SECURITIES AND EXCHANGE COMMISSION   --------------------
                             Washington, D.C. 20549            SEC FILE NUMBER
                                   FORM 12b-25              --------------------

                                                                CUSIP NUMBER
                           NOTIFICATION OF LATE FILING

(Check One): |X| Form 10-K   |_| Form 20-F   |_| Form 11-K   |_| Form 10-Q
             |_| Form N-SAR  |_| Form N-CSR

For Period Ended: December 31, 2008
|_| Transition Report on Form 10-K
|_| Transition Report on Form 20-F
|_| Transition Report on Form 11-K
|_| Transition Report on Form 10-Q
|_| Transition Report on Form N-SAR
For the Transition Period Ended: ___________________

    Nothing in this form shall be construed to imply that the Commission has
                   verified any information contained herein.

If the notification relates to a portion of the filing checked above, identify
the Item(s) to which the notification relates:



Arbios Systems, Inc.
Full Name of Registrant

Former Name if Applicable

200 E. Del Mar Boulevard, #320
Address of Principal Executive Office (Street and Number)

Pasadena, California  91105
City, State and Zip Code

PART II - RULES 12b-25(b) AND (c)

If the subject report could not be filed without unreasonable effort or expense
and the registrant seeks relief pursuant to Rule 12b-25(b), the following should
be completed. (Check box if appropriate)

|X|   (a) The reasons described in reasonable detail in Part III of this form
      could not be eliminated without unreasonable effort or expense;

|X|   (b) The subject annual report, semi-annual report, transition report on
      Form 10-K, Form 20-F, 11-K, Form N-SAR, or N-CSR, or portion thereof, will
      be filed on or before the fifteenth calendar day following the prescribed
      due date; or the subject quarterly report or transition report on Form
      10-Q, or portion thereof will be filed on or before the fifth calendar day
      following the prescribed due date; and

|_|   (c) The accountant's statement or other exhibit required by Rule 12b-25(c)
      has been attached if applicable.


State below in reasonable detail the reasons why Form 10-K, 20-F, 11-K, 10-Q,
N-SAR, or the transition report or portion thereof, could not be filed within
the prescribed time period.

On January 9, 2009, the Company filed a voluntary bankruptcy petition under
Chapter 11. As a result of the bankruptcy proceedings and the Company's limited
resources, the Company has not been able to complete its financial statements or
draft the narrative description of its current status by the Form 10-K filing
deadline. Accordingly, the Company requires additional time to complete its Form


(1) Name and telephone number of person to contact in regard to this

            Scott Hayashi                 626                   356-3105
       ----------------------      -------------------       -----------------
              (Name)                   (Area Code)          (Telephone Number)

(2)   Have all other periodic reports required under Section 13 or 15(d) of the
      Securities Exchange Act of 1934 or Section 30 of the Investment Company
      Act of 1940 during the preceding 12 months or for such shorter period that
      the registrant was required to file such report(s) been filed? If answer
      is no, identify report(s). |X| Yes |_| No

(3)   Is it anticipated that any significant change in results of operations
      from the corresponding period for the last fiscal year will be reflected
      by the earnings statements to be included in the subject report or portion
      thereof? |_| Yes |X| No

If so, attach an explanation of the anticipated change, both narratively and
quantitatively, and, if appropriate, state the reasons why a reasonable estimate
of the results cannot be made.


                              Arbios Systems, Inc.
                  (Name of Registrant as Specified in Charter)

has caused this notification to be signed on its behalf by the undersigned
hereunto duly authorized.

Date:  March 31, 2009               By  /s/ Scott Hayashi
                                        Scott Hayashi, Chief Financial Officer

INSTRUCTION: The form may be signed by an executive officer of the registrant of
by any other duly authorized representative. The name and title of the person
signing the form shall be typed or printed beneath the signature. If the
statement is signed on behalf of the registrant by an authorized representative
(other than an executive officer), evidence of the representative's authority to
sign on behalf of the registrant shall be filed with the form.