SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G
                                (RULE 13d - 102)

INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO 13d-1(b), (c) AND (d)
               AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2(b)

                               (Amendment No.___)*

                           Exact Sciences Corporation
                                (Name of Issuer)

                          Common Stock, $.01 par value
                         (Title of Class of Securities)

                                    30063P105
                                 (CUSIP Number)

                                December 16, 2005
             (Date of Event which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

                                [ ] Rule 13d-1(b)
                                [x] Rule 13d-1(c)
                                [ ] Rule 13d-1(d)

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                       (Continued on the Following Pages)





1.  NAMES OF REPORTING PERSONS
    I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

     Paloma International L.P.

2.  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

     (a) [x]
     (b) [ ]

3.  SEC USE ONLY

4.  CITIZENSHIP OR PLACE OF ORGANIZATION

     Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH:

5.  SOLE VOTING POWER

     0

6.  SHARED VOTING POWER

     1,516,646

7.  SOLE DISPOSITIVE POWER

     0

8.  SHARED DISPOSITIVE POWER

     1,516,646

9.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     1,516,646

10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ]

11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     5.76%

12. TYPE OF REPORTING PERSON*

     PN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!



1.  NAMES OF REPORTING PERSONS
    I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

     S. Donald Sussman

2.  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

     (a) [x]
     (b) [ ]

3.  SEC USE ONLY

4.  CITIZENSHIP OR PLACE OF ORGANIZATION

     United States

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5.  SOLE VOTING POWER

     0

6.  SHARED VOTING POWER

     1,516,646

7.  SOLE DISPOSITIVE POWER

     0

8.  SHARED DISPOSITIVE POWER

     1,516,646

9.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     1,516,646

10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ]

11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     5.76%

12. TYPE OF REPORTING PERSON*

     IN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!



1.  NAMES OF REPORTING PERSONS
    I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

     MAK Capital One L.L.C.

2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

     (a) [x]
     (b) [ ]

3. SEC USE ONLY

4. CITIZENSHIP OR PLACE OF ORGANIZATION

     Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH:

5. SOLE VOTING POWER

     0

6. SHARED VOTING POWER

     1,516,646

7. SOLE DISPOSITIVE POWER

     0

8. SHARED DISPOSITIVE POWER

     1,516,646

9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     1,516,646

10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ]

11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     5.76%

12. TYPE OF REPORTING PERSON*

     PN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!



1.  NAMES OF REPORTING PERSONS
    I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

     MAK Capital Fund LP

2.  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

     (a) [x] (b) [ ]

3.  SEC USE ONLY

4.  CITIZENSHIP OR PLACE OF ORGANIZATION

     Bermuda

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH:

5.  SOLE VOTING POWER

     0

6.  SHARED VOTING POWER

     117,880

7.  SOLE DISPOSITIVE POWER

     0

8.  SHARED DISPOSITIVE POWER

     117,880

9.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     117,880

10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [  ]

11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     0.45%

12. TYPE OF REPORTING PERSON*

     PN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!




1. NAMES OF REPORTING PERSONS
   I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

     Michael A. Kaufman

2.  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

     (a) [x]
     (b) [ ]

3.  SEC USE ONLY

4.  CITIZENSHIP OR PLACE OF ORGANIZATION

     United States

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5.  SOLE VOTING POWER

     0

6.  SHARED VOTING POWER

     1,634,526

7.  SOLE DISPOSITIVE POWER

     0

8.  SHARED DISPOSITIVE POWER

     1,634,526

9.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     1,634,526

10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [  ]

11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

     6.21%

12. TYPE OF REPORTING PERSON*

     IN

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!




This report reflects the shares of Common Stock (as defined below) beneficially
owned by the Reporting Persons (as defined below) as of December 26, 2005.

ITEM 1(a).        Name of Issuer:

     Exact Sciences Corporation (the "Issuer").

Item 1(b).        Address of Issuer's Principal Executive Offices:

     100 Campus Drive
     Marlborough, Massachusetts 01752

Item 2(a).        Name of Persons Filing:

     The names of the persons filing this statement on Schedule 13G are:  Paloma
International L.P., a Delaware limited partnership ("Paloma"), S. Donald Sussman
("Mr.  Sussman"),  MAK Capital One L.L.C., a Delaware limited  liability company
("MAK  Capital"),  MAK  Capital  Fund LP, a Bermuda  limited  partnership  ("MAK
Fund"), and Michael A. Kaufman ("Mr. Kaufman," and collectively,  the "Reporting
Persons").

Item 2(b).        Address of Principal Business Office or, if None, Residence:

     The principal business address for Paloma is Two American Lane,  Greenwich,
Connecticut 06836.

     The principal  business  address for Mr.  Sussman is 6100 Red Hook Quarter,
18B, Suites C, 1-6, St. Thomas, United States Virgin Islands 00802.

     The principal  business address for MAK Fund is c/o Dundee Leeds Management
Services Ltd., 129 Front Street, Hamilton, HM 12, Bermuda.

     The principal  business  address for each of MAK Capital and Mr. Kaufman is
590 Madison Avenue, 9th Floor, New York, New York 10022.

Item 2(c).        Citizenship:

     Paloma is a Delaware limited partnership.

     MAK Capital is a Delaware limited liability company.

     MAK Fund is a Bermuda limited partnership.

     Mr. Sussman and Mr. Kaufman are citizens of the United States.

Item 2(d).        Title of Class of Securities

     Common Stock, $.01 par value (the "Common Stock").

Item 2(e).        CUSIP Number:  30063P105

Item 3.           If This Statement is Filed Pursuant to Rule 13d-1(b),
                  or 13d-2(b) or (c), Check Whether the Person Filing is a:

     (a) [ ] Broker or dealer registered under Section 15 of the Exchange Act.

     (b) [ ] Bank as defined in Section 3(a)(6) of the Exchange Act.

     (c) [ ] Insurance company defined in Section 3(a)(19) of the Exchange Act.



     (d) [ ] Investment  company  registered  under Section 8 of the  Investment
             Company Act.

     (e) [ ] An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E).

     (f) [ ] An employee  benefit plan or endowment fund in accordance with Rule
             13d-1(b)(1)(ii)(F).

     (g) [ ] A parent holding  company or control person in accordance with Rule
             13d-1(b)(1)(ii)(G).

     (h) [ ] A savings  association  as defined in Section  3(b) of the  Federal
             Deposit Insurance Act.

     (i) [ ] A church plan that is excluded from the definition of an investment
             company under Section 3(c)(14) of the Investment Company Act;

     (j) [ ] Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

     If this statement is filed pursuant to Rule 13d-1(c), check this box [x]

Item 4.   Ownership.

     Provide  the  following  information  regarding  the  aggregate  number and
percentage of the class of securities of the issuer identified in Item 1.

     (a)  Amount beneficially owned:

          The Reporting Persons  collectively  beneficially own 1,634,526 shares
          of Common Stock.

     (b) Percent of class:

          The Reporting Persons have beneficial ownership of 1,634,526 shares of
          Common Stock  constituting  6.21% of all of the outstanding  shares of
          Common Stock.

     (c)  Number of shares as to which such person has:

          (i)   Sole power to vote or to direct the vote

                Not applicable.

          (ii)  Shared power to vote or to direct the vote

                Paloma, Mr. Sussman, MAK Capital and Mr. Kaufman have shared
                power to vote or direct the vote of the 1,516,646  shares of
                Common Stock owned by Paloma.

                MAK Fund and Mr. Kaufman have shared power to vote or direct
                the vote of the 117,880  shares of Common Stock owned by MAK
                Fund.

          (iii) Sole power to dispose or to direct the disposition of

                Not applicable.

          (iv)  Shared power to dispose or to direct the disposition of



                Paloma, Mr. Sussman, MAK Capital and Mr. Kaufman have shared
                power to dispose or direct the  disposition of the 1,516,646
                shares of Common Stock owned by Paloma.

                MAK Fund and Mr.  Kaufman  have  shared  power to dispose or
                direct the disposition of the 117,880 shares of Common Stock
                owned by MAK Fund.

Item 5.     Ownership of Five Percent or Less of a Class.

     If this  statement  is being  filed to report  the fact that as of the date
hereof the Reporting Persons have ceased to be the beneficial owner of more than
five percent of the class of securities, check the following [ ].

Item 6.     Ownership of More than Five Percent on Behalf of Another Person.

     Not applicable.

Item 7.     Identification and Classification of the Subsidiary Which Acquired
            the Security Being Reported on by the Parent Holding Company.

     Paloma holds its 1,516,646 shares of Common Stock that it beneficially owns
through its wholly-owned  subsidiary,  Sunrise Partners Limited  Partnership,  a
Delaware limited partnership.

Item 8.     Identification and Classification of Members of the Group.

     See Exhibit B attached hereto.

Item 9.     Notice of Dissolution of Group.

     Not applicable.

Item 10.    Certification.

     By  signing  below  the  undersigned  certifies  that,  to the  best of its
knowledge and belief, the securities referred to above were not acquired and are
not held for the purpose of or with the effect of changing  or  influencing  the
control of the issuer of the  securities  and were not acquired and are not held
in connection with or as a participant in any transaction having that purpose or
effect.



                                   SIGNATURES

     After reasonable inquiry and to the best of its knowledge and belief,  each
of the undersigned  certifies that the information  with respect to it set forth
in this statement is true, complete, and correct.


Dated:  December 27, 2005

        PALOMA INTERNATIONAL L.P.
        By: Paloma GP LLC, general partner


            By: /s/ Michael J. Berner
                ---------------------
                    Michael J. Berner
                    Vice President


          /s/ S. Donald Sussman
          ----------------------
              S. Donald Sussman


        MAK CAPITAL ONE L.L.C.


            By: /s/ Michael A. Kaufman
                ----------------------
                    Michael A. Kaufman
                    Managing Member


        MAK CAPITAL FUND LP
        By: MAK GP LLC, general partner


            By: /s/ Michael A. Kaufman
                ----------------------
                    Michael A. Kaufman
                    Managing Member



        /s/ Michael A. Kaufman
        ----------------------
            Michael A. Kaufman





                                    EXHIBIT A
                             JOINT FILING AGREEMENT

     The  undersigned  hereby  agree that the  statement  on  Schedule  13G with
respect to the Common Stock of Exact  Sciences  Corporation  dated  December 27,
2005 is, and any further  amendments  thereto signed by each of the  undersigned
shall  be,  filed  on  behalf  of each  of the  undersigned  pursuant  to and in
accordance  with the provisions of Rule 13d-1(k)  under the Securities  Exchange
Act of 1934, as amended.


Dated:  December 27, 2005

        PALOMA INTERNATIONAL L.P.
        By: Paloma GP LLC, general partner


            By: /s/ Michael J. Berner
                ---------------------
                    Michael J. Berner
                    Vice President


          /s/ S. Donald Sussman
          ----------------------
              S. Donald Sussman


        MAK CAPITAL ONE L.L.C.


            By: /s/ Michael A. Kaufman
                ----------------------
                    Michael A. Kaufman
                    Managing Member


        MAK CAPITAL FUND LP
        By: MAK GP LLC, general partner


            By: /s/ Michael A. Kaufman
                ----------------------
                    Michael A. Kaufman
                    Managing Member



        /s/ Michael A. Kaufman
        ----------------------
            Michael A. Kaufman




                                    EXHIBIT B
                     IDENTIFICATION OF MEMBERS OF THE GROUP


Paloma International L.P.
S. Donald Sussman
MAK Capital One L.L.C.
MAK Capital Fund LP
Michael A. Kaufman