New York, USA – In recent days, BOC Sciences, one of the world’s leading chemical and pharmaceutical provider, announced to add more than 100 inhibitors of SARS-CoV-2 to its present inhibitor base to help the drug discovery of scientific research institutions during the COVID-19 pandemic.
COVID-19 is spreading rapidly around the world, and the virus that causes this infectious disease is a new coronavirus called SARS-CoV-2 (formerly known as 2019-nCoV). SARS-CoV-2 is the seventh coronavirus known to infect humans. It can cause severe acute respiratory symptoms and spread in humans through respiratory droplets or contact.
The study of viral structure is very important for the development of effective antiviral drugs. As far as is known, the S protein, one of the four main structural proteins of SARS-CoV-2, plays an important role in SARS-CoV-2 virus infection. The S protein of SARS-CoV-2 enters the host cell through the binding of angiotensin-converting enzyme 2 (ACE2) and is then triggered by the serine protease TMPRSS2. After the virus enters the host cell, RNA-dependent RNA polymerase (RdRp) catalyzes the synthesis of viral RNA by combining cofactors nsp7 and nsp8. Finally, SARS-CoV-2 produces three virulence factors Nsp1, Nsp3c and ORF7a to interfere with human immunity. Recently, according to research reports, the main protease Mpro of SARS-CoV-2 is closely related to the reproduction of the virus. Therefore, the S protein, TMPRSS2, ACE2, RdRp and Mpro are regarded as the main targets.
BOC Sciences provides more than 100 SARS-CoV-2 inhibitors to assist drug development of pharmaceutical companies or institutions. The main inhibitor products provided by BOC Sciences include but are not limited to:
Carmustine is a nitrogen mustard oil ß-chloro-nitrosourea compound, used as an alkylating agent. It can cause cross-linking of DNA and RNA, thereby inhibiting DNA synthesis, RNA production and RNA translation (protein synthesis). Carmustine also binds and modifies glutathione reductase. Carmustine is highly lipophilic and can easily cross the blood-brain barrier.
Chloroquine phosphate can inhibit TLR signaling in plasma cell-like dendritic cells (pDC). Chloroquine has been shown to inhibit the parasitic enzyme heme polymerase and may also interfere with nucleic acid biosynthesis.
Raltegravir is an HIV integrase chain transfer inhibitor that blocks the function of HIV integrase required for viral replication. Raltegravir is a prescription drug approved by the US Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children. Raltegravir is always used in combination with other HIV drugs when it is used to treat HIV infection.
Hydroxychloroquine sulfate is an autophagy inhibitor that can induce autophagic cell death. It is a synthetic derivative of quinolone, has the characteristics of chemotherapy and antibiotics, and can inhibit plasma heme polymerase. Hydroxychloroquine sulfate can reduce inflammation in patients with autoimmune diseases.
Bictegravir is an effective HIV-1 integrase inhibitor. By blocking integrase, it can prevent the reproduction of HIV and reduce the HIV content in patients. Bictegravir was derived from the earlier compound dolutegravir by scientists from Gilead Sciences. Bictegravir can inhibit HIV-1 virus infection in MT-2 cells, MT-4 cells, CD4 + T cells and macrophages without showing cytotoxicity.
Remdesivir is a nucleoside analog prodrug, and it has effective antiviral activity against various viruses in vitro, including Ebola virus, Marburg virus, HCoV-NL63, HCoV-OC43, HCoV-229E, mouse hepatitis virus (MHV), SARS-CoV, MERS-CoV, HKU5 and PDCoV. According to reports, Remdesivir has potential antiviral activity against SARS-CoV-2.
Natamycin is a polyene amphoteric macrolide antibiotic with antifungal properties. It is also known as pimacin and is mainly used to treat fungal eye infections. It is often used as an eye drop, and also as a preservative in the food industry.
In addition to existing inhibitors, BOC Sciences also provides customized synthesis services for new inhibitors from small-scale to bulk quantities. And the products from BOC Sciences are only for lab research, not for patients. For more information about the SARS-CoV-2 inhibitors, please visit the website of BOC Sciences: https://www.bocsci.com/products/sars-cov-2-3055.html.
About BOC Sciences
With high-profiled experts specialized in multi-disciplines like drug discovery, chemistry and life science, BOC Sciences is a reliable vendor of a comprehensive collection of chemicals for scientists and researchers in both academia and industry. Over the last twenty years, it has gained a fame as well as valuable trust from customers worldwide in the supply of chemicals like small molecule inhibitors, APIs, pharmaceutical excipients, intermediates and natural compounds. In addition, it also provides all-stage-covering drug R&D services to support the pharmaceutical industry.