Registration No. 333-107978

--------------------------------------------------------------------------------
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

            --------------------------------------------------------

                                 AMENDMENT NO. 1
                                       TO
                                    FORM S-3
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

            --------------------------------------------------------

                               CELGENE CORPORATION
             (Exact name of Registrant as specified in its charter)

            --------------------------------------------------------

           DELAWARE                  7 Powder Horn Drive        22-2711928
(State or other jurisdiction of   Warren, New Jersey 07059   (I.R.S. Employer
incorporation or organization)         (732) 271-1001       Identification No.)

    (Address, Including Zip Code, and Telephone Number, Including Area Code,
                  of Registrant's Principal Executive Offices)

            --------------------------------------------------------

                                 JOHN W. JACKSON
                CHAIRMAN OF THE BOARD AND CHIEF EXECUTIVE OFFICER
                               CELGENE CORPORATION
                  7 POWDER HORN DRIVE, WARREN, NEW JERSEY 07059
                                 (732) 271-1001
                (Name, Address, Including Zip Code, and Telephone
               Number, Including Area Code, of Agent for Service)

            --------------------------------------------------------

                          Copies of Communications to:
                             Robert A. Cantone, Esq.
                               Proskauer Rose LLP
                  1585 Broadway, New York, New York 10036-8299
                                 (212) 969-3000

            --------------------------------------------------------

         APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC: From
time to time or at one time after the effective date of this Registration
Statement.

         If the only securities being registered on this Form are being offered
pursuant to dividend or interest or interest investment plans, please check the
following box. |_|

         If any of the securities being registered on this Form are to be
offered on a delayed or continuous basis pursuant to Rule 415 under the
Securities Act of 1933, other than securities offered only in connection with
dividend or interest reinvestment plans, check the following box. |X|

         If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list the Securities Act registration statement number of the earlier
effective registration statement for the same offering. |_|

         If this Form is a post-effective amendment filed pursuant to Rule
462(c) under the Securities Act, check the following box and list the Securities
Act registration statement number of the earlier effective registration
statement for the same offering. |_|

         If delivery of the prospectus is expected to be made pursuant to Rule
434, please check the following box. |_|

         CALCULATION OF REGISTRATION FEE



=======================================================================================================
Title of each Class of          Amount To Be    Proposed Maximum     Proposed Maximum        Amount of
Securities To Be Registered      Registered      Offering Price          Aggregate         Registration
                                                  Per Unit (1)      Offering Price (1)          Fee
-------------------------------------------------------------------------------------------------------
                                                                                 
Common Stock,
par value $.01 per share       79,620 shares        $38.76               $3,086,071          $391.00(2)
=======================================================================================================


(1)  Based on the average of the high and low selling prices per share as
     reported on the Nasdaq National Market on August 8, 2003. Estimated
     pursuant to Rule 457(c) under the Securities Act of 1933, as amended,
     solely for the purpose of calculating the registration fee.

(2) $216.00 of this fee has previously been paid by the Registrant.





The Registrant hereby amends this registration statement on such date or dates
as may be necessary to delay its effective date until the Registrant shall file
a further amendment which specifically states that this Registration Statement
shall thereafter become effective in accordance with Section 8(a) of the
Securities Act of 1933 or until the Registration Statement shall become
effective on such date as the Commission, acting pursuant to said Section 8(a),
may determine.





PROSPECTUS


                               CELGENE CORPORATION

                                  79,620 SHARES
                                  COMMON STOCK
                           (PAR VALUE $0.01 PER SHARE)

                            ------------------------

The shares of common stock are being sold by the selling securityholders listed
beginning on page 14. We will not receive any proceeds from the sale by the
selling securityholders of any shares of common stock. The selling
securityholders may offer the common stock, in negotiated transactions or
otherwise, at market prices prevailing at the time of sale or at negotiated
prices. In addition, the common stock may be offered from time to time through
ordinary brokerage transactions on the Nasdaq National Market. See "Plan of
Distribution" on page 16. The selling securityholders may be deemed to be
"underwriters" as defined in the Securities Act of 1933, as amended (the
"Securities Act"). If any broker-dealers are used by the selling
securityholders, any commissions paid to broker-dealers and, if broker-dealers
purchase any common stock as principals, any profits received by such
broker-dealers on the resale of the common stock, may be deemed to be
underwriting discounts or commissions under the Securities Act. In addition, any
profits realized by the selling securityholders may be deemed to be underwriting
commissions. Other than selling commissions and fees and stock transfer taxes,
we will pay all expenses of the registration of the common stock. Our common
stock is traded on the Nasdaq National Market under the symbol "CELG." The last
reported sale price on November 13, 2003 was $41.00 per share.

                            ------------------------

INVESTING IN OUR COMMON STOCK INVOLVES RISKS. SEE "RISK FACTORS" BEGINNING ON
PAGE 3.

                            ------------------------

NEITHER THE SECURITIES AND EXCHANGE COMMISSION NOR ANY STATE SECURITIES
COMMISSION HAS APPROVED OR DISAPPROVED OF THESE SECURITIES OR DETERMINED IF THIS
PROSPECTUS IS TRUTHFUL OR COMPLETE. ANY REPRESENTATION TO THE CONTRARY IS A
CRIMINAL OFFENSE.


                                November 14, 2003



                                TABLE OF CONTENTS

                                                                            PAGE

ABOUT THIS PROSPECTUS.........................................................1
SUMMARY.......................................................................2
RISK FACTORS..................................................................3
FORWARD-LOOKING STATEMENTS...................................................11
USE OF PROCEEDS..............................................................11
DESCRIPTION OF CAPITAL STOCK.................................................12
SELLING SECURITYHOLDERS......................................................14
PLAN OF DISTRIBUTION.........................................................16
LEGAL MATTERS................................................................17
EXPERTS......................................................................17
WHERE YOU CAN FIND MORE INFORMATION..........................................18
INCORPORATION BY REFERENCE...................................................18


                                       i



                              ABOUT THIS PROSPECTUS

This prospectus is part of a registration statement that we filed with the
Securities and Exchange Commission using a "shelf" registration or continuous
offering process. Under this shelf registration process, selling securityholders
may from time to time sell the securities described in this prospectus in one or
more offerings.

This prospectus provides you with a general description of the securities that
the selling securityholders may offer. A selling securityholder may be required
to provide you with a prospectus supplement containing specific information
about the selling securityholder and the terms of the securities being offered.
That prospectus supplement may include additional risk factors or other special
considerations applicable to those securities. A prospectus supplement may also
add, update or change information in this prospectus. If there is any
inconsistency between the information in this prospectus and any prospectus
supplement, you should rely on the information in that prospectus supplement.
You should read both this prospectus and any prospectus supplement together with
the additional information described under the heading "Where You Can Find More
Information."

In this prospectus and any prospectus supplement, unless otherwise indicated,
the terms "we," "us," "our" and "Celgene" refer to Celgene Corporation and its
consolidated subsidiaries.

                            ------------------------

We have not authorized any dealer, salesman or other person to give any
information or to make any representation other than those contained or
incorporated by reference in this prospectus and any accompanying supplement to
this prospectus. You must not rely upon any information or representation not
contained or incorporated by reference in this prospectus or any accompanying
prospectus supplement. This prospectus and any accompanying supplement to this
prospectus do not constitute an offer to sell or the solicitation of an offer to
buy any securities other than the registered securities to which they relate,
nor do this prospectus and any accompanying supplement to this prospectus
constitute an offer to sell or the solicitation of an offer to buy securities in
any jurisdiction to any person to whom it is unlawful to make such offer or
solicitation in such jurisdiction. The information contained in this prospectus
and any supplement to this prospectus is accurate as of the respective dates on
their covers. When we deliver this prospectus or a supplement or make a sale
pursuant to this prospectus or a supplement, we are not implying that the
information is current as of the date of the delivery or sale.


                                       1



                                     SUMMARY

This summary contains basic information about us and this offering. Because it
is a summary, it does not contain all of the information that you should
consider before investing. You should read this entire prospectus (and any
prospectus supplement) carefully and the information we incorporate by reference
into it, including the section entitled "Risk Factors," before making an
investment decision.

                               CELGENE CORPORATION

We are a fully-integrated biopharmaceutical company, incorporated in 1986 as a
Delaware corporation.

We are primarily engaged in the discovery, development and commercialization of
novel therapies designed to treat cancer and immunological diseases through
regulation of cellular, genomic and proteomic targets. We had total revenues of
$135.7 million in 2002 and $190.7 million for the nine-month period ended
September 30, 2003, and a net loss of $100.0 million in 2002 and net income of
$8.1 million for the nine-month period ended September 30, 2003. The net loss
for 2002 included a charge to operations of $32.2 million attributable to a
litigation settlement and related agreements and $55.7 million related to an
acquired in-process research and development charge in connection with the
acquisition of Anthrogenesis Corp. We had an accumulated deficit of $322.4
million at December 31, 2002 and $314.2 million at September 30, 2003. Since our
inception in 1986, we have financed our working capital requirements primarily
through product sales, public and private sales of our equity securities and
debt, income earned on the investment of the proceeds from the sale of such
securities and revenues from research contracts and license payments.

We were incorporated in Delaware in 1986. Our principal executive offices are
located at 7 Powder Horn Drive, Warren, New Jersey 07059. Our telephone number
at this location is (732) 271-1001. Our website is located at
http://www.celgene.com. The information contained on our website is not a part
of this prospectus.


                                       2



                                  RISK FACTORS

You should carefully consider the risks described below before making an
investment decision. The risks described below are not the only ones facing our
company. Additional risks not presently known to us or that we currently deem
immaterial may also impair our business operations.

Our business, financial condition and results of operations could be materially
adversely affected by any of these risks. The trading price of our common stock
could decline due to any of these risks, and you may lose all or part of your
investment.

This prospectus, including the documents it incorporates by reference, also
contains forward-looking statements that involve risks and uncertainties. Our
actual results could differ materially from those anticipated in these
forward-looking statements as a result of certain factors, including the risks
faced by us described below and elsewhere in this prospectus.

INDUSTRY RISKS

WE HAVE A HISTORY OF OPERATING LOSSES AND AN ACCUMULATED DEFICIT.

We have sustained losses in each year since our incorporation in 1986. We
sustained a net loss of $100.0 million, which included $32.2 million
attributable to a litigation settlement and related agreements and $55.7 million
related to an acquired in-process research and development charge in connection
with the Anthrogenesis acquisition, and $1.9 million for the years ended
December 31, 2002 and 2001, respectively. For the nine-month period ended
September 30, 2003, we recorded net income of $8.1 million. We had an
accumulated deficit of $322.4 million at December 31, 2002 and of $314.2 million
at September 30, 2003. We expect to make substantial expenditures to further
develop and commercialize our products. We also expect that our rate of spending
will accelerate as the result of increased clinical trial costs and expenses
associated with regulatory approval and commercialization of products now in
development.

IF WE ARE UNSUCCESSFUL IN DEVELOPING AND COMMERCIALIZING OUR PRODUCTS, OUR
BUSINESS, FINANCIAL CONDITION AND RESULTS OF OPERATIONS COULD BE MATERIALLY
ADVERSELY AFFECTED WHICH COULD IMPACT NEGATIVELY ON THE VALUE OF OUR COMMON
STOCK.

Many of our products and processes are in the early or mid-stages of development
and will require the commitment of substantial resources, extensive research,
development, preclinical testing, clinical trials, manufacturing scale-up and
regulatory approval prior to being ready for sale. With the exception of
Focalin(TM), Alkeran(R) and THALOMID(R), all of our other products will require
further development, clinical testing and regulatory approvals. If it becomes
too expensive to sustain our present commitment of resources on a long-term
basis, we will be unable to continue our necessary development activities.
Furthermore, we cannot be certain that our clinical testing will render
satisfactory results, or that we will receive required regulatory approval for
our products. If any of our products, even if developed and approved, cannot be
successfully commercialized, our business, financial condition and results of
operations could be materially adversely affected which could impact negatively
on the value of our common stock.

DURING THE NEXT SEVERAL YEARS, WE WILL BE VERY DEPENDENT ON THE COMMERCIAL
SUCCESS OF THALOMID(R), FOCALIN(TM), ALKERAN(R) AND THE ENTIRE RITALIN(R)
PRODUCT LINE.

At our present level of operations, we may not be able to attain or maintain
profitability if physicians prescribe THALOMID(R) only foR patients who are
diagnosed with erytherma nodosum leprosum, or ENL. ENL, a complication of
leprosy, is a chronic bacterial disease. Under current regulations of the U.S.
Food and Drug Administration, we are precluded from promoting THALOMID(R)
outside this approved use. The market for the use of THALOMID(R) in patients
suffering from ENL is relatively small. We have conducted clinical studies that
appear to show that THALOMID(R) is active when used to treat disorders other
than ENL, such as multiple myeloma, but we do not know whether we will succeed
in receiving regulatory approval to market THALOMID(R) for additional
indications. FDA regulations place restrictions on our ability to communicate
the results of additional clinical studies to patients and physicians without


                                       3



first obtaining approval from the FDA to expand the authorized uses for this
product. In addition, if adverse experiences are reported in connection with the
use of THALOMID(R) by patients, this could undermine physician and patient
comfort with the product, could limit the commercial success of the product and
could even impact the acceptance of THALOMID(R) in the ENL market. We are
dependent upon royalties from Novartis Pharma AG's entire Ritalin(R) product
line as well as Focalin(TM), although we cannot directly impact their ability to
successfully commercialize these products and we have annual minimum purchase
requirements relating to Alkeran, which we license from GlaxoSmithKline through
March 31, 2006. Additionally, our revenues would be negatively impacted if a
generic version of any of these products were to be approved.

WE FACE A RISK OF PRODUCT LIABILITY CLAIMS AND MAY NOT BE ABLE TO OBTAIN
SUFFICIENT INSURANCE ON COMMERCIALLY REASONABLE TERMS OR WITH ADEQUATE COVERAGE.

We may be subject to product liability or other claims based on allegations that
the use of our technology or products has resulted in adverse effects, whether
by participants in our clinical trials or by patients using our products.
Thalidomide, when used by pregnant women, has resulted in serious birth defects.
Therefore, necessary and strict precautions must be taken by physicians
prescribing the drug to women with childbearing potential. These precautions may
not be observed in all cases or, if observed, may not be effective. Use of
thalidomide has also been associated, in a limited number of cases, with other
side effects, including nerve damage. Although we have product liability
insurance that we believe is appropriate, we may be unable to obtain additional
coverage on commercially reasonable terms if required, or our coverage may be
inadequate to protect us in the event claims are asserted against us. Our
obligation to defend against or pay any product liability or other claim may be
expensive and divert the efforts of our management and technical personnel.

IF OUR PRODUCTS ARE NOT ACCEPTED BY THE MARKET, DEMAND FOR OUR PRODUCTS WILL
DETERIORATE OR NOT MATERIALIZE AT ALL.

It is necessary that our, and our distribution partner's, products, including
THALOMID(R) Alkeran(R) and Focalin(TM), achieve market acceptance once they
receive regulatory approval, if regulatory approval is required. A number of
factors render the degree of market acceptance of our products uncertain,
including the extent to which we can demonstrate the products' efficacy, safety
and advantages, if any, over competing products, as well as the reimbursement
policies of third-party payors, such as government and private insurance plans.
In particular, thalidomide, when used by pregnant women, has resulted in serious
birth defects, and the negative history associated with thalidomide and birth
defects may decrease the market acceptance of THALOMID(R). In addition, the
products that we are attempting to develop through our Celgene Cellular
Therapeutics division may represent substantial departures from established
treatment methods and will compete with a number of traditional drugs and
therapies which are now, or may be in the future, manufactured and marketed by
major pharmaceutical and biopharmaceutical companies. Furthermore, public
attitudes may be influenced by claims that stem cell therapy is unsafe, and stem
cell therapy may not gain the acceptance of the public or the medical community.
If our products are not accepted by the market, demand for our products will
deteriorate or not materialize at all.

WE MAY EXPERIENCE SIGNIFICANT FLUCTUATIONS IN OUR QUARTERLY OPERATING RESULTS.

We have historically experienced, and expect to continue for the foreseeable
future to experience, significant fluctuations in our quarterly operating
results. These fluctuations are due to a number of factors, many of which are
outside our control, and may result in volatility of our stock price. Future
operating results will depend on many factors, including:

o    demand for our products;

o    regulatory approvals for our products;

o    the timing of the introduction and market acceptance of new products by us
     or competing companies;

o    the timing and recognition of certain research and development milestones
     and license fees; and

o    our ability to control our costs.


                                       4



WE HAVE NO COMMERCIAL MANUFACTURING FACILITIES AND WE ARE DEPENDENT ON TWO
SUPPLIERS FOR THE RAW MATERIAL AND ONE MANUFACTURER FOR THE FORMULATION AND
ENCAPSULATION OF THALOMID(R) AND ARE DEPENDENT ON TWO SUPPLIERS FOR THE RAW
MATERIAL AND ONE MANUFACTURER FOR THE TABLETING AND PACKAGING OF FOCALIN(TM).

We currently have no facilities for manufacturing any products on a commercial
scale. Currently, we can obtain all of our bulk drug material for THALOMID(R)
from two suppliers, ChemSyn Laboratories, a Division of Eagle-Picher
Technologies, L.L.C., and Sifavitor s.p.a., and we rely on a single
manufacturer, Penn Pharmaceutical Services Limited, to formulate and encapsulate
THALOMID(R). In addition, we currently can obtain all of our bulk active
pharmaceutical ingredient for Focalin(TM) from two suppliers, Johnson Matthey
Inc. and Seigfried USA, Inc., and we rely on a single manufacturer, Mikart,
Inc., for the packaging and tableting of Focalin(TM). Presently, we are actively
seeking alternative sources to each of Penn and Mikart. The FDA requires that
all suppliers of pharmaceutical bulk material and all manufacturers of
pharmaceuticals for sale in or from the United States achieve and maintain
compliance with the FDA's current Good Manufacturing Practice, or cGMP,
regulations and guidelines. (cGMP are regulations established by the FDA that
govern the manufacture, processing, packing, storage and testing of drugs
intended for human use.) If the operations of either Penn or Mikart were to
become unavailable for any reason, any required FDA review and approval of the
operations of an alternative could cause a delay in the manufacture of
THALOMID(R) or Focalin(TM). Although we have an option to purchase the
THALOMID(R) manufacturing operations of Penn, we intend to continue to utilize
outside manufacturers if and when needed to produce our other products on a
commercial scale. If our outside manufacturers do not meet our requirements for
quality, quantity or timeliness, or do not achieve and maintain compliance with
all applicable regulations, demand for our products or our ability to continue
manufacturing such products could substantially decline, to the extent we depend
on these outside manufacturers.

WE HAVE LIMITED MARKETING AND DISTRIBUTION CAPABILITIES.

Although we have an approximately 180-person commercialization group to support
our products, we may be required to seek a corporate partner to provide
marketing services with respect to our other products. Any delay in developing
these resources could substantially delay or curtail the marketing of these
products. We have contracted with Ivers Lee Corporation, d/b/a Sharp, a
specialty distributor, to distribute THALOMID(R). If Sharp does not perform its
obligations, our ability to distribute THALOMID(R) maY be severely restricted.

WE ARE DEPENDENT ON COLLABORATIONS AND LICENSES WITH THIRD PARTIES.

Our ability to fully commercialize our products, if developed, may depend to
some extent upon our entering into joint ventures or other arrangements with
established pharmaceutical and biopharmaceutical companies with the requisite
experience and financial and other resources to obtain regulatory approvals and
to manufacture and market such products. Our present joint ventures and licenses
include an agreement with Novartis Pharma AG with respect to the joint research
of SERMs, and a separate agreement wherein we have granted to Novartis an
exclusive license (excluding Canada) for the development and commercialization
of Focalin(TM), or d-MPH; an agreement with Biovail Corporation International,
wherein we granted to Biovail exclusive Canadian marketing rights for d-MPH; and
agreements with Pharmion Corporation and Penn Pharmaceuticals Services Limited
to expand the THALOMID(R) franchise internationally. Our present and future
arrangements may be jeopardized if any or all of the following occur:

o    we are not able to enter into additional joint ventures or other
     arrangements on acceptable terms, if at all;

o    our joint ventures or other arrangements do not result in a compatible work
     environment;

o    our joint ventures or other arrangements do not lead to the successful
     development and commercialization of any products;

o    we are unable to obtain or maintain proprietary rights or licenses to
     technology or products developed in connection with our joint ventures or
     other arrangements; or

o    we are unable to preserve the confidentiality of any proprietary rights or
     information developed in connection with our joint ventures or other
     arrangements.


                                       5



THE HAZARDOUS MATERIALS WE USE IN OUR RESEARCH AND DEVELOPMENT COULD RESULT IN
SIGNIFICANT LIABILITIES THAT COULD EXCEED OUR INSURANCE COVERAGE AND FINANCIAL
RESOURCES.

We use some hazardous materials in our research and development activities.
While we believe we are currently in substantial compliance with the federal,
state and local laws and regulations governing the use of these materials, we
cannot be certain that accidental injury or contamination will not occur. Any
such accident or contamination could result in substantial liabilities, that
could exceed our insurance coverage and financial resources. Additionally, the
cost of compliance with environmental and safety laws and regulations may
increase in the future, requiring us to expend more financial resources either
in compliance or in purchasing supplemental insurance coverage.

THE PHARMACEUTICAL INDUSTRY IS SUBJECT TO EXTENSIVE GOVERNMENT REGULATION WHICH
PRESENTS NUMEROUS RISKS TO US.

The preclinical development, clinical trials, manufacturing marketing and
labeling of pharmaceuticals are all subject to extensive regulation by numerous
governmental authorities and agencies in the United States and other countries.
If we are delayed in receiving, or are unable to obtain at all, necessary
governmental approvals, we will be unable to effectively market our products.

The testing, marketing and manufacturing of our products require regulatory
approval, including approval from the FDA and, in some cases, from the U.S.
Environmental Protection Agency or governmental authorities outside of the
United States that perform roles similar to those of the FDA and EPA. Certain of
our pharmaceutical products, such as Focalin(TM), fall under the Controlled
SubstanceS Act of 1970 that requires authorization by the U.S. Drug Enforcement
Agency of the U.S. Department of Justice in order to handle and distribute these
products. The regulatory approval process presents several risks to us:

o    In general, preclinical tests and clinical trials can take many years, and
     require the expenditure of substantial resources, and the data obtained
     from these tests and trials can be susceptible to varying interpretation
     that could delay, limit or prevent regulatory approval.

o    Delays or rejections may be encountered during any stage of the regulatory
     process based upon the failure of the clinical or other data to demonstrate
     compliance with, or upon the failure of the product to meet, a regulatory
     agency's requirements for safety, efficacy and quality or, in the case of a
     product seeking an orphan drug indication, because another designee
     received approval first.

o    Requirements for approval may become more stringent due to changes in
     regulatory agency policy, or the adoption of new regulations or
     legislation.

o    The scope of any regulatory approval, when obtained, may significantly
     limit the indicated uses for which a product may be marketed and may impose
     significant limitations in the nature of warnings, precautions and
     contraindications that could materially affect the profitability of the
     drug.

o    Approved drugs, as well as their manufacturers, are subject to continuing
     and on-going review, and discovery of previously unknown problems with
     these products or the failure to adhere to manufacturing or quality control
     requirements may result in restrictions on their manufacture, sale or use
     or in their withdrawal from the market.

o    Regulatory authorities and agencies may promulgate additional regulations
     restricting the sale of our existing and proposed products.

o    Once a product receives marketing approval, the FDA may not permit us to
     market that product for broader or different applications, or may not grant
     us clearance with respect to separate product applications that represent
     extensions of our basic technology. In addition, the FDA may withdraw or
     modify existing clearances in a significant manner or promulgate additional
     regulations restricting the sale of our present or proposed products.

o    Our labeling and promotional activities relating to our products are
     regulated by the FDA and state regulatory agencies and, in some
     circumstances, by the Federal Trade Commission and DEA, and are subject to
     associated risks. If we fail to comply with FDA regulations prohibiting


                                       6



     promotion of off-label uses and the promotion of products for which
     marketing clearance has not been obtained, the FDA could bring an
     enforcement action against us that could inhibit our marketing capabilities
     as well as result in penalties.

In addition, stem cells intended for human use are subject to FDA regulations
requiring, among other things, certain infectious disease testing. New FDA
regulations anticipated in 2003 may relate to screening of potential donors and
donations for certain infectious diseases and the establishment of quality
controls, recordkeeping and other practices related to the manufacture of human
tissue. Currently, we are required to be, and are, licensed to operate in New
York and New Jersey, two of the states in which we currently collect placentas
and umbilical cord blood for our allogeneic and private stem cell banking
businesses. If other states adopt similar licensing requirements, we would need
to obtain such licenses to continue operating. If we are delayed in receiving,
or are unable to obtain at all, necessary licenses, we will be unable to provide
services in those states which would impact negatively on our revenues.

WE MAY NOT BE ABLE TO PROTECT OUR INTELLECTUAL PROPERTY.

Our success will depend, in part, on our ability to obtain and enforce patents,
protect trade secrets, obtain licenses to technology owned by third parties,
when necessary, and conduct our business without infringing upon the proprietary
rights of others. The patent positions of pharmaceutical and biopharmaceutical
firms, including ours, can be uncertain and involve complex legal and factual
questions. In addition, the coverage sought in a patent application may not be
obtained or may be significantly reduced before the patent is issued.
Consequently, if our pending applications, or a pending application that we have
licensed-in from third parties, do not result in the issuance of patents or, if
any patents that are issued do not provide significant proprietary protection or
commercial advantage, our ability to sustain the necessary level of intellectual
property upon which our success depends may be restricted.

Moreover, different countries have different procedures for obtaining patents,
and patents issued in different countries provide different degrees of
protection against the use of a patented invention by others. Therefore, if the
issuance to us or our licensor, in a given country, of a patent covering an
invention is not followed by the issuance, in other countries, of patents
covering the same invention, or if any judicial interpretation of the validity,
enforceability or scope of the claims in a patent issued in one country is not
similar to the interpretation given to the corresponding patent issued in
another country, our ability to protect our intellectual property in other
countries may be limited.

Under the current U.S. patent laws, patent applications in the United States are
maintained in secrecy from six to 18 months, and publications of discoveries in
the scientific and patent literature often lag behind actual discoveries. Thus,
we may discover, sometime in the future, that we, or the third parties from whom
we have licensed patents or patent applications, were not the first to make the
inventions covered by the patents and patent applications in which we have
rights, or that such patents and patent applications were not the first to be
filed on such inventions. In the event that a third party has also filed a
patent application for any of the inventions described in our patents or patent
applications, or those we have licensed-in, we could become involved in an
interference proceeding declared by the U.S. Patent and Trademark Office to
determine priority of invention. Such an interference could result in the loss
of an issued U.S. patent or loss of any opportunity to secure U.S. patent
protection for that invention. Even if the eventual outcome is favorable to us,
such interference proceedings could result in substantial cost to us.

Furthermore, even if our patents, or those we have licensed-in, are issued, our
competitors may still challenge the scope, validity or enforceability of our
patents in court, requiring us to engage in complex, lengthy and costly
litigation. Alternatively, our competitors may be able to design around such
patents and compete with us using the resulting alternative technology. If any
of our issued or licensed patents are infringed, we may not be successful in
enforcing our intellectual property rights or defending the validity or
enforceability of our issued patents.

It is also possible that third-party patent applications and patents could issue
with claims that cover certain aspects of the subject matter claimed in the
patents owned or optioned by us or licensed to us, which may limit our ability
to practice under our patents, and may impede our efforts to obtain meaningful
patent protection of our own. If patents are issued to third parties that
contain competitive or conflicting claims, we may be legally prohibited from
pursuing research, development or commercialization of potential products or be
required to obtain licenses to these patents or to develop or obtain alternative
technology. We may be legally prohibited from using patented technology, may not


                                       7



be able to obtain any license to the patents and technologies of third parties
on acceptable terms, if at all, or may not be able to obtain or develop
alternative technologies. Consequently, if we cannot successfully defend against
any patent infringement suit that may be brought against us by a third party, we
may lose the ability to practice certain subject matter delineated by patent
claims that we have exclusive rights to, whether by ownership or by license, and
that may have a material adverse effect on our business.

We rely upon trademarks and service marks to protect our rights to the
intellectual property used in our business. On October 29, 2003, we filed a
lawsuit against Centocor, Inc. to prevent Centocor's use of the term "I.M.I.D.s"
in connection Centocor's products, which use, we believe, is likely to cause
confusion with our IMiDs(TM) mark for compounds being developed by us
to treat cancer and inflammatory diseases. If we are not successful in this
suit, it may be necessary for us to adopt a different trademark for that class
of compounds and thereby lose the value we believe we have built in the
IMiDs(TM) mark.

Further, we rely upon unpatented proprietary and trade secret technology that we
try to protect, in part, by confidentiality agreements with our collaborative
partners, employees, consultants, outside scientific collaborators, sponsored
researchers and other advisors. If these agreements are breached, we may not
have adequate remedies for any such breach. Despite precautions taken by us,
others may obtain access to or independently develop our proprietary technology
or such technology may be found to be non-proprietary or not a trade secret.

In addition, our right to practice the inventions claimed in some patents that
relate to THALOMID(R) arises under licenses granted to us by others, including
The Rockefeller University and Children's Medical Center Corporation, or CMCC.
In addition to these patents, which relate to thalidomide, we have also licensed
from CMCC certain patents relating to thalidomide analogs. In December 2002, we
entered into an exclusive license agreement with CMCC and EntreMed. Inc. in
connection with the settlement of certain pending litigation by and among us,
EntreMed, and the U.S. Patent and Trademark Office relating to the issuance of
certain CMCC patent applications covering thalidomide analogs. These patent
applications had been licensed exclusively to EntreMed in the field of
thalidomide analogs. In conjunction with the settlement of these suits, we
acquired preferred shares and warrants which, if converted into EntreMed common
shares, would constitute, as of March 31, 2003, 49% of the outstanding shares of
EntreMed, and EntreMed terminated its license agreements with CMCC relating to
thalidomide analogs. In turn, CMCC exclusively licensed to us these patents and
patent applications, which relate to analogs, metabolites, precursors and
hydrolysis products of thalidomide, and all stereoisomers thereof. The December
2002 exclusive license to us is worldwide and royalty-bearing, and grants us
complete control over the prosecution of the licensed thalidomide analog patent
rights. The December 2002 agreement also grants us an option to inventions in
the field of thalidomide analogs that may be developed at CMCC in the laboratory
of Dr. Robert D'Amato, pursuant to the terms and conditions of a separate
Sponsored Research Agreement negotiated between us and CMCC.

While we believe these confidentiality and license agreements to be valid and
enforceable, our rights under these agreements may not continue or disputes
concerning these agreements may arise. If any of the foregoing should occur, we
may be unable to rely upon our unpatented proprietary and trade secret
technology, or we may be unable to use the third party proprietary technology we
have licensed-in, either of which may prevent or hamper us from successfully
pursuing our business.

THE PHARMACEUTICAL INDUSTRY IS HIGHLY COMPETITIVE AND SUBJECT TO RAPID AND
SIGNIFICANT TECHNOLOGICAL CHANGE.

The pharmaceutical industry in which we operate is highly competitive and
subject to rapid and significant technological change. Our present and potential
competitors include major pharmaceutical and biotechnology companies, as well as
specialty pharmaceutical firms, such as:

o    Bristol-Myers Squibb Co., which potentially competes in clinical trials
     with our IMiDs(TM)and SelCIDs(TM);

o    Genentech Inc., which potentially competes in clinical trials with our
     IMiDs(TM)and SelCIDs(TM);

o    AstraZeneca, which potentially competes in clinical trials with our
     IMiDs(TM)and SelCIDs(TM);

o    Millennium Pharmaceuticals, which potentially competes in clinical trials
     with our IMiDs(TM)and SelCIDs(TM)as well as with THALOMID(R);


                                       8



o    Genta Inc., which potentially competes with our IMiDs(TM)and SelCIDs(TM)as
     well as with THALOMID(R);

o    Cell Therapeutics, which potentially competes in clinical trials with our
     IMiDs(TM)and SelCIDs(TM)as well as with THALOMID(R);

o    Vertex Pharmaceuticals Inc., which potentially competes in clinical trials
     with our kinase inhibitors; and

o    IDEC Pharmaceuticals Corporation and Ilex Oncology, Inc., both of which are
     generally developing drugs that address the oncology and immunology
     markets, although we are not aware of specific competing products.

Many of these companies have considerably greater financial, technical and
marketing resources than us. We also experience competition from universities
and other research institutions and, in some instances, we compete with others
in acquiring technology from these sources. The pharmaceutical industry has
undergone, and is expected to continue to undergo, rapid and significant
technological change, and we expect competition to intensify as technical
advances in the field are made and become more widely known. The development of
products or processes by our competitors with significant advantages over those
that we are seeking to develop could cause the marketability of our products to
stagnate or decline.

SALES OF OUR PRODUCTS ARE DEPENDENT ON THIRD-PARTY REIMBURSEMENT.

Sales of our products will depend, in part, on the extent to which the costs of
our products will be paid by health maintenance, managed care, pharmacy benefit
and similar health care management organizations, or reimbursed by government
health administration authorities, private health coverage insurers and other
third-party payors. These health care management organizations and third-party
payors are increasingly challenging the prices charged for medical products and
services. Additionally, the containment of health care costs has become a
priority of federal and state governments, and the prices of drugs have been
targeted in this effort. If these organizations and third-party payors do not
consider our products to be cost-effective, they may not reimburse providers of
our products or, if they do, the level of reimbursement may not be sufficient to
allow us to sell our products on a profitable basis.

WE MAY NOT REALIZE THE BENEFITS OF THE COMBINED BUSINESSES AS A RESULT OF THE
ANTHROGENESIS ACQUISITION, WHICH COULD DIMINISH THE EXPECTED BENEFITS OF THE
ACQUISITION.

Achieving the expected benefits of the Anthrogenesis acquisition, which was
consummated on December 31, 2002, will depend in large part on the successful
integration and management of certain aspects of the combined businesses in a
timely and efficient manner and the scale-up and commercialization of
Anthrogenesis' technologies and products. We must integrate the information
systems, product development, administration and other operations of the
combined company. This may be difficult and unpredictable because of possible
cultural conflicts and different opinions on technical, operational and other
integration decisions. We must also integrate the employees of the combined
company. The operations, management and personnel of the combined company may
not be compatible, and we may experience the loss of key personnel for that
reason.

We expect to incur costs from integrating Anthrogenesis' operations and
personnel. These costs may be substantial and may include costs for:

o    employee retention and development; and

o    integration of operating policies, procedures and systems.

If we are not successful in these integration efforts, we may not realize the
full expected benefits of the Anthrogenesis acquisition.

RISKS RELATED TO OUR COMMON STOCK

THE PRICE OF OUR COMMON STOCK MAY FLUCTUATE SIGNIFICANTLY, WHICH MAY MAKE IT
DIFFICULT FOR YOU TO SELL THE COMMON STOCK WHEN YOU WANT OR AT PRICES YOU FIND
ATTRACTIVE.


                                       9



There has been significant volatility in the market prices for publicly traded
shares of biopharmaceutical companies, including ours. We expect that the market
price of our common stock will continue to fluctuate. Holders who have received
common stock upon conversion will also be subject to the risk of volatility and
depressed prices. In 2001, the intra-day price of our common stock fluctuated
from a high of $38.88 to a low of $14.40. In 2002, the intra-day price of our
common stock fluctuated from a high of $32.20 to a low of $11.32. During the
nine-month period ended September 30, 2003, the intra-day price of our common
stock fluctuated from a high of $48.88 to a low of $20.15. On October 31, 2003,
our common stock closed at a price of $41.69. The price of our common stock may
not remain at or exceed current levels. The following factors may have an
adverse impact on the market price of our common stock:

o    results of our clinical trials;

o    announcements of technical or product developments by our competitors;

o    market conditions for pharmaceutical and biotechnology stocks;

o    market conditions generally;

o    governmental regulation;

o    health care legislation;

o    public announcements regarding medical advances in the treatment of the
     disease states that we are targeting;

o    patent or proprietary rights developments;

o    changes in third-party reimbursement policies for our products; or

o    fluctuations in our operating results.

In addition, the stock market in general has experienced extreme volatility that
has often been unrelated to the operating performance of a particular company.
These broad market fluctuations may adversely affect the market price of our
common stock.

THE NUMBER OF SHARES OF OUR COMMON STOCK ELIGIBLE FOR FUTURE SALE COULD
ADVERSELY AFFECT THE MARKET PRICE OF OUR COMMON STOCK.

Future sales of substantial amounts of our common stock could adversely affect
the market price of our common stock. As of October 31, 2003, there were
outstanding stock options and warrants for 11,872,310 shares of common stock, of
which 10,797,246 were currently exercisable at an exercise price range between
$0.15 and $70.00, with an average exercise price of $22.96. These amounts
include outstanding options and warrants of Anthrogenesis that we assumed as
part of our acquisition of Anthrogenesis on December 31, 2002 and that were
converted into outstanding options and warrants of our common stock pursuant to
an exchange ratio.

OUR SHAREHOLDER RIGHTS PLAN AND CERTAIN CHARTER AND BY-LAW PROVISIONS MAY DETER
A THIRD PARTY FROM ACQUIRING US AND MAY IMPEDE THE STOCKHOLDERS' ABILITY TO
REMOVE AND REPLACE OUR MANAGEMENT OR BOARD OF DIRECTORS.

Our board of directors has adopted a shareholder rights plan, the purpose of
which is to protect stockholders against unsolicited attempts to acquire control
of us that do not offer a fair price to all of our stockholders. The rights plan
may have the effect of dissuading a potential acquirer from making an offer for
our common stock at a price that represents a premium to the then current
trading price.

Our board of directors has the authority to issue, at any time, without further
stockholder approval, up to 5,000,000 shares of preferred stock, and to
determine the price, rights, privileges and preferences of those shares. An
issuance of preferred stock could discourage a third party from acquiring a
majority of our outstanding voting stock. Additionally, our board of directors


                                       10



has adopted certain amendments to our by-laws intended to strengthen the board's
position in the event of a hostile takeover attempt. These provisions could
impede the stockholders' ability to remove and replace our management and/or
board of directors.

Furthermore, we are subject to the provisions of Section 203 of the Delaware
General Corporation Law, an anti-takeover law, which may also dissuade a
potential inquirer of our common stock.

                           FORWARD-LOOKING STATEMENTS

Certain statements contained or incorporated by reference in this prospectus are
forward-looking statements concerning our business, financial condition, results
of operations and economic performance. Forward-looking statements within the
meaning of Section 27A of the Securities Act of 1933 and within the meaning of
Section 21E of the Securities Exchange Act of 1934 are included, for example, in
the discussions about:

o    our strategy;

o    new product development or product introduction;

o    product sales, royalties and contract revenues;

o    expenses and net income;

o    our credit risk management;

o    our liquidity;

o    our asset/liability risk management; and

o    our operational and legal risks.

These statements involve risks and uncertainties. Actual results may differ
materially from those expressed or implied in those statements. Factors that
could cause such differences include, but are not limited to, those discussed
under "Risk Factors."

                                 USE OF PROCEEDS

The selling securityholders will receive all of the proceeds from the sale of
common stock under this prospectus. We will not receive any proceeds from these
sales. See "Selling Securityholders" for a list of those persons receiving
proceeds from the sale of common stock.


                                       11



                          DESCRIPTION OF CAPITAL STOCK

Our authorized capital stock consists of 120,000,000 shares of common stock, par
value $.01 per share, and 5,000,000 shares of preferred stock, par value $.01
per share, of which 520 shares have been designated Series A convertible
preferred stock and 20,000 shares have been designated as Series B convertible
preferred stock. As of October 31, 2003, there were 81,210,352 shares of common
stock outstanding, no shares of Series A convertible preferred stock outstanding
and no shares of Series B convertible preferred stock outstanding.

COMMON STOCK

Holders of common stock are entitled to one vote for each share held on all
matters submitted to a vote of stockholders, and do not have cumulative voting
rights. Holders of common stock are entitled to receive ratably such dividends,
if any, as may be declared by our board of directors out of funds legally
available therefor, and subject to any preferential dividend rights of any then
outstanding preferred stock. Upon our liquidation, dissolution or winding up,
the holders of common stock are entitled to receive ratably our net assets
available after the payment of all debts and other liabilities and subject to
any liquidation preference of any then outstanding preferred stock. Holders of
common stock have no preemptive, subscription or conversion rights. There are no
redemption or sinking fund provisions applicable to the common stock. The
outstanding shares of common stock are, and the shares offered hereby will be
when issued and paid for, fully paid and non-assessable.

PREFERRED STOCK

Our board of directors has the authority, subject to certain restrictions,
without further stockholder approval, to issue, at any time and from time to
time, shares of preferred stock in one or more series. Each such series shall
have such number of shares, designations, preferences, voting powers,
qualifications, and special or relative rights or privileges as shall be
determined by our board of directors, which may include, among others, dividend
rights, voting rights, redemption and sinking fund provisions, liquidation
preferences, conversion rights and preemptive rights, to the full extent now or
hereafter permitted by the laws of the State of Delaware.

The rights of the holders of common stock will be subject to, and may be
adversely affected by, the rights of holders of any preferred stock that may be
issued in the future. Such rights may include voting and conversion rights which
could adversely affect the holders of the common stock. Satisfaction of any
dividend preferences of outstanding preferred stock would reduce the amount of
funds available, if any, for the payment of dividends on common stock. Holders
of preferred stock would typically be entitled to receive a preference payment.

SHAREHOLDER RIGHTS PLAN

Our board of directors has adopted a shareholder rights plan. The shareholder
rights plan was adopted to give our board of directors increased power to
negotiate in our best interests and to discourage appropriation of control of us
at a price that is unfair to our stockholders. It is not intended to prevent
fair offers for acquisition of control determined by our board of directors to
be in the best interests of us and our stockholders, nor is it intended to
prevent a person or group from obtaining representation on or control of our
board of directors through a proxy contest, or to relieve our board of directors
of its fiduciary duty to consider any proposal for our acquisition in good
faith.

The shareholder rights plan involves the distribution of one "right" as a
dividend on each outstanding share of our common stock to all holders of record
on September 26, 1996, and an ongoing distribution of one right with respect to
each share of our common stock issued subsequently. Each right shall entitle the
holder to purchase one-tenth of a share of common stock. The rights trade in
tandem with the common stock until, and become exercisable upon, the occurrence
of certain triggering events, and the exercise price is based on the estimated
long-term value of our common stock. The exercise of these rights becomes
economically attractive upon the triggering of certain "flip-in" or "flip-over"
rights which work in conjunction with the shareholder rights plan's basic
provisions. The flip-in rights will permit their holders to purchase shares of
common stock at a discounted rate, resulting in substantial dilution of an
acquiror's voting and economic interests in us. The flip-over element of the
shareholder rights plan involves some mergers or significant asset purchases,


                                       12



which trigger certain rights to purchase shares of the acquiring or surviving
company at a discount. The shareholder rights plan contains a "permitted offer"
exception which allows offers determined by our board of directors to be in our
best interests and our stockholders to take place free of the diluting effects
of the shareholder rights plan's mechanisms.

Our board of directors retains the right, at all times prior to acquisition of
15% or more of our voting common stock by an acquiror, to discontinue the
shareholder rights plan through the redemption of all rights, or to amend the
shareholder rights plan in any respect. We have recently amended the
shareholders rights plan to provide that a qualified institutional investor (as
defined in the amendment) will not trigger any rights under the plan until it
beneficially owns at least 17% of the shares of our outstanding common stock,
rather than 15%.

DELAWARE LAW AND SOME BY-LAW PROVISIONS

Our board of directors has adopted certain amendments to our by-laws intended to
strengthen our board of directors' position in the event of a hostile takeover
attempt. These by-law provisions have the following effects:

o    they provide that only persons who are nominated in accordance with the
     procedures set forth in the by-laws shall be eligible for election as our
     directors, except as may be otherwise provided in the by-laws;

o    they provide that only business brought before the annual meeting by our
     board of directors or by a stockholder who complies with the procedures set
     forth in the by-laws may be transacted at an annual meeting of
     stockholders;

o    they provide that only the chairman of the board, if any, the chief
     executive officer, the president, the secretary or a majority of our board
     of directors may call special meetings of our stockholders;

o    they establish a procedure for our board of directors to fix the record
     date whenever stockholder action by written consent is undertaken; and

o    they require a vote of holders of two-thirds of the outstanding shares of
     common stock to amend certain by-law provisions.

Furthermore, we are subject to the provisions of Section 203 of the Delaware
General Corporation Law, an anti-takeover law. In general, the statute prohibits
a publicly held Delaware corporation from engaging in a "business combination"
with an "interested stockholder" for a period of three years after the date of
the transaction in which the person became an interested stockholder, unless the
business combination is approved in a prescribed manner. For purposes of Section
203, a "business combination" includes a merger, asset sale or other transaction
resulting in a financial benefit to the interested stockholder, and an
"interested stockholder" is a person who, together with affiliates and
associates, owns, or within three years prior, did own, 15% or more of the
corporation's voting stock.

TRANSFER AGENT AND REGISTRAR

The transfer agent and registrar for the common stock is American Stock Transfer
& Trust Company. It is located at 59 Maiden Lane, New York, NY 10038, and its
telephone number is (718) 921-8200.


                                       13



                             SELLING SECURITYHOLDERS

Selling securityholders, including their transferees, pledgees or donees or
their successors, may from time to time offer and sell pursuant to this
prospectus any or all of the shares of common stock beneficially owned by each
selling securityholder. Each selling securityholder named below has an address
in care of Celgene Corporation, 7 Powder Horn Drive, Warren, New Jersey 07059.

The following table sets forth information, with respect to the selling
securityholders and the shares of common stock beneficially owned by each
selling securityholder that may be offered pursuant to this prospectus. The
selling securityholders may offer all, some or none of the shares of common
stock. Because the selling securityholders may offer all or some portion of the
common stock, we cannot estimate the amount of the common stock that will be
held by the selling securityholders upon termination of any of these sales. The
percentage of shares of common stock beneficially owned by each selling
securityholder is based on 81,210,352 shares of common stock outstanding on
October 31, 2003.




                                                                                        Shares Beneficially
                     Shares Beneficially                                                    Owned After
Name of Selling      Owned Prior to the        Percentage of         Number of Shares    Completion of the
Securityholder            Offering           Shares Outstanding           Offered              Offering
---------------      --------------------    ------------------      ----------------    ------------------
                                                                                      
Michael Karin            20,404(1)                  *                      20,404                 --
Tony Hunter               5,000(2)                  *                       5,000                 --
Roger Davis               5,000(3)                  *                       5,000                 --
Miles Houslay             5,000(4)                  *                       5,000                 --
Heinz Gschwend            5,000(5)                  *                       5,000                 --
Robert Gale               5,000(6)                  *                       5,000                 --
Joseph Bertino            5,000(7)                  *                       5,000                 --
Howard Burris             5,000(8)                  *                       5,000                 --
Angus Dalgliesch          5,000(9)                  *                       5,000                 --
Robert Ozols              5,000(10)                 *                       5,000                 --
Daniel Von Hoff           5,000(11)                 *                       5,000                 --
Ronald Bukowski           5,000(12)                 *                       5,000                 --


--------

(1)  Represents 20,000 shares of Celgene common stock issuable upon exercise of
     options, 107 shares of common stock previously issued and 297 shares of
     common stock issuable upon attainment of milestone.
(2)  Represents 5,000 shares of Celgene common stock issuable upon exercise of
     option.
(3)  Represents 5,000 shares of Celgene common stock issuable upon exercise of
     option.
(4)  Represents 5,000 shares of Celgene common stock issuable upon exercise of
     option.
(5)  Represents 5,000 shares of Celgene common stock issuable upon exercise of
     option.
(6)  Represents 5,000 shares of Celgene common stock issuable upon exercise of
     option.
(7)  Represents 5,000 shares of Celgene common stock issuable upon exercise of
     option.
(8)  Represents 5,000 shares of Celgene common stock issuable upon exercise of
     option.
(9)  Represents 5,000 shares of Celgene common stock issuable upon exercise of
     option.
(10) Represents 5,000 shares of Celgene common stock issuable upon exercise of
     option.
(11) Represents 5,000 shares of Celgene common stock issuable upon exercise of
     option.
(12) Represents 5,000 shares of Celgene common stock issuable upon exercise of
     option.


                                       14






                                                                                        Shares Beneficially
                     Shares Beneficially                                                    Owned After
Name of Selling      Owned Prior to the        Percentage of         Number of Shares    Completion of the
Securityholder            Offering           Shares Outstanding           Offered              Offering
---------------      --------------------    ------------------      ----------------    ------------------
                                                                                      
Joseph A. Didonato          107(13)                 *                         107                 --
Makio Hayakawa              107(14)                 *                         107                 --
David M. Rothwart           107(15)                 *                         107                 --
Ebrahim Zandi               107(16)                 *                         107                 --
Shellwater & Co.          1,742(17)                 *                       1,742                 --
Anning Lin                  119(18)                 *                         119                 --
Christian Trautwein         178(19)                 *                         178                 --
Jasodhara Ray               178(20)                 *                         178                 --
University of
  Massachusetts           1,571(21)                 *                       1,571                 --


*    Represents less than 1%

None of the selling securityholders nor any of their affiliates, officers,
directors or principal equity holders has held any position or office or has any
material relationship with us within the past three years.

Information concerning the securityholders may change from time to time and any
changed information will be set forth in supplements to this prospectus if and
when necessary.

--------

(13) Represents 107 shares of Celgene common stock previously issued.
(14) Represents 107 shares of Celgene common stock previously issued.
(15) Represents 107 shares of Celgene common stock previously issued.
(16) Represents 107 shares of Celgene common stock previously issued.
(17) Represents 1,742 shares of common stock issuable upon attainment of
     milestone.
(18) Represents 119 shares of Celgene common stock issuable upon attainment of
     milestone.
(19) Represents 178 shares of Celgene common stock issuable upon attainment of
     milestone.
(20) Represents 178 shares of Celgene common stock issuable upon attainment of
     milestone.
(21) Represents 1,571 shares of Celgene common stock issuable upon attainment of
     milestone.

                                       15



                              PLAN OF DISTRIBUTION

We will not receive any of the proceeds of the sale of shares of common stock
offered by this prospectus. The common stock may be sold from time to time to
purchasers:

o    directly by the selling securityholders; or

o    through underwriters, broker-dealers or agents who may receive compensation
     in the form of discounts, concessions or commissions from the selling
     securityholders or the purchasers of the common stock.

The selling securityholders and any such broker-dealers or agents who
participate in the distribution of the common stock may be deemed to be
underwriters. As a result, any profits on the sale of the common stock by
selling securityholders and any discounts, commissions or concessions received
by any such broker-dealers or agents may be deemed to be underwriting discounts
and commissions under the Securities Act. If the selling securityholders were
deemed to be underwriters, the selling securityholders may be subject to
statutory liabilities including, but not limited to, those of Sections 11, 12
and 17 of the Securities Act and Rule 10b-5 under the Securities Exchange Act of
1934, as amended (the "Exchange Act").

If the common stock is sold through underwriters or broker-dealers, the selling
securityholders will be responsible for underwriting discounts or commissions or
agent's commissions. The common stock may be sold in one or more transactions
at:

o    fixed prices;

o    prevailing market prices at the time of sale;

o    varying prices determined at the time of sale; or

o    negotiated prices.

These sales may be effected in transactions:

o    on any national securities exchange or quotation service on which the
     common stock may be listed or quoted at the time of the sale, including the
     Nasdaq National Market;

o    in the over-the-counter market;

o    in transactions otherwise than on such exchanges or services or in the
     over-the-counter market; or

o    through the writing of options.

These transactions may include block transactions or crosses. Crosses are
transactions in which the same broker acts as an agent on both sides of the
transaction.

In connection with the sales of the common stock, the selling securityholders
may enter into hedging transactions with broker-dealers. These broker-dealers
may in turn engage in short sales of the common stock in the course of hedging
their positions. The selling securityholders may also sell the common stock
short and deliver the common stock to close out short positions, or loan or
pledge the common stock to broker-dealers or financial institutions that, in
turn, may sell the common stock.

To our knowledge, there are currently no plans, arrangements or understandings
between any selling securityholders and any underwriter, broker-dealer or agent
regarding the sale of the common stock by the selling securityholders. Selling
securityholders may decide to sell all or a portion of the common stock offered
by them pursuant to this prospectus or may decide not to sell the underlying


                                       16



common stock under this prospectus. In addition, any selling securityholder may
transfer, devise or give the common stock by other means not described in this
prospectus. Any shares of common stock covered by this prospectus that qualify
for sale pursuant to Rule 144 of the Securities Act may be sold under Rule 144
or ather than pursuant to this prospectus.

Our common stock is quoted on the Nasdaq National Market under the symbol
"CELG."

The selling securityholders and any other persons participating in the
distribution of the common stock will be subject to the Exchange Act. The
Exchange Act rules include, without limitation, Regulation M, which may limit
the timing of purchases and sales of any of the common stock by the selling
securityholders and any such other person. In addition, Regulation M of the
Exchange Act may restrict the ability of any person engaged in the distribution
of the common stock to engage in market making activities with respect to the
particular common stock being distributed for a period of up to five business
days prior to the commencement of such distribution. This may affect the
marketability of the common stock and the ability to engage in market making
activities with respect to the common stock.

We will pay substantially all of the expenses incidental to the registration,
offering and sale of the common stock by the securityholders other than
commissions, fees and discounts of underwriters, brokers, dealers and agents.

                                  LEGAL MATTERS

Proskauer Rose LLP, New York, New York, will pass on the validity of the
issuance of the securities offered in this prospectus.

                                     EXPERTS

The consolidated financial statements and schedule of Celgene Corporation and
subsidiaries as of December 31, 2002 and 2001, and for each of the years in the
three-year period ended December 31, 2002, have been incorporated by reference
herein and in the registration statement in reliance upon the report of KPMG
LLP, independent accountants, incorporated by reference herein, and upon the
authority of said firm as experts in accounting and auditing. The audit report
covering the December 31, 2002 consolidated financial statements refers to the
Company's adoption of Statement of Financial Accounting Standards No. 141,
"Business Combinations" effective July 1, 2001.

The statements in this prospectus under the caption "Risk Factors--We may not be
able to protect our intellectual property" have been reviewed and approved by
Mathews, Collins, Shepherd & McKay, P.A. and are included herein in reliance
upon such review and approval as experts in U.S. patent law.

The statements in this prospectus that relate to U.S. patent rights licensed
from The Rockefeller University and Children's Medical Center Corporation under
the caption "Risk Factors--We may not be able to protect our intellectual
property" have been reviewed and approved by Pennie & Edmonds LLP as our special
patent counsel for these matters, and are included herein in reliance upon their
review and approval as experts in U.S. patent law.

With the exception of statements regarding stem cell related activities, the
statements describing legal and regulatory requirements in this prospectus under
the caption "Risk Factors--The pharmaceutical industry is subject to extensive
government regulation which presents numerous risks to us" have been reviewed
and, assuming the accuracy of the factual statements made, approved by
Kleinfeld, Kaplan and Becker, LLP as experts in such matters, and are included
herein in reliance upon such review and approval.

The statements in this prospectus that relate to trademarks under the caption
"Risk Factors--We may not be able to protect our intellectual property" have
been reviewed by Cozen O'Conner as our special trademarks counsel for these
matters and are included herein in reliance upon such review and approval.


                                       17



                       WHERE YOU CAN FIND MORE INFORMATION

We file reports with the Securities and Exchange Commission, or the SEC, on a
regular basis that contain financial information and results of operations. You
may read or copy any document that we file with the SEC at the SEC's Public
Reference Room at 450 Fifth Street, N.W., Washington, D.C. 20549. You may obtain
information about the Public Reference Room by calling the SEC for more
information at 1-800-SEC-0330. Our SEC filings are also available at the SEC's
website at http://www.sec.gov.

Our common stock is listed on the Nasdaq National Market and we are required to
file reports, proxy statements and other information with Nasdaq. You may read
any document we file with Nasdaq at the offices of the Nasdaq Stock Market, Inc.
which is located at 1735 K Street, N.W., Washington, D.C. 20006.

Our Securities and Exchange Commission filings are also available to the public
on the Securities and Exchange Commission's Internet website at
http://www.sec.gov.

                           INCORPORATION BY REFERENCE

The SEC allows us to "incorporate by reference" information in documents that we
file with it. We have elected to use a similar procedure in connection with this
prospectus, which means that we can disclose important information by referring
you to those documents that are considered part of this prospectus. Information
that we file later with the SEC will automatically update and supersede the
previously filed information. We incorporate by reference the documents listed
below and any future filings we make with the SEC under Sections 13(a), 13(c),
14 or 15(d) of the Exchange Act after the date of this prospectus and prior to
the termination of the offering of the common stock under this prospectus.

o    Our Annual Report on Forms 10-K and 10-K/A for our fiscal year ended
     December 31, 2002, which includes our consolidated financial statements as
     of December 31, 2002 and 2001 and for each of the years in the three year
     period ended December 31, 2002.

o    Our Quarterly Reports on Form 10-Q for our fiscal quarters ended March 31,
     2003, June 30, 2003 and September 30, 2003.

o    Our Reports on Form 8-K filed on January 2 and 3, 2003, June 5, 2003,
     August 4 and 14, 2003 and October 23, 2003.

You may request a copy of these filings, at no cost, by writing to or
telephoning us at the following address:

         Investor Relations
         Celgene Corporation
         7 Powder Horn Drive
         Warren, New Jersey  07059
         Tel: (732) 271-1001


                                       18



                                     PART II

                     INFORMATION NOT REQUIRED IN PROSPECTUS

ITEM 14.          OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION.

An estimate (other than the SEC registration fee) of the fees and expenses of
issuance and distribution of the common stock offered hereby all of which will
be paid by Celgene Corporation ("Celgene") is as follows:

                  SEC registration fee..............................  $   391
                  NASDAQ National Market listing fee................  $ 2,000
                  Legal fees and expenses...........................  $10,000
                  Accounting fees and expenses......................  $10,000
                  Printing Costs....................................  $   721
                                             Total..................  $23,112

ITEM 15.          INDEMNIFICATION OF DIRECTORS AND OFFICERS.

The General Corporation Law of the State of Delaware ("DGCL") permits Celgene
and its stockholders to limit directors' exposure to liability for certain
breaches of the directors' fiduciary duty, either in a suit on behalf of Celgene
or in an action by stockholders of Celgene.

The Certificate of Incorporation of Celgene (the "Charter") eliminates the
liability of directors to stockholders or Celgene for monetary damages arising
out of the directors' breach of their fiduciary duty of care. The Charter also
authorizes Celgene to indemnify its directors, officers, incorporators,
employees and agents with respect to certain costs, expenses and amounts
incurred in connection with an action, suit or proceeding by reason of the fact
that such person was serving as a director, officer, incorporator, employee or
agent of Celgene. In addition, the Charter permits Celgene to provide additional
indemnification rights to its officers and directors and to indemnify them to
the greatest extent possible under the DGCL. Celgene has entered into
indemnification agreements with each of its officers and directors and intends
to enter into indemnification agreements with each of its future officers and
directors. Pursuant to such indemnification agreements, Celgene has agreed to
indemnify its officers and directors against certain liabilities, including
liabilities arising out of the offering made by this Registration Statement.

Celgene maintains a standard form of officers' and directors' liability
insurance policy which provides coverage to the officers and directors of
Celgene for certain liabilities, including certain liabilities which may arise
out of this Registration Statement.

ITEM 16.          EXHIBITS.

The exhibits listed in the Exhibit Index as filed as part of this Registration
Statement.


EXHIBIT
NUMBER                 DESCRIPTION
-------                ---------------------------------------------------------
5.1                    Opinion of Proskauer Rose LLP.*
23.1                   Consent of KPMG LLP.
23.2                   Consent of Pennie & Edmonds LLP.
23.3                   Consent of Kleinfeld, Kaplan and Becker, LLP.
23.4                   Consent of Mathew, Collins, Shepherd & McKay, P.A.


                                      II-1



23.5                   Consent of Proskauer Rose LLP (incorporated by reference
                       to Exhibit 5.1).*
23.6                   Consent of Cozen O'Conner
24.1                   Power of Attorney (included in Signature Page).*

* Previously filed.

ITEM 17.          UNDERTAKINGS.

The undersigned Registrant hereby undertakes:

              (1) To file, during any period in which offers or sales are being
                  made, a post-effective amendment to this Registration
                  Statement: (i) to include any prospectus required by Section
                  10(a)(3) of the Securities Act of 1933; (ii) to reflect in the
                  prospectus any facts or events arising after the effective
                  date of the Registration Statement (or the most recent
                  post-effective amendment thereof) which, individually or in
                  the aggregate, represent a fundamental change in the
                  information set forth in the Registration Statement.
                  Notwithstanding the foregoing, any increase or decrease in
                  volume of securities offered (if the total dollar value of
                  securities offered would not exceed that which was registered)
                  and any deviation from the low or high end of the estimated
                  maximum offering range may be reflected in the form of
                  prospectus filed with the Commission pursuant to Rule 424(b)
                  if, in the aggregate, the changes in volume and price
                  represent no more than a 20 percent change in the maximum
                  aggregate offering price set forth in the "Calculation of
                  Registration Fee" table in the effective registration
                  statement; and (iii) to include any material information with
                  respect to the plan of distribution not previously disclosed
                  in the Registration Statement or any material change to such
                  information in the Registration Statement; provided, however,
                  that (i) and (ii) do not apply if the Registration Statement
                  is on Form S-3 or Form S-8, and the information required to be
                  included in a post-effective amendment by (i) and (ii) is
                  contained in periodic reports filed with or furnished to the
                  Commission by the Registrant pursuant to Section 13 or Section
                  15(d) of the Securities Exchange Act of 1934 that are
                  incorporated by reference in the Registration Statement.

              (2) That, for the purpose of determining any liability under the
                  Securities Act of 1933, each such post-effective amendment
                  shall be deemed to be a new registration statement relating to
                  the securities offered therein, and the offering of such
                  securities at that time shall be deemed to be the initial bona
                  fide offering thereof.

              (3) To remove from registration by means of a post-effective
                  amendment any of the securities being registered which remain
                  unsold at the termination of the offering.

Insofar as indemnification for liabilities arising under the Securities Act may
be permitted to directors, officers and controlling persons of the Registrant
pursuant to the foregoing provisions, or otherwise, the Registrant has been
advised that in the opinion of the Securities and Exchange Commission such
indemnification is against public policy as expressed in the Securities Act of
1933 and is, therefore, unenforceable. In the event that a claim for
indemnification against such liabilities (other than the payment by the
Registrant of expenses incurred or paid by a director, officer or controlling
person of the Registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the Registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit to a court of appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in the Securities
Act and will be governed by the final adjudication of such issue.

The undersigned Registrant hereby undertakes that, for purposes of determining
any liability under the Securities Act of 1933, each filing of the Registrant's
annual report pursuant to Section 13(a) or Section 15(d) of the Securities
Exchange Act of 1934 that is incorporated by reference in the Registration
Statement shall be deemed to be a new registration statement relating to the


                                      II-2



securities offered therein, and the offering of such securities at that time
shall be deemed to be the initial bona fide offering thereof.

The undersigned Registrant hereby undertakes that:

              (1) For purposes of determining any liability under the Securities
                  Act of 1933, the information omitted from the form of
                  prospectus filed as part of this Registration Statement in
                  reliance upon Rule 430A and contained in a form of prospectus
                  filed by the Registrant pursuant to Rule 424(b)(1) or (4) or
                  497(h) under the Securities Act of 1933 shall be deemed to be
                  part of this Registration Statement as of the time it was
                  declared effective.

              (2) For the purpose of determining any liability under the
                  Securities Act of 1933, each post-effective amendment that
                  contains a form of prospectus shall be deemed to be a new
                  registration statement relating to the securities offered
                  therein, and the offering of such securities at that time
                  shall be deemed to be the initial bona fide offering thereof.


                                      II-3



                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-3 and has duly caused this Amendment
No. 1 to the Registration Statement 333-107978 to be signed on its behalf by the
undersigned, thereunto duly authorized, in the City of Warren, State of New
Jersey, on November 14, 2003.



                                                 CELGENE CORPORATION


                                                 By: /s/ John W. Jackson
                                                     ---------------------------
                                                     John W. Jackson
                                                     Chairman of the Board
                                                     and Chief Executive Officer


Pursuant to the requirements of the Securities Act of 1933, this Amendment No. 1
to the Registration Statement 333-107978 has been signed below by the persons
whose signatures appear below, which persons have signed such Registration
Statement in the capacities indicated on November 14, 2003:

Signature                                    Title
---------                                    -----

/s/ John W. Jackson                          Chairman of the Board and Chief
-----------------------------                Executive Officer (Principal
John W. Jackson                              Executive Officer)

          *                                  President, Chief Operating Officer,
-----------------------------                Director
Sol J. Barer

/s/ Robert J. Hugin                          Chief Financial Officer, Director
-----------------------------                (Principal Accounting and Financial
Robert J. Hugin                              Officer)

          *                                  Director
-----------------------------
Jack L. Bowman

          *                                  Director
-----------------------------
Frank T. Cary

          *                                  Director
-----------------------------
Michael D. Casey

          *                                  Director
-----------------------------
Arthur Hull Hayes, Jr.

          *                                  Director
-----------------------------
Gilla Kaplan

          *                                  Director
-----------------------------
Richard C.E. Morgan

          *                                  Director
-----------------------------
Walter L. Robb





Signature                                    Title
---------                                    -----

/s/ John W. Jackson
-------------------
John W. Jackson
Attorney-in-Fact


*Executed by Attorney-in-Fact



                                INDEX TO EXHIBITS


 5.1 -- Opinion of Proskauer Rose LLP.*

23.1 -- Consent of KPMG LLP.

23.2 -- Consent of Pennie & Edmonds LLP.

23.3 -- Consent of Kleinfeld, Kaplan and Becker, LLP.

23.4 -- Consent of Mathew, Collins, Shepherd & McKay, P.A.

23.5 -- Consent of Proskauer Rose LLP (incorporated by reference to
        Exhibit 5.1).*

23.6 -- Consent of Cosen O'Conner

24.1 -- Power of Attorney (included in Signature Page).*

* Previously filed.