UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

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                                    FORM 6-K

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                            REPORT OF FOREIGN ISSUER

                       Pursuant to Rule 13a-16 or 15d-16
                     of the Securities Exchange Act of 1934


                                 NOVEMBER 2 2005


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                                NOVO NORDISK A/S
             (Exact name of Registrant as specified in its charter)


                                    NOVO ALLE
                               DK-2880, BAGSVAERD
                                     DENMARK
                    (Address of principal executive offices)

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Indicate by check mark whether the registrant files or will file annual reports
under cover of Form 20-F or Form 40-F

                       Form 20-F [X]     Form 40-F [ ]


Indicate by check mark whether the registrant by furnishing the information
contained in this Form is also thereby furnishing the information to the
Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.

                             Yes [ ]     No [X]


If "Yes" is marked, indicate below the file number assigned to the registrant in
connection with Rule 12g-32(b):82-_____________________


DIRECTOR/PDMR SHAREHOLDING

TRADING IN NOVO  NORDISK  SHARES BY BOARD  MEMBERS,  EXECUTIVES  AND  ASSOCIATED
PERSONS AS REPORTED TO NOVO NORDISK ON 28 OCTOBER 2005

In  accordance  with  Section 28a of the Danish  Securities  Trading  Act,  Novo
Nordisk is required on a daily basis to publish  trading in Novo Nordisk  shares
by the company's  board  members,  executives  and their  associated  persons as
reported by those persons to Novo Nordisk.

Please find below a statement of such trading in shares issued by Novo Nordisk.

NAME                                         KURT ANKER NIELSEN
REASON FOR REPORTING                         BOARD MEMBER
FINANCIAL INSTRUMENT AND ID CODE             NOVO NORDISK B SHARES DK 001028081
TYPE OF TRANSACTION                          SALE OF SHARES
DATE OF TRANSACTION                          28 OCTOBER 2005
PLACE OF TRANSACTION                         COPENHAGEN STOCK EXCHANGE
VOLUME OF TRANSACTION                        3,000 SHARES
TOTAL VALUE OF TRANSACTION                   DKK 930,000




NAME                                         KURT ANKER NIELSEN
REASON FOR REPORTING                         BOARD MEMBER
FINANCIAL INSTRUMENT AND ID CODE             NOVO NORDISK B SHARES DK 001028081
TYPE OF TRANSACTION                          EXERCISE OF OPTIONS (PURCHASE OF
                                             SHARES)
DATE OF TRANSACTION                          28 OCTOBER 2005
PLACE OF TRANSACTION                         COPENHAGEN STOCK EXCHANGE
VOLUME OF TRANSACTION                        3,000 SHARES
TOTAL VALUE OF TRANSACTION                   DKK 375,000

DEFINITIONS AND BACKGROUND INFORMATION:




PUBLICATION

Publication  shall  take place the day after Novo  Nordisk  receives  sufficient
information  on the trading.  Publication is only required when the total amount
of  transactions  of a specific board  member/executive  and his/her  associated
persons in any one calendar year has reached 5,000 euros.

WHO ARE BOARD MEMBERS, EXECUTIVES AND ASSOCIATED PERSONS?

Board members and executives are members of the Board of Directors and Executive
Management, respectively, of Novo Nordisk A/S. Associated persons are defined as
the  following  persons  associated  to a board  member/executive:  1) spouse or
cohabitant,  2)  children  under the age of 18 years,  3)  relatives  defined as
brothers,  sisters, parents,  grandparents etc, children,  grandchildren etc who
have shared the same  household with a board  member/executive  for at least one
year,  and  4)  any  legal  person,  including  a  company,  a  foundation  or a
partnership,   which  is   controlled   directly  or   indirectly   by  a  board
member/executive  and/or  a  person  mentioned  in  1)-3),  or to  which a board
member/executive   and/or  a  person   mentioned   in   1)-3)   has   managerial
responsibilities  or economic  interests  substantially  equivalent to the legal
person.

WHAT IS TRADING/TRANSACTION?

Trading is any kind of  transaction,  including  shares  purchased  or otherwise
acquired,  shares sold or otherwise  disposed,  gifts,  mortgages and grants and
exercise of options, but not heritage.

WHAT IS FINANCIAL INSTRUMENT AND ID CODE?

Financial instrument includes shares listed on the Copenhagen Stock Exchange and
London Stock Exchange as well as ADRs listed on New York Stock Exchange,  except
for ADRs held in 401(k)  retirement plan by US-based  employees.  The ID code is
the code (ISIN  DK001028081)  of the Novo Nordisk share on the Copenhagen  Stock
Exchange, the code (NVOB) on London Stock Exchange or the code (NVO) on New York
Stock Exchange.

WHAT IS DATE AND PLACE OF TRANSACTION?

Date of transaction is the actual  transaction date. The place of transaction is
the actual place of  transaction,  ie Copenhagen  Stock  Exchange,  London Stock
Exchange or New York Stock Exchange.

WHAT IS VOLUME AND VALUE OF TRANSACTION?

The volume of  transaction  is the number of shares (of DKK 2 nominal  value) or
other  financial  instruments  traded.  The  transaction  value is the number of
shares traded  multiplied  by the  transaction  price.  The exchange rate of the
Danish  Central Bank  (Nationalbanken)  on the date of  transaction  is used for
calculating  the  transaction  value in DKK in case of  shares  traded on London
Stock Exchange and ADRs listed on New York Stock Exchange.



Novo Nordisk is a healthcare  company and a world leader in diabetes  care.  The
company has the broadest diabetes product  portfolio in the industry,  including
the most  advanced  products  within the area of insulin  delivery  systems.  In
addition,  Novo Nordisk has a leading  position within areas such as haemostasis
management, growth hormone therapy and hormone replacement therapy. Novo Nordisk
manufactures  and  markets  pharmaceutical  products  and  services  that make a
significant  difference to patients,  the medical  profession and society.  With
headquarters in Denmark,  Novo Nordisk employs  approximately  21,200  full-time
employees  in 78  countries,  and markets its  products in 179  countries.  Novo
Nordisk's B shares are listed on the stock  exchanges in Copenhagen  and London.
Its ADRs are listed on the New York Stock Exchange  under the symbol 'NVO'.  For
more information, visit novonordisk.com.

For further information please contact:

 Media:                                     Investors:
 Outside North America:                     Outside North America:

 Elin K Hansen                              Mogens Thorsager Jensen
 Tel (direct): (+45) 4442 3450              Tel (direct): (+45) 4442 7945

                                            Christian Qvist Frandsen
                                            Tel (direct): (+45) 4443 5182

 In North America:                          In North America:

 Susan T Jackson                            Mads Veggerby Lausten
 Tel (direct): (+1) 609 919 7776            Tel (direct): (+1) 609 919 7937


Stock Exchange Announcement No. 26/2005



                                   SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf of the
undersigned, thereunto duly authorized.

Date: NOVEMBER 2 2005                          NOVO NORDISK A/S
                             ---------------------------------------------------
                                            Lars Rebien Sorensen,
                                     President and Chief Executive Officer