FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person * MARIO ERNEST   2. Issuer Name and Ticker or Trading Symbol CHIMERIX INC [CMRX] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) C/O CHIMERIX, INC., 2505 MERIDIAN PARKWAY, SUITE 340 3. Date of Earliest Transaction (Month/Day/Year) 08/06/2015 (Street) DURHAM, NC 27713 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 08/06/2015   M   3,521 A $ 5.05 128,052 D   Common Stock 08/06/2015   M   750 A $ 23.26 128,802 D   Common Stock 08/06/2015   M   129 A $ 23.26 128,931 D   Common Stock 08/06/2015   M   832 A $ 45.15 129,763 D

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Stock Option (Right to Buy)

$ 5.05

08/06/2015

M

3,521

(1)

02/03/2023

Common Stock

3,521

$ 0

31,690

D

Stock Option (Right to Buy)

$ 23.26

08/06/2015

M

750

(2)

06/19/2024

Common Stock

750

$ 0

0

D

Stock Option (Right to Buy)

$ 23.26

08/06/2015

M

129

(2)

06/19/2024

Common Stock

129

$ 0

0

D

Stock Option (Right to Buy)

$ 45.15

08/06/2015

M

832

(3)

06/21/2025

Common Stock

832

$ 0

9,151

D

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
MARIO ERNEST C/O CHIMERIX, INC. 2505 MERIDIAN PARKWAY, SUITE 340 DURHAM, NC 27713	X

Signatures

/s/ Timothy W. Trost, C.P.A., attorney-in-fact		08/07/2015
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	In accordance with its terms, the shares underlying the option are subject to vesting as follows: the shares vest at a rate of 1/48th per month during the four years following February 4, 2013.
(2)	The shares subject to the option vest in a series of twelve equal monthly installments from the date of grant on June 20, 2014 such that the option is fully vested on the one-year anniversary of the date of the grant.
(3)	The shares subject to the option vest in twelve equal monthly installments from the date of grant such that the option is fully vested on the one-year anniversary of the date of the grant.

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