UNITED STATES
                        SECURITIES EXCHANGE COMMISSION
                            Washington, D.C. 20549

--------------------------------------------------------------------------------


                                 SCHEDULE 13G

                   Under the Securities Exchange Act of 1934
                               (Amendment No. 2)*

                               THERAVANCE, INC.
                               ----------------
                               (Name of Issuer)


                   Common Stock, $0.01 par value per share
                   ---------------------------------------
                        (Title of Class of Securities)


                                  88338T104
                                  ---------
                                (CUSIP Number)


                              December 31, 2007
                              -----------------
            (Date of Event which Requires Filing of this Statement)


Check  the  appropriate  box to  designate  the rule  pursuant  to which  this
Schedule is filed:

                            [ ]   Rule 13d-1(b)

                            [X]   Rule 13d-1(c)

                            [ ]   Rule 13d-1(d)

* The  remainder  of this  cover  page  shall be  filled  out for a  reporting
person's  initial  filing on this form with  respect to the  subject  class of
securities,  and for any subsequent  amendment  containing  information  which
would alter the disclosures provided in a prior cover page.

The  information  required  in the  remainder  of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities  Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however,  see
the Notes).


                         Continued on following pages
                               Page 1 of 9 Pages
                            Exhibit Index: Page 8



                                 SCHEDULE 13G

CUSIP No.: 88338T104                                           Page 2 of 9 Pages

.................................................................................
1.        Names of Reporting Persons.

          CHESAPEAKE PARTNERS MANAGEMENT CO., INC.

          I.R.S. Identification Nos. of above persons (entities only):
.................................................................................
2.        Check the Appropriate Box if a Member of a Group

          (a) [  ]

          (b) [  ]
.................................................................................
3.        SEC Use Only
.................................................................................
4.        Citizenship or Place of Organization                    Maryland
.................................................................................
Number of             5.       Sole Voting Power                  0
Shares                ..........................................................
Beneficially          6.       Shared Voting Power                4,208,842
Owned by Each         ..........................................................
Reporting             7.       Sole Dispositive Power             0
Person With           ..........................................................
                      8.       Shared Dispositive Power           4,208,842
.................................................................................
9.        Aggregate Amount Beneficially Owned by Each Reporting Person

          4,208,842
.................................................................................
10.       Check if the Aggregate Amount in Row (9) Excludes Certain Shares   [ ]
.................................................................................
11.       Percent of Class Represented by Amount in Row (9)

          8.2% based on 51,505,987 Shares outstanding as of October 31, 2007
.................................................................................
12.       Type of Reporting Person:

          CO
.................................................................................



                                 SCHEDULE 13G

CUSIP No.: 88338T104                                           Page 3 of 9 Pages

.................................................................................
1.        Names of Reporting Persons.

          MARK D. LERNER

          I.R.S. Identification Nos. of above persons (entities only):
.................................................................................
2.        Check the Appropriate Box if a Member of a Group

          (a) [  ]

          (b) [  ]
.................................................................................
3.        SEC Use Only
.................................................................................
4.        Citizenship or Place of Organization         United States of America
.................................................................................
Number of             5.       Sole Voting Power         0
Shares                ..........................................................
Beneficially          6.       Shared Voting Power       4,208,842
Owned by Each         ..........................................................
Reporting             7.       Sole Dispositive Power    0
Person With           ..........................................................
                      8.       Shared Dispositive Power  4,208,842
.................................................................................
9.        Aggregate Amount Beneficially Owned by Each Reporting Person

          4,208,842
.................................................................................
10.       Check if the Aggregate Amount in Row (9) Excludes Certain Shares   [ ]
.................................................................................
11.       Percent of Class Represented by Amount in Row (9)

          8.2% based on 51,505,987 Shares outstanding as of October 31, 2007
.................................................................................
12.       Type of Reporting Person:

           HC; IA
.................................................................................



                                 SCHEDULE 13G

CUSIP No.: 88338T104                                           Page 4 of 9 Pages

.................................................................................
1.        Names of Reporting Persons.

          TRACI LERNER

          I.R.S. Identification Nos. of above persons (entities only):
.................................................................................
2.        Check the Appropriate Box if a Member of a Group

          (a) [  ]

          (b) [  ]
.................................................................................
3.        SEC Use Only
.................................................................................
4.        Citizenship or Place of Organization          United States of America
.................................................................................
Number of             5.       Sole Voting Power         0
Shares                ..........................................................
Beneficially          6.       Shared Voting Power       4,208,842
Owned by Each         ..........................................................
Reporting             7.       Sole Dispositive Power    0
Person With           ..........................................................
                      8.       Shared Dispositive Power  4,208,842
.................................................................................
9.        Aggregate Amount Beneficially Owned by Each Reporting Person

          4,208,842
.................................................................................
10.       Check if the Aggregate Amount in Row (9) Excludes Certain Shares   [ ]
.................................................................................
11.       Percent of Class Represented by Amount in Row (9)

          8.2% based on 51,505,987 Shares outstanding as of October 31, 2007
.................................................................................
12.       Type of Reporting Person:

          HC; IA
.................................................................................



                                                               Page 5 of 9 Pages

Item 1(a).      Name of Issuer:

                Theravance, Inc.  (the "Issuer")

Item 1(b).      Address of Issuer's Principal Executive Offices:

                901 Gateway Boulevard, South San Francisco, CA 94080

Item 2(a).      Name of Person Filing

                This  Statement  is filed on behalf  of each of the  following
persons (collectively, the "Reporting Persons"):

                i)    Chesapeake Partners Management Co., Inc. ("CPMC");

                ii)   Mark D. Lerner ("Mr. Lerner"); and

                iii)  Traci Lerner ("Ms. Lerner").

                This Statement  relates to Shares (as defined herein) held for
the accounts of each of Chesapeake  Partners Limited  Partnership,  a Maryland
limited  partnership  ("CPLP");  and Chesapeake  Partners  Master Fund Ltd., a
Cayman Islands exempted company ("CPMF"). CPMC serves as investment manager to
each of CPLP and CPMF.  CPMC also serves as the General  Partner of CPLP.  Mr.
Lerner and Ms. Lerner are officers of CPMC. In such capacities,  each of CPMC,
Mr. Lerner and Ms. Lerner may be deemed to have voting and  dispositive  power
over the Shares held for each of CPLP and CPMF.

Item 2(b).      Address of Principal Business Office or, if None, Residence

                The address of the principal  business office of each of CPMC,
Mr.  Lerner and Ms.  Lerner is 2800 Quarry Lake Drive,  Suite 300,  Baltimore,
Maryland 21209.

Item 2(c).      Citizenship:

                i)   CPMC is a Maryland corporation;

                ii)  Mr. Lerner is a citizen of the United States of America;
                     and

                iii) Ms. Lerner is a citizen of the United States of America.

Item 2(d).      Title of Class of Securities:

                Common Stock, $0.01 par value per share (the "Shares").

Item 2(e).      CUSIP Number:

                88338T104

Item 3.         If This  Statement is Filed Pursuan to  ss.ss.240.13d-1(b)  or
                240.13d-2(b) or (c), Check Whether the Person Filing is a:

                This Item 3 is not applicable.



                                                               Page 6 of 9 Pages

Item 4.         Ownership:

Item 4(a).      Amount Beneficially Owned:

                As of December 31, 2007,  the Reporting  Persons may be deemed
to be the beneficial  owner of 4,208,842  Shares.  This amount consists of (A)
2,145,927  Shares held for the account of CPLP, and (B) 2,062,915  Shares held
for the account of CPMF.

Item 4(b).      Percent of Class:

                The  number of Shares of which the  Reporting  Persons  may be
deemed to be the beneficial owner constitutes  approximately 8.2% of the total
number of Shares outstanding (based upon information provided by the Issuer in
its  most  recently  filed   quarterly   report  on  Form  10-Q,   there  were
approximately 51,505,987 shares outstanding as of October 31, 2007).

Item 4(c).      Number of Shares of which such person has:

CPMC, Mr. Lerner and Ms. Lerner:
--------------------------------

(i) Sole power to vote or direct the vote:                                   0

(ii) Shared power to vote or direct the vote:                        4,208,842

(iii) Sole power to dispose or direct the disposition of:                    0

(iv) Shared power to dispose or direct the disposition of:           4,208,842

Item 5.         Ownership of Five Percent or Less of a Class:

                This Item 5 is not applicable.

Item 6.         Ownership  of More than  Five  Percent  on  Behalf of  Another
                Person:

                This Item 6 is not applicable.

Item 7.         Identification  and  Classification  of the  Subsidiary  Which
                Acquired the Security  Being Reported on By the Parent Holding
                Company:

                See disclosure in Item 2 hereof.

Item 8.         Identification and Classification of Members of the Group:

                This Item 8 is not applicable.

Item 9.         Notice of Dissolution of Group:

                This Item 9 is not applicable.

Item 10.        Certification:

                By signing below each of the Reporting Persons certifies that,
to the best of their  knowledge and belief,  the securities  referred to above
were not  acquired  and are not held for the  purpose of or with the effect of
changing or  influencing  the control of the issuer of the securities and were
not acquired and are not held in connection  with or as a  participant  in any
transaction having that purpose or effect.



                                                               Page 7 of 9 Pages

                                   SIGNATURE

      After  reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Date: February 14, 2008                CHESAPEAKE PARTNERS MANAGEMENT CO., INC.


                                       By: /s/ Mark D. Lerner
                                           ----------------------------
                                       Name:  Mark D. Lerner
                                       Title: Vice President



Date: February 14, 2008                MARK D. LERNER


                                       /s/ Mark D. Lerner
                                       --------------------------------



Date: February 14, 2008                TRACI LERNER


                                       /s/ Traci Lerner
                                       --------------------------------


                                                               Page 8 of 9 Pages

                                  EXHIBIT INDEX


Ex.                                                                    Page No.
---                                                                    --------

A.  Joint  Filing  Agreement,  dated February 14, 2008 by and
    among  Chesapeake Partners Management Co., Inc., Mark D. Lerner
    and Traci Lerner...............................................      9




                                                               Page 9 of 9 Pages



                                   EXHIBIT A

                            JOINT FILING AGREEMENT

      The  undersigned  hereby  agree that the  statement  on Schedule  13G with
respect to the Common Stock of  Theravance,  Inc.  dated as of February 14, 2008
is, and any amendments thereto (including  amendments on Schedule 13D) signed by
each of the undersigned  shall be, filed on behalf of each of us pursuant to and
in accordance with the provisions of Rule 13d-1(k) under the Securities Exchange
Act of 1934, as amended.

Date: February 14, 2008                 CHESAPEAKE PARTNERS MANAGEMENT CO., INC.


                                        By: /s/ Mark D. Lerner
                                           --------------------
                                        Name: Mark D. Lerner
                                        Title:   Vice President



Date: February 14, 2008                 MARK D. LERNER

                                        /s/ Mark D. Lerner
                                        -----------------------




Date: February 14, 2008                 TRACI LERNER

                                        /s/ Traci Lerner
                                        -----------------------