UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549
                                -----------------

                                  SCHEDULE 13D
                    Under the Securities Exchange Act of 1934
                                (Amendment No. 2)

                              Aeterna Zentaris Inc.
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                                (Name of Issuer)

                                  Common Shares
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                         (Title of Class of Securities)

                                    007975204
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                                 (CUSIP Number)

                             Marc Paquet, Secretary
                    Societe Generale de Financement du Quebec
                          600, de la Gauchetiere Ouest
                                   Bureau 1700
                                Montreal, Quebec
                                 Canada H3B 4L8

                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                               February 17, 2006
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             (Date of Event Which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  that is the subject of this  Schedule  13D, and is filing this
schedule because of ss.ss.240.13d-1(e),  240.13d-1(f) or 240.13d-1(g), check the
following box. ___

                               Page 1 of 10 Pages



CUSIP No. 007975204                   13D

 1.    Names of Reporting Persons
       I.R.S. Identification Nos. of Above Persons (entities only)
       Societe Generale de Financement du Quebec
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 2.    Check the Appropriate Box if a Member of a Group (See Instructions)
       (a) ___
       (b) ___
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 3.    SEC Use Only
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 4.    Source of Funds (See Instructions)
       OO
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 5.    Check if Disclosure of Legal Proceedings Is Required
       Pursuant to Items 2(d) or 2(e). ___
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 6.    Citizenship or Place of Organization
       Quebec, Canada
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  Number of Shares       7.  Sole Voting Power
 Beneficially Owned          8,810,878
  by Each Reporting     ------------------------------------------------------
   Person With:          8.  Shared Voting Power
                             0
                        ------------------------------------------------------
                         9.  Sole Dispositive Power
                             8,810,878
                        ------------------------------------------------------
                        10.  Shared Dispositive Power
                             0
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11.  Aggregate Amount Beneficially Owned by Each Reporting Person
     8,810,878
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12.  Check if the Aggregate Amount in Row (11) Excludes Certain Shares
     (See Instructions)
      ___
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13.  Percent of Class Represented by Amount in Row (11)
     16.6%
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14.  Type of Reporting Person (See Instructions)
     CO
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                               Page 2 of 10 Pages



CUSIP No. 007975204                   13D

------------------------------------------------------------------------------
 1.  Names of Reporting Persons
     I.R.S. Identification Nos. of Above Persons (entities only)
     SGF Sante Inc.
------------------------------------------------------------------------------
 2.  Check the Appropriate Box if a Member of a Group (See Instructions)
     (a) ___ (b) ___
------------------------------------------------------------------------------
 3.  SEC Use Only
------------------------------------------------------------------------------
 4.  Source of Funds (See Instructions)
     OO
------------------------------------------------------------------------------
 5.  Check if Disclosure of Legal Proceedings Is Required
     Pursuant to Items 2(d) or 2(e).  ___
------------------------------------------------------------------------------
 6.  Citizenship or Place of Organization
     Quebec, Canada
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  Number of Shares      7.  Sole Voting Power
 Beneficially Owned          8,810,878
 by Each Reporting     -------------------------------------------------------
   Person With:         8.  Shared Voting Power
                            0
                       -------------------------------------------------------
                        9.  Sole Dispositive Power
                            8,810,878
                       -------------------------------------------------------
                       10.  Shared Dispositive Power
                            0
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11.  Aggregate Amount Beneficially Owned by Each Reporting Person
     8,810,878
------------------------------------------------------------------------------
12.  Check if the Aggregate Amount in Row (11) Excludes Certain Shares
     (See Instructions)
      ___
------------------------------------------------------------------------------
13.  Percent of Class Represented by Amount in Row (11)
     16.6%
------------------------------------------------------------------------------
14.  Type of Reporting Person (See Instructions)
     CO
------------------------------------------------------------------------------

                               Page 3 of 10 Pages



CUSIP No. 007975204                   13D


This amended statement on Schedule 13D amends and supplements the Schedule 13D
originally filed on April 19, 2002, as amended and restated on April 19, 2003
(as previously amended and amended hereby, the "Schedule 13D") by Societe
Generale de Financement du Quebec, and relates to the common shares, no par
value, of Aeterna Zentaris Inc.

General Amendments to Schedule 13D:

In addition to the amendments to specific items of the Schedule 13D as set forth
below in this Amendment No. 2 thereto, all references to "Subordinate Voting
Shares" in the Schedule 13D shall be amended to read "Common Shares". This
change reflects the exchange by the Company on May 26, 2004 of all Subordinate
Voting Shares of the Company for Common Shares at an exchange ratio of one
Common Share for each Subordinate Voting Share exchanged.

Item 1.  Security and Issuer

Item 1 of the Schedule 13D is hereby amended by deleting the first paragraph of
such Item and replacing it with the following:

         "This Schedule 13D relates to the common shares, no par value (the
         "Common Shares"), of Aeterna Zentaris Inc. (formerly know as Aeterna
         Laboratories Inc., the "Company"), a Quebec corporation duly
         incorporated under the Canada Business Corporations Act, which has its
         principal executive offices at 1405, boulevard du Parc-Technologique,
         Quebec, Quebec, Canada G1P 4P5."

Item 3.  Source and Amount of Funds or Other Consideration

Item 3 of the Schedule 13D is hereby amended and restated in its entirety as
follows:

         "On March 31, 2003, SGF Sante granted a term loan (the "Term Loan") of
         CAN$12,500,000 in favour of the Company under a loan agreement a copy
         of which is attached hereto as Exhibit 2 which is incorporated herein
         by reference. This loan agreement also related to another
         CAN$12,500,000 term loan granted to the Company by another party. The
         Term Loan was scheduled to mature on March 31, 2006 and bore interest
         at an annual rate of 12%. Interest was payable once a year on the
         anniversary date of the Term Loan, subject to the Company's right to
         defer payment of interest on the Term Loan until March 31, 2006. SGF
         Sante had the option to convert all or any part of the Term Loan, plus
         accrued and unpaid interest thereon, at any time during the term into
         Common Shares of the Company, calculated at a price of CAN$5.05 per
         share.

         SGF Sante obtained the funds for the Term Loan entirely from its own
         resources.

         On February 17, 2006 SGF Sante exercised its right to convert the
         entire unpaid principal balance of CAN$12,500,000 and CAN$5,061,600 of
         interest due on the Term Loan through the maturity date of March 31,
         2006 into 3,477,544 Common Shares."

Item 4.  Purpose of Transaction

Item 4 of the Schedule 13D is hereby amended by deleting the first two
paragraphs of such Item and replacing them with the following:

         "SGF, through its wholly-owned subsidiary SGF Sante, (1) made the Term
         Loan and (2) exercised its right to convert into Common Shares the
         unpaid principal and interest outstanding on the Term Loan, for
         investment purposes. SGF intends to review its investment in the
         Company periodically and may, depending on relevant economic and
         financial markets conditions and matters relating to the Company,
         acquire additional securities of the Company or sell any such
         securities. Any


                               Page 4 of 10 Pages



CUSIP No. 007975204                   13D


         subsequent  acquisition or disposition of such  securities may be made
         by way of market purchases and sales, private agreements or otherwise.

         Except as described above,  neither SGF nor SGF Sante has any plans or
         proposals which relate to or would result in:"

Item 5.  Interest in Securities of the Issuer

Item 5(a) of the Schedule 13D is hereby amended by deleting the first paragraph
of such Item and replacing it with the following:

         "SGF, through its wholly-owned subsidiary SGF Sante, may, pursuant to
         Rule 13d-3 of the Exchange Act, be deemed to be the beneficial owner of
         8,810,878 Common Shares. This constitutes approximately 16.6% of the
         outstanding shares after giving effect to the shares issuable upon
         conversion of the Term Loan described above and based on 53,104,902
         Common Shares outstanding as of February 17, 2006."

Item 6. Contracts, Arrangements, Understandings or relationships with Respect to
Securities of the Issuer

Item 6 of the Schedule 13D is hereby amended and restated in its entirety as
follows:

         "The  information  provided in Item 4 above is incorporated  herein by
         reference.

         SGF Sante is a party to an agreement dated April 9, 2002 (the "Voting
         Agreement") with Mr. Eric Dupont, the then controlling shareholder of
         the Company, under which Mr. Dupont agreed (i) to vote his shares of
         the Company in favor of the election of a representative of SGF Sante,
         and a representative designated jointly by SGF Sante and Mr. Dupont, to
         the Company's board of directors and (ii) as long as Mr. Dupont owned a
         majority of the votes attaching to the voting shares of the Company,
         not to vote his shares in favor of certain significant changes
         affecting the Company without the prior consent of SGF Sante. A copy of
         this agreement was filed with the filers' previous statement on
         Schedule 13D dated April 19, 2002."

         Effective on May 29, 2004, Mr. Dupont ceased to own a majority of the
         votes attaching to the voting shares of the Company. As a result, most
         of SGF's and SGF Sante's rights thereunder terminated, except for Mr.
         Dupont's undertaking to vote his shares in favour of the election of a
         representative of SGF Sante and a representative designated jointly by
         SGF Sante and Mr. Dupont to the board of directors of the Company.

Item 7.  Material to Be Filed as Exhibits

Item 7 of the Schedule 13D is hereby amended (1) by deleting Exhibit 1 to the
Schedule 13D in its entirety and replacing it with Exhibit 1 hereto.

                               Page 5 of 10 Pages



CUSIP No. 007975204                   13D

                                    SIGNATURE

         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

         Dated March _6__, 2006


                                             SOCIETE GENERALE DE FINANCEMENT
                                             DU QUEBEC


                                             By: (Signed) Marc Paquet
                                                 --------------------
                                                 Name: Marc Paquet
                                                 Title: Secretary


                                             SGF SANTE INC.


                                             By: (Signed) Marc Paquet
                                                 --------------------
                                                 Name: Marc Paquet
                                                 Title: Secretary

                               Page 6 of 10 Pages




                                INDEX OF EXHIBITS


   Exhibit                          Description
   Number
     1.        Name, title, principal business address, principal occupation and
               citizenship of each director and executive officer of SGF or SFG
               Sante.



                               Page 7 of 10 Pages