New York, USA – Creative Biogene, a world leader in viral vector-based gene delivery technologies for gene and cell therapy, recently announced a wide range of products and services for the efficient design, development, manufacturing and analytical testing of adenovirus vector. In addition, a broad range of types of recombinant adenovirus products has been established in-house to facilitate adenovirus development.
Adenovirus, as a replication-defective adenovirus vector system that has been widely used for gene delivery in many cell types, which vector is mainly non-enveloped, non-integrated, free, double-stranded DNA virus. With a strong safety record, adenovirus and recombinant adenovirus vectors have been widely used in gene function research and human gene therapy. And adenovirus packaging via QVirus™ Platform in recombinant protein expression systems in vitro and in vivo showed almost 100% gene delivery in most cell types.
Creative Biogene is capable to provide large promoter and marker gene portfolio to guarantee flexibility in vector design, and produce high titer adenovirus particles suitable for in vitro cell tests or in vivo animal experiments within several weeks based on standardized product quality.
Besides, Creative Biogene has extensive expertise in all aspects of adenoviral vector technology, from the design of vector constructs to current good manufacturing practices (cGMP) to preclinical applications and related quality assurance. Our in-house scientists have developed 293T and HEK293 production cell lines for adhesion and suspension culture GMP adenovirus vector production methods. With the increase in biopharmaceutical funding in gene therapy, industry partners need their cooperators to achieve a higher level of GMP compliance in the early stages of clinical development.
The reasons that Creative Biogene stands out from many competitors are based on its rich experience in constructing and producing various forms of adenovirus vectors. Moreover, its optimized platform covers elements including raw materials, plasmids, cell lines, MCB/WCB, upstream/downstream processes, analysis, batch records, SOP, trained personnel. And experienced in-house researchers can conduct on-site integration process and release testing.
“Except for the above-mentioned services, Creative Biogene is also professional in offering other types of adenovirus service, such as Replication-Competent Adenovirus Testing, as well as Adenovirus Production for Autophagy Flux Detection,” said Marcia Brady, the marketing director of Creative Biogene, she also claimed, “For more than a decade, Creative Biogene has been optimizing our adenovirus production system, including adenovirus plasmid construction and low endotoxin plasmid preparation, host cells for adenovirus packaging and adenovirus packaging processes, small and large-scale lentivirus purification process. And for specific needs, we can also offer customized programs to satisfy our partners.”
About QVirus™ Platform
Qvirus Platform, as a division of Creative Biogene, providing world-class packaging services for a variety of virus vector products. The expertise and years of experience have made Qvirus platform become a well-recognized industry leader in supporting the development of gene therapy and scientists worldwide.