemable convertible Series E preferred stock at $8.00 per share in exchange for the conversion of $6.0 million in notes payable to shareholders and $5.0 million in cash. All of the shares of redeemable convertible Series A, B, C, D and E preferred stock were converted into common stock upon the completion of the Company's initial public offering on July 27, 2000.

7.  SHAREHOLDERS' EQUITY

    On July 27, 2000, the Company sold 5 million shares of common stock at $18.00 per share through an Initial Public Offering. On August 27, 2000, the underwriters exercised their option to acquire an additional 750,000 shares, also at $18.00 per share.

F–44


    In November 1995, the Company adopted the 1995 Stock Option/Stock Issuance Plan, under which 2,350,000 shares of common stock were reserved for issuance of stock and stock options granted by the Company. In July 2000, the Company adopted the 2000 Stock Incentive Plan (the "Plan") as the successor plan to the 1995 Stock Option/Stock Issuance Plan. 3,300,000 shares of common stock were reserved under the Plan, including shares rolled over from the 1995 Plan. The Plan provides for the grant of incentive and nonstatutory options. The exercise price of incentive stock options must equal at least the fair value on the date of grant, and the exercise price of nonstatutory stock options may be no less than 85% of the fair value on the date of grant. The options generally vest over a four-year period and all expire ten years after the date of grant.

    A summary of the Company's stock option activity and related information is as follows:

 
  Years Ended December 31,

 
  2000
  1999
  1998
 
  Options
  Weighted
Average
Exercise
Price

  Options
  Weighted
Average
Exercise
Price

  Options
  Weighted
Average
Exercise
Price

Outstanding at beginning of period   934,510   $ 0.71   980,075   $ 0.49   483,720   $ 0.31
Granted   1,602,755     7.03   191,500     1.50   1,087,700     0.51
Exercised   (359,362 )   0.96   (190,790 )   0.38   (464,242 )   0.40
Forfeited   (91,061 )   2.59   (46,275 )   0.75   (127,103 )   0.34
   
 
 
 
 
 
Outstanding at end of period   2,086,842   $ 5.44   934,510   $ 0.71   980,075   $ 0.49
   
 
 
 
 
 
Exercisable   574,933   $ 1.65   418,469   $ 0.53   204,893   $ 0.35
   
 
 
 
 
 

    Exercise prices for options outstanding as of December 31, 2000 ranged from $0.30 to $25.00. The weighted-average remaining contractual life of those options is approximately eight years. The weighted-average fair value of the options granted in 2000, 1999 and 1998 is $5.62, $0.39 and $0.13 per share, respectively.

    At December 31, 2000, options for 1,108,502 shares were available for future grant.

    Pro forma information regarding net income or loss is required by SFAS No. 123, and has been determined as if the Company had accounted for its employee stock options under the fair value method of that Statement. The fair value of these options was estimated at the date of grant using the Black-Scholes option pricing model with the following weighted average assumptions in 2000, 1999 and 1998: risk- free interest rate of 6.0%; dividend yield of 0%; and a weighted-average life of five years. The Company used a volatility factor of 70%, 0%, and 0% during the years ended December 31, 2000, 1999 and 1998, respectively.

F–45


    For purposes of adjusted pro forma disclosures, the estimated fair value of the options is amortized to expense over the vesting period. The Company's adjusted pro forma information is as follows:

 
  Years Ended December 31,
 
 
  2000
  1999
  1998
 
Adjusted pro forma net loss   $ (13,301,547 ) $ (3,435,570 ) $ (6,296,500 )
Adjusted pro forma net loss per share   $ (1.01 ) $ (3.05 ) $ (8.23 )

    The pro forma effect on net loss for 2000, 1999 and 1998 is not likely to be representative of the pro forma effects on reported net income or loss in future years because these amounts reflect less than four years of vesting.

    Following is a further breakdown of the options outstanding as of December 31, 2000:

Range of Exercise
Prices

  Options Outstanding
  Weighted Average
Remaining Life in Years

  Weighted Average
Exercise Price

  Options Exercisable
  Weighted Average
Exercise Price of
Options Exercisable

$  0.20 — 1.50   625,515   7.4   $ 0.80   387,328   $ 0.73
$  2.50 — 6.56   876,982   8.9   $ 2.66   176,506   $ 2.61
$  8.00 — 12.00   272,600   9.3   $ 8.88   1,099   $ 8.00
$ 14.11 — 25.00   311,745   9.7   $ 19.53   10,000   $ 19.88
     
           
     
      2,086,842             574,933      
     
           
     

    In June 2000, the board of directors and shareholders adopted the Employee Stock Purchase Plan (the "Purchase Plan"). A total of 250,000 shares of the Company's common stock have been reserved for issuance under the Purchase Plan. The Purchase Plan permits eligible employees to purchase common stock at a discount, but only through payroll deductions, during defined offering periods. The price at which stock is purchased under the Purchase Plan is equal to 85% of the fair market value of the common stock on the first or last day of the offering period, whichever is lower. In addition, the Purchase Plan provides for annual increases of shares available for issuance under the Purchase Plan beginning with fiscal 2001. Employee participation in the Purchase Plan has not yet commenced.

    In conjunction with the Company's initial public offering completed in July 2000, the Company has recorded deferred stock compensation totaling approximately $2.7 million and $1.0 million during the years ended December 31, 2000 and 1999, respectively, representing the difference at the date of grant between the exercise or purchase price and estimated fair value of the Company's common stock as estimated by the Company's management for financial reporting purposes in accordance with APB No. 25. Deferred compensation is included as a reduction of stockholders' equity and is being amortized to expense on an accelerated basis in accordance with over the vesting period of the options and restricted stock. During the years ended December 31, 2000 and 1999, the Company recorded

F–46


amortization of stock-based compensation expense of approximately $1.4 million and $0.3 million, respectively.

    In years prior to 1999, the Company has issued warrants to purchase a total of 468,522 shares of common and preferred stock in connection with convertible bridge notes issued to investors and obligations under capital leases. The warrants had exercise prices ranging from $.01 to $2.00 per share. The Company determined the relative fair value of the warrants at issuance was not material; accordingly, no value has been assigned to the warrants.

    In connection with the issuance of notes payable in December 1999 and March 2000, the Company issued warrants to investors to purchase a total of 234,738 shares of redeemable convertible preferred stock at a purchase price of $5.00 per share. The estimated fair value of the warrants of $1.2 million was based on using the Black Scholes valuation model and was recorded as interest expense in 2000.

    703,260 warrants have been exercised as of December 31, 2000.

    At December 31, 2000 common shares reserved for future issuance consist of the following:

Warrants   200,000
Stock options   3,195,344
Employee Stock purchase plan   250,000
   
    3,645,344
   

8.  INCOME TAXES

    At December 31, 2000, the Company had federal and California income tax net operating loss carryforwards of approximately $16,970,000 and $12,860,000, respectively. The difference between the federal and California net tax operating loss carryforwards is primarily attributable to the capitalization of research and development expenses for California income tax purposes.

    The federal and California tax loss carryforwards will begin to expire in 2010 and 2003, respectively, unless previously utilized. The Company also has federal and California research tax credit carryforwards of approximately $1,255,000 and $801,000, respectively, which will begin to expire in 2010 unless previously utilized.

    Pursuant to Sections 382 and 383 of the Internal Revenue Code, annual use of the Company's net operating loss and credit carryforwards may be limited if cumulative changes in ownership of more than 50% occur during any three year period.

F–47


    Significant components of the Company's deferred tax assets are shown below. A valuation allowance of $12,035,000 has been recognized to offset the deferred tax assets as realization of such assets is uncertain.

 
  December 31,
 
 
  2000
  1999
 
Deferred tax assets:              
  Net operating loss carryforwards   $ 6,680,000   $ 5,776,000  
  Research and development credits     1,775,000     935,000  
  Capitalized research and development expenses     2,732,000     179,000  
  Other, net     848,000     632,000  
   
 
 
Total deferred tax assets     12,035,000     7,522,000  
Valuation allowance for deferred tax assets     (12,035,000 )   (7,522,000 )
   
 
 
Net deferred tax assets   $   $  
   
 
 

9.  RETIREMENT PLAN

    In 1996, the Company established a 401(k) plan covering substantially all domestic employees. The Company pays all administrative fees of the plan. The plan contains provisions allowing for the Company to declare a match up to 25% of funds contributed to the plan by employees. There were no matching contributions declared by the Company for the years ended December 31, 2000, 1999 and 1998.

10.  SIGNIFICANT CUSTOMERS, SUPPLIERS AND FOREIGN OPERATIONS

    Most of the Company's operations and long-lived assets are based in the United States. Discovery Technologies Ltd., located near Basel, Switzerland, had long-lived assets totalling $3,098,373 and $2,354,836 at December 31, 2000 and 1999, respectively.

    The geographic breakdown of our revenues for the years ended December 31, 2000, 1999 and 1998 are as follows:

 
  2000
  1999
  1998
 
United States   66 % 74 % 58 %
Foreign countries   34 % 26 % 42 %
   
 
 
 
    100 % 100 % 100 %

    Major customers, responsible for 10% or more of revenues, include collaborative partners and pharmaceutical and biotechnology companies. The percentages of sales of each of these third party

F–48


major customers to total revenue derived from third parties for the years ended December 31, 2000, 1999 and 1998 were as follows:

 
  Years Ended December 31,
 
 
  2000
  1999
  1998
 
Customer A   14 %    
Customer B   12 % 22 % 8 %
Customer C   10 %    
Customer D   7 % 20 % 3 %
Customer E   1 % 7 % 23 %

    The Company depends on sole source suppliers for the mesh component of its reactors, the RF tags used in its commercial products and the two dimensional bar code tags used in its NanoKan reactors.

11.  QUARTERLY FINANCIAL DATA (UNAUDITED)

    The following financial information reflects all normal recurring adjustments which are, in the opinion of management, necessary for a fair statement of the results of the interim periods. Summarized quarterly data for fiscal 2000 are as follows (in thousands, except per share data):

 
   
  2000 Quarter Ended
   
 
 
  Mar 31
  Jun 30
  Sep 30
  Dec 31
 
Revenues   $ 5,173   $ 9,528   $ 10,159   $ 11,403  
Cost of product and services     3,053     4,724     5,034     5,531  
   
 
 
 
 
Gross margin     2,120     4,804     5,125     5,872  
   
 
 
 
 
Loss from operations     (437 )   (9,435 )   (1,582 )   (1,727 )
   
 
 
 
 
Net loss   $ (1,630 ) $ (9,315 ) $ (631 ) $ (121 )
   
 
 
 
 
Net loss per share, basic and diluted(1)   $ (1.23 ) $ (1.03 ) $ (0.03 ) $ (0.01 )
   
 
 
 
 
Pro forma net loss per share, basic and diluted(1),(2)   $ (0.21 ) $ (0.55 ) $ (0.03 ) $ (0.01 )
   
 
 
 
 

(1)
Net loss per share is computed independently for each of the quarters presented. Therefore, the sum of the quarterly net loss per share will not necessarily equal the total for the year.
(2)
Pro forma basic and diluted net loss per common share gives effect to the assumed conversion of preferred stock, which automatically converted to common stock upon the completion of the Company's initial public offering (using the "as-if converted" method) from the original date of issuance.

12.  SUBSEQUENT EVENTS (UNAUDITED)

    On January 12, 2001, the Company acquired Systems Integration Drug Discovery Company, Inc., a privately-held company located in Tucson, Arizona, for approximately $12 million in cash. The acquisition was accounted for as a purchase in accordance with the provisions of APB No. 16.

    On February 27, 2001, the Company agreed to acquire Xenometrix, Inc., a publicly-held company located in Boulder, Colorado for approximately $2.5 million in cash. The acquisition is expected to close in the second quarter of 2001, and will be accounted for as a purchase in accordance with the provisions of APB No. 16.

F–49



Annex A



AGREEMENT AND PLAN OF MERGER
Dated as of June 12, 2001
Among
Axys Pharmaceuticals, Inc.,
Applera Corporation,
And
Angel Acquisition Sub, Inc.





TABLE OF CONTENTS

 
  Page

ARTICLE I THE MERGER   A-1
  SECTION 1.01    The Merger   A-1
  SECTION 1.02    Closing   A-1
  SECTION 1.03    Effective Time of the Merger   A-1
  SECTION 1.04    Effects of the Merger   A-2
  SECTION 1.05    Certificate of Incorporation; By-laws   A-2
  SECTION 1.06    Directors   A-2
  SECTION 1.07    Officers   A-2
  SECTION 1.08    Effect on Capital Stock   A-2
  SECTION 1.09    Exchange of Certificates   A-3
  SECTION 1.10    Treatment of Options   A-5
  SECTION 1.11    Treatment of Debt Securities, Convertible Notes and Company Warrants   A-6

ARTICLE II REPRESENTATIONS AND WARRANTIES OF THE COMPANY

 

A-7
  SECTION 2.01    Organization, Standing and Corporate Power   A-7
  SECTION 2.02    Subsidiaries and Minority Investments   A-8
  SECTION 2.03    Capital Structure   A-9
  SECTION 2.04    Authority   A-10
  SECTION 2.05    Noncontravention   A-10
  SECTION 2.06    SEC Documents; Financial Statements   A-11
  SECTION 2.07    Undisclosed Liabilities   A-11
  SECTION 2.08    Information Supplied   A-12
  SECTION 2.09    Absence of Certain Changes or Events   A-12
  SECTION 2.10    Litigation   A-12
  SECTION 2.11    Labor Matters   A-12
  SECTION 2.12    Permits; Compliance with Laws   A-13
  SECTION 2.13    Employee Benefit Plans   A-13
  SECTION 2.14    Taxes   A-14
  SECTION 2.15    Properties   A-15
  SECTION 2.16    Environmental Matters   A-15
  SECTION 2.17    Contracts; Debt Instruments   A-16
  SECTION 2.18    Intellectual Property   A-17
  SECTION 2.19    Brokers and Other Advisors   A-18
  SECTION 2.20    Opinion of Financial Advisor   A-18
  SECTION 2.21    Board Recommendation; State Antitakeover Law   A-18
  SECTION 2.22    Required Company Vote   A-19
  SECTION 2.23    Rights Agreement   A-19
  SECTION 2.24    Affiliate Transactions   A-19

ARTICLE III REPRESENTATIONS AND WARRANTIES OF PARENT

 

A-19
  SECTION 3.01    Organization, Standing and Corporate Power   A-19
  SECTION 3.02    Capital Structure   A-19
  SECTION 3.03    Authority   A-20
  SECTION 3.04    Noncontravention   A-21
  SECTION 3.05    Parent SEC Documents; Financial Statements   A-21
  SECTION 3.06    Undisclosed Liabilities   A-22
  SECTION 3.07    Information Supplied   A-22

A–i


  SECTION 3.08    Absence of Certain Changes or Events   A-22
  SECTION 3.09    Litigation; Compliance with Laws   A-22
  SECTION 3.10    Brokers   A-23
  SECTION 3.11    Interim Operations of Merger Sub   A-23
  SECTION 3.12    Required Vote   A-23

ARTICLE IV COVENANTS RELATING TO CONDUCT OF BUSINESS PRIOR TO MERGER

 

A-23
  SECTION 4.01    Conduct of Business by the Company   A-23
  SECTION 4.02    Conduct of Business by Parent   A-25
  SECTION 4.03    Employment Arrangements   A-25
  SECTION 4.04    Tax Elections   A-26
  SECTION 4.05    Tax-Free Reorganization Treatment   A-26
  SECTION 4.06    Other Actions   A-26

ARTICLE V ADDITIONAL AGREEMENTS

 

A-26
  SECTION 5.01    Preparation of Form S-4 and Proxy Statement; Stockholder Meeting   A-26
  SECTION 5.02    Access to Information; Confidentiality   A-27
  SECTION 5.03    Reasonable Best Efforts   A-27
  SECTION 5.04    Indemnification   A-28
  SECTION 5.05    Public Announcements   A-29
  SECTION 5.06    No Solicitation   A-29
  SECTION 5.07    Benefit Matters   A-30
  SECTION 5.08    Stock Exchange Listing   A-30
  SECTION 5.09    Letters of the Company's Accountants   A-31
  SECTION 5.10    Rights Agreement   A-31
  SECTION 5.11    Convertible Notes   A-31
  SECTION 5.12    Non-solicitation of Employees   A-31
  SECTION 5.13    Stock Options   A-31

ARTICLE VI CONDITIONS PRECEDENT

 

A-31
  SECTION 6.01    Conditions to Each Party's Obligation To Effect the Merger   A-31
  SECTION 6.02    Conditions to Obligations of Parent and Merger Sub   A-32
  SECTION 6.03    Conditions to Obligation of the Company   A-33

ARTICLE VII TERMINATION, AMENDMENT AND WAIVER

 

A-33
  SECTION 7.01    Termination   A-33
  SECTION 7.02    Effect of Termination   A-34
  SECTION 7.03    Amendment   A-34
  SECTION 7.04    Extension; Waiver   A-34
  SECTION 7.05    Procedure for Termination, Amendment, Extension or Waiver   A-35

ARTICLE VIII GENERAL PROVISIONS

 

A-35
  SECTION 8.01    Nonsurvival of Representations and Warranties   A-35
  SECTION 8.02    Fees and Expenses   A-35
  SECTION 8.03    Notices   A-36
  SECTION 8.04    Interpretation   A-36
  SECTION 8.05    Counterparts   A-36
  SECTION 8.06    Entire Agreement; No Third-Party Beneficiaries   A-36
  SECTION 8.07    GOVERNING LAW   A-37
  SECTION 8.08    Assignment   A-37
  SECTION 8.09    Enforcement   A-37

A–ii



Index of Defined Terms

Term

  Section
2000 Balance Sheet   2.07
AB Stock   3.02(a)
Action   5.04(a)
Acquisition Agreements   2.17(a)(vii)
Affiliate   2.20
Bylaws   2.01
Certificate of Incorporation   2.01
Certificate of Merger   1.03
Certificates   1.08(d)
Closing   1.02
Closing Date   1.02
Code   Recitals
Company   Preamble
Company Common Stock   Recitals
Company Disclosure Schedule   Article II
Company Insurance   5.04(b)
Company Material Adverse Effect   2.01
Company Permits   2.12
Company Plans   2.13(a)
Company SEC Documents   2.06
Company Stock Option   1.10(a)
Company Stock Plans   1.10(a)
Company Stockholder Approval   Recitals
Company Warrants   1.11(b)
Confidentiality Agreement   5.02
Contract   2.17(a)
Control   2.20
Controlled Group   2.13(c)
Convertible Notes   1.11(a)
Convertible Notes Indenture   1.11(a)
DGCL   Recitals
Effective Time   1.03
Environmental Laws   2.16(c)(i)
Environmental Report   2.16(c)(ii)
Equity Interest   2.02(b)(ii)
ERISA   2.13(a)
Exchange Act   2.05(b)
Exchange Agent   1.09(a)
Exchange Fund   1.09(a)
Exchange Ratio   1.08(c)
Final Offering Period   1.10(d)
Form S-4   2.08
GAAP   2.06(b)
Governmental Entity   2.05(b)
HSR Act   2.05(b)
Incentive stock options   1.10(a)
Indebtedness   2.03(c)
Indenture   1.11(a)

A–iii


Indemnified Party   5.04(a)
Intellectual Property   2.18(a)
JP Morgan   2.19
Knowledge of the Company   2.02(a)
Knowledge of Parent   3.09(a)
Laws   2.05(a)
Licensed Patent Intellectual Property   2.18(a)
Liens   2.02(a)
Material Contracts   2.17(a)
Material Intellectual Property   2.18(a)
Materials of Environmental Concern   2.16(c)(iii)
Merger   Recitals
Merger Consideration   1.08(c)
Merger Sub   Preamble
Minority Investment   2.02(b)(iii)
Minority Investment Documents   2.02(a)
Morgan Stanley   3.10
NYSE   1.09(c)
Parent   Preamble
Parent Common Stock   1.08(c)
Parent Common Stock Price   1.08(c)
Parent Disclosure Schedule   Article III
Parent Material Adverse Effect   3.01
Parent Preferred Stock   3.02(a)
Parent SEC Documents   3.05
Parent Stock Option   1.10(a)
Parent Stock Plans   3.02(a)
Parent Subsidiaries   3.01
Person   1.09(g)
Proxy Statement   5.01(a)
Registered Intellectual Property   2.18(a)
Remedial Action   2.16(c)(iv)
Rights   1.09(d)
Rights Agreement   1.09(d)
SEC   2.05(b)
Securities Act   2.06(a)
Stock Purchase Plan   2.03
Stockholders Meeting   5.01(c)
Subsidiary   2.02(b)(i)
Subsidiary Documents   2.02(a)
Superior Proposal   5.06
Surviving Company   1.01
Taxes   2.14
Tax Return   2.14
Third Party   8.02(a)(i)(A)
Transaction Proposals   5.06
Transactions   1.02
Trustee   1.11(a)
Voting Debt   2.03(a)
WARN   2.11

A–iv


    AGREEMENT AND PLAN OF MERGER, dated as of June 12, 2001, among Applera Corporation, a Delaware corporation ("Parent"), Angel Acquisition Sub, Inc., a Delaware corporation and a direct wholly owned subsidiary of Parent ("Merger Sub"), and Axys Pharmaceuticals, Inc., a Delaware corporation (the "Company").


W I T N E S S E T H:

    WHEREAS, the respective boards of directors of Parent, Merger Sub and the Company have determined that the merger of Merger Sub with and into the Company (the "Merger"), upon the terms and subject to the conditions set forth in this Agreement, would be fair and in the best interests of their respective stockholders;

    WHEREAS, such boards of directors have approved the Merger, pursuant to which each share of common stock, par value $.001 per share, of the Company (the "Company Common Stock," which term also refers to and includes, unless the context otherwise requires, the associated Rights (as defined below)), other than shares owned by the Company, Parent or Merger Sub, will be converted into the right to receive the Merger Consideration (as defined below), upon the terms and subject to the conditions set forth herein and in accordance with the applicable provisions of the General Corporation Law of the State of Delaware (the "DGCL") and Certificate of Incorporation (as defined below);

    WHEREAS, the Merger and this Agreement require the vote of the holders of a majority of the outstanding shares of the Company Common Stock for the approval thereof (the "Company Stockholder Approval");

    WHEREAS, Parent, Merger Sub and the Company desire to make certain representations, warranties, covenants and agreements in connection with the Merger and also to prescribe various conditions to the Merger; and

    WHEREAS, for federal income tax purposes, it is intended that the Merger shall qualify as a reorganization within the meaning of Section 368(a) of the Internal Revenue Code of 1986, as amended (the "Code").

    NOW, THEREFORE, in consideration of the foregoing and the mutual covenants and agreements herein contained, and intending to be legally bound hereby, the parties hereto hereby agree as follows:


ARTICLE I

THE MERGER

    Section 1.01  The Merger.  Upon the terms and subject to the conditions set forth in this Agreement, and in accordance with the DGCL, Merger Sub shall be merged with and into the Company at the Effective Time. At the Effective Time, the separate corporate existence of Merger Sub shall cease, and the Company shall continue as the surviving corporation (hereinafter sometimes referred to as the "Surviving Company").

    Section 1.02  Closing.  Unless this Agreement shall have been terminated and the Merger and the other transactions contemplated by this Agreement (collectively, the "Transactions") shall have been abandoned pursuant to Section 8.01, and subject to the satisfaction or waiver of the conditions set forth in Article VI, the closing of the Merger (the "Closing") will take place at 10:00 a.m. on the second business day after satisfaction of the conditions set forth in Section 6.01 (or as soon as practicable thereafter following satisfaction or waiver of the conditions set forth in Sections 6.02 and 6.03) (the "Closing Date"), at the offices of Simpson Thacher & Bartlett, 3330 Hillview Avenue, Palo Alto, California 94304, unless another date, time or place is agreed to in writing by the parties hereto.

    SECTION 1.03  Effective Time of the Merger.  On the Closing Date, the parties shall cause the Merger to be consummated by filing with the Secretary of State of the State of Delaware a certificate

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of merger as contemplated by the DGCL (the "Certificate of Merger") executed in accordance with the relevant provisions of the DGCL and shall make all other filings or recordings required under the DGCL to be filed on such date. The Merger shall become effective at such time (the "Effective Time") as the Certificate of Merger is duly filed with the Secretary of State of the State of Delaware, or at such other time as is permissible in accordance with the DGCL and as Merger Sub and the Company shall agree should be specified in the Certificate of Merger.

    SECTION 1.04  Effects of the Merger.  At the Effective Time, the Merger shall have the effects set forth in this Agreement, the Certificate of Merger and the applicable provisions of the DGCL. Without limiting the generality of the foregoing, and subject thereto, at the Effective Time (a) the Surviving Company shall possess all rights, privileges, powers and franchises, both public and private, and all of the property, real, personal, and mixed of each of the Company and Merger Sub and all obligations belonging to or due to Merger Sub or the Company, all of which shall be vested in the Surviving Company without any further act or deed; and (b) the Surviving Company shall be liable for all the obligations of Merger Sub and the Company.

    SECTION 1.05  Certificate of Incorporation; By-laws.  (a) At the Effective Time, and without any further action on the part of the Company or Merger Sub, the certificate of incorporation of the Company, as in effect at the Effective Time, shall be the certificate of incorporation of the Surviving Corporation until thereafter amended as provided therein or by the DGCL.

    (b) At the Effective Time, and without any further action on the part of the Company or Merger Sub, the by-laws of Merger Sub as in effect at the Effective Time shall be the by-laws of the Surviving Corporation until thereafter changed or amended as provided therein or by the DGCL.

    SECTION 1.06  Directors.  The directors of Merger Sub at the Effective Time shall be the directors of the Surviving Corporation, until the earlier of their resignation or removal or until their respective successors are duly elected and qualified, as the case may be.

    SECTION 1.07  Officers.  The officers of the Company at the Effective Time shall be the officers of the Surviving Corporation, until the earlier of their resignation or removal or until their respective successors are duly elected and qualified, as the case may be.

    SECTION 1.08  Effect on Capital Stock.  As of the Effective Time, by virtue of the Merger and without any action on the part of the Company, Merger Sub or any holder of any shares of Company Common Stock or any shares of capital stock of Merger Sub:

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    SECTION 1.09  Exchange of Certificates.  (a) Exchange Agent. As of or as soon as reasonably practicable after the Effective Time, Parent shall enter into an agreement with such bank or trust company as may be designated by Parent (the "Exchange Agent") which shall provide that Parent shall deposit with the Exchange Agent, for the benefit of the holders of Certificates, for exchange in accordance with this Article I, certificates representing the shares of Parent Common Stock, together with any dividends or distributions with respect thereto with a record date after the Effective Time, and any cash payable in lieu of any fractional shares of Parent Common Stock (such shares of Parent Common Stock and cash being hereinafter referred to as the "Exchange Fund") issuable pursuant to Section 1.08 in exchange for outstanding shares of Company Common Stock.

    (b)  Exchange Procedures.  As soon as reasonably practicable after the Effective Time, the Exchange Agent shall mail to each holder of record of Certificates immediately prior to the Effective Time whose shares were converted into shares of Parent Common Stock pursuant to Section 1.08, (i) a letter of transmittal (which shall specify that delivery shall be effected, and risk of loss and title to the Certificates shall pass, only upon delivery of the Certificates to the Exchange Agent, and which shall be in customary form and have such other provisions as Parent may reasonably specify and be reasonably acceptable to the Company) and (ii) instructions for use in effecting the surrender of the Certificates in exchange for certificates representing shares of Parent Common Stock. Upon surrender of a Certificate for cancellation to the Exchange Agent together with such letter of transmittal, duly executed, the holder of such Certificate shall be entitled to receive in exchange therefor a certificate representing that number of whole shares of Parent Common Stock which such holder has the right to receive in respect of the Certificate surrendered pursuant to the provisions of this Article I (after taking into account all shares of Company Common Stock then held by such holder), certain dividends and other distributions in accordance with Section 1.09(c) hereof and cash in lieu of any fractional shares in

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accordance with Section 1.09(e) hereof, and the Certificate so surrendered shall forthwith be cancelled. In the event of a transfer of ownership of shares of Company Common Stock which is not registered in the transfer records of the Company, a certificate representing the proper number of shares of Parent Common Stock may be issued to a transferee if the Certificate is presented to the Exchange Agent, accompanied by all documents required to evidence and effect such transfer and by evidence that any applicable stock transfer taxes have been paid. Until surrendered as contemplated by this Section 1.09 each Certificate shall be deemed at any time after the Effective Time to represent only the right to receive upon such surrender Parent Common Stock into which the shares of Company Common Stock represented by such Certificate have been converted as provided in this Article I and the right to receive upon such surrender cash in lieu of any fractional shares of Parent Common Stock as contemplated by this Section 1.09.

    (c)  Distributions with Respect to Unexchanged Shares.  No dividends or other distributions with respect to Parent Common Stock with a record date after the Effective Time shall be paid to the holder of any unsurrendered Certificate with respect to the shares of Parent Common Stock represented thereby, and no cash payment in lieu of fractional shares shall be paid to any such holder pursuant to Section 1.09(e) until the surrender of such Certificate in accordance with this Article I. Subject to the effect of applicable laws, following surrender of any such Certificate, there shall be issued or paid to the holder of such certificate, a certificate representing the number of whole shares of Parent Common Stock issued in exchange therefor without interest, (i) at the time of such surrender, the amount of any cash payable in lieu of a fractional share of Parent Common Stock to which such holder is entitled pursuant to Section 1.09(e) and the amount of any dividends or other distributions with a record date after the Effective Time theretofore paid (but withheld pursuant to the immediately preceding sentence) with respect to such whole shares of Parent Common Stock, and (ii) at the appropriate payment date, the amount of any dividends or other distributions with a record date after the Effective Time but prior to such surrender and a payment date subsequent to such surrender payable with respect to such whole shares of Parent Common Stock.

    (d)  No Further Ownership Rights in Company Common Stock.  All shares of Parent Common Stock issued upon conversion of shares of Company Common Stock in accordance with the terms hereof, and all cash paid pursuant to Sections 1.09(c) and 1.09(e) hereof, shall be deemed to have been issued in full satisfaction of all rights pertaining to such shares of Company Common Stock (including with respect to the rights to acquire one one-hundredth of a share of Series A Junior Participating Preferred Stock of the Company (the "Rights") issued pursuant to the Rights Agreement dated as of October 8, 1998, as amended, between the Company and Computershare Investor Services, L.L.C., as rights agent (the "Rights Agreement")), and there shall be no further registration of transfers on the stock transfer books of the Surviving Corporation of the shares of Company Common Stock that were outstanding prior to the Effective Time. If, after the Effective Time, Certificates are presented to the Surviving Corporation for any reason, they shall be cancelled and exchanged as provided in this Article I.

    (e)  No Fractional Shares.  (i) No certificates or scrip representing fractional shares of Parent Common Stock shall be issued upon the surrender for exchange of Certificates, and such fractional share interests will not entitle the owner thereof to vote or to any rights of a stockholder of Parent. In lieu of such issuance of fractional shares, the Exchange Agent shall pay each holder of Certificates an amount in cash equal to the product obtained by multiplying (A) the fractional share interest to which such holder (after taking into account all shares of Company Common Stock held immediately prior to the Effective Time by such holder) would otherwise be entitled by (B) the Parent Common Stock Price.

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    (f)  Termination of Exchange Fund.  Any portion of the Exchange Fund deposited with the Exchange Agent pursuant to this Section 1.09 which remains undistributed to the holders of the Certificates for six months after the Effective Time shall be delivered to the Parent, upon demand, and any holders of Certificates prior to the Merger who have not theretofore complied with this Article I shall thereafter look only to the Parent and only as general creditors thereof for payment of their claim for Parent Common Stock, cash in lieu of fractional shares of Parent Common Stock and any dividends or distributions with respect to Parent Common Stock to which such holders may be entitled.

    (g)  No Liability.  None of Parent, Merger Sub, the Company or the Exchange Agent shall be liable to any individual, corporation, limited liability company, partnership, association, trust, unincorporated organization, other entity or group (as defined in Section 13(d)(3) of the Exchange Act) (a "Person") in respect of any shares of Parent Common Stock (or dividends or distributions with respect thereto) or cash from the Exchange Fund delivered to a public official pursuant to any applicable abandoned property, escheat or similar law. If any Certificates shall not have been surrendered prior to three years after the Effective Time, or immediately prior to such earlier date on which any Merger Consideration, or any dividends or distributions with respect to Parent Common Stock would otherwise escheat to or become the property of any Governmental Entity, any such Merger Consideration or cash shall, to the extent permitted by applicable law, become the property of the Surviving Corporation, free and clear of all claims or interest of any Person previously entitled thereto.

    (h)  Investment of Exchange Fund.  The Exchange Agent shall invest any cash included in the Exchange Fund, as directed by Parent on a daily basis. Any interest and other income resulting from such investments shall be paid to Parent.

    (i)  Withholding of Tax.  Parent or the Exchange Agent will be entitled to deduct and withhold from the Merger Consideration otherwise payable pursuant to this Agreement to any holder of Company Common Stock such amounts as Parent (or any Affiliate thereof) or the Exchange Agent are required to deduct and withhold with respect to the making of such payment under the Code, or any applicable provision of U.S. federal, state, local or non-U.S. tax law. To the extent that such amounts are properly withheld by Parent or the Exchange Agent, such withheld amounts will be treated for all purposes of this Agreement as having been paid to the holder of the Company Common Stock in respect of whom such deduction and withholding were made by Parent or the Exchange Agent.

    (j)  Lost Certificates.  If any Certificate shall have been lost, stolen or destroyed, upon the making of any affidavit of that fact by the Person claiming such Certificate to be lost, stolen or destroyed, the indemnification by such Person of the Surviving Company and, if required by the Surviving Company, the posting by such Person of a bond in such reasonable amount as the Surviving Company may direct as indemnity against any claim that may be made against it with respect to such Certificate, the Exchange Agent will deliver in exchange for such lost, stolen or destroyed Certificate the applicable Merger Consideration with respect to the shares of Company Common Stock formerly represented thereby.

    SECTION 1.10  Treatment of Options.  (a) At the Effective Time, each outstanding option to purchase Company Common Stock (a "Company Stock Option") issued pursuant to the Company's 1989 Stock Option Plan, 1997 Equity Incentive Plan and 1997 Non-Officer Equity Incentive Plan (collectively with the 1994 Non-Employee Directors' Stock Option Plan, the "Company Stock Plans"), whether vested or unvested, shall be converted into an option (a "Parent Stock Option") to acquire, on the same terms and conditions as were applicable under such Company Stock Option, a number of shares of Parent Common Stock equal to (1) the number of shares of Company Common Stock subject to such Company Stock Option multiplied by (2) the Exchange Ratio, rounded down to the nearest whole share, at a price per share equal to (x) the exercise price per share for such Company Stock Option divided by (y) the Exchange Ratio, rounded up to the nearest whole cent; provided, however,

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that the exercise price per share of each Parent Stock Option held by an individual who is an employee of or consultant to the Company or any Subsidiary as of the Effective Time will not exceed the closing price of a share of Parent Common Stock on the NYSE Composite Transaction Tape on the date immediately prior to the Closing Date.

    (b) Prior to the Effective Time, the board of directors of Parent and its compensation committee, as applicable, shall take all necessary action to assume and adopt, as of the Effective Time, the Company's 1997 Equity Incentive Plan, and shall have the discretion to assume and adopt, as of the Effective Time, each other Company Stock Plan in which a Parent Stock Option is outstanding following the Effective Time and which has not terminated by its terms. Within ten (10) business days after the Effective Time, Parent shall deliver to the holders of Company Stock Options appropriate notices pursuant to the Company Stock Plans. If necessary, Parent shall comply with the terms of the Company Stock Plans and ensure, to the extent required by, and subject to the provisions of, the Company Stock Plans and applicable law, that Company Stock Options that qualified as incentive stock options prior to the Effective Time continue to qualify as incentive stock options after the Effective Time.

    (c) Parent shall take all corporate action necessary to reserve for issuance a sufficient number of shares of Parent Common Stock for delivery upon exercise of Parent Stock Options. No later than five business days after the Effective Time, Parent shall file a registration statement on Form S-3 or Form S-8, as the case may be (or any successor or other appropriate forms), or another appropriate form, with respect to the shares of Parent Common Stock subject to such options to the fullest extent permitted by law and shall use its reasonable best efforts to maintain the effectiveness of such registration statement or registration statements (and maintain the current status of the prospectus or prospectuses contained therein) for so long as such options remain outstanding.

    (d) Each outstanding purchase right under the Stock Purchase Plan shall be exercised for the purchase of shares of Company Common Stock at the price per share determined pursuant to the Stock Purchase Plan on the date immediately prior to the Closing Date, pursuant to Section 12(b)(iii) of the Stock Purchase Plan (the "Final Offering Period"). Immediately following the Final Offering Period and upon or prior to the Effective Time, the Company shall take all action necessary to provide that the Stock Purchase Plan shall be terminated and that no Person has any further right to purchase Company Common Stock under the Stock Purchase Plan.

    SECTION 1.11  Treatment of Debt Securities, Convertible Notes and Company Warrants.  (a) All debt securities of the Company that are outstanding as of the Effective Time shall remain outstanding after the Effective Time in accordance with their respective terms and provisions. Pursuant to the Indenture, dated as of September 22, 2000 (the "Indenture") between the Company and U.S. Bank Trust National Association, as trustee (the "Trustee") and to Section 8.04 of the First Supplemental Indenture, dated as of September 22, 2000 (together with the Indenture, the "Convertible Notes Indenture"), between the Company and the Trustee relating to the Company's 8% Senior Secured Convertible Notes (the "Convertible Notes"), prior to the Effective Time, the Company and Parent shall enter into an agreement providing that (i) each holder of Convertible Notes outstanding at the Effective Time shall have the right to convert such Convertible Notes into the number of shares of Parent Common Stock which would be receivable at the Effective Time by a holder of the number of shares of Company Common Stock deliverable upon conversion of such Convertible Notes immediately prior to the Effective Time, and subject to future adjustments of the conversion price of the Convertible Notes as provided for in Section 8.03 of the Supplemental Indenture and (ii) Parent shall be jointly and severally liable with the Company for the payment and performance by the Company of all of the Company's obligations under the Convertible Notes Indenture, the Notes, the related note purchase agreements and warrants and the other agreements, instruments and documents contemplated thereby.

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    (b) At the Effective Time, each of the warrants to purchase shares of Company Common Stock (the "Company Warrants") which is outstanding and unexercised immediately prior thereto shall, pursuant to the terms of such Company Warrant, cease to represent a right to acquire shares of Company Common Stock and shall be converted automatically into a warrant to purchase such number of shares of Parent Common Stock as the holder of such Company Warrant would have been entitled to receive pursuant to the Merger had such holder exercised such warrant in full immediately prior to the Effective Time, at a price per share equal to (y) the aggregate exercise price for the shares of Company Common Stock otherwise purchasable pursuant to such Company Warrant divided by (z) the number of full shares of Parent Common Stock deemed purchasable pursuant to such Company Warrant, and subject to future adjustments in accordance with the terms of such Company Warrant, provided however that with respect to the Company Warrants issued to members of Reedland Capital Partners, if the value of Parent Common Stock issuable with respect to one share of Company Common Stock immediately prior to the Effective Time is greater than the stock purchase price as defined in such Company Warrants effective at the Effective Time (which price as defined in such Company Warrants is currently $4.0625), such Company Warrants will expire unless exercised prior to the Effective Time.

    (c) Prior to the Effective Time, the Company shall deliver to the holders of Convertible Notes and Company Warrants appropriate notices (in form and substance reasonably satisfactory to Parent) setting forth such holders' rights pursuant to the Convertible Notes Indenture and the applicable warrant agreements with respect thereto to the extent required by the terms of the Convertible Notes Indenture and the applicable warrant agreements.

    (d) Parent shall take all corporate action necessary to reserve for issuance a sufficient number of shares of Parent Common Stock for delivery upon conversion of the Convertible Notes and exercise of the Company Warrants.


ARTICLE II

REPRESENTATIONS AND WARRANTIES OF THE COMPANY

    Except as set forth in the written disclosure schedule dated as of the date of this Agreement and previously delivered by the Company to Parent (the "Company Disclosure Schedule") (it being understood that the Company Disclosure Schedule shall be arranged in sections corresponding to the sections contained in this Agreement, and the disclosures in any section of the Company Disclosure Schedule shall qualify the representations in the corresponding section of this Article II and all applicable representations in other sections of this Article II to the extent that such qualification is readily apparent), the Company hereby represents and warrants to Parent and Merger Sub as follows:

    SECTION 2.01  Organization, Standing and Corporate Power.  Each of the Company and each of its Subsidiaries is duly organized, validly existing and in good standing under the laws of the jurisdiction of its incorporation and has the requisite corporate and authority necessary to own, lease and operate its properties and to carry on its business as it is now being conducted. Each of the Company and each of its Subsidiaries is duly qualified or licensed as a foreign corporation or entity to do business, and is in good standing, in each jurisdiction where the character of its properties owned, leased or operated by it or the nature of its activities makes such qualification or licensing necessary, except where the failure to be so duly qualified or licensed and in good standing would not, individually or in the aggregate, reasonably be expected to have any materially adverse effect on the business, assets, liabilities, financial condition or results of operations of the Company and its Subsidiaries taken as a whole other than any such effect resulting from any change, effect, event, occurrence, state of facts or development relating to the industry in which the Company operates in general and not specifically relating to the Company or on the ability of the Company to perform its obligations under this Agreement (a "Company Material Adverse Effect"). Attached to Section 2.01 of the Company Disclosure

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Schedule are complete and correct copies of the Company's certificate of incorporation, as amended (the "Certificate of Incorporation"), and the Company's by-laws, as amended (the "By-Laws"), as currently in effect.

    SECTION 2.02  Subsidiaries and Minority Investments.  (a) Section 2.02 of the Company Disclosure Schedule sets forth a list of (i) all Subsidiaries of the Company together with the jurisdiction of incorporation or formation of each such Subsidiary and the percentage of each class or type of each such Subsidiary's outstanding Equity Interests owned by the Company or another Subsidiary of the Company and (ii) all Minority Investments of the Company together with the percentage of each class or type of outstanding Equity Interests owned by the Company or another Subsidiary of the Company. Section 2.02 of the Company Disclosure Schedule identifies (i) the certificates of incorporation and by-laws (or equivalent organizational documents) of, and any investor rights, voting, co-sale or other similar agreements applicable to, each of its Subsidiaries (the "Subsidiary Documents") and (ii) any investor rights, voting, co-sale or other agreements to which the Company or its Subsidiaries are party and, to the Knowledge of the Company, the certificates of incorporation and by-laws (or equivalent organizational documents), in each case with respect to each of its Minority Investments (the "Minority Investment Documents"), and the Company has heretofore made available to Parent a true and correct copy of each such Subsidiary Document and Minority Investment Document. Such Subsidiary Documents and Minority Investment Documents are in full force and effect and no other charter or organizational documents or investor rights, voting, co-sale or other similar agreements are applicable to or binding on the Company or its Subsidiaries with respect to the Equity Interests of the Subsidiaries or Minority Investments. None of the Company's Subsidiaries nor, to the knowledge of the employees of the Company set forth on Schedule 2.02 hereto (the "Knowledge of the Company"), any Minority Investment is in violation of any provision of its certificate of incorporation of bylaws or equivalent organizational documents. Neither the Company nor any Subsidiary owns any Equity Interests in any Person other than the Subsidiaries and the Minority Investments. All of the outstanding Equity Interests of the Company's Subsidiaries owned by the Company or its Subsidiaries are duly authorized, validly issued, fully-paid and nonassessable, and all such Equity Interests and all of the Equity Interests of the Minority Investments owned or held by the Company or its Subsidiaries are owned by the Company or another Subsidiary of the Company, free and clear of all security interests, liens, claims, pledges, charges or other encumbrances of any nature whatsoever ("Liens") or any restriction on the right to vote, sell or otherwise dispose of such Equity Interests and were issued in compliance with all applicable federal and state securities Laws.

    (b)  As used herein: (i) "Subsidiary" of the Company or any other Person means any corporation, limited liability company, partnership, joint venture or other entity of which the Company or such other Person, as the case may be (either alone or through or together with any other Subsidiaries), (A) owns, directly or indirectly, 50% or more of the stock or other interests the holders of which are generally entitled to vote for the election of the board of directors or other governing body of such Person (or, if there are no such voting interests, 50% or more of the Equity Interests) or (B) serves as a general partner or managing member; (ii) "Equity Interest" means with respect to any Person, any and all shares, interests, participations, rights in, or other equivalents (however designated and whether voting or non-voting) of, such Person's capital stock or other equity interests (including, without limitation, partnership or membership interests in a partnership or limited liability company or any other interest or participation that confers on a Person the right to receive a share of the profits and loss, or distributions of assets, of the issuing Person) whether outstanding on the date hereof or issued after the date hereof, and any and all warrants, options or other rights to acquire (including without limitation, any securities convertible into or exchangeable for) any such Equity Interests; and (iii) "Minority Investment" of the Company or any other Person means any corporation, limited liability company, partnership, joint venture or other entity of which the Company or such other Person, as the case may be (either alone or through or together with any other Subsidiary), owns, directly or indirectly, more than 5% of the Equity Interests but which is not a Subsidiary of the Company or such other Person.

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    SECTION 2.03  Capital Structure.  (a) The authorized capital stock of the Company consists of 100,000,000 shares of Company Common Stock, par value $.001 per share, and 10,000,000 shares of Company Preferred Stock, par value $.001 per share. As of the close of business on June 7, 2001, there were: (i) 40,048,880 shares of Company Common Stock issued and outstanding; (ii) 9,886 shares of Company Common Stock held in the treasury of the Company and no shares of Company Common Stock held by Subsidiaries of the Company; (iii) 10,644,566 shares of Company Common Stock reserved for issuance upon exercise of Company Stock Options available for grant pursuant to the Company Stock Plans; (iv) 5,260,447 shares of Company Common Stock issuable upon exercise of awarded but unexercised Company Stock Options, with an exercise price per each awarded but unexercised Company Stock Option as set forth in the Company Disclosure Schedule; (v) 289,532 shares of Company Common Stock reserved for issuance pursuant to the Company's Employee Stock Purchase Plan (the "Stock Purchase Plan"); (vi) 1,899,234 shares of Company Common Stock issuable upon exercise of Company Warrants then outstanding and with an exercise price for each such Company Warrant as is set forth in the Company Disclosure Schedule; (vii) 3,682,720 shares of Company Common Stock issuable upon conversion of the Convertible Notes (for which Convertible Notes the conversion price under the Convertible Notes Indenture is $7.06); (viii) no shares of Preferred Stock issued and outstanding; (ix) 500,000 shares of Series A Junior Participating Preferred Stock reserved for issuance pursuant to the Rights Agreement; and (x) no shares of Company Preferred Stock in the treasury of the Company. Except as set forth above, as of June 7, 2001, there were no shares of capital stock or other equity securities of the Company issued, reserved for issuance or outstanding.

    (b) All outstanding shares of capital stock of the Company are, and all shares which may be issued pursuant to the Company Stock Plans and the Company Warrants will be, when issued and paid for in accordance with the terms of the Company Warrants and the Company Stock Plans, duly authorized, validly issued, fully paid and nonassessable and not subject to preemptive rights. All securities issued by the Company were issued in compliance in all material respects with all applicable federal and state securities laws and all applicable rules and regulations promulgated thereunder. No shares of capital stock of the Company are owned by any Subsidiary of the Company.

    (c) Except as set forth in Section 2.03(a), there is no outstanding Indebtedness of the Company having the right to vote (or convertible into, or exchangeable for, securities having the right to vote) on any matters on which stockholders of the Company may vote (collectively, "Voting Debt"). As used herein, "Indebtedness" means, with respect to any Person, without duplication, (i) all obligations of such Person for borrowed money, or with respect to deposits or advances of any kind to such Person, (ii) all obligations of such Person evidenced by bonds, debentures, notes or similar instruments, (iii) all obligations of such Person under conditional sale or other title retention agreements relating to property purchased by such Person, (iv) all obligations of such Person issued or assumed as the deferred purchase price of property or services (excluding obligations of such Person to creditors for raw materials, inventory, services and supplies incurred in the ordinary course of such Person's business), (v) all capitalized lease obligations of such Person, (vi) all obligations of others secured by any Lien on property or assets (excluding encumbrances in the form of restrictions on use of Intellectual Property contained in license agreements or scientific collaboration agreements) owned or acquired by such Person, whether or not the obligations secured thereby have been assumed, (vii) all obligations of such Person under interest rate or currency hedging transactions (valued at the termination value thereof), (viii) all letters of credit issued for the account of such Person and (ix) all guarantees and arrangements having the economic effect of a guarantee of such Person of any Indebtedness of any other Person. Except as set forth in Section 2.03(a), there are no options, warrants or other rights, agreements, arrangements or commitments of any character binding on the Company or any of its Subsidiaries relating to the issued or unissued Equity Interests of the Company or any of its Subsidiaries or obligating the Company or any of its Subsidiaries to issue, sell, repurchase, redeem or otherwise acquire or make any payment with respect to any Equity Interests of the Company or any of

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its Subsidiaries or any Minority Interests held by the Company or any of its Subsidiaries. To the Knowledge of the Company as of the date hereof, there are no irrevocable proxies with respect to shares of capital stock of the Company or any of its Subsidiaries. There are no agreements or arrangements pursuant to which the Company is or could be required to register shares of Company Common Stock or other securities under the Securities Act of 1933, as amended (the "Securities Act").

    (d) Between June 7, 2001 and the date of this Agreement, the Company has not issued or reserved for issuance any Company Common Stock, Company Stock Options or other Equity Interests of the Company, except (i) the issuance of Company Common Stock as a result of the exercise of Company Stock Options outstanding at June 7, 2001 and (ii) upon conversion or exercise of Convertible Notes or Company Warrants outstanding on the date of this Agreement. Between December 31, 2000 and the date of this Agreement, neither the Company nor any of its Subsidiaries has (A) repurchased, redeemed or otherwise acquired any Equity Interests of the Company or any of its Subsidiaries or (B) declared, set aside, made or paid any dividend or distribution in respect of any of its Equity Interests and the board of directors of the Company has not resolved to do any of the foregoing.

    SECTION 2.04  Authority.  The Company has all necessary corporate power and authority to execute and deliver this Agreement and to perform its obligations hereunder and to consummate the Transactions. The execution and delivery of this Agreement by the Company and the consummation by the Company of the Transactions have been duly and validly authorized by all necessary corporate action of the Company other than the adoption of this Agreement by the Company's stockholders in accordance with the DGCL and the Certificate of Incorporation and Bylaws, and no other corporate proceedings on the part of the Company are necessary to authorize this Agreement or to consummate the Merger (other than the adoption of this Agreement by the Company's stockholders in accordance with the DGCL and the Certificate of Incorporation and Bylaws and the filing and recordation of the appropriate documents with respect to the Merger in accordance with the DGCL). This Agreement has been duly and validly executed and delivered by the Company and, assuming the due authorization, execution and delivery hereof by Parent and Merger Sub, constitutes the legal, valid and binding obligation of the Company, enforceable against the Company in accordance with its terms, except to the extent limited by bankruptcy, insolvency, moratorium, fraudulent conveyance, or other Laws affecting the rights of creditors generally, and to the extent that the availability of equitable remedies may be limited by equitable principles.

    SECTION 2.05  Noncontravention.  (a) The execution and delivery of this Agreement by the Company does not, and the performance of this Agreement by the Company and the consummation of the Transactions will not, (i) conflict with or violate the Certificate of Incorporation or Bylaws or the certificate of incorporation or bylaws (or equivalent formation documents) of each of the Subsidiaries of the Company, (ii) assuming that all consents, approvals and authorizations contemplated by clauses (i)-(iv), inclusive, of Section 2.05(b) hereof have been obtained and all filings described in such clauses have been made (and declared effective, if applicable), conflict with or violate any law, statute, ordinance, rule, regulation, order, judgment or decree (collectively, "Laws") applicable to the Company or any of its Subsidiaries or, to the Knowledge of the Company, any of its Minority Investments or by which any of their respective properties is bound or affected, or (iii) result in any breach of or constitute a default (or an event that with notice or lapse of time or both would become a default) under, or give to others any rights of termination, amendment, acceleration or cancellation of, or alteration of rights under or require the consent or approval of any Person under, or result in the creation of a Lien on any of the properties or assets of the Company or any of its Subsidiaries pursuant to, any note, bond, mortgage, indenture, contract, agreement, lease, license, permit, franchise, joint venture, limited liability or partnership agreement or other instrument to which the Company or any of its Subsidiaries is a party or by which the Company or any of its Subsidiaries or any of their respective properties is bound or affected, including any Subsidiary Document and any Minority Investment Document, except, in the case of clauses (ii) and (iii) of this Section 3.05(a), for any conflict, violation,

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breach, default, impairment, right or lack of consent or approval that would not, individually or in the aggregate, reasonably be expected to have a Company Material Adverse Effect.

    (b) The execution and delivery of this Agreement by the Company does not, and the performance of this Agreement by the Company and the consummation of the Transactions by the Company will not, require any consent, approval, authorization or permit of, or filing with or notification to, any federal, state or local court or governmental or regulatory authority or agency, domestic or foreign (each, a "Governmental Entity"), except (i) the filing of a premerger notification and report form by the Company under the HSR Act, (ii) the filing of the Certificate of Merger with the Secretary of State of the State of Delaware and appropriate documents with the relevant authorities of other states in which the Company is qualified to do business, (iii) the filing with the Securities and Exchange Commission (the "SEC") of the Form S-4 and such reports under the Securities Exchange Act of 1934, as amended, and the SEC rules and regulations promulgated thereunder (the "Exchange Act") as may be required in connection with this Agreement and the Transactions, (iv) consents, approvals, authorizations, permits, filings or notifications which have heretofore been obtained or made, as the case may be, by the Company and are in full force and effect or (v) where the failure to obtain such consents, approvals, authorizations or permits, or to make such filings or notifications, would not, individually or in the aggregate, reasonably be expected to have a Company Material Adverse Effect.

    SECTION 2.06  SEC Documents; Financial Statements.  (a) The Company has filed on a timely basis all forms, reports and documents required to be filed with the SEC since January 1, 1998 (all forms, reports and documents filed by the Company with the SEC since January 1, 1998, in each case including all exhibits and schedules thereto and documents incorporated by reference therein, such documents together with any documents filed during such period by the Company with the SEC on a voluntary basis on Current Reports on Form 8-K are referred to herein as the "Company SEC Documents"). The Company SEC Documents (i) complied as to form in all material respects with the requirements of the Securities Act of 1933, as amended, and the SEC rules and regulations promulgated thereunder (the "Securities Act") or the Exchange Act, as the case may be, and the rules and regulations thereunder, each as in effect on the date so filed or amended, and (ii) did not at the time they were filed (or if amended or superseded by a filing then on the date of such filing, which filing must have occurred prior to the date of this Agreement for the Company SEC Documents otherwise filed prior to the date of this Agreement) contain any untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary in order to make the statements therein, in the light of the circumstances under which they were made, not misleading.

    (b) Each of the audited and unaudited consolidated financial statements (including, in each case, any related notes thereto) contained in the Company SEC Documents were prepared in accordance with United States generally accepted accounting principles ("GAAP") applied on a consistent basis throughout the periods involved (except as may be indicated in the notes thereto or in the Company SEC Documents), and each fairly presents the consolidated financial position of the Company and its Subsidiaries at the respective dates thereof and the consolidated results of their operations and cash flows for the periods indicated, except that the unaudited interim financial statements were or are subject to normal and recurring year-end adjustments and do not contain all of the footnote disclosures required by GAAP.

    SECTION 2.07  Undisclosed Liabilities.  Neither the Company nor any of its Subsidiaries has any liabilities or obligations of any nature (whether accrued, absolute, contingent or otherwise) required by GAAP to be recognized or disclosed on a consolidated balance sheet of the Company and its Subsidiaries or in the notes thereto, except (i) liabilities reflected in the consolidated audited balance sheet of the Company as of December 31, 2000 or the notes thereto (the "2000 Balance Sheet") and (ii) liabilities incurred since December 31, 2000 in the ordinary course of business consistent with past practice that, individually or in the aggregate, would not reasonably be expected to have a Company Material Adverse Effect.

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    SECTION 2.08  Information Supplied.  None of the information supplied or to be supplied by the Company for inclusion or incorporation by reference in (i) the registration statement on Form S-4 to be filed with the SEC by Parent in connection with the issuance of Parent Common Stock in the Merger (the "Form S-4"), at the time the Form S-4 is filed with the SEC, at any time it is amended or supplemented or at the time it becomes effective under the Securities Act, or (ii) the Proxy Statement, at the date it is first mailed to the Company's stockholders or at the time of the Stockholders Meeting, will contain any untrue statement of a material fact or omit to state any material fact required to be stated therein or necessary in order to make the statements therein, in the light of the circumstances under which they are made, not misleading. The Proxy Statement will comply as to form in all material respects with the requirements of the Exchange Act and the rules and regulations promulgated thereunder, except that no representation is made by the Company with respect to statements made or incorporated by reference therein based on information supplied in writing by Parent or Merger Sub specifically for inclusion or incorporation by reference therein.

    SECTION 2.09  Absence of Certain Changes or Events.  Since December 31, 2000, the Company has conducted its business only in the ordinary course consistent with past practice, and there is not and has not been: (a) any condition, event or occurrence, individually or in the aggregate, resulting in a Company Material Adverse Effect, (b) any condition, event or occurrence which, individually or in the aggregate, would reasonably be expected to have or give rise to a Company Material Adverse Effect; or (c) any action which, if it had been taken or occurred after the execution of this Agreement, would have required the consent of Parent pursuant to this Agreement.

    SECTION 2.10  Litigation.  There is no suit, claim, action, proceeding or investigation pending or, to the Knowledge of the Company, threatened against the Company or any of its Subsidiaries, or against or involving any properties or rights of the Company or any of its Subsidiaries, which would, individually or in the aggregate, reasonably be expected to result in a Company Material Adverse Effect. Section 2.10 of the Company Disclosure Schedule sets forth as of the date of this Agreement the suits, claims, actions, proceedings and investigations pending, or to the Knowledge of the Company, threatened against the Company or any of its Subsidiaries which if adversely determined would result in a liability to the Company in excess of $500,000. To the Knowledge of the Company, neither the Company nor any of its Subsidiaries nor any of their respective properties is or are subject to any order, writ, judgment, injunction, decree, determination or award having, or which would reasonably be expected to have a Company Material Adverse Effect. To the Knowledge of the Company, as of the date of this Agreement, no officer or director of the Company or any of its Subsidiaries has been served with or otherwise has written notice of a written complaint naming such officer or director as a defendant in any litigation commenced by stockholders of the Company or any of its Subsidiaries with respect to the performance of his or her duties as an officer and/or director of the Company or any of its Subsidiaries under any federal or state Law (including litigation under federal and state securities Laws).

    SECTION 2.11  Labor Matters.  Neither the Company nor any of its Subsidiaries is a party to, or bound by, any collective bargaining agreement, contract or other agreement or understanding with a labor union or labor organization. To the Knowledge of the Company, neither the Company nor any of its Subsidiaries is the subject of any proceeding asserting that it or any Subsidiary has committed an unfair labor practice or seeking to compel it to bargain with any labor organization as to wages or conditions of employment. There is no strike, work stoppage, lock-out or other similar labor dispute involving it or any of its Subsidiaries pending or, to the Knowledge of the Company, threatened; and no employee grievance pending or, to the Knowledge of the Company, threatened against the Company or any of its Subsidiaries which, individually or in the aggregate, would reasonably be expected to have a Company Material Adverse Effect. The Company and each Subsidiary is in compliance with all applicable Laws, agreements, contracts, and policies relating to employment, employment practices, wages, hours, and terms and conditions of employment except for failures so to comply, if any, that

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individually or in the aggregate would not reasonably be expected to have a Company Material Adverse Effect. The Company and its Subsidiaries have complied in all material respects with their payment obligations to all employees of the Company and its Subsidiaries in respect of all wages, salaries, commissions, bonuses, benefits and other compensation due and payable to such employees under any Company policy, practice, agreement, plan, program or any Law. The Company and its Subsidiaries are not liable for any severance pay or other payments to any employee or former employee arising from the termination of employment under any benefit or severance policy, practice, agreement, plan, or program of the Company or any of its Subsidiaries, nor to the Knowledge of the Company will the Company or any of its Subsidiaries have any liability which exists or arises, or may be deemed to exist or arise, under any applicable law or otherwise, as a result of the Transactions. The Company and its Subsidiaries are in compliance with its obligations pursuant to the Worker Adjustment and Retraining Notification Act of 1988 ("WARN"), to the extent applicable. Each employee of the Company or any of its Subsidiaries has signed an agreement with respect to confidentiality, nonsolicitation and assignment of inventions with the Company or such Subsidiary, which agreements are each in the form heretofore provided to Parent.

    SECTION 2.12  Permits; Compliance with Laws.  (a) The Company and its Subsidiaries hold all permits, licenses, variances, exemptions, orders and approvals of all Governmental Entities other than those the failure of which to hold would not reasonably be expected to have a Company Material Adverse Effect (the "Company Permits"). The Company and its Subsidiaries are in material compliance with the terms of the Company Permits.

    (b) The businesses of the Company and its Subsidiaries are not being conducted in violation of any law (domestic or foreign), ordinance or regulation of any Governmental Entity, except for possible violations that, individually or in the aggregate, do not and would not reasonably be expected to have a Company Material Adverse Effect.

    SECTION 2.13  Employee Benefit Plans.  (a) The Company Disclosure Schedule contains a true and complete list of each "employee benefit plan" (within the meaning of section 3(3) of the Employee Retirement Income Security Act of 1974, as amended ("ERISA")) (including, without limitation, multiemployer plans within the meaning of Section 3(37) of ERISA)), stock purchase, stock option, severance, employment, change-in-control, fringe benefit, collective bargaining, bonus, incentive, deferred compensation and all other employee benefit plans, agreements, programs, policies or other arrangements relating to compensation, benefits or entitlements, whether or not subject to ERISA (including any funding mechanism therefor now in effect or required in the future as a result of the Transactions or otherwise), whether formal or informal, oral or written, legally binding or not under which any employee or former employee or director or former director of the Company or any of its Subsidiaries, or any consultant or independent contractor to the Company or any of its Subsidiaries, has any present or future right to benefits or under which the Company or any of its Subsidiaries has any present or future liability. All such plans, agreements, programs, policies and arrangements are herein collectively referred to as the "Company Plans."

    (b) With respect to each Company Plan, the Company has delivered or made available to Parent a current, accurate and complete copy (or, to the extent no such copy exists, an accurate description) thereof and, to the extent applicable, (i) any related trust agreement, annuity contract or other funding instrument; (ii) the most recent IRS determination letter; (iii) the current summary plan description and other written communications (or a description of any oral communications) by the Company to its employees concerning the extent of the benefits provided under a Company Plan; and (iv) for the three most recent years (A) the Form 5500 and attached schedules; (B) audited financial statements; (C) actuarial valuation reports; and (D) attorney's response to an auditor's request for information.

    (c) Each Company Plan has been established and administered in material compliance with its terms and with the applicable provisions of ERISA, the Code and other applicable laws, rules and

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regulations (including the applicable laws, rules and regulations of any foreign jurisdiction), in each case, in all material respects. Each Company Plan that is intended to be qualified within the meaning of Code Section 401(a) is so qualified and has received a favorable determination letter as to its qualification and to the Knowledge of the Company nothing has occurred, whether by action or failure to act, which would cause the loss of such qualification. With respect to any Company Plan, no actions, suits or claims (other than routine claims for benefits in the ordinary course) are pending or, to the best Knowledge of the Company, threatened; to the Knowledge of the Company no facts or circumstances exist which could give rise to any such actions, suits or claims and the Company will promptly notify Parent in writing of any pending claims or, to the Knowledge of the Company, any threatened claims arising between the date hereof and the Effective Time. Neither the Company nor, to the Knowledge of the Company, any other party has engaged in a non-exempt prohibited transaction, as such term is defined under Code Section 4975 or ERISA Section 406, which would subject the Company or Parent or its Subsidiaries to any material taxes, penalties or other liabilities under the Code or ERISA. To the Knowledge of the Company, no event has occurred and no condition exists that would subject the Company, either directly or by reason of its affiliation with any member of its "Controlled Group" (defined as any organization which is a member of a controlled group of organizations within the meaning of Code Sections 414(b), (c), (m) or (o)), to any material tax, fine or penalty imposed by ERISA, the Code or other applicable laws, rules and regulations (including the applicable laws, rules and regulations of any foreign jurisdiction). All insurance premiums required to be paid and all contributions required to be made under the terms of any Company Plan, the Code, ERISA or other applicable laws, rules and regulations (including the applicable laws, rules and regulations of any foreign jurisdiction) as of the Effective Time have been or will be timely paid or made prior thereto and adequate reserves have been provided for on the Company's balance sheet for any premiums (or portions thereof) and for all benefits attributable to service on or prior to the Effective Time. For each Company Plan with respect to which a Form 5500 has been filed, no material change has occurred with respect to the matters covered by the most recent Form since the date thereof. No Company Plan provides for an increase in benefits on or after the Effective Time.

    (d) No Company Plan is subject to Title IV of ERISA, and no Company Plan is a multiemployer plan as defined in Section 4001(A)(3) of ERISA. The Company has never contributed to or sponsored any multiemployer plan or any plan subject to Title IV of ERISA. No Company Plan or related trust is intended to meet the requirements for tax-favored treatment under Code Section 501(c)(9).

    (e) No unfunded Company Plan exists that must be accounted for in accordance with SFAS No. 87, 106 or 112.

    (f)  No Company Plan exists which could result in the payment to any Company employee of any money or other property or rights or accelerate or provide any other rights or benefits to any Company employee as a result of the Transactions, whether or not such payment would constitute a parachute payment within the meaning of Code section 280G, and there is no contract, plan or arrangement (written or otherwise) covering any employee or former employee of the Company or any of its Subsidiaries that, individually or collectively, could give rise to the payment of any amount or receipt of any other rights or benefits that would not be deductible pursuant to the terms of Code section 280G or limitations on deductibility under Code section 162(m).

    SECTION 2.14  Taxes.  Each of the Company and each of its Subsidiaries has timely filed or had filed on its behalf all Tax Returns required to be filed by it and all such returns are true, complete and correct, or requests for extensions to file such Tax Returns have been timely filed, granted and have not expired and has paid all Taxes shown as due on such returns. The Company has provided adequate reserves in its financial statements for any Taxes that have not been paid, whether or not shown as being due on such Tax Returns. No claim for unpaid Taxes has been asserted in writing by a Tax authority or has become a lien against the property of the Company or any of its Subsidiaries (other

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than with respect to Taxes not yet due and payable). No audit or other proceeding with respect to any Taxes due from or with respect to the Company or any of its Subsidiaries or any Tax Return filed by the Company or any of its Subsidiaries is being conducted by any Governmental Entity or Tax authority and the Company and its Subsidiaries have not received notification in writing that any such audit or other proceeding with respect to Taxes or any Tax Return is pending. No extension of the statute of limitations on the assessment of any Taxes has been granted by the Company or any of its Subsidiaries. Neither the Company nor any of its Subsidiaries is subject to liability for Taxes of any Person (other than the Company or its Subsidiaries), arising from the application of Treasury Regulation section 1.1502-6 or any analogous provision of state, local or foreign law, or as a transferee or successor, by contract, or otherwise. None of the Company or any of its Subsidiaries is a party to, is bound by or has any obligation under any Tax sharing or Tax indemnity agreement or similar contract or arrangement. None of the Company or any of its Subsidiaries has been a party to any distribution occurring during the last two years in which the parties to such distribution treated the distribution as one to which Section 355 of the Code is applicable. All Taxes required to be withheld, collected or deposited by or with respect to the Company and each Subsidiary have been timely withheld, collected or deposited as the case may be, and to the extent required, have been paid to the relevant taxing authority. As used herein: (i) 'Taxes" shall mean all taxes of any kind, including, without limitation, those on or measured by or referred to as income, gross receipts, sales, use, ad valorem, franchise, profits, license, withholding, payroll, employment, excise, severance, stamp, occupation, premium, value added, property or windfall profits taxes, customs, duties or similar fees, assessments or charges of any kind whatsoever, together with any interest and any penalties, additions to tax or additional amounts imposed by any Governmental Entity, and (ii) 'Tax Return" shall mean any return, declaration, report, claim for refund, information return or statement relating to Taxes, including any schedule or attachment thereto, and including any amendment thereof.

    SECTION 2.15  Properties.  Except where the failure to have good and valid title would not interfere in any material respect with the conduct of the business of the Company and its Subsidiaries as currently conducted, the Company and each of its Subsidiaries have good title to, or valid leasehold interests in, or otherwise the right to use all their material properties and assets, and such assets and properties at the Effective Time will be free and clear of any Liens except for (a) Liens for current Taxes which are not delinquent, or are being contested in good faith, (b) mechanics', workers', materialmen's and other like Liens arising in the ordinary course of business, (c) zoning ordinances, rights of way, easements, licenses, reservations, covenants, conditions or restrictions on the use of any of the real property which do not, individually or in the aggregate, materially interfere with the use of such real property and (d) encumbrances in the form of restrictions on use of Intellectual Property contained in license agreements or scientific collaboration agreements. Neither the Company nor any of its Subsidiaries is obligated under or bound by any option, right of first refusal, purchase contract, or other contractual right to sell or dispose of any real or personal tangible property or any portions thereof or interests therein which property, portions and interests, either individually or in the aggregate, are material to the Company.

    SECTION 2.16  Environmental Matters.  (a) Except as could not, individually or in the aggregate, reasonably be expected to result in a Company Material Adverse Effect: (i) the Company and each of its Subsidiaries are in compliance with all applicable Environmental Laws, and during all applicable statute of limitations periods have complied with all applicable Environmental Laws; and (ii) neither the Company nor any of its Subsidiaries has, nor would reasonably be expected to have, any obligation to undertake any Remedial Activity, at any property owned or leased by any of them or at any other property.

    (b) The Company has furnished, or made available to Buyer, or to its representatives, true and complete copies of all material Environmental Reports in the possession or control of the Company or of its Subsidiaries, or fairly described to Buyer or to its representatives the contents of such reports.

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    (c) As used herein: (i) 'Environmental Laws" means any and all Laws or other legally enforceable requirements (including, without limitation, common law) of any Governmental Entity, regulating, relating to or imposing liability or standards of conduct concerning protection of the environment or of human health, or employee health and safety; (ii) 'Environmental Report" means any report, study, assessment or audit that addresses any issue of actual or potential noncompliance with, actual or potential liability under or cost arising out of, or actual or potential impact on the business of the Company or any of its Subsidiaries in connection with, any Environmental Law or any proposed or anticipated change in or addition to any Environmental Law relating to the Company or any of its Subsidiaries or any entity for which any of them may be liable; (iii) 'Materials of Environmental Concern" means any gasoline or petroleum (including crude oil or any fraction thereof) or petroleum products, polychlorinated biphenyls, urea-formaldehyde insulation, asbestos, pollutants, contaminants and radioactivity that is regulated pursuant to or could result in liability under any Environmental Law; and (iv) 'Remedial Action" means any action to (A) investigate, clean up, remove or treat any Materials of Environmental Concern, or (B) prevent the release or threat of release of any Materials of Environmental Concern.

    SECTION 2.17  Contracts; Debt Instruments.  (a) Section 2.17(a) of the Company Disclosure Schedule accurately lists as of the date hereof the following contracts, agreements, commitments, arrangements, leases, licenses, policies and instruments, whether written or oral (a "Contract") to which the Company or any of its Subsidiaries is a party or by which it or any of its Subsidiaries is bound (collectively, "Material Contracts"):

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    (b) Neither the Company nor any of its Subsidiaries is, and to the Knowledge of the Company no other party is, in default or breach of any Material Contract, except for those defaults which would not, individually or in the aggregate, reasonably be expected to have a Company Material Adverse Effect, and there has not occurred any event that with the lapse of time or the giving of notice or both would constitute such a default, except for those defaults which would not, individually or in the aggregate, reasonably be expected to have a Company Material Adverse Effect. Each Material Contract constitutes the legal, valid and binding obligation of the Company, enforceable against the Company in accordance with its terms, except to the extent limited by bankruptcy, insolvency, moratorium, fraudulent conveyance, or other Laws affecting the rights of creditors generally, and to the extent that the availability of equitable remedies may be limited by equitable principles, and no Person has the right to terminate or repudiate any Material Contract on less than 30 days prior notice or, to the Knowledge of the Company as of the date hereof, has repudiated any provision of any Material Contract. No claim of a breach of any representation, warranty or covenant and no other claim for indemnification has been made by or against the Company or any of its Subsidiaries under any Acquisition Agreement prior to the date hereof that has not been fully resolved prior to the date hereof. The Company is not a party to any Material Contract that is required to be disclosed as an exhibit to the SEC Documents in accordance with the rules and regulations of the SEC that has not been so disclosed.

    SECTION 2.18  Intellectual Property.  (a) Section 2.18(a) of the Company Disclosure Schedule sets forth all Intellectual Property owned by the Company or its Subsidiaries that is registered or filed with any Governmental Entity (the "Registered Intellectual Property"), all licenses of patented Intellectual Property to or from third parties (the "Licensed Patent Intellectual Property") and all other licenses of Intellectual Property other than licenses generally commercially available on standard terms to or from third parties by the Company or any of its Subsidiaries that are material to the business of the Company and its Subsidiaries (together with the Registered Intellectual Property and the Licensed Patent Intellectual Property, the "Material Intellectual Property"). As used herein, "Intellectual Property" means all rights, privileges and priorities provided under federal, state, foreign and multinational law relating to intellectual property, including without limitation all (i) (A) inventions, discoveries, processes, formulae, designs, methods, techniques, procedures, concepts, developments, technology, new and useful improvements thereof and know-how relating thereto, whether or not patented or eligible for patent protection; (B) copyrights and copyrightable works, including computer applications, programs, software, databases and related items; (C) trademarks, service marks, trade names, brand

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names, corporate names, logos and trade dress, the goodwill of any business symbolized thereby, and all common-law rights relating thereto; (D) trade secrets and other confidential information; and (ii) all registrations, applications, recordings, and licenses or other similar agreements related to the foregoing.

    (b) The Company and its Subsidiaries own or have the right to use all Intellectual Property necessary for the Company and its Subsidiaries to conduct their business substantially as it is currently conducted and consistent with past practice.

    (c) All of the Registered Intellectual Property owned by the Company or any of its Subsidiaries is subsisting and unexpired, has not been abandoned and, to the Knowledge of the Company, does not infringe or otherwise impair the intellectual property rights of any third party. To the Knowledge of the Company, all of the Registered Intellectual Property licensed or used by the Company or any of its Subsidiaries is subsisting and unexpired, has not been abandoned and, to the Knowledge of the Company, does not infringe or otherwise impair the intellectual property rights of any third party. None of the Material Intellectual Property owned by the Company or any of its Subsidiaries is the subject of any license, security interest, Lien or other agreement granting rights therein to any third party other than the Material Contracts. To the Knowledge of the Company, the Company has not misappropriated the trade secrets, technology, know-how, inventions or the like of any third party. No judgment, decree, injunction, rule or order has been rendered by any Governmental Entity which would limit, cancel or question the validity of, or the Company's or its Subsidiaries' rights in and to any Intellectual Property in any respect that could reasonably be expected to have, individually or in the aggregate, a Company Material Adverse Effect. The Company has not received written notice, and does not otherwise have knowledge, of any pending or threatened suit, action or proceeding that seeks to limit, cancel or question the validity of, or the Company's or its Subsidiaries' rights in and to any Intellectual Property, which, if adversely determined, could reasonably be expected to have, individually or in the aggregate, a Company Material Adverse Effect. The Company and its Subsidiaries have taken reasonable steps to protect, maintain and safeguard their material Intellectual Property, including any Material Intellectual Property for which improper or unauthorized disclosure would impair its value or validity, and have executed appropriate nondisclosure agreements and made appropriate filings and registrations in connection with the foregoing.

    SECTION 2.19  Brokers and Other Advisors.  No broker, investment banker, financial advisor or other Person, other than JP Morgan Chase & Co. ("JP Morgan"), the fees and expenses of which will be paid by the Company (pursuant to fee agreements, copies of which have been provided to Parent), is entitled to any broker's, finder's, financial advisor's or other similar fee or commission in connection with the Transactions based upon arrangements made by or on behalf of the Company or any of its Subsidiaries.

    SECTION 2.20  Opinion of Financial Advisor.  The Company has received as of the date of this Agreement the opinion of JP Morgan to the effect that, as of such date, the Merger Consideration is fair, from a financial point of view, to the holders of Company Common Stock (other than Parent and its Affiliates). As used herein, (i) 'Affiliate" means a Person that directly or indirectly, through one or more intermediaries, Controls, is controlled by, or is under common control with, the first mentioned Person; and (ii) 'Control" (including the terms "controlled by" and "under common control with") means the possession, directly or indirectly or as trustee or executor, of the power to direct or cause the direction of the management or policies of a Person, whether through the ownership of stock, as trustee or executor, by contract or credit arrangement or otherwise.

    SECTION 2.21  Board Recommendation; State Antitakeover Law.  The board of directors of the Company, at a meeting duly called and held, has by unanimous vote of those directors present (i) determined that this Agreement and the Transactions, including the Merger, are fair to and in the best interests of the stockholders of the Company and has taken all actions necessary on the part of the Company to render the restrictions on business combinations contained in Section 203 of the DGCL

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inapplicable to this Agreement and the Merger, and (ii) resolved to recommend that the holders of the shares of Company Common Stock approve this Agreement and the Transactions, including the Merger.

    SECTION 2.22  Required Company Vote.  The Company Stockholder Approval, being the affirmative vote of a majority of the outstanding shares of the Company Common Stock, is the only vote of the holders of any class or series of the Company's securities necessary to approve this Agreement, the Merger and the other Transactions.

    SECTION 2.23  Rights Agreement.  The Rights Agreement has been amended so as to provide that neither Parent nor Merger Sub will become an "Acquiring Person" or a "Principal Party" and that no "Shares Acquisition Date" or "Distribution Date" (as such terms are defined in the Rights Agreement) will occur as a result of the approval, execution, delivery or performance of this Agreement or the consummation of the Merger. A true and correct copy of the Rights Agreement as so amended has been delivered to Parent.

    SECTION 2.24  Affiliate Transactions.  As of the date hereof, there are no existing Contracts, transactions, indebtedness or other arrangements, or any related series thereof, between the Company or any of its Subsidiaries, on the one hand, and any of the directors, officers or other Affiliates of the Company and its Subsidiaries, on the other hand.


ARTICLE III

REPRESENTATIONS AND WARRANTIES OF PARENT

    Except as set forth in the written disclosure schedule dated as of the date of this Agreement and previously delivered by Parent to the Company (the "Parent Disclosure Schedule") (it being understood that the Parent Disclosure Schedule shall be arranged in sections corresponding to the sections contained in this Agreement, and the disclosures in any section of the Parent Disclosure Schedule shall qualify all of the representations in the corresponding section of this Article III and all applicable representations in other sections of this Article III to the extent that such qualification is readily apparent), Parent hereby represents and warrants to the Company as follows:

    SECTION 3.01  Organization, Standing and Corporate Power.  Each of Parent, Merger Sub and each of Parent's "significant Subsidiaries" (within the meaning of Rule 1-02 of Regulation S-X of the SEC) (collectively, the "Parent Subsidiaries") is duly organized, validly existing and in good standing under the laws of the jurisdiction of its incorporation or formation and has the requisite corporate or other power and authority necessary to own, lease and operate its properties and to carry on its business as it is now being conducted. Each of Parent, Merger Sub and each of the Parent Subsidiaries is duly qualified or licensed as a foreign corporation or entity to do business, and is in good standing, in each jurisdiction where the character of its properties owned, leased or operated by it or the nature of its activities makes such qualification or licensing necessary, except where the failure to be so duly qualified or licensed and in good standing would not, individually or in the aggregate, reasonably be expected to have any materially adverse effect on the business, assets, liabilities, financial condition or results of operations of Applera Corporation—Celera Genomics Group, taken as a whole, other than any such effect resulting from any change, effect, event, occurrence, state of facts or development relating to the industry in which Parent operates in general and not specifically relating to Parent or on the ability of Parent and Merger Sub to perform its obligations under this Agreement (a "Parent Material Adverse Effect"). Parent has made available to the Company complete and correct copies of its certificate of incorporation and by-laws and the certificate of incorporation and by-laws of Merger Sub.

    SECTION 3.02  Capital Structure.  (a) As of the date of this Agreement, the authorized capital stock of Parent consists of 1,255,000,000 shares of common stock of Parent (consisting of 1,000,000,000 shares of Parent Common Stock and 225,000,000 shares of Applera Corporation—Applied Biosystems

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Group Common Stock, par value $.01 per share ("AB Stock")) and 10,000,000 shares of preferred stock of Parent (the "Parent Preferred Stock"). As of the close of business on June 11, 2001, there were: (i) 61,561,502.74 shares of Parent Common Stock issued and outstanding; (ii) 13,717 shares of Parent Common Stock held in the treasury of Parent; (iii) 14,127,347.26 shares of Parent Common Stock reserved for issuance pursuant to Parent's stock option plans, Parent's employee stock purchase plans and Parent's Director Stock Purchase and Deferred Compensation Plan (collectively, the "Parent Stock Plans"); (iv) 13,018,883 shares of Parent Common Stock issuable upon exercise of awarded but unexercised stock options; (v) 56,350 shares of Parent Common Stock issuable upon exercise of currently outstanding warrants to purchase Parent Common Stock; (vi) 1,432,200 shares of Parent Common Stock issuable upon exercise of an option held by a third party; (vii) 211,265,745.85 shares of AB Stock issued and outstanding; (viii) 5,105 shares of AB Stock held in the treasury of Parent; (ix) 31,613,807.05 shares of AB Stock reserved for issuance pursuant to Parent Stock Plans; (x) 27,811,815 shares of AB Stock issuable upon exercise of awarded but unexercised stock options; (xi) 214,794 shares of AB Stock issuable upon exercise of currently outstanding warrants to purchase AB Stock; and (xii) no shares of Parent Preferred Stock outstanding. Except as set forth above and except for shares of participating junior preferred stock issuable pursuant to the Shareholders' Protection Rights Plan, dated as of April 28, 1999 between Parent and BankBoston, N.A., as of the close of business on June 11, 2001, there were no shares of capital stock or other equity securities of Parent issued, reserved for issuance or outstanding.

    (b) All outstanding shares of capital stock of Parent are, and all shares which may be issued as described above will be, when issued, duly authorized, validly issued, fully paid and nonassessable and not subject to preemptive rights.

    (c) There is no outstanding Voting Debt of Parent. Except as set forth above, there are no options, warrants or other rights, agreements, arrangements or commitments of any character binding on Parent relating to the issued or unissued Equity Interests of Parent or obligating Parent to issue, sell, repurchase, redeem or otherwise acquire or make any payment with respect to any Equity Interests of Parent or any of its Subsidiaries.

    (d) Between June 11, 2001 and the date of this Agreement, Parent has not issued or reserved for issuance any Parent Common Stock or other Equity Interests of Parent, except pursuant to or as permitted by the terms of the Parent Stock Plans. Between December 31, 2000 and the date of this Agreement, Parent has not (A) repurchased, redeemed or otherwise acquired any Equity Interests of Parent or (B) declared, set aside, made or paid any dividend or distribution in respect of any of its Equity Interests (other than regular quarterly cash dividends on AB Stock), and the board of directors of Parent has not resolved to do any of the foregoing.

    (e) As of the date hereof, the authorized capital stock of Merger Sub consists of 1,000 shares of common stock, par value $.01 per share, all of which have been validly issued, are fully paid and nonassessable and are owned by Parent, free and clear of any Lien, and as of the Closing Date, all the issued and outstanding shares of the common stock of Merger Sub will be owned by Parent free and clear of any Lien.

    SECTION 3.03  Authority.  Parent and Merger Sub have all necessary corporate power and authority to execute and deliver this Agreement and to perform their respective obligations hereunder and to consummate the Transactions. The execution and delivery of this Agreement by Parent and Merger Sub and the consummation by Parent and Merger Sub of the Transactions have been duly and validly authorized by all necessary corporate action on the part of Parent and Merger Sub. This Agreement has been duly and validly executed and delivered by each of Parent and Merger Sub and, assuming the due authorization, execution and delivery hereof by the Company, constitutes the legal, valid and binding obligation of each of Parent and Merger Sub, enforceable against such parties in accordance with its terms, except to the extent limited by bankruptcy, insolvency, moratorium,

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fraudulent conveyance, or other Laws affecting the rights of creditors generally, and to the extent that the availability of equitable remedies may be limited by equitable principles. All shares of Parent Common Stock that may be issued pursuant to the Agreement shall when issued in accordance with this Agreement be duly authorized, validly issued, fully paid and nonassessable and not be subject to preemptive rights. The board of directors of Parent has made a determination that as of the Effective Time the assets, business and liabilities of the Company shall be for the benefit of the Celera Genomics Group of Parent and shall be attributed in their entirety to the Celera Genomics Group of Parent as of the Effective Time, in accordance with the provisions of Sections 2.5(a)(i) and 2.6(f) of Parent's certificate of incorporation, as in effect as of the date hereof.

    SECTION 3.04  Noncontravention.  (a) The execution and delivery of this Agreement by each of Parent and Merger Sub does not, and the performance of this Agreement by Parent and Merger Sub and the consummation of the Transactions will not, (i) conflict with or violate the respective certificates of incorporation and by-laws of Parent and Merger Sub, (ii) assuming that all consents, approvals and authorizations contemplated by clauses (i)-(v), inclusive, of Section 3.04(b) hereof have been obtained and all filings described in such clauses have been made (and declared effective, if applicable), conflict with or violate any Laws applicable to Parent or any Parent Subsidiaries or by which any of their respective properties is bound or affected, or (iii) result in any breach of or constitute a default (or an event that with notice or lapse of time or both would become a default) under, or give to others any rights of termination, amendment, acceleration or cancellation of, or alteration of rights under or require the consent or approval of any Person under, or result in the creation of a Lien on any of the properties or assets of Parent or any Parent Subsidiaries pursuant to, any note, bond, mortgage, indenture, contract, agreement, lease, license, permit, franchise, joint venture, limited liability or partnership agreement or other instrument to which Parent or any of its Subsidiaries is a party or by which Parent or any Parent Subsidiaries or any of their respective properties is bound or affected, except, in the case of clauses (ii) and (iii) of this Section 3.04(a), for any conflict, violation, breach, default, impairment, right or lack of consent or approval that would not, individually or in the aggregate, reasonably be expected to have a Parent Material Adverse Effect.

    (b) The execution and delivery of this Agreement by Parent and Merger Sub do not, and the performance of this Agreement by Parent and Merger Sub and the consummation of the Transactions by Parent and Merger Sub will not, require any consent, approval, authorization or permit of, or filing with or notification to, any Governmental Entity, except (i) the filing of a premerger notification and report form by Parent under the HSR Act, (ii) the filing of the Certificate of Merger with the Secretary of State of the State of Delaware and appropriate documents with the relevant authorities of other states in which the Company is qualified to do business, (iii) the filing with the SEC of the Form S-4 and such reports under the Exchange Act as may be required in connection with this Agreement and the Transactions, (iv) consents, approvals, orders, authorizations, registrations, declarations, filings or notices as may be required under the "takeover" or "blue sky" laws of various states, (v) consents, approvals, authorizations, permits, filings or notifications which have heretofore been obtained or made, as the case may be, by Parent and are in full force and effect or (vi) where the failure to obtain such consents, approvals, authorizations or permits, or to make such filings or notifications, would not, individually or in the aggregate, reasonably be expected to have a Parent Material Adverse Effect.

    SECTION 3.05  Parent SEC Documents; Financial Statements.  (a) Parent and its predecessors have filed on a timely basis all forms, reports and documents required to be filed with the SEC since January 1, 1998 (all forms, reports and documents filed by Parent and its predecessors with the SEC since January 1, 1998, in each case including all exhibits and schedules thereto and documents incorporated by reference therein, such documents together with any documents filed during such period by Parent with the SEC on a voluntary basis on Current Reports on Form 8K are referred to herein as the "Parent SEC Documents"). The Parent SEC Documents (i) complied as to form in all material respects with the requirements of the Securities Act or the Exchange Act, as the case may be,

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and the rules and regulations thereunder, each as in effect on the date so filed or amended, and (ii) did not at the time they were filed (or if amended or superseded by a filing, which filing must have occurred prior to the date of this Agreement for the Parent SEC Documents otherwise filed prior to the date of this Agreement, then on the date of such filing) contain any untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary in order to make the statements therein, in the light of the circumstances under which they were made, not misleading.

    (b) Each of the audited and unaudited consolidated financial statements (including, in each case, any related notes thereto) contained in the Parent SEC Documents were prepared in accordance with GAAP applied on a consistent basis throughout the periods involved (except as may be indicated in the notes thereto or in the Parent SEC Documents), and each fairly presents the consolidated financial position of Parent and the Parent Subsidiaries at the respective dates thereof and the consolidated results of their operations and cash flows for the periods indicated, except that the unaudited interim financial statements were or are subject to normal and recurring year-end adjustments and do not contain all of the footnote disclosures required by GAAP.

    SECTION 3.06  Undisclosed Liabilities.  Neither Parent nor any Parent Subsidiary has any liabilities or obligations of any nature (whether accrued, absolute, contingent or otherwise) required by GAAP to be recognized or disclosed on a consolidated balance sheet of Parent and its Subsidiaries or in the notes thereto, except (i) liabilities reflected in the audited consolidated balance sheet of the Parent as of June 30, 2000, and (iii) liabilities incurred since June 30, 2000 in the ordinary course of business consistent with past practice that, individually or in the aggregate, would not reasonably be expected to have a Parent Material Adverse Effect.

    SECTION 3.07  Information Supplied.  None of the information supplied or to be supplied by Parent or Merger Sub for inclusion or incorporation by reference in (i) the Form S-4 will, at the time the Form S-4 is filed with the SEC, at any time it is amended or supplemented or at the time it becomes effective under the Securities Act, or (ii) the Proxy Statement will, at the date it is first mailed to the Company's stockholders or at the time of the Stockholders Meeting, contain any untrue statement of a material fact or omit to state any material fact required to be stated therein or necessary in order to make the statements therein, in the light of the circumstances under which they are made, not misleading. The Form S-4 will comply as to form in all material respects with the requirements of the Securities Act and the rules and regulations promulgated thereunder, except that no representation is made by Parent or Merger Sub with respect to statements made or incorporated by reference therein based on information supplied in writing by the Company specifically for inclusion or incorporation by reference therein.

    SECTION 3.08  Absence of Certain Changes or Events.  Since December 31, 2000, there is not and has not been: (a) any condition, event or occurrence, individually or in the aggregate, resulting in a Parent Material Adverse Effect; (b) any condition, event or occurrence which, individually or in the aggregate, would reasonably be expected to have or give rise to a Parent Material Adverse Effect; or (c) any action which, if it had been taken or occurred after the execution of this Agreement, would have required the consent of the Company pursuant to this Agreement.

    SECTION 3.09  Litigation; Compliance with Laws.  (a) There is no suit, action, arbitration, proceeding or investigation pending, or, to the knowledge of the employees of Parent set forth on Schedule 3.09 hereto (the "Knowledge of Parent"), threatened against Parent or any of its Subsidiaries that, individually or in the aggregate, would reasonably be expected to have a Parent Material Adverse Effect. To the Knowledge of Parent, neither Parent nor any of its Subsidiaries nor any of their respective properties is or are subject to any order, writ, judgment, injunction, decree, determination or award having, or which would reasonably be expected to have, a Parent Material Adverse Effect.

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    (b) The businesses of Parent and its Subsidiaries are not being conducted in violation of any law (domestic or foreign), ordinance or regulation of any Governmental Entity, except for possible violations that, individually or in the aggregate, do not and could not reasonably be expected to have a Parent Material Adverse Effect.

    SECTION 3.10  Brokers.  No broker, investment banker, financial advisor or other Person, other than Morgan Stanley and Co. Incorporated ("Morgan Stanley"), the fees and expenses of which will be paid by Parent, is entitled to any broker's, finder's, financial advisor's or other similar fee or commission in connection with the Transactions based upon arrangements made by or on behalf of Parent or Merger Sub.

    SECTION 3.11  Interim Operations of Merger Sub.  Merger Sub was formed on June 8, 2001 solely for the purpose of engaging in the Transactions, has engaged in no other business activities and has conducted its operations only as contemplated hereby.

    SECTION 3.12  Required Vote.  This Agreement has been approved by Parent, as the sole stockholder of Merger Sub. No other vote of holders of any class or series of securities of Parent or Merger Sub is necessary to approve this Agreement and the Transactions.


ARTICLE IV

COVENANTS RELATING TO CONDUCT OF BUSINESS PRIOR TO MERGER.

    SECTION 4.01  Conduct of Business by the Company.  During the period from the date of this Agreement to the Effective Time, the Company shall, and shall cause its Subsidiaries to, act and carry on their respective businesses in the ordinary course of business consistent with past practice and use its and their respective reasonable best efforts to preserve substantially intact their current business organizations, keep available the services of their current officers and employees and preserve their relationships with customers, suppliers, licensors, licensees, development partners, and others having significant business dealings with them. Without limiting the generality of the foregoing, during the period from the date of this Agreement to the Effective Time, except as provided in Section 4.01 of the Company Disclosure Schedule and except as expressly provided in this Agreement (but excluding for this purpose any provisions of the Company Disclosure Schedule other than those contained in Section 4.01 or 4.03 thereof) the Company shall not, and shall not permit any of its Subsidiaries to:

    (a) (i) declare, set aside or pay any dividends on, or make any other distributions in respect of, any of its capital stock, (ii) split, combine or reclassify any capital stock of the Company or any Subsidiary or issue or authorize the issuance of any other Equity Interests in respect of, in lieu of or in substitution for shares of capital stock of the Company or any Subsidiary, or (iii) purchase, redeem or otherwise acquire any Equity Interests of the Company or any of its Subsidiaries;

    (b) authorize for issuance, issue, deliver, sell, pledge or otherwise encumber any Equity Interest of the Company or any of its Subsidiaries, other than (i) the issuance of Company Common Stock upon the exercise of Company Warrants outstanding on the date of this Agreement in accordance with their present terms, (ii) the issuance of Company Common Stock upon the exercise of Company Stock Options awarded prior to the date of this Agreement but unexercised on the date of this Agreement (or granted after the date hereof in accordance with Section 4.03 hereof) in accordance with their present terms, (iii) the issuance of Company Common Stock pursuant to the Company's Employee Stock Purchase Plan in accordance with its present terms, (iv) the conversion of the Convertible Notes in accordance with their present terms, (v) the issuance of Company Common Stock in order to pay interest on the Convertible Notes, should the Company so elect, in accordance with their present terms and (vi) the sale of shares of capital stock of Akkadix Corporation, DNA Sciences, Inc. or Discovery Partners International, Inc. upon the exercise of options outstanding as of the date hereof pursuant to the 1999 Key Personnel Stock Option Plan;

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    (c) amend (i) the Certificate of Incorporation or By-Laws or the comparable charter or organizational documents of any Subsidiary of the Company or (ii) the Rights Agreement;

    (d) acquire or agree to acquire by merging or consolidating with, or by purchasing a substantial portion of the stock or assets of, or by any other manner, any business or any corporation, partnership, joint venture, association or other business organization or division thereof;

    (e) sell, lease, license, mortgage or otherwise encumber or subject to any Lien or otherwise dispose of (i) any of its properties or assets, other than any such properties or assets the value of which do not exceed $50,000 individually and $250,000 in the aggregate, except the granting of purchase money security interests in the ordinary course of business consistent with past practice or (ii) any Minority Investments or other Equity Interests in any other Person (other than as set forth in Section 4.01(b)(vi));

    (f)  (i) incur any Indebtedness for borrowed money or guarantee any such Indebtedness of another Person, issue or sell any debt securities or warrants or other rights to acquire any debt securities of the Company or any of its Subsidiaries, guarantee any debt securities of another Person, enter into any "keep well" or other agreement to maintain any financial statement condition of another Person or enter into any arrangement having the economic effect of any of the foregoing, except for short-term borrowings incurred in the ordinary course of business consistent with past practice and other than pursuant to equipment lease financing not to exceed $250,000, in the aggregate, or (ii) make any loans, advances or capital contributions to, or Minority Investments or other investments in, any other Person, other than to the Company;

    (g) make or agree to make any capital expenditures, except capital expenditures described in the capital expenditure budget attached as Annex A to Section 4.01(g) of the Company Disclosure Schedule and such additional capital expenditures as do not exceed $50,000 individually and $250,000 in the aggregate; or acquire or agree to acquire any other assets, other than inventory and supplies in the ordinary course of business consistent with past practice;

    (h) (i) waive, release, grant, or transfer any rights of material value or modify or change in any material respect any existing material license, lease, contract or other document, other than in the ordinary course of business consistent with past practice, (ii) pay, discharge or satisfy any claims (including claims of stockholders), liabilities or obligations (absolute, accrued, asserted or unasserted, contingent or otherwise), other than the payment, discharge or satisfaction of liabilities or obligations in the ordinary course of business consistent with past practice or in accordance with their terms as in effect on the date hereof or (iii) settle or compromise any litigation or claim other than settlements or compromises of litigation or claims that do not relate to this Agreement or the Transactions and do not provide for injunctive or similar relief and where the amount paid (after giving effect to insurance proceeds actually received) in settlement or compromise does not exceed $50,000 individually or $250,000 in the aggregate;

    (i)  adopt a plan of complete or partial liquidation or resolutions providing for or authorizing such a liquidation or a dissolution, merger, consolidation, restructuring, recapitalization or reorganization;

    (j)  enter into or amend any collective bargaining agreement;

    (k) enter into or amend in any material respect any Material Contract of the type specified in clause (iii), (v), (vi), (vii) or (viii) of Section 2.17(a) hereof, or any Contract, transaction, indebtedness or other arrangement of the type described in Section 2.24 hereof; or enter into or amend any Material Contract of the type specified in Section 2.17(a)(ii) hereof;

    (l)  change any accounting principle used by it, except as required by GAAP;

    (m) transfer to any Person any rights to its Intellectual Property other than the granting of end-user licenses and the right to grant end-user sublicenses in the ordinary course of business

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consistent with past practice to customers of the Company or its Subsidiaries to the extent such licenses are necessary to permit such customers to use products purchased from the Company or such Subsidiaries;

    (n) enter into or amend any agreement pursuant to which any other party is granted exclusive development, marketing or other exclusive rights of any type or scope with respect to any of its research, products, Intellectual Property or other technology; or

    (o) authorize, or commit or agree to take, any of the foregoing actions.

    SECTION 4.02  Conduct of Business by Parent.  During the period from the date of this Agreement to the Effective Time, Parent shall not (a) declare, set aside or pay any dividends on, or make any other distributions in respect of, Parent Common Stock or (b) split, combine or reclassify the Parent Common Stock or issue or authorize the issuance of any other Equity Interests in lieu of or in substitution for shares of Parent Common Stock.

    SECTION 4.03  Employment Arrangements.  Except as set forth in Section 4.03 of the Company Disclosure Schedule or as expressly provided in this Agreement (but excluding for this purpose any provisions of the Company Disclosure Schedule other than those contained in Section 4.01 or 4.03 thereof):

    (a) Except as may be required by applicable law, neither the Company nor any of its Subsidiaries shall (i) adopt or amend (except as may be required by law) any bonus, profit sharing, compensation, stock option, pension, retirement, deferred compensation, employment or other employee benefit plan, agreement, trust, fund or other arrangement for the benefit or welfare of any employee, director or former director or employee or (ii) increase the compensation or fringe benefits of any director, employee or former director or employee or pay any benefit not required by any existing plan, arrangement or agreement, in the case of clause (ii) other than increases for individuals (other than officers and directors) in the ordinary course of business consistent with past practice.

    (b) neither the Company nor any of its Subsidiaries shall hire or terminate any employee or consultant, except in the ordinary course of business consistent with past practice, and except to the extent required under applicable law or under existing Company Plans.

    (c) Except pursuant to the terms of this Agreement, neither the Company nor any of its Subsidiaries shall grant any new or modified change in control, incentive, severance or termination arrangement or increase or accelerate any benefits payable under its change in control, incentive, severance or termination pay policies in effect on the date hereof.

    (d) Neither the Company nor any of its Subsidiaries shall effectuate a "plant closing" or "mass layoff," as those terms are defined in WARN, affecting in whole or in part any site of employment, facility, operating unit or employee of the Company or any Subsidiary, without notifying Merger Sub or its Affiliates in advance and without complying with the notice requirements and other provisions of WARN.

    (e) Recognizing that the retention of the employees of the Company and its Subsidiaries is to the material benefit of Parent, in the event that the human resources manager, the vice presidents of human resources, medicinal chemistry or biology, the senior vice president of research and pre-clinical development or any other officer of the Company more senior than such senior vice president, receives any written or oral indication from any employee at level 22 or above that such employee intends to terminate his or her employment with the Company or any of its Subsidiaries within sixty (60) days, the Company shall notify Parent within three (3) business days in order that Parent may meet with such employee, provided that in the event any such indication is in the form of a formal written notice of resignation, the Company shall notify Parent by the next business day.

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    SECTION 4.04  Tax Elections.  Neither the Company nor any of its Subsidiaries shall make or change any Tax election, settle or compromise any material federal, state, local or foreign Tax liability, change any annual Tax accounting period, change any method of Tax accounting, file any amended material Tax Return, enter into any closing agreement relating to any material Tax, surrender any right to claim a material Tax refund, or consent to any extension or waiver of the statute of limitations period applicable to any material Tax claim or assessment.

    SECTION 4.05  Tax-Free Reorganization Treatment.  (a) Neither Company nor Parent shall, nor shall they permit any of their respective Subsidiaries to, take or cause to be taken any action that would disqualify the Merger as a reorganization within the meaning of Section 368(a) of the Code.

    (b) Each of the Company and Parent shall report the Merger as a reorganization within the meaning of Section 368 of the Code, unless otherwise required pursuant to a "determination" within the meaning of Section 1313(a) of the Code.

    SECTION 4.06  Other Actions.  Neither the Company nor Parent shall, or shall permit any of their respective Subsidiaries to, (a) intentionally take any action that, if taken on or prior to the date of this Agreement, would have resulted in any of its representations and warranties set forth in this Agreement being untrue in any material respect, or (b) intentionally take any action that would or reasonably might be expected to, result in any of the conditions to the Merger set forth in Article VI not being satisfied. The Company and Parent shall promptly advise the other party orally and in writing of (i) any action of the type set forth in clause (a) above, (ii) the failure by such party to comply with any covenant, condition or agreement hereunder and (iii) any event which could reasonably be expected to cause the conditions set forth in Article VI not being satisfied; provided, however, that no such notice shall affect the representations, warranties, covenants and agreements of the parties or the conditions to their obligations hereunder.


ARTICLE V

ADDITIONAL AGREEMENTS

    SECTION 5.01  Preparation of Form S-4 and Proxy Statement; Stockholder Meeting.  (a) Promptly following the date of this Agreement, the Company shall prepare the proxy statement with respect to the vote by the Company's stockholders with respect to the Transactions (the "Proxy Statement"), and Parent shall prepare and file with the SEC the Form S-4, in which the Proxy Statement will be included. Parent and the Company shall each use its reasonable best efforts to have the Form S-4 declared effective under the Securities Act as promptly as practicable after such filing. The Company will use its reasonable best efforts to cause the Proxy Statement to be mailed to the Company's stockholders as promptly as practicable after the Form S-4 is declared effective under the Securities Act. Parent shall also take any action (other than qualifying to do business in any state in which it is not now so qualified or filing a general consent to service of process) required to be taken under any applicable state securities laws in connection with the registration and qualification of the Parent Common Stock to be issued in the Merger, and the Company shall furnish all information relating to the Company and its stockholders as may be reasonably requested in connection with any such action. The information provided and to be provided by Parent, Merger Sub and the Company, respectively, (i) for use in the Form S-4, at the time the Form S-4 becomes effective, shall be true and correct in all material respects and shall not omit to state a material fact required to be stated therein or necessary to make such information not misleading and (ii) for use in the Proxy Statement, on the date the Proxy Statement is mailed to the Company's stockholders and on the date of the Stockholders Meeting referred to below, shall be true and correct in all material respects and shall not omit to state any material fact required to be stated therein or necessary in order to make such information, in the light of the circumstances under which the statements therein were made, not misleading, and the Company

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and Parent each agree to correct any information provided by it for use in the Form S-4 and the Proxy Statement which shall have become false or misleading.

    (b) All mailings to the Company's stockholders in connection with the Merger, including the Proxy Statement, shall be subject to the prior review, comment and approval of Parent (such approval not to be unreasonably withheld or delayed).

    (c) The Company will, as promptly as practicable following the date of this Agreement and in consultation with Parent, duly call, give notice of, convene and hold a meeting of its stockholders (the "Stockholders Meeting") for the purpose of approving this Agreement and the Transactions to the extent required by the DGCL. The Company will, through its board of directors, recommend to its stockholders approval of the foregoing matters, as set forth in Section 2.21; provided, however, that, subject to compliance with the provisions of Section 5.06 hereof, the board of directors of the Company may fail to make or withdraw or modify such recommendation to the extent permitted by Section 5.06. Any such recommendation, together with a copy of the opinion referred to in Section 2.20, shall be included in the Proxy Statement. The Company will use its best efforts to hold such meeting as soon as practicable after the Form S-4 shall have been declared effective.

    SECTION 5.02  Access to Information; Confidentiality.  The Company shall, and shall cause its Subsidiaries, officers, employees, counsel, financial advisors and other representatives to, afford to Parent and its representatives reasonable access during normal business hours, during the period prior to the Effective Time to its properties, books, contracts, commitments, personnel and records, and, during such period, the Company shall, and shall cause its Subsidiaries, officers, employees and representatives to, furnish or make available promptly to Parent (i) a copy of each report, schedule, registration statement and other document filed by it during such period pursuant to the requirements of federal or state securities laws and (ii) all other information concerning its business, properties, financial condition, operations and personnel as Parent may from time to time reasonably request. Each of the Company and Parent will hold, and will cause their respective directors, officers, employees, accountants, counsel, financial advisors and other representatives and Affiliates to hold, any nonpublic information with respect to the other party in confidence to the extent required by, and in accordance with, the provisions of the confidentiality agreement, dated April 2, 2001, between Parent and the Company (the "Confidentiality Agreement"). No investigation pursuant to this Section 5.02 shall affect any representations or warranties of the parties herein or the conditions to the obligations of the parties hereto.

    SECTION 5.03  Reasonable Best Efforts.  Upon the terms and subject to the conditions set forth in this Agreement, each of the parties hereto agrees to use its reasonable best efforts to take, or cause to be taken, all actions, and to do, or cause to be done, and to assist and cooperate with the other parties hereto in doing, all things necessary, proper or advisable under applicable laws and regulations to consummate and make effective, in the most expeditious manner practicable, the Merger and the other Transactions, including (i) obtaining all consents, approvals, waivers, licenses, permits or authorizations as are required to be obtained (or, which if not obtained, would result in an event of default, termination or acceleration of any agreement or any put right under any agreement) under any applicable law or regulation or from any Governmental Entities or third parties in connection with the Transactions and (ii) defending any lawsuits or other proceedings challenging this Agreement. Notwithstanding anything to the contrary contained herein, no party hereto nor any of their Affiliates shall be required to make any disposition of or enter into any agreement to hold separate, any Subsidiary, asset or business, or take any other action that Parent determines could significantly reduce the value of the Company or the benefits that Parent expects to derive from the Merger, and the Company and its Subsidiaries shall not agree to take any such action without the prior written consent of Parent.

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    SECTION 5.04  Indemnification.  (a) To the fullest extent permitted under applicable law Parent shall, and shall cause the Surviving Company to indemnify and hold harmless, each present and former director or officer of the Company or any of its Subsidiaries and their respective estates, heirs, personal representatives successors and assigns (each, an "Indemnified Party," and collectively, the "Indemnified Parties") against any costs or expenses (including reasonable fees and expenses of counsel) as incurred, judgments, fines, losses, claims, damages, liabilities and amounts paid in settlement in connection with any claim, action, suit, proceeding or investigation, whether civil, criminal, administrative or investigative (collectively, an "Action") (x) arising out of or pertaining to the Transactions, or (y) in whole or in part on or arising in whole or in part out of the fact that such Person is or was a director, officer or employee of the Company, with respect to any acts or omissions occurring at or prior to the Effective Time, to the same extent as provided in the Certificate of Incorporation or By-laws as in effect on the date hereof, or the Company's indemnification contracts with the Indemnified Parties (to the extent such contracts have been disclosed to Parent and are identified in Section 5.04 of the Company Disclosure Schedule), to the extent permitted by applicable Law in each case for a period of six years after the date hereof. In the event of any such Action, (whether arising before or after the Effective Time) and subject to the specific terms of any indemnification contract, (i) any counsel retained by the Indemnified Parties for any period after the Effective Time shall be reasonably satisfactory to the Surviving Company (it being understood that Latham & Watkins is acceptable to Parent and the Surviving Corporation), (ii) after the Effective Time, the Surviving Company shall pay the reasonable fees and expenses of such counsel, promptly after statements therefor are received, and (iii) the Surviving Company will cooperate in the defense of any such Action; provided, however, that in the event any claim or claims for indemnification are made within such six year period, all rights to indemnification in respect of any such claim or claims shall continue until the disposition of any and all such claims; provided, further, that: (A) promptly after receipt by an Indemnified Party of notice of any such Action, the Indemnified Party shall, if a claim in respect thereof is to be made against the Surviving Company notify the Surviving Company in writing of this claim or the commencement of that Action and shall deliver to Parent and the Surviving Corporation the undertaking, if any, required by Section 145(e) of the DGCL; (B) the Surviving Company shall be entitled to participate in the defense of any such Action, and, to the extent it wishes, assume the defense thereof with counsel reasonably satisfactory to the Indemnified Party or Indemnified Parties, as the case may be; (C) the Surviving Company shall not, in connection with any one such Action or separate but substantially similar or related Actions in the same jurisdiction arising out of the same general allegations or circumstances, be liable for the reasonable fees and expenses of more than one separate firm of attorneys at any time for all such Indemnified Parties as a group unless there is, under applicable standards of professional conduct, a conflict between the positions of any two or more Indemnified Parties that would preclude or render inadvisable joint or multiple representation of such parties; (D) no Indemnified Party may settle any such Action, without the prior written consent of the Surviving Company; and (E) the Surviving Company shall not settle any such Action, unless the Indemnified Party that is subject of such action is fully released as a result thereof.

    (b) Parent shall cause to be maintained in effect for six years from the Effective Time directors' and officers' liability insurance coverage covering Persons who are directors and officers of the Company on the date of this Agreement, with respect to matters occurring prior to the Effective Time, and containing terms and conditions which are not less advantageous to such Persons than the policies of the Company in effect on the date hereof (the "Company Insurance"); provided that Parent shall not be required to spend annually in excess of 200% of the annual premium for the Company Insurance paid by the Company as of the date of this Agreement.

    (c) Nothing in this Agreement is intended to, shall be construed to or shall release, waive or impair any rights to directors' and officers' insurance claims under any policy that is or has been in existence with respect to the Company or any of its officers, directors or employees, it being

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understood and agreed that the indemnification provided for in this Section 5.04 is not prior to or in substitution for any such claims under such policies.

    SECTION 5.05  Public Announcements.  Neither Parent and Merger Sub, on the one hand, nor the Company, on the other hand, will issue any press release or public statement with respect to the Transactions without the other party's prior consent (such consent not to be unreasonably withheld or delayed), except as may be required by applicable law, court process or by obligations pursuant to any agreement with any securities exchange or quotation system on which securities of the disclosing party are listed or quoted. In addition to the foregoing, Parent, Merger Sub and the Company will consult with each other before issuing, and provide each other the opportunity to review and comment upon, any such press release or other public statements with respect to such transactions. The parties agree that the initial press release or releases to be issued with respect to the Transactions shall be mutually agreed upon prior to the issuance thereof. The provisions of this Section 5.05 shall not affect the obligations of the parties under Section 5.02 hereof or under the Confidentiality Agreement.

    SECTION 5.06  No Solicitation.  Neither the Company nor any of its Subsidiaries shall (whether directly or indirectly through advisors, agents or other intermediaries), nor shall the Company or any of its Subsidiaries authorize or permit any of its or their officers, directors, agents, representatives, advisors or Subsidiaries to, (a) solicit, initiate or take any action knowingly to facilitate the submission of inquiries, proposals or offers from any Person (other than Merger Sub or Parent) relating to (i) any acquisition or purchase of 15% or more of the consolidated assets of the Company and its Subsidiaries or of over 15% of any class of equity securities of the Company or any of its Subsidiaries, (ii) any tender offer (including a self tender offer) or exchange offer that if consummated would result in any Person beneficially owning 15% or more of any class of equity securities of the Company or any of its Subsidiaries, or (iii) any merger, consolidation, business combination, sale of substantially all assets, recapitalization, liquidation, dissolution or similar transaction involving the Company or any of its Subsidiaries whose assets, individually or in the aggregate, constitute more than 15% of the consolidated assets of the Company other than the Transactions (collectively, "Transaction Proposals"), or agree to or endorse any Transaction Proposal, or (b) enter into or participate in any discussions or negotiations regarding any actual or potential Transaction Proposal (other than with Merger Sub or Parent), or furnish to any other Person (other than Merger Sub or Parent), any non-public information with respect to its business, properties or assets in connection with any actual or potential Transaction Proposal, or otherwise knowingly assist or participate in, cooperate with, facilitate or encourage, any effort or attempt by any other Person (other than Merger Sub or Parent) to do or seek any of the foregoing; provided, however, that neither the foregoing nor any provision of this Agreement shall prohibit the Company (either directly or indirectly through advisors, agents or other intermediaries), from taking any of the following actions in the event a Third Party has made a bona fide Transaction Proposal that the Company's board of directors determines in good faith could result in a Superior Proposal, subject in each case to compliance with the other provisions of this Section 5.06: (A) furnishing information pursuant to an appropriate confidentiality letter (which letter shall not be less favorable to the Company in any material respect than the Confidentiality Agreement) concerning the Company and its businesses, properties or assets to such Third Party, (B) engaging in discussions or negotiations with such Third Party, (C) taking and disclosing to its stockholders a position as required by Rule 14d-9 or Rule 14e-2(a) under the Exchange Act, or (D) failing to make or withdrawing or modifying its recommendation referred to in Sections 2.21 and 5.01(c), but in each case referred to in clauses (A) through (D) only to the extent that the board of directors of the Company shall have concluded in good faith in consultation with outside counsel that the failure to take such action would violate the fiduciary duties of the board of directors of the Company to the stockholders of the Company under applicable law; provided, further, that the board of directors of the Company shall not take any of the foregoing actions referred to in clauses (A) through (D) until after reasonable notice to Parent with respect to such action. If the board of directors of the Company receives a Transaction Proposal, then the Company shall promptly inform Parent of all of the material terms and conditions of

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such proposal and the identity of the Person making it and shall keep Parent informed on a prompt and current basis of the status, terms and content of any discussions regarding such Transaction Proposal, including any changes to the terms of such Transaction Proposal. The Company will immediately cease and cause its advisors, agents and other intermediaries to cease any and all existing activities, discussions or negotiations with any parties conducted heretofore with respect to any actual or potential Transaction Proposal, and shall use its reasonable best efforts to cause any such parties in possession of confidential information about the Company that was furnished by or on behalf of the Company to return or destroy all such information in the possession of any such party or in the possession of any agent or advisor of any such party. As used herein, a "Superior Proposal" means any of the transactions described in clause (i), (ii) or (iii) of the definition of Transaction Proposal (with all of the percentages included in the definition of such term raised to 50% for purposes of this definition) with respect to which the board of directors of the Company shall have concluded in good faith, after consultation with its outside legal counsel and its financial advisor(s), is reasonably capable of being completed (including the presence of financing commitments, if applicable) and represents a financially superior transaction for the holders of Company Common Stock to the Merger. Notwithstanding anything to the contrary contained in this Section 5.06 or elsewhere in this Agreement, prior to the Effective Time, the Company may, in connection with a possible Acquisition Proposal, refer any third party to this Section 5.06, Section 7.01 and Section 8.02 and make a copy of such sections available to a Third Party.

    SECTION 5.07  Benefit Matters.  (a) During the period from the Effective Time until July 1, 2002, employees of the Company shall participate in employee benefit plans (as defined in Section 3(3) of ERISA), but including any vacation or paid time off benefits and excluding any stock compensation plans, programs and arrangements (collectively, "Included Benefits") maintained by Parent or the Surviving Corporation providing benefits no less favorable, in the aggregate, than those benefits provided under the Included Benefits of the Company in effect on the date hereof. Notwithstanding the foregoing, the standard for maintenance of benefits shall apply to the Company's Holiday Bonus Plan only until December 31, 2001.

    (b) Parent will cause the Surviving Corporation to (i) waive all limitations as to preexisting conditions, exclusions and waiting periods with respect to participation and coverage requirements applicable to the employees of the Company under any Parent welfare plan that such employees may be eligible to participate in after the Effective Time and (ii) provide each employee of the Company with credit for any co-payments and deductibles paid prior to the Effective Time in satisfying any applicable deductible or out-of-pocket requirements under any Parent welfare plans that such employees are eligible to participate in after the Effective Time.

    (c) On and after the Effective Time, Parent shall cause the Surviving Company and any employee benefit plans maintained by Parent or the Surviving Company in which employees of the Company and Subsidiaries participate to recognize the service with the Company and Subsidiaries of each such employee for purposes of determining entitlement to vacation and vacation pay and for purposes of vesting and eligibility under any employee benefit plan, but not for purposes of benefit accrual under any "employee pension benefit plan" as defined in Section 3(2) of ERISA. Such service shall be determined in accordance with the practices and procedures of the Company and the Company Plans in effect immediately prior to the Effective Time, as if such service had been rendered to Parent.

    SECTION 5.08  Stock Exchange Listing.  Parent shall use all reasonable efforts to cause the shares of Parent Common Stock to be issued in the Merger and the shares of Parent Common Stock to be reserved for issuance upon exercise of Company Stock Options, Company Warrants and the Convertible Notes to be approved for listing on the NYSE.

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    SECTION 5.09  Letters of the Company's Accountants.  The Company shall use its reasonable best efforts to cause to be delivered to Parent a comfort letter of Ernst & Young LLP, the Company's independent public accountants, dated a date within two business days before the Form S-4 shall become effective and a comfort letter of Ernst & Young LLP dated a date within two business days before the Closing Date, each addressed to Parent, in form and substance reasonably satisfactory to Parent and customary in scope and substance for letters delivered by independent public accountants in connection with registration statements similar to the Form S-4.

    SECTION 5.10  Rights Agreement.  The board of directors of the Company shall take all action (in addition to that referred to in Section 2.23 hereof) necessary or desirable (including amending the Rights Agreement) in order to render the Rights inapplicable to the Merger and the other Transactions. Except in connection with the foregoing sentence, the board of directors of the Company shall not, without the prior written consent of Parent, (a) amend the Rights Agreement or (b) take any action with respect to, or make any determination under, the Rights Agreement, in each case in order to facilitate any Transaction Proposal.

    SECTION 5.11  Convertible Notes.  Prior to the Effective Time, the board of directors of the Company shall take all action necessary to determine that the provisions referred to in Sections 1.11(a)(i) and 1.11(a)(ii) hereof shall constitute all such provisions as are necessary to protect the interest of the holders of the Convertible Notes pursuant to the terms thereof, including without limitation pursuant to Section 8.04(a) of the Convertible Notes Indenture.

    SECTION 5.12  Non-solicitation of Employees.  Each of Parent and the Company agrees that for a period of one (1) year following a termination of this Agreement, such party shall not, and shall cause its Subsidiaries not to, raid the employees employed by the other party or its Subsidiaries, in violation of California legal principles. For the avoidance of doubt, the foregoing provision will not prevent a party from hiring any employee (a) as a result of a general public solicitation or a solicitation conducted through a third-party recruiter or similar agent to whom the soliciting party has not identified such employee, (b) who contacts such soliciting party on his or her own initiative without any solicitation from the soliciting party, or (c) who has not been employed by the other party during the preceding six (6) months.

    SECTION 5.13  Stock Options.  In the event the Parent or any of its Subsidiaries terminates the employment of any employee of the Company without cause within ninety (90) days after the Effective Time, Parent will cause all vested Parent Stock Options issued pursuant to Section 1.10 hereof held by such terminated employee to be amended to provide that the exercise period for such vested Parent Stock Options shall be extended so as to permit their exercise by such terminated employee for a period of twelve (12) months after the date of his or her termination of employment; provided, however, that any such amendment to a Parent Stock Option intended to qualify as an "incentive stock option" within the meaning of Section 421 of the Code shall be subject to the consent of such terminated employee. For the avoidance of doubt, this Section 5.13 does not provide for any changes to the vesting provisions contained in any Parent Stock Option.


ARTICLE VI

CONDITIONS PRECEDENT

    SECTION 6.01  Conditions to Each Party's Obligation To Effect the Merger.  The respective obligation of each party to effect the Merger is subject to the satisfaction or waiver on or prior to the Closing Date of the following conditions:

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    SECTION 6.02  Conditions to Obligations of Parent and Merger Sub.  The obligations of Parent and Merger Sub to effect the Merger are further subject to the following conditions:

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    SECTION 6.03  Conditions to Obligation of the Company.  The obligation of the Company to effect the Merger is further subject to the following conditions:


ARTICLE VII

TERMINATION, AMENDMENT AND WAIVER

    SECTION 7.01  Termination.  This Agreement may be terminated and abandoned at any time prior to the Effective Time, whether before or after the Company Stockholder Approval:

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    SECTION 7.02  Effect of Termination.  In the event of termination of this Agreement by either the Company or Parent as provided in Section 7.01, this Agreement shall forthwith become void and have no effect, without any liability or obligation on the part of Parent, Merger Sub or the Company, other than the provisions of Sections 2.19, 3.10, the penultimate sentence of 5.02, 5.12, 8.02 and 8.07 hereof, and this Section 7.02. Nothing contained in this Section shall relieve any party for any breach of the representations, warranties, covenants or agreements set forth in this Agreement.

    SECTION 7.03  Amendment.  This Agreement may be amended by the parties at any time before or after any required approval of matters presented in connection with the Merger by the stockholders of the Company; provided, however, that after any such approval, there shall be made no amendment that by law requires further approval by such stockholders without the further approval of such stockholders. This Agreement may not be amended except by an instrument in writing signed on behalf of each of the parties.

    SECTION 7.04  Extension; Waiver.  At any time prior to the Effective Time, the parties may (a) extend the time for the performance of any of the obligations or other acts of the other parties,

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(b) waive any inaccuracies in the representations and warranties contained in this Agreement or in any document delivered pursuant to this Agreement or (c) subject to the proviso contained in Section 7.03 hereof, waive compliance with any of the agreements or conditions contained in this Agreement. Any agreement on the part of a party to any such extension or waiver shall be valid only if set forth in an instrument in writing signed on behalf of such party. The failure of any party to this Agreement to assert any of its rights under this Agreement or otherwise shall not constitute a waiver of such rights.

    SECTION 7.05  Procedure for Termination, Amendment, Extension or Waiver.  A termination of this Agreement pursuant to Section 7.01, an amendment of this Agreement pursuant to Section 7.03 or an extension or waiver pursuant to Section 7.04 shall, in order to be effective, require in the case of Parent, Merger Sub or the Company, action by its board of directors or the duly authorized designee of its board of directors.


ARTICLE VIII

GENERAL PROVISIONS

    SECTION 8.01  Nonsurvival of Representations and Warranties.  None of the representations and warranties in this Agreement or in any instrument delivered pursuant to this Agreement shall survive the Effective Time and all such representations and warranties will be extinguished on consummation of the Merger and neither the Company, the Parent, Merger Sub, nor any officer, director or employee or shareholder of any of them shall be under any liability whatsoever with respect to any such representation or warranty after such time. This Section 8.01 shall not limit any covenant or agreement of the parties that by its terms contemplates performance after the Effective Time.

    SECTION 8.02  Fees and Expenses.  (a) (i) If this Agreement shall have been terminated by either party pursuant to Section 7.01(d) or by Parent pursuant to Section 7.01(g)(ii) as a result of a willful breach by the Company of this Agreement following the occurrence of any event specified in clause (x) below) and the following shall have occurred:

then the Company shall, (1) in the case of clause (a)(ii) above, promptly, but in no event later than one (A) business day after the termination of this Agreement pursuant to Section 7.01(e) or (B) the date of termination in the case of a termination under Section 7.01(f) and (2) in the case of clause (a)(i) above, promptly, but in no event later than one business day after an event specified in subclause (y) thereof shall have occurred, pay Parent a fee in cash of $5,600,000 plus out-of-pocket fees and expenses incurred by Parent not exceeding $900,000, which amount shall be payable in same day funds. No termination of this Agreement shall be effective until such fee is paid. For purposes of clauses (a)(i)(y) above, the term "Takeover Proposal" shall have the same meaning assigned to such term in Section 5.06 except that all references therein to "15%" shall be deemed to be references to "35%."

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    (b) Except as provided otherwise in Section 7.02(a) above, all costs and expenses incurred in connection with this Agreement and the Transactions shall be paid by the party incurring such expenses, except that the cost of filing, printing and distributing the Proxy Statement and the Form S-4 shall be borne seventy-five percent (75%) by Parent and twenty-five percent (25%) the Company.

    SECTION 8.03  Notices.  All notices, requests, claims, demands and other communications under this Agreement shall be in writing and shall be deemed given if delivered personally or sent by overnight courier (providing proof of delivery) to the parties at the following addresses (or at such other address for a party as shall be specified by like notice):


 

 

(a)

 

if to Parent or Merger Sub, to

 

 

 

 

Applera Corporation
301 Merrit 7
Norwalk, CT 06851-1070
Attention: General Counsel

 

 

 

 

with a copy to:

 

 

 

 

Simpson Thacher & Bartlett
3330 Hillview Avenue
Palo Alto, CA 94304
Attention: Richard Capelouto, Esq.

 

 

(b)

 

if to the Company, to

 

 

 

 

Axys Pharmaceuticals, Inc.
180 Kimball Way
South San Francisco, CA 94080
Attention: General Counsel

 

 

 

 

with a copy to:

 

 

 

 

Latham & Watkins
135 Commonwealth Drive
Menlo Park, CA 94025
Attention: Ora T. Fisher, Esq.

    SECTION 8.04  Interpretation.  When a reference is made in this Agreement to a Section, Exhibit or Schedule, such reference shall be to a Section of, or an Exhibit or Schedule to, this Agreement unless otherwise indicated. The table of contents and headings contained in this Agreement are for reference purposes only and shall not affect in any way the meaning or interpretation of this Agreement. Whenever the words "include," "includes" or "including" are used in this Agreement, they shall be deemed to be followed by the words "without limitation".

    SECTION 8.05  Counterparts.  This Agreement may be executed in one or more counterparts, all of which shall be considered one and the same agreement and shall become effective when one or more counterparts have been signed by each of the parties and delivered to the other parties.

    SECTION 8.06  Entire Agreement; No Third-Party Beneficiaries.  This Agreement and the Confidentiality Agreement and the other agreements referred to herein constitute the entire agreement, and supersede all prior agreements and understandings, both written and oral, among the parties with respect to the subject matter of this Agreement. This Agreement, other than Article I and Section 5.04, is not intended to confer upon any Person other than the parties any rights or remedies.

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    SECTION 8.07  GOVERNING LAW.  THIS AGREEMENT SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF DELAWARE, REGARDLESS OF THE LAWS THAT MIGHT OTHERWISE GOVERN UNDER APPLICABLE PRINCIPLES OF CONFLICTS OF LAWS.

    SECTION 8.08  Assignment.  Neither this Agreement nor any of the rights, interests or obligations under this Agreement shall be assigned, in whole or in part, by operation of law or otherwise by any of the parties without the prior written consent of the other parties. Subject to the preceding sentence, this Agreement will be binding upon, inure to the benefit of, and be enforceable by, the parties and their respective successors and assigns.

    SECTION 8.09  Enforcement.  The parties agree that irreparable damage would occur in the event that any of the provisions of this Agreement were not performed in accordance with their specific terms or were otherwise breached. It is accordingly agreed that the parties shall be entitled to an injunction or injunctions to prevent breaches of this Agreement and to enforce specifically the terms and provisions of this Agreement.

    IN WITNESS WHEREOF, Parent, Merger Sub and the Company have caused this Agreement to be signed by their respective officers thereunto duly authorized, all as of the date first written above.


 

 

APPLERA CORPORATION

 

 

By:

 

/s/ Peter Barrett

        Name:   Peter Barrett
        Title:   Vice President

 

 

ANGEL ACQUISITION SUB, INC.

 

 

By:

 

/s/ Peter Barrett

        Name:   Peter Barrett
        Title:   President

 

 

AXYS PHARMACEUTICALS, INC.

 

 

By:

 

/s/ Paul J. Hastings

        Name:   Paul J. Hastings
        Title:   President and Chief Executive Officer

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Annex B

[JP MORGAN H&Q LETTERHEAD]

June 12, 2001

STRICTLY CONFIDENTIAL

The Board of Directors
Axys Pharmaceuticals, Inc.
180 Kimball Way
South San Francisco, CA 94080

Members of the Board of Directors:

You have requested our opinion as to the fairness, from a financial point of view, to the holders of common stock, par value $0.001 per share (the "Company Common Stock"), of Axys Pharmaceuticals, Inc. (the "Company") of the Exchange Ratio (as defined below), based upon the trading price of the Merger Partner Common Stock as of the date hereof, in the proposed merger (the "Merger") of Angel Acquisition Sub, Inc. (the "Merger Sub"), a wholly owned subsidiary of Applera Corporation (the "Merger Partner") with and into the Company. Pursuant to the Agreement and Plan of Merger (the "Agreement"), among the Merger Partner, the Merger Sub, and the Company, the Company will become a wholly owned subsidiary of the Merger Partner, and each outstanding share of Company Common Stock, other than shares of Company Common Stock held in treasury or owned by the Merger Partner or the Merger Sub, will be converted into the right to receive shares of the Merger Partner—Celera Genomics Group common stock, par value $0.01 per share (the "Merger Partner Common Stock") equal to an exchange ratio (the "Exchange Ratio") determined based on the average of the closing sales prices ("Merger Partner Common Stock Price") of the Merger Partner Common Stock on the New York Stock Exchange Composite Transactions Tape on each of the 10 consecutive trading days immediately preceding the second trading day prior to the Effective Time (as such term is defined in the Agreement).

The Exchange Ratio shall be determined as follows: (a) if the Merger Partner Common Stock Price is equal to or greater than $45.77 and less than or equal to $48.23, then the Exchange Ratio shall mean 0.1016; (b) if the Merger Partner Common Stock Price is greater than $48.23, then the Exchange Ratio shall mean $4.90 divided by the Merger Partner Common Stock Price, but in no event less than 0.0813; and (c) if the Merger Partner Common Stock Price is less than $45.77, then the Exchange Ratio shall mean $4.65 divided by the Merger Partner Common Stock Price, but in no event greater than 0.1355.

In arriving at our opinion, we have (i) reviewed a draft of the Agreement dated June 11, 2001; (ii) reviewed certain publicly available business and financial information concerning the Company and the Celera Genomics Group, a business of Merger Partner that is the tracking business of the Merger Partner underlying the Merger Partner Common Stock, a trading stock issued by the Merger Partner, and the industries in which they operate; (iii) compared the proposed financial terms of the Merger with the publicly available financial terms of certain transactions involving companies we deemed relevant and the consideration received for such companies; (iv) compared the financial and operating performance of the Company and the Celera Genomics Group with publicly available information concerning certain other companies we deemed relevant and reviewed the current and historical market prices of the Company Common Stock and the Merger Partner Common Stock and certain publicly traded securities of such other companies; (v) reviewed certain internal financial analyses and forecasts prepared by the management of the Company relating to its business; and (vi) performed such other

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financial studies and analyses and considered such other information as we deemed appropriate for the purposes of this opinion.

In addition, we have held discussions with certain members of the management of the Company and the representatives of Celera Genomics Group with respect to certain aspects of the Merger, and the past and current business operations of the Company and the Celera Genomics Group, the financial condition and future prospects and operations of the Company and the Celera Genomics Group, the effects of the Merger on the financial condition and future prospects of the Company and the Celera Genomics Group, and certain other matters we believed necessary or appropriate to our inquiry.

In giving our opinion, we have relied upon and assumed, without independent verification, the accuracy and completeness of all information that was publicly available or was furnished to us by the Company, the Celera Genomics Group and the Merger Partner or otherwise reviewed by us, and we have not assumed any responsibility or liability therefor. We have not conducted any valuation or appraisal of any assets or liabilities, nor have any such valuations or appraisals been provided to us. In relying on financial analyses and forecasts provided to us, we have assumed that they have been reasonably prepared based on assumptions reflecting the best currently available estimates and judgments by management and its representatives as to the expected future results of operations and financial condition of the Company and the Celera Genomics Group to which such analyses or forecasts relate. We have also assumed that the Merger will qualify as a tax-free reorganization for United States federal income tax purposes, and that the other transactions contemplated by the Agreement will be consummated as described in the Agreement. We have relied as to all legal matters relevant to rendering our opinion upon the advice of counsel. We have also assumed that the definitive Agreement will not differ in any material respects from the draft thereof furnished to us. We have further assumed that all material governmental, regulatory or other consents and approvals necessary for the consummation of the Merger will be obtained without any adverse effect on the Company, the Celera Genomics Group or the Merger Partner or on the contemplated benefits of the Merger.

Our opinion is necessarily based on economic, market and other conditions as in effect on, and the information made available to us as of, the date hereof. It should be understood that subsequent developments may affect this opinion and that we do not have any obligation to update, revise, or reaffirm this opinion. Our opinion is limited to the fairness, from a financial point of view, to the holders of the Company Common Stock of the Exchange Ratio in the proposed Merger, based upon the trading price of the Merger Partner Common Stock as of the date hereof, and we express no opinion as to the underlying decision by the Company to engage in the Merger. We are expressing no opinion herein as to the price at which the Merger Partner Common Stock will trade at any future time.

We have acted as financial advisor to the Company with respect to the proposed Merger and will receive a fee from the Company for our services. We will also receive an additional fee if the proposed Merger is consummated. We will receive a fee from the Company for the delivery of this opinion. In the past, we have provided investment banking and other financial advisory services to the Company, including as a manager in a public offering of securities in 1996, and have received fees for rendering these services. In the ordinary course of our businesses, we and our affiliates may actively trade the debt and equity securities of the Company or the Merger Partner for our own account or for the accounts of customers and, accordingly, we may at any time hold long or short positions in such securities.

On the basis of and subject to the foregoing, it is our opinion as of the date hereof that the Exchange Ratio in the proposed Merger is fair, from a financial point of view, to the holders of the Company Common Stock.

This letter is provided to the Board of Directors of the Company in connection with and for the purposes of its evaluation of the Merger. This opinion does not constitute a recommendation to any

B–2


stockholder of the Company as to how such stockholder should vote with respect to the Merger or any other matter. This opinion may not be disclosed, referred to, or communicated (in whole or in part) to any third party for any purpose whatsoever except with our prior written approval. This opinion may be reproduced in full in any proxy or information statement mailed to stockholders of the Company but may not otherwise be disclosed publicly in any manner without our prior written approval.

Very truly yours,

/s/ J.P. MORGAN SECURITIES INC.

J.P. Morgan Securities Inc.

B–3



PART II
INFORMATION NOT REQUIRED IN PROSPECTUS


Item 20. Indemnification of Directors and Officers.

    Section 145 of the Delaware General Corporation Law permits Applera's board of directors to indemnify any person against expenses (including attorneys' fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by him or her in connection with any threatened, pending or completed action (except settlements or judgments in derivative suits), suit or proceeding in which such person is made a party by reason of his or her being or having been a director, officer, employee or agent of the company, in terms sufficiently broad to permit such indemnification under certain circumstances for liabilities (including reimbursement for expenses incurred) arising under the Securities Act. The Delaware General Corporation Law provides that indemnification pursuant to its provisions is not exclusive of other rights of indemnification to which a person may be entitled under any bylaw, agreement, vote of stockholders or disinterested directors, or otherwise.

    Applera's certificate of incorporation and bylaws provide for indemnification of Applera directors and officers to the fullest extent permitted by law.

    As permitted by sections 102 and 145 of the Delaware General Corporation Law, Applera's certificate of incorporation eliminates a director's personal liability for monetary damages to Applera and its stockholders arising from a breach or alleged breach of a director's fiduciary duty except for liability under section 174 of the Delaware General Corporation Law, for liability for any breach of the director's duty of loyalty to Applera or its stockholders, for acts or omissions not in good faith or which involve intentional misconduct or a knowing violation of law or for any transaction from which the director derived an improper personal benefit.

    The directors and officers of Applera are covered by insurance policies indemnifying against certain liabilities, including certain liabilities arising under the Securities Act that might be incurred by them in such capabilities and against which they cannot be indemnified by the company.


Item 21. Exhibits and Financial Statement Schedules.

Exhibit Number

  Description
2.1   Agreement and Plan of Merger, dated as of June 12, 2001, among Applera Corporation, Angel Acquisition Sub, Inc. and Axys Pharmaceuticals, Inc. (included as Annex A to the Prospectus).

3.1

 

Certificate of Incorporation of Applera Corporation (incorporated by reference to Exhibit 3.1 to Applera Corporation's Quarterly Report on Form 10-Q for the fiscal quarter ended December 31, 2000 (Commission file number 1-4389)).

3.2

 

Bylaws of Applera Corporation (incorporated by reference to Exhibit 3.2 to Applera Corporation's Registration Statement on Form S-4 (No. 333-67797)).

4

 

Shareholder Protection Rights Agreement, dated as of April 28, 1999, between Applera Corporation and BankBoston, N.A. (incorporated by reference to Exhibit 4.1 to Applera Corporation's Registration Statement on Form S-4 (No. 333-67797)).

5.1**

 

Opinion of Simpson Thacher & Bartlett as to the legality of the securities.

8.1**

 

Opinion of Simpson Thacher & Bartlett regarding tax matters.

8.2**

 

Opinion of Latham & Watkins regarding tax matters.

II–1



21

 

Subsidiaries of Applera Corporation (incorporated by reference to Exhibit 21 of Applera's Annual Report on Form 10-K for the fiscal year ended June 30, 2000).

23.1*

 

Consent of PricewaterhouseCoopers LLP.

23.2*

 

Consent of Ernst & Young LLP (regarding Axys Pharmaceuticals, Inc.).

23.3*

 

Consent of Ernst & Young LLP (regarding Discovery Partners International, Inc.).

23.4**

 

Consent of Simpson Thacher & Bartlett (included in Exhibits 5.1 and 8.1).

23.5**

 

Consent of Latham & Watkins (included in Exhibit 8.2).

24.1

 

Powers of Attorney (included on the signature page hereto).

99.1

 

Opinion of JPMorgan H&Q (included as Annex B to the Prospectus).

99.2*

 

Consent of JPMorgan H&Q.

99.3*

 

Form of Proxy for Special Meeting of Stockholders of Axys Pharmaceuticals, Inc.

*
Filed herewith.

**
To be filed by amendment.


Item 22. Undertakings.

    (a) The undersigned registrant hereby undertakes:

    (b) The undersigned registrant hereby undertakes that, for purposes of determining any liability under the Securities Act of 1933, each filing of the registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Securities Exchange Act of 1934) that is incorporated by reference in the registration statement will be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time will be deemed to be the initial bona fide offering thereof.

II–2


    (c) Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the Securities and Exchange Commission that such indemnification is against public policy as expressed in the Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Act and will be governed by the final adjudication of such issue.

    (d) The undersigned registrant hereby undertakes that:

    (e) The undersigned registrant hereby undertakes to respond to requests for information that is incorporated by reference into the prospectus pursuant to Item 4, 10(b), 11, or 13 of this form, within one business day of receipt of such request, and to send the incorporated documents by first class mail or other equally prompt means. This includes information contained in documents filed subsequent to the effective date of the registration statement through the date of responding to the request.

    (f)  The undersigned registrant hereby undertakes to supply by means of a post-effective amendment all information concerning a transaction, and the company being acquired involved therein, that was not the subject of and included in the registration statement when it became effective.

II–3



SIGNATURES

    Pursuant to the requirements of the Securities Act, the registrant has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Norwalk, State of Connecticut, on July 9, 2001.

    Applera Corporation

 

 

By:

 

/s/ 
WILLIAM B. SAWCH   
    Name: William B. Sawch
    Title: Senior Vice President and General Counsel


POWER OF ATTORNEY

    We, the undersigned directors and officers of the registrant, do hereby constitute and appoint Tony L. White and William B. Sawch, or either of them, our true and lawful attorneys and agents, to do any and all acts and things in our name and on our behalf in our capacities as directors and officers and to execute any and all instruments for us and in our names in the capacities indicated below, which said attorneys and agents, or either of them, may deem necessary or advisable to enable the registrant to comply with the Securities Act and any rules, regulations and requirements of the Securities and Exchange Commission, in connection with this registration statement, including specifically, but without limitation, power and authority to sign for us or any of us in our names in the capacities indicated below, any and all amendments (including post-effective amendments) hereto, and we do hereby ratify and confirm all that said attorneys and agents, or either of them, shall do or cause to be done by virtue hereof.

    Pursuant to the requirements of the Securities Act, this registration statement has been signed by the following persons in the capacities and on the dates indicated.

Signature
  Title
  Date

 

 

 

 

 
/s/ TONY L. WHITE   
Tony L. White
  Chairman of the Board of Directors, President and Chief Executive Officer (principal executive officer)   July 9, 2001

/s/ 
DENNIS L. WINGER   
Dennis L. Winger

 

Senior Vice President and Chief Financial Officer (principal financial officer)

 

July 9, 2001

/s/ 
VIKRAM JOG   
Vikram Jog

 

Corporate Controller (principal accounting officer)

 

July 9, 2001

/s/ 
RICHARD H. AYERS   
Richard H. Ayers

 

Director

 

July 9, 2001

/s/ 
JEAN-LUC BELINGARD   
Jean-Luc Belingard

 

Director

 

July 9, 2001

II–4



/s/ 
ROBERT H. HAYES   
Robert H. Hayes

 

Director

 

July 9, 2001

/s/ 
ARNOLD J. LEVINE   
Arnold J. Levine

 

Director

 

July 9, 2001

/s/ 
THEODORE E. MARTIN   
Theodore E. Martin

 

Director

 

July 9, 2001

/s/ 
GEORGES C. ST. LAURENT, JR.   
Georges C. St. Laurent, Jr.

 

Director

 

July 9, 2001

/s/ 
CAROLYN W. SLAYMAN   
Carolyn W. Slayman

 

Director

 

July 9, 2001

/s/ 
ORIN R. SMITH   
Orin R. Smith

 

Director

 

July 9, 2001

/s/ 
JAMES R. TOBIN   
James R. Tobin

 

Director

 

July 9, 2001

II–5



EXHIBIT INDEX

Exhibit Number

  Description
2.1   Agreement and Plan of Merger, dated as of June 12, 2001, among Applera Corporation, Angel Acquisition Sub, Inc. and Axys Pharmaceuticals, Inc. (included as Annex A to the Prospectus).

3.1

 

Certificate of Incorporation of Applera Corporation (incorporated by reference to Exhibit 3.1 to Applera Corporation's Quarterly Report on Form 10-Q for the fiscal quarter ended December 31, 2000 (Commission file number 1-4389)).

3.2

 

Bylaws of Applera Corporation (incorporated by reference to Exhibit 3.2 to Applera Corporation's Registration Statement on Form S-4 (No. 333-67797)).

4

 

Shareholder Protection Rights Agreement, dated as of April 28, 1999, between Applera Corporation and BankBoston, N.A. (incorporated by reference to Exhibit 4.1 to Applera Corporation's Registration Statement on Form S-4 (No. 333-67797)).

5.1**

 

Opinion of Simpson Thacher & Bartlett as to the legality of the securities.

8.1**

 

Opinion of Simpson Thacher & Bartlett regarding tax matters.

8.2**

 

Opinion of Latham & Watkins regarding tax matters.

21

 

Subsidiaries of Applera Corporation (incorporated by reference to Exhibit 21 of Applera's Annual Report on Form 10-K for the fiscal year ended June 30, 2000).

23.1*

 

Consent of PricewaterhouseCoopers LLP.

23.2*

 

Consent of Ernst & Young LLP (regarding Axys Pharmaceuticals, Inc.).

23.3*

 

Consent of Ernst & Young LLP (regarding Discovery Partners International, Inc.).

23.4**

 

Consent of Simpson Thacher & Bartlett (included in Exhibits 5.1 and 8.1).

23.5**

 

Consent of Latham & Watkins (included in Exhibit 8.2).

24.1

 

Powers of Attorney (included on the signature page hereto).

99.1

 

Opinion of JPMorgan H&Q (included as Annex B to the Prospectus).

99.2*

 

Consent of JPMorgan H&Q.

99.3*

 

Form of Proxy for Special Meeting of Stockholders of Axys Pharmaceuticals, Inc.

*
Filed herewith.

**
To be filed by amendment.



QuickLinks

NOTICE OF SPECIAL MEETING OF STOCKHOLDERS TO BE HELD ON [ ], 2001
REFERENCE TO ADDITIONAL INFORMATION
TABLE OF CONTENTS
QUESTIONS AND ANSWERS ABOUT THE MERGER
SUMMARY OF THE PROXY STATEMENT/PROSPECTUS
SELECTED HISTORICAL CONSOLIDATED AND COMBINED FINANCIAL INFORMATION AND SELECTED UNAUDITED PRO FORMA CONSOLIDATED AND COMBINED FINANCIAL INFORMATION
Applera Corporation Selected Unaudited Pro Forma Consolidated Financial Information
Celera Genomics Group Selected Unaudited Pro Forma Combined Financial Information
SELECTED HISTORICAL CONSOLIDATED FINANCIAL INFORMATION OF AXYS
COMPARATIVE PER SHARE INFORMATION (UNAUDITED)
COMPARATIVE PER SHARE MARKET PRICE AND DIVIDEND INFORMATION
RISK FACTORS
THE SPECIAL MEETING
THE MERGER
INFORMATION ABOUT AXYS
Partnered Pipeline—Preclinical
Proprietary Pipeline—Oncology & Specialty Therapeutic Areas
MANAGEMENT OF AXYS
SUMMARY COMPENSATION TABLE
Option Grants In Last Fiscal Year
Aggregated Option Exercises In Last Fiscal Year And Year-End Option Value
INFORMATION ABOUT APPLERA AND ANGEL ACQUISITION
UNAUDITED PRO FORMA CONDENSED CONSOLIDATED AND COMBINED FINANCIAL STATEMENTS
APPLERA CORPORATION UNAUDITED PRO FORMA CONDENSED CONSOLIDATED BALANCE SHEET March 31, 2001 (amounts in thousands)
CELERA GENOMICS GROUP UNAUDITED PRO FORMA CONDENSED COMBINED BALANCE SHEET March 31, 2001 (amounts in thousands)
APPLERA CORPORATION UNAUDITED PRO FORMA CONSOLIDATED STATEMENT OF OPERATIONS Nine Months Ended March 31, 2001 (Dollar amounts in thousands except per share amounts)
APPLERA CORPORATION UNAUDITED PRO FORMA CONSOLIDATED STATEMENT OF OPERATIONS Twelve Months Ended June 30, 2000 (Dollar amounts in thousands except per share amounts)
CELERA GENOMICS GROUP UNAUDITED PRO FORMA COMBINED STATEMENT OF OPERATIONS Nine Months Ended March 31, 2001 (Dollar amounts in thousands)
CELERA GENOMICS GROUP UNAUDITED PRO FORMA COMBINED STATEMENT OF OPERATIONS Twelve Months Ended June 30, 2000 (Dollar amounts in thousands)
DESCRIPTION OF APPLERA CAPITAL STOCK
COMPARISON OF STOCKHOLDER RIGHTS
EXPERTS
LEGAL OPINIONS
SUBMISSION OF STOCKHOLDER PROPOSALS
SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS
WHERE YOU CAN FIND MORE INFORMATION
INDEX TO FINANCIAL STATEMENTS
REPORT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS
AXYS PHARMACEUTICALS, INC. BALANCE SHEETS (In thousands, except share and per share amounts)
AXYS PHARMACEUTICALS, INC. STATEMENTS OF OPERATIONS (In thousands, except per share amounts)
AXYS PHARMACEUTICALS, INC. STATEMENTS OF STOCKHOLDERS' EQUITY (In thousands, except share and per share amounts)
AXYS PHARMACEUTICALS, INC. STATEMENTS OF CASH FLOW (In thousands)
AXYS PHARMACEUTICALS, INC. NOTES TO FINANCIAL STATEMENTS
AXYS PHARMACEUTICALS, INC. CONDENSED BALANCE SHEETS (In thousands)
AXYS PHARMACEUTICALS, INC. CONDENSED STATEMENTS OF OPERATIONS (Unaudited) (In thousands, except per share amounts)
AXYS PHARMACEUTICALS, INC. CONDENSED STATEMENTS OF CASH FLOWS (Unaudited) (In thousands)
AXYS PHARMACEUTICALS, INC. NOTES TO CONDENSED FINANCIAL STATEMENTS March 31, 2001 (Unaudited)
REPORT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS
DISCOVERY PARTNERS INTERNATIONAL, INC. CONSOLIDATED BALANCE SHEETS
DISCOVERY PARTNERS INTERNATIONAL, INC. CONSOLIDATED STATEMENTS OF OPERATIONS
DISCOVERY PARTNERS INTERNATIONAL, INC. CONSOLIDATED STATEMENTS OF CASH FLOWS
DISCOVERY PARTNERS INTERNATIONAL, INC. NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
TABLE OF CONTENTS
Index of Defined Terms
W I T N E S S E T H
ARTICLE I THE MERGER
ARTICLE II REPRESENTATIONS AND WARRANTIES OF THE COMPANY
ARTICLE III REPRESENTATIONS AND WARRANTIES OF PARENT
ARTICLE IV COVENANTS RELATING TO CONDUCT OF BUSINESS PRIOR TO MERGER.
ARTICLE V ADDITIONAL AGREEMENTS
ARTICLE VI CONDITIONS PRECEDENT
ARTICLE VII TERMINATION, AMENDMENT AND WAIVER
ARTICLE VIII GENERAL PROVISIONS
PART II INFORMATION NOT REQUIRED IN PROSPECTUS
SIGNATURES
POWER OF ATTORNEY
EXHIBIT INDEX