Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0104
Expires: January 31, 2005
Estimated average burden hours per response... 0.5

(Print or Type Responses)
1. Name and Address of Reporting Person *
  KIRBY PAMELA J
 2. Date of Event Requiring Statement (Month/Day/Year)
05/02/2014		 3. Issuer Name and Ticker or Trading Symbol
SCYNEXIS INC [SCYX]
(Last)
(First)
(Middle)
C/O SCYNEXIS, INC.,, 3501 C TRICENTER BOULEVARD		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

DURHAM, NC 27713		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Common Stock Warrant (right to buy) 01/31/2014 01/30/2019 Common Stock 12,745 $ 0.2 D  
Series D-2 Preferred Stock 12/11/2013   (1) Common Stock 12,745 (1) $ (1) D  
Stock Option (right to buy) 01/13/2006 01/12/2015 Common Stock 735 $ 20.4 D  
Stock Option (right to buy) 10/20/2009 10/19/2015 Common Stock 4,313 $ 20.4 D  
Stock Option (right to buy) 07/19/2008 07/18/2017 Common Stock 490 $ 20.4 D  
Stock Option (right to buy) 04/18/2009 04/17/2018 Common Stock 1,470 $ 20.4 D  
Stock Option (right to buy) 04/23/2010 04/22/2019 Common Stock 1,470 $ 25.5 D  
Stock Option (right to buy) 07/15/2011 07/14/2020 Common Stock 1,470 $ 25.91 D  
Stock Option (right to buy) 04/21/2012 04/20/2021 Common Stock 1,715 $ 30.6 D  
Stock Option (right to buy) 04/20/2013 07/11/2022 Common Stock 1,715 $ 24.48 D  
Stock Option (right to buy) 04/21/2014 12/19/2023 Common Stock 1,715 $ 55.08 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
KIRBY PAMELA J
C/O SCYNEXIS, INC.,
3501 C TRICENTER BOULEVARD
DURHAM, NC 27713		   X      

Signatures

/s/ Eileen Pruette, by power of attorney 05/02/2014
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The Series D-2 Preferred Stock is convertible into Common Stock of the Issuer on a 1-for-20.4 basis at any time at the holder's election, and automatically upon the closing of the Issuer's initial public offering, and has no expiration date.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, See Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.