Form N-Q

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, DC 20549

FORM N-Q


QUARTERLY SCHEDULE OF PORTFOLIO HOLDINGS OF REGISTERED MANAGEMENT INVESTMENT COMPANY

Investment Company Act file number         811-7616         

        Nuveen Missouri Premium Income Municipal Fund         
(Exact name of registrant as specified in charter)

Nuveen Investments
        333 West Wacker Drive, Chicago, Illinois 60606         
(Address of principal executive offices) (Zip code)


Kevin J. McCarthy Vice President and Secretary
        333 West Wacker Drive, Chicago, Illinois 60606         
(Name and address of agent for service)

Registrant's telephone number, including area code:         312-917-7700        

Date of fiscal year end:            5/31          

Date of reporting period:         8/31/09         

Form N-Q is to be used by management investment companies, other than small business investment companies registered on Form N-5 (§§ 239.24 and 274.5 of this chapter), to file reports with the Commission, not later than 60 days after the close of the first and third fiscal quarters, pursuant to rule 30b1-5 under the Investment Company Act of 1940 (17 CFR 270.30b1-5). The Commission may use the information provided on Form N-Q in its regulatory, disclosure review, inspection, and policymaking roles.

A registrant is required to disclose the information specified by Form N-Q, and the Commission will make this information public. A registrant is not required to respond to the collection of information contained in Form N-Q unless the Form displays a currently valid Office of Management and Budget ("OMB") control number. Please direct comments concerning the accuracy of the information collection burden estimate and any suggestions for reducing the burden to the Secretary, Securities and Exchange Commission, 450 Fifth Street, NW, Washington, DC 20549-0609. The OMB has reviewed this collection of information under the clearance requirements of 44 U.S.C. § 3507.

Item 1. Schedule of Investments


  Portfolio of Investments (Unaudited)       
      Nuveen Missouri Premium Income Municipal Fund (NOM)       
  August 31, 2009       
Principal    Optional Call     
Amount (000)  Description (1)  Provisions (2)  Ratings (3)  Value 
  Consumer Staples – 3.3% (2.2% of Total Investments)       
$      1,000  Missouri Development Finance Board, Solid Waste Disposal Revenue Bonds, Procter and Gamble  No Opt. Call  AA–  $      981,930 
  Inc., Series 1999, 5.200%, 3/15/29 (Alternative Minimum Tax)       
  Education and Civic Organizations – 2.1% (1.4% of Total Investments)       
250  Lincoln University, Missouri, Auxiliary System Revenue Bonds, Series 2007, 5.125%, 6/01/37 –  6/17 at 100.00  AAA  251,665 
  AGC Insured       
365  Missouri Health and Educational Facilities Authority, Revenue Bonds, Webster University,  4/11 at 100.00  Baa1  370,212 
  Series 2001, 5.500%, 4/01/18 – NPFG Insured       
615  Total Education and Civic Organizations      621,877 
  Health Care – 21.7% (14.3% of Total Investments)       
710  Cape Girardeau County Industrial Development Authority, Missouri, Health Facilities Revenue  6/17 at 100.00  N/R  612,141 
  Bonds, Southeast Missouri Hospital Association, Series 2007, 5.000%, 6/01/27       
930  Cass County, Missouri, Hospital Revenue Bonds, Series 2007, 5.625%, 5/01/38  11/16 at 100.00  N/R  754,193 
480  Clinton County Industrial Development Authority, Missouri, Revenue Bonds, Cameron Regional  12/17 at 100.00  N/R  288,058 
  Medical Center, Series 2007, 5.000%, 12/01/37       
750  Joplin Industrial Development Authority, Missouri, Health Facilities Revenue Bonds, Freeman  2/15 at 102.00  BBB+  680,108 
  Health System, Series 2004, 5.500%, 2/15/29       
500  Missouri Health & Educational Facilities Authority, St. Luke’s Episcopal– Presbyterian  6/11 at 101.00  AAA  507,495 
  Hospitals Revenue Bonds, Series 2001, 5.250%, 12/01/26 – FSA Insured       
  Missouri Health and Educational Facilities Authority, Revenue Bonds, BJC Health System,       
  Series 2003:       
1,500  5.125%, 5/15/25  5/13 at 100.00  AA  1,518,285 
1,155  5.250%, 5/15/32  5/13 at 100.00  AA  1,159,920 
425  Missouri Health and Educational Facilities Authority, Revenue Bonds, Lake Regional Health  2/10 at 100.00  N/R  424,983 
  System, Series 1996, 6.500%, 2/15/21       
500  Missouri Health and Educational Facilities Authority, Revenue Bonds, Lake Regional Health  2/14 at 100.00  BBB+  442,975 
  System, Series 2003, 5.700%, 2/15/34       
6,950  Total Health Care      6,388,158 
  Housing/Multifamily – 3.9% (2.6% of Total Investments)       
400  Jefferson County Industrial Development Authority, Missouri, Multifamily Housing Revenue  12/11 at 100.00  N/R  370,348 
  Bonds, Lakewood Apartments Project, Series 2001B, 5.750%, 11/01/34 (Mandatory put 11/01/16)       
  (Alternative Minimum Tax)       
275  Missouri Housing Development Commission, Multifamily Housing Revenue Bonds, Series 2001II,  12/11 at 100.00  AA  283,852 
  5.250%, 12/01/16       
500  St. Charles County Industrial Development Authority, Missouri, FHA-Insured Multifamily Housing  10/09 at 101.00  AAA  500,685 
  Revenue Bonds, Ashwood Apartments, Series 1998A, 5.600%, 4/01/30 – FSA Insured (Alternative       
  Minimum Tax)       
1,175  Total Housing/Multifamily      1,154,885 
  Housing/Single Family – 5.7% (3.8% of Total Investments)       
70  Missouri Housing Development Commission, Single Family Mortgage Revenue Bonds, Homeownership  3/10 at 100.00  AAA  72,369 
  Loan Program, Series 2000B-1, 6.250%, 3/01/31 (Alternative Minimum Tax)       
750  Missouri Housing Development Commission, Single Family Mortgage Revenue Bonds, Homeownership  9/16 at 100.00  AAA  709,275 
  Loan Program, Series 2007A-1, 4.700%, 9/01/27 (Alternative Minimum Tax)       
1,000  Missouri Housing Development Commission, Single Family Mortgage Revenue Bonds, Homeownership  3/17 at 100.00  AAA  904,600 
  Loan Program, Series 2007C-1, 4.800%, 9/01/38 (Alternative Minimum Tax)       
1,820  Total Housing/Single Family      1,686,244 
  Long-Term Care – 7.7% (5.1% of Total Investments)       
1,750  Cole County Industrial Development Authority, Missouri, Revenue Bonds, Lutheran Senior  2/14 at 100.00  N/R  1,447,285 
  Services – Heisinger Project, Series 2004, 5.500%, 2/01/35       
475  Lees Summit Industrial Development Authority, Missouri, Revenue Bonds, John Knox Village  8/17 at 100.00  N/R  372,167 
  Obligated Group, Series 2007A, 5.125%, 8/15/32       
500  St. Louis County Industrial Development Authority, Missouri, Revenue Bonds, Friendship Village  9/17 at 100.00  N/R  434,120 
  of West County, Series 2007A, 5.500%, 9/01/28       
2,725  Total Long-Term Care      2,253,572 
  Materials – 2.0% (1.3% of Total Investments)       
750  Sugar Creek, Missouri, Industrial Development Revenue Bonds, Lafarge North America Inc.,  6/13 at 101.00  BBB–  573,240 
  Series 2003A, 5.650%, 6/01/37 (Alternative Minimum Tax)       
  Tax Obligation/General – 27.0% (17.9% of Total Investments)       
1,500  Camdenton Reorganized School District R3, Camden County, Missouri, General Obligation Bonds,  No Opt. Call  AAA  1,614,510 
  Series 2005, 5.250%, 3/01/24 – FSA Insured       
500  Jackson County School District R-7, Lees Summit, Missouri, General Obligation Refunding and  3/12 at 100.00  AAA  544,035 
  Improvement Bonds, Series 2002, 5.250%, 3/01/18 – FSA Insured       
500  Missouri School Boards Association, Lease Participation Certificates, Clay County School  3/17 at 100.00  AAA  535,140 
  District 53 Liberty, Series 2007, 5.250%, 3/01/27 – FSA Insured       
1,630  North Kansas City School District, Missouri, General Obligation Bonds, Series 2003A,  3/13 at 100.00  AA+  1,728,077 
  5.000%, 3/01/23       
1,000  Puerto Rico, General Obligation and Public Improvement Bonds, Series 2001A, 5.500%, 7/01/20 –  No Opt. Call  A  1,010,490 
  NPFG Insured       
2,020  Ritenour Consolidated School District, St. Louis County, Missouri, General Obligation Bonds,  No Opt. Call  A1  2,228,888 
  Series 1995, 7.375%, 2/01/12 – FGIC Insured       
270  St. Louis County Pattonville School District R3, Missouri, General Obligation Bonds, Series  3/14 at 100.00  AAA  297,427 
  2004, 5.250%, 3/01/20 – FSA Insured       
7,420  Total Tax Obligation/General      7,958,567 
  Tax Obligation/Limited – 22.1% (14.6% of Total Investments)       
600  Chesterfield, Missouri, Certificates of Participation, Series 2005, 5.000%, 12/01/24 –  12/15 at 100.00  Aa1  611,562 
  FGIC Insured       
80  Cottleville, Missouri, Certificates of Participation, Series 2006, 5.250%, 8/01/31  8/14 at 100.00  N/R  67,656 
400  Fenton, Missouri, Tax Increment Revenue Bonds, Gravois Bluffs Redevelopment Project, Series  4/14 at 100.00  N/R  372,316 
  2006, 4.500%, 4/01/21       
315  Fulton, Missouri, Tax Increment Revenue Bonds, Fulton Commons Redevelopment Project, Series  6/16 at 100.00  N/R  216,411 
  2006, 5.000%, 6/01/28       
475  Kansas City Tax Increment Financing District, Missouri, Tax Increment Revenue Bonds,  6/14 at 102.00  N/R  361,143 
  Briarcliff West Project, Series 2006A, 5.400%, 6/01/24       
415  Missouri Development Finance Board, Independence, Infrastructure Facilities Revenue Bonds,  3/16 at 100.00  A+  403,770 
  Crackerneck Creek Project, Series 2006C, 5.000%, 3/01/28       
360  Missouri Development Finance Board, Infrastructure Facilities Revenue Bonds, Branson Landing  6/15 at 100.00  A  298,732 
  Project, Series 2005A, 5.000%, 6/01/35       
450  Monarch-Chesterfield Levee District, St. Louis County, Missouri, Levee District Improvement  3/10 at 101.00  A  462,519 
  Bonds, Series 1999, 5.750%, 3/01/19 – NPFG Insured       
500  Osage Beach, Missouri, Tax Increment Revenue Bonds, Prewitts Point Transportation Development  5/12 at 102.00  N/R  350,420 
  District, Series 2006, 5.000%, 5/01/23       
600  Riverside, Missouri, L-385 Levee Redevelopment Plan Tax Increment Revenue Bonds, Series 2004,  5/15 at 100.00  A  594,162 
  5.250%, 5/01/20       
2,000  Springfield Public Building Corporation, Missouri, Lease Revenue Bonds, Jordan Valley Park  6/10 at 100.00  N/R  2,011,020 
  Projects, Series 2000A, 6.125%, 6/01/21 – AMBAC Insured       
  St. Joseph Industrial Development Authority, Missouri, Tax Increment Bonds, Shoppes at North       
  Village Project, Series 2005A:       
340  5.375%, 11/01/24  11/14 at 100.00  N/R  275,563 
400  5.500%, 11/01/27  11/14 at 100.00  N/R  316,444 
200  St. Joseph Industrial Development Authority, Missouri, Tax Increment Bonds, Shoppes at North  11/14 at 100.00  N/R  156,582 
  Village Project, Series 2005B, 5.500%, 11/01/27       
7,135  Total Tax Obligation/Limited      6,498,300 
  Transportation – 4.7% (3.1% of Total Investments)       
500  Kansas City, Missouri, Passenger Facility Charge Revenue Bonds, Kansas City International  4/11 at 101.00  A  477,195 
  Airport, Series 2001, 5.000%, 4/01/23 – AMBAC Insured (Alternative Minimum Tax)       
1,000  St. Louis Land Clearance Redevelopment Authority, Missouri, Revenue Refunding and Improvement  9/09 at 102.00  N/R  910,620 
  Bonds, LCRA Parking Facilities, Series 1999C, 7.000%, 9/01/19       
1,500  Total Transportation      1,387,815 
  U.S. Guaranteed – 30.0% (19.9% of Total Investments) (4)       
685  Fenton, Missouri, Tax Increment Refunding and Improvement Revenue Bonds, Gravois Bluffs  10/12 at 100.00  N/R (4)  778,215 
  Redevelopment Project, Series 2002, 6.125%, 10/01/21 (Pre-refunded 10/01/12)       
2,500  Missouri Health and Educational Facilities Authority, Revenue Bonds, SSM Healthcare System,  6/11 at 101.00  AA– (4)  2,719,325 
  Series 2001A, 5.250%, 6/01/28 (Pre-refunded 6/01/11) – AMBAC Insured       
1,000  Missouri Health and Educational Facilities Authority, Revenue Bonds, St. Anthony’s Medical  12/10 at 101.00  N/R (4)  1,076,850 
  Center, Series 2000, 6.250%, 12/01/30 (Pre-refunded 12/01/10)       
1,380  Springfield Center City Development Corporation, Missouri, Lease Revenue Bonds, Jordan Valley  11/11 at 100.00  A1 (4)  1,495,547 
  Park Parking Garage, Series 2002D, 5.000%, 11/01/22 (Pre-refunded 11/01/11) – AMBAC Insured       
80  St. Louis County Pattonville School District R3, Missouri, General Obligation Bonds, Series  3/14 at 100.00  AAA  92,025 
  2004, 5.250%, 3/01/20 (Pre-refunded 3/01/14) – FSA Insured       
500  St. Louis County, Missouri, GNMA Collateralized Mortgage Revenue Bonds, Series 1993D, 5.650%,  No Opt. Call  N/R (4)  574,300 
  7/01/20 (Alternative Minimum Tax) (ETM)       
1,000  St. Louis Municipal Finance Corporation, Missouri, Leasehold Revenue Bonds, Carnahan  2/12 at 100.00  N/R (4)  1,113,380 
  Courthouse, Series 2002A, 5.750%, 2/15/16 (Pre-refunded 2/15/12) – FGIC Insured       
950  Texas County, Missouri, Hospital Revenue Bonds, Texas County Memorial Hospital, Series 2000,  6/10 at 100.00  N/R (4)  1,000,217 
  7.250%, 6/15/25 (Pre-refunded 6/15/10)       
8,095  Total U.S. Guaranteed      8,849,859 
  Water and Sewer – 9.9% (6.6% of Total Investments)       
2,965  Missouri Environmental Improvement and Energy Resources Authority, Water Facility Revenue  12/16 at 100.00  AAA  2,537,388 
  Bonds, Missouri-American Water Company, Series 2006, 4.600%, 12/01/36 – AMBAC       
  Insured (Alternative Minimum Tax) (UB)       
350  Missouri Environmental Improvement and Energy Resources Authority, Water Pollution Control  No Opt. Call  Aaa  392,227 
  Revenue Bonds, State Revolving Fund Program – Kansas City Project, Series 1997C,       
  6.750%, 1/01/12       
3,315  Total Water and Sewer      2,929,615 
$      42,500  Total Long-Term Investments (cost $42,697,335) – 140.1%      41,284,062 
  Short-Term Investments – 10.9% (7.2% of Total Investments)       
  Tax Obligation/Limited – 10.9% (7.2% of Total Investments)       
$         3,200  Kansas City, Missouri, Special Obligation Bonds, H. Roe Bartle Convention Center Refunding,  9/09 at 100.00  VMIG-1  3,200,000 
  Variable Rate Demand Obligations, Series 2008F, 0.370%, 4/15/25 (5)       
  Total Short-Term Investments (cost $3,200,000)      3,200,000 
  Total Investments (cost $45,897,335) – 151.0%      44,484,062 
  Floating Rate Obligations – (7.6)%      (2,225,000)
  Other Assets Less Liabilities – 10.9%      3,203,801 
  Preferred Shares, at Liquidation Value – (54.3)% (6)      (16,000,000)
  Net Assets Applicable to Common Shares – 100%      $    29,462,863 


Fair Value Measurements 
In determining the value of the Fund’s investments various inputs are used. These inputs are summarized 
in the three broad levels listed below: 
Level 1 – Quoted prices in active markets for identical securities. 
Level 2 – Other significant observable inputs (including quoted prices for similar securities, interest rates, 
             prepayment speeds, credit risk, etc.). 
Level 3 – Significant unobservable inputs (including management’s assumptions in determining the fair 
             value of investments). 
The inputs or methodology used for valuing securities are not an indication of the risk associated with 
investing in those securities. 
The following is a summary of the Fund’s fair value measurements as of August 31, 2009: 

  Level 1  Level 2  Level 3  Total 
Investments:         
Municipal Bonds  $ —  $41,284,062  $ —  $41,284,062 
Short-Term Investments  —  3,200,000  —  3,200,000 
Total  $ —  $44,484,062  $ —  $44,484,062 

Income Tax Information 
The following information is presented on an income tax basis. Differences between amounts for financial 
statement and federal income tax purposes are primarily due to timing differences in recognizing taxable 
market discount, timing differences in recognizing certain gains and losses on investment transactions and 
the treatment of investments in inverse floating rate transactions subject to Statement of Financial 
Accounting Standards No. 140 (SFAS No. 140), if any. To the extent that differences arise that are 
permanent in nature, such amounts are reclassified within the capital accounts on the Statement of 
Assets and Liabilities presented in the annual report, based on their federal tax basis treatment; temporary 
differences do not require reclassification. Temporary and permanent differences do not impact the net 
asset value of the Fund. 
At August 31, 2009, the cost of investments was $43,652,717. 
Gross unrealized appreciation and gross unrealized depreciation of investments at August 31, 2009, 
were as follows: 

Gross unrealized:   
  Appreciation  $ 1,350,786 
  Depreciation  (2,743,661)
Net unrealized appreciation (depreciation) of investments  $(1,392,875)

(1)  All percentages shown in the Portfolio of Investments are based on net assets applicable to Common 
  shares unless otherwise noted. 
(2)  Optional Call Provisions: Dates (month and year) and prices of the earliest optional call or redemption. 
  There may be other call provisions at varying prices at later dates. Certain mortgage-backed securities 
  may be subject to periodic principal paydowns. 
(3)  Ratings: Using the higher of Standard & Poor's Group ("Standard & Poor's") or Moody's Investor Service, 
  Inc. ("Moody's") rating. Ratings below BBB by Standard & Poor's or Baa by Moody's are considered to be 
  below investment grade. 
(4)  Backed by an escrow or trust containing sufficient U.S. Government or U.S. Government agency securities 
  which ensure the timely payment of principal and interest. Such investments are normally considered to 
  be equivalent to AAA rated securities. 
(5)  Investment has a maturity of more than one year, but has variable rate and demand features which 
  qualify it as a short-term investment. The rate disclosed is that in effect at the end of the reporting 
  period. This rate changes periodically based on market conditions or a specified market index. 
(6)  Preferred Shares, at Liquidation Value as a percentage of Total Invetments is 36.0%. 
N/R  Not rated. 
(ETM)  Escrowed to maturity. 
(UB)  Underlying bond of an inverse floating rate trust reflected as a financing transaction pursuant to the 
  provisions of SFAS No. 140. 

Item 2. Controls and Procedures.

  1. The registrant's principal executive and principal financial officers, or persons performing similar functions, have concluded that the registrant's disclosure controls and procedures (as defined in Rule 30a-3(c) under the Investment Company Act of 1940, as amended (the "1940 Act") (17 CFR 270.30a-3(c))) are effective, as of a date within 90 days of the filing date of this report that includes the disclosure required by this paragraph, based on their evaluation of the controls and procedures required by Rule 30a-3(b) under the 1940 Act (17 CFR 270.30a-3(b)) and Rule 13a-15(b) or 15d-15(b) under the Securities Exchange Act of 1934 (17 CFR 240.13a-15(b) or 240.15d-15(b)).
  2. There were no changes in the registrant's internal control over financial reporting (as defined in Rule 30a-3(d) under the 1940 Act (17 CFR 270.30a-3(d)) that occurred during the registrant's last fiscal quarter that have materially affected, or are reasonably likely to materially affect, the registrant's internal control over financial reporting.

Item 3. Exhibits.

File as exhibits as part of this Form a separate certification for each principal executive officer and principal financial officer of the registrant as required by Rule 30a-2(a) under the 1940 Act (17 CFR 270.30a-2(a)), exactly as set forth below: See EX-99 CERT attached hereto.


SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

(Registrant)         Nuveen Missouri Premium Income Municipal Fund         

By (Signature and Title)          /s/ Kevin J. McCarthy                    
                                                  Kevin J. McCarthy
                                                  Vice President and Secretary

Date         October 30, 2009        

Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated.

By (Signature and Title)         /s/ Gifford R. Zimmerman                    
                                                 Gifford R. Zimmerman
                                                 Chief Administrative Officer (principal executive officer) 

Date         October 30, 2009        

By (Signature and Title)         /s/ Stephen D. Foy                              
                                                 Stephen D. Foy
                                                 Vice President and Controller (principal financial officer) 

Date        October 30, 2009