Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
RIVERA LUPE M
  2. Issuer Name and Ticker or Trading Symbol
EXELIXIS INC [EXEL]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
SVP, Operations
(Last)
(First)
(Middle)
C/O EXELIXIS, INC., 249 EAST GRAND AVE., PO BOX 511
3. Date of Earliest Transaction (Month/Day/Year)
08/04/2009
(Street)

SOUTH SAN FRANCISCO, CA 94083-0511
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number. SEC 1474 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Option (right to buy) $ 7.85 08/04/2009   D     3,750 12/20/2003(1) 12/19/2012 Common Stock 3,750 (2) 0 D  
Option (right to buy) $ 5.63 08/05/2009   A   3,000   08/05/2010(3) 10/17/2015 Common Stock 3,000 (2) 3,000 D  
Option (right to buy) $ 7.92 08/04/2009   D     20,000 08/01/2005(1) 07/31/2014 Common Stock 20,000 (4) 0 D  
Option (right to buy) $ 5.63 08/05/2009   A   16,000   08/05/2010(3) 10/17/2015 Common Stock 16,000 (4) 16,000 D  
Option (right to buy) $ 8.15 08/04/2009   D     5,000 06/01/2004(1) 05/31/2013 Common Stock 5,000 (5) 0 D  
Option (right to buy) $ 5.63 08/05/2009   A   4,000   08/05/2010(3) 10/17/2015 Common Stock 4,000 (5) 4,000 D  
Option (right to buy) $ 8.9 08/04/2009   D     150,000 12/12/2006(1) 12/11/2015 Common Stock 150,000 (6) 0 D  
Option (right to buy) $ 5.63 08/05/2009   A   105,000   08/05/2010(3) 10/17/2015 Common Stock 105,000 (6) 105,000 D  
Option (right to buy) $ 5.63 08/05/2009   A   15,000   08/05/2010(7) 10/17/2015 Common Stock 15,000 (6) 15,000 D  
Option (right to buy) $ 8.92 08/04/2009   D     45,000 12/13/2005(1) 12/12/2014 Common Stock 45,000 (8) 0 D  
Option (right to buy) $ 5.63 08/05/2009   A   36,000   08/05/2010(3) 10/17/2015 Common Stock 36,000 (8) 36,000 D  
Option (right to buy) $ 8.99 08/04/2009   D     60,000 12/08/2007(1) 12/07/2016 Common Stock 60,000 (9) 0 D  
Option (right to buy) $ 5.63 08/05/2009   A   29,999   08/05/2010(3) 10/17/2015 Common Stock 29,999 (9) 29,999 D  
Option (right to buy) $ 5.63 08/05/2009   A   18,001   08/05/2010(7) 10/17/2015 Common Stock 18,001 (9) 18,001 D  
Option (right to buy) $ 9.91 08/04/2009   D     100,000 12/06/2008(1) 12/05/2017 Common Stock 100,000 (10) 0 D  
Option (right to buy) $ 5.63 08/05/2009   A   31,666   08/05/2010(3) 10/17/2015 Common Stock 31,666 (10) 31,666 D  
Option (right to buy) $ 5.63 08/05/2009   A   48,334   08/05/2010(7) 10/17/2015 Common Stock 48,334 (10) 48,334 D  
Option (right to buy) $ 11.93 08/04/2009   D     30,000 07/09/2008(1) 07/08/2017 Common Stock 30,000 (11) 0 D  
Option (right to buy) $ 5.63 08/05/2009   A   11,500   08/05/2010(3) 10/17/2015 Common Stock 11,500 (11) 11,500 D  
Option (right to buy) $ 5.63 08/05/2009   A   12,500   08/05/2010(7) 10/17/2015 Common Stock 12,500 (11) 12,500 D  
Option (right to buy) $ 12.25 08/04/2009   D     25,000 02/01/2003(1) 01/31/2012 Common Stock 25,000 (12) 0 D  
Option (right to buy) $ 5.63 08/05/2009   A   6,250   08/05/2010(3) 10/17/2015 Common Stock 6,250 (12) 6,250 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
RIVERA LUPE M
C/O EXELIXIS, INC.
249 EAST GRAND AVE., PO BOX 511
SOUTH SAN FRANCISCO, CA 94083-0511
      SVP, Operations  

Signatures

 /s/ James B. Bucher, Attorney in Fact   08/06/2009
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The option provided for vesting as follows: twenty five percent (25%) of the shares one year from date of grant, and the remaining shares in 36 equal monthly installments thereafter.
(2) On August 4, 2009, the Issuer cancelled, pursuant to the Issuer's option exchange program, an option for 3,750 shares of the Issuer's common stock granted to the reporting person on December 20, 2002. In exchange, on August 5, 2009, the reporting person received a replacement option for 3,000 shares of the Issuer's common stock, having an exercise price of $5.63.
(3) Option granted pursuant to Issuer's 2000 Equity Incentive Plan. One hundred percent (100%) of the shares vest one year from date of grant.
(4) On August 4, 2009, the Issuer cancelled, pursuant to the Issuer's option exchange program, an option for 20,000 shares of the Issuer's common stock granted to the reporting person on August 1, 2004. In exchange, on August 5, 2009, the reporting person received a replacement option for 16,000 shares of the Issuer's common stock, having an exercise price of $5.63.
(5) On August 4, 2009, the Issuer cancelled, pursuant to the Issuer's option exchange program, an option for 5,000 shares of the Issuer's common stock granted to the reporting person on June 1, 2003. In exchange, on August 5, 2009, the reporting person received a replacement option for 4,000 shares of the Issuer's common stock, having an exercise price of $5.63.
(6) On August 4, 2009, the Issuer cancelled, pursuant to the Issuer's option exchange program, an option for 150,000 shares of the Issuer's common stock granted to the reporting person on December 12, 2005. In exchange, on August 5, 2009, the reporting person received two replacement options for 105,000 and 15,000 shares of the Issuer's common stock, respectively, each having an exercise price of $5.63.
(7) Option granted pursuant to Issuer's 2000 Equity Incentive Plan. Thirty-three percent (33%) of the shares vest one year from date of grant, and the remaining shares vest in 24 equal monthly installments thereafter.
(8) On August 4, 2009, the Issuer cancelled, pursuant to the Issuer's option exchange program, an option for 45,000 shares of the Issuer's common stock granted to the reporting person on December 13, 2004. In exchange, on August 5, 2009, the reporting person received a replacement option for 36,000 shares of the Issuer's common stock, having an exercise price of $5.63.
(9) On August 4, 2009, the Issuer cancelled, pursuant to the Issuer's option exchange program, an option for 60,000 shares of the Issuer's common stock granted to the reporting person on December 8, 2006. In exchange, on August 5, 2009, the reporting person received two replacement options for 29,999 and 18,001 shares of the Issuer's common stock, respectively, each having an exercise price of $5.63.
(10) On August 4, 2009, the Issuer cancelled, pursuant to the Issuer's option exchange program, an option for 100,000 shares of the Issuer's common stock granted to the reporting person on December 6, 2007. In exchange, on August 5, 2009, the reporting person received two replacement options for 31,666 and 48,334 shares of the Issuer's common stock, respectively, each having an exercise price of $5.63.
(11) On August 4, 2009, the Issuer cancelled, pursuant to the Issuer's option exchange program, an option for 30,000 shares of the Issuer's common stock granted to the reporting person on July 9, 2007. In exchange, on August 5, 2009, the reporting person received two replacement options for 11,500 and 12,500 shares of the Issuer's common stock, respectively, each having an exercise price of $5.63.
(12) On August 4, 2009, the Issuer cancelled, pursuant to the Issuer's option exchange program, an option for 25,000 shares of the Issuer's common stock granted to the reporting person on February 1, 2002. In exchange, on August 5, 2009, the reporting person received a replacement option for 6,250 shares of the Issuer's common stock, having an exercise price of $5.63.

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